Corynebacterium glutamicum genes encoding novel proteins

ABSTRACT

Isolated nucleic acid molecules, designated MCP nucleic acid molecules, which encode novel MCP proteins from  Corynebacterium glutamicum  are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCP proteins, mutated MCP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from  C. glutamicum  based on genetic engineering of MCP genes in this organism.

RELATED APPLICATIONS

This application is a continuation of U.S. application Ser. No. 09/605,703, filed Jun. 27, 2000, which claims priority to U.S. Provisional Patent Application Ser. No. 60/142,764, filed Jul. 8, 1999, and U.S. Provisional Patent Application Ser. No. 60/152,318, filed Sep. 3, 1999. The entire contents of these aforementioned applications are hereby expressly incorporated herein by reference.

INCORPORATION OF MATERIAL SUBMITTED ON COMPACT DISKS

This application incorporates herein by reference the material contained on the compact disks submitted herewith as part of this application. Specifically, the file “seqlist.txt” (8.19 MB) contained on each of Copy 1, Copy 2 and the CFR copy of the Sequence Listing is hereby incorporated herein by reference. In addition the files “Appendix A.txt” (1.34 MB) and “Appendix B.txt” (481 KB) contained on the compact disks entitled “Appendices Copy 1” and “Appendices Copy 2” are hereby incorporated herein by reference. Each of these files were created on Mar. 28, 2005. LENGTHY TABLES FILED ON CD The patent application contains a lengthy table section. A copy of the table is available in electronic form from the USPTO web site (http://seqdata.uspto.gov/?pageRequest=docDetail&DocID=US20070042474A1). An electronic copy of the table will also be available from the USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3).

BACKGROUND OF THE INVENTION

Certain products and by-products of naturally-occurring metabolic processes in cells have utility in a wide array of industries, including the food, feed, cosmetics, and pharmaceutical industries. These molecules, collectively termed ‘fine chemicals’, include organic acids, both proteinogenic and non-proteinogenic amino acids, nucleotides and nucleosides, lipids and fatty acids, diols, carbohydrates, aromatic compounds, vitamins and cofactors, and enzymes. Their production is most conveniently performed through the large-scale culture of bacteria developed to produce and secrete large quantities of one or more desired molecules. One particularly useful organism for this purpose is Corynebacterium glutamicum, a gram positive, nonpathogenic bacterium. Through strain selection, a number of mutant strains have been developed which produce an array of desirable compounds. However, selection of strains improved for the production of a particular molecule is a time-consuming and difficult process.

SUMMARY OF THE INVENTION

The invention provides novel bacterial nucleic acid molecules which have a variety of uses. These uses include the identification of microorganisms which can be used to produce fine chemicals, the modulation of fine chemical production in C. glutamicum or related bacteria, the typing or identification of C. glutamicum or related bacteria, as reference points for mapping the C. glutamicum genome, and as markers for transformation. These novel nucleic acid molecules encode proteins, referred to herein as marker and fine chemical production (MCP) proteins.

C. glutamicum is a gram positive, aerobic bacterium which is commonly used in industry for the large-scale production of a variety of fine chemicals, and also for the degradation of hydrocarbons (such as in petroleum spills) and for the oxidation of terpenoids. The MCP nucleic acid molecules of the invention, therefore, can be used to identify microorganisms which can be used to produce fine chemicals, e.g., by fermentation processes. Modulation of the expression of the MCP nucleic acids of the invention, or modification of the sequence of the MCP nucleic acid molecules of the invention, can be used to modulate the production of one or more fine chemicals from a microorganism (e.g., to improve the yield or production of one or more fine chemicals from a Corynebacterium or Brevibacterium species).

The MCP nucleic acids of the invention may also be used to identify an organism as being Corynebacterium glutamicum or a close relative thereof, or to identify the presence of C. glutamicum or a relative thereof in a mixed population of microorganisms. The invention provides the nucleic acid sequences of a number of C. glutamicum genes; by probing the extracted genomic DNA of a culture of a unique or mixed population of microorganisms under stringent conditions with a probe spanning a region of a C. glutamicum gene which is unique to this organism, one can ascertain whether this organism is present. Although Corynebacterium glutamicum itself is nonpathogenic, it is related to species pathogenic in humans, such as Corynebacterium diphtheriae (the causative agent of diphtheria); the detection of such organisms is of significant clinical relevance.

The MCP nucleic acid molecules of the invention may also serve as reference points for mapping of the C. glutamicum genome, or of genomes of related organisms. Similarly, these molecules, or variants or portions thereof, may serve as markers for genetically engineered Corynebacterium or Brevibacterium species.

The MCP proteins encoded by the novel nucleic acid molecules of the invention may be involved, for example, in the direct or indirect production of one or more fine chemicals from C. glutamicum. The MCP proteins of the invention may also participate in the degradation of hydrocarbons or the oxidation of terpenoids. These proteins may also be utilized for the identification of Corynebacterium glutamicum or organisms related to C. glutamicum; the presence of an MCP protein specific to C. glutamicum and related species in a mixture of proteins may indicate the presence of one of these bacteria in the sample. Further, these MCP proteins may have homologues in plants or animals which are involved in a disease state or condition; these proteins thus may serve as useful pharmaceutical targets for drug screening and the development of therapeutic compounds.

Given the availability of cloning vectors for use in Corynebacterium glutamicum, such as those disclosed in Sinskey et al., U.S. Pat. No. 4,649,119, and techniques for genetic manipulation of C. glutamicum and the related Brevibacterium species (e.g., lactofermentum) (Yoshihama et al, J. Bacteriol. 162: 591-597 (1985); Katsumata et al., J. Bacteriol. 159: 306-311 (1984); and Santamaria et al., J. Gen. Microbiol. 130: 2237-2246 (1984)), the nucleic acid molecules of the invention may be utilized in the genetic engineering of this organism to modulate the production of one or more fine chemicals. This modulation may be due to a direct effect of manipulation of a gene of the invention, or it may be due to an indirect effect of such manipulation. For example, by modifying the activity of a protein involved in the biosynthesis or degradation of a fine chemical (i.e., through mutagenesis of the corresponding gene), one may directly modulate the ability of the cell to synthesize or to degrade this compound, thereby modulating the yield and/or efficiency of production of the fine chemical. Similarly, by modulating the activity of a protein which regulates a fine chemical metabolic pathway, one may directly influence whether the production of the desired compound is up- or down-regulated, either of which will modulate the yield or efficiency of production of the fine chemical from the cell.

Indirect modulation of fine chemical production may also result by modifying the activity of a protein of the invention (i.e., by mutagenesis of the corresponding gene) such that the overall ability of the cell to grow and divide or to remain viable and productive is increased. The production of fine chemicals from C. glutamicum is generally accomplished by the large-scale fermentative culture of these microorganisms, conditions which are frequently suboptimal for growth and cell division. By engineering a protein of the invention (e.g., a stress response protein, a cell wall protein, or proteins involved in the metabolism of compounds necessary for cell growth and division to occur, such as nucleotides and amino acids) such that it is better able to survive, grow, and multiply in such conditions, it may be possible to increase the number and productivity of such engineered C. glutamicum cells in large-scale culture, which in turn should result in increased yields and/or efficiency of production of one or more desired fine chemicals. Further, the metabolic pathways of any cell are necessarily interrelated and coregulated. By altering the activity or regulation of any one metabolic pathway in C. glutamicum (i.e., by altering the activity of one of the proteins of the invention which participates in such a pathway), it is possible to concomitantly alter the activity or regulation of other metabolic pathways in this microorganism, which may be directly involved in the synthesis or degradation of a fine chemical.

The invention provides novel nucleic acid molecules which encode proteins, referred to herein as MCP proteins, which are capable of, for example, modulating the production or efficiency of production of one or more fine chemicals from C. glutamicum, or of serving as identifying markers for C. glutamicum or related organisms. Nucleic acid molecules encoding an MCP protein are referred to herein as MCP nucleic acid molecules. In a preferred embodiment, the MCP protein is capable of modulating the production or efficiency of production of one or more fine chemicals from C. glutamicum, or of serving as identifying markers for C. glutamicum or related organisms. Examples of such proteins include those encoded by the genes set forth in Table 1.

Accordingly, one aspect of the invention pertains to isolated nucleic acid molecules (e.g., cDNAs, DNAs, or RNAs) comprising a nucleotide sequence encoding an MCP protein or biologically active portions thereof, as well as nucleic acid fragments suitable as primers or hybridization probes for the detection or amplification of MCP-encoding nucleic acid (e.g., DNA or mRNA). In particularly preferred embodiments, the isolated nucleic acid molecule comprises one of the nucleotide sequences set forth in Appendix A or the coding region or a complement thereof of one of these nucleotide sequences. In other particularly preferred embodiments, the isolated nucleic acid molecule of the invention comprises a nucleotide sequence which hybridizes to or is at least about 50%, preferably at least about 60%, more preferably at least about 70%, 80% or 90%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more homologous to a nucleotide sequence set forth in Appendix A, or a portion thereof. In other preferred embodiments, the isolated nucleic acid molecule encodes one of the amino acid sequences set forth in Appendix B. The preferred MCP proteins of the present invention also preferably possess at least one of the MCP activities described herein.

In another embodiment, the isolated nucleic acid molecule encodes a protein or portion thereof wherein the protein or portion thereof includes an amino acid sequence which is sufficiently homologous to an amino acid sequence of Appendix B, e.g., sufficiently homologous to an amino acid sequence of Appendix B such that the protein or portion thereof maintains an MCP activity. Preferably, the protein or portion thereof encoded by the nucleic acid molecule maintains the ability to modulate the production or efficiency of production of one or more fine chemicals from C. glutamicum, or of serving as an identifying marker for C. glutamicum or related organisms. In one embodiment, the protein encoded by the nucleic acid molecule is at least about 50%, preferably at least about 60%, and more preferably at least about 70%, 80%, or 90% and most preferably at least about 95%, 96%, 97%, 98%, or 99% or more homologous to an amino acid sequence of Appendix B (e.g., an entire amino acid sequence selected from those sequences set forth in Appendix B). In another preferred embodiment, the protein is a full length C. glutamicum protein which is substantially homologous to an entire amino acid sequence of Appendix B (encoded by an open reading frame shown in Appendix A).

In another preferred embodiment, the isolated nucleic acid molecule is derived from C. glutamicum and encodes a protein (e.g., an MCP fusion protein) which includes a biologically active domain which is at least about 50% or more homologous to one of the amino acid sequences of Appendix B and is able to modulate the yield, production, and/or efficiency of production of one or more fine chemicals from C. glutamicum, to degrade hydrocarbons, to oxidize terpenoids, to serve as a target for drug development, or to serve as an identifying marker for C. glutamicum or related organisms, and which also includes heterologous nucleic acid sequences encoding a heterologous polypeptide or regulatory regions.

In another embodiment, the isolated nucleic acid molecule is at least 15 nucleotides in length and hybridizes under stringent conditions to a nucleic acid molecule comprising a nucleotide sequence of Appendix A. Preferably, the isolated nucleic acid molecule corresponds to a naturally-occurring nucleic acid molecule. More preferably, the isolated nucleic acid encodes a naturally-occurring C. glutamicum MCP protein, or a biologically active portion thereof.

Another aspect of the invention pertains to vectors, e.g., recombinant expression vectors, containing the nucleic acid molecules of the invention, and host cells into which such vectors have been introduced. In one embodiment, such a host cell is used to produce an MCP protein by culturing the host cell in a suitable medium. The MCP protein can then be isolated from the medium or the host cell.

Yet another aspect of the invention pertains to a genetically altered microorganism in which an MCP gene has been introduced or altered. In one embodiment, the genome of the microorganism has been altered by introduction of a nucleic acid molecule of the invention encoding wild-type or mutated MCP sequence as a transgene. In another embodiment, an endogenous MCP gene within the genome of the microorganism has been altered, e.g., functionally disrupted, by homologous recombination with an altered MCP gene. In another embodiment, an endogenous or introduced MCP gene in a microorganism has been altered by one or more point mutations, deletions, or inversions, but still encodes a functional MCP protein. In still another embodiment, one or more of the regulatory regions (e.g., a promoter, repressor, or inducer) of an MCP gene in a microorganism has been altered (e.g., by deletion, truncation, inversion, or point mutation) such that the expression of the MCP gene is modulated. In a preferred embodiment, the microorganism belongs to the genus Corynebacterium or Brevibacterium, with Corynebacterium glutamicum being particularly preferred. In a preferred embodiment, the microorganism is also utilized for the production of a desired compound, such as an amino acid, with lysine being particularly preferred.

In another aspect, the invention provides a method of identifying the presence or activity of Corynebacterium diphtheriae in a subject. This method includes detection of one or more of the nucleic acid or amino acid sequences of the invention (e.g., the sequences set forth in Appendix A or Appendix B) in a subject, thereby detecting the presence or activity of Corynebacterium diphtheriae in the subject.

Still another aspect of the invention pertains to an isolated MCP protein or a portion, e.g., a biologically active portion, thereof. In a preferred embodiment, the isolated MCP protein or portion thereof is capable of modulating the production or efficiency of production of one or more fine chemicals from C. glutamicum, or of serving as an identifying marker for C. glutamicum or related organisms. In another preferred embodiment, the isolated MCP protein or portion thereof is sufficiently homologous to an amino acid sequence of Appendix B such that the protein or portion thereof maintains the ability to, for example, modulate the production or efficiency of production of one or more fine chemicals from C. glutamicum, or to serve as identifying markers for C. glutamicum or related organisms.

The invention also provides an isolated preparation of an MCP protein. In preferred embodiments, the MCP protein comprises an amino acid sequence of Appendix B. In another preferred embodiment, the invention pertains to an isolated full length protein which is substantially homologous to an entire amino acid sequence of Appendix B (encoded by an open reading frame set forth in Appendix A). In yet another embodiment, the protein is at least about 50%, preferably at least about 60%, and more preferably at least about 70%, 80%, or 90%, and most preferably at least about 95%, 96%, 97%, 98%, or 99% or more homologous to an entire amino acid sequence of Appendix B. In other embodiments, the isolated MCP protein comprises an amino acid sequence which is at least about 50% or more homologous to one of the amino acid sequences of Appendix B and is able to modulate the yield, production, and/or efficiency of production of one or more fine chemicals from C. glutamicum, to degrade hydrocarbons, to oxidize terpenoids, to serve as a target for drug development, or to serve as an identifying marker for C. glutamicum or related organisms.

Alternatively, the isolated MCP protein can comprise an amino acid sequence which is encoded by a nucleotide sequence which hybridizes, e.g., hybridizes under stringent conditions, or is at least about 50%, preferably at least about 60%, more preferably at least about 70%, 80%, or 90%, and even more preferably at least about 95%, 96%, 97%, 98,%, or 99% or more homologous, to a nucleotide sequence of Appendix B. It is also preferred that the preferred forms of MCP proteins also have one or more of the MCP bioactivities described herein.

The MCP polypeptide, or a biologically active portion thereof, can be operatively linked to a non-MCP polypeptide to form a fusion protein. In preferred embodiments, this fusion protein has an activity which differs from that of the MCP protein alone. In other preferred embodiments, this fusion protein is capable of modulating the yield, production and/or efficiency of production of one or more fine chemicals from C. glutamicum, or of serving as an identifying marker for C. glutamicum or related organisms. In particularly preferred embodiments, integration of this fusion protein into a host cell modulates production of a desired compound from the cell.

In another aspect, the invention provides methods for screening molecules which modulate the activity of an MCP protein, either by interacting with the protein itself or a substrate or binding partner of the MCP protein, or by modulating the transcription or translation of an MCP nucleic acid molecule of the invention.

Another aspect of the invention pertains to a method for producing a fine chemical. This method involves the culturing of a cell containing a vector directing the expression of an MCP nucleic acid molecule of the invention, such that a fine chemical is produced. In a preferred embodiment, this method further includes the step of obtaining a cell containing such a vector, in which a cell is transfected with a vector directing the expression of an MCP nucleic acid. In another preferred embodiment, this method further includes the step of recovering the fine chemical from the culture. In a particularly preferred embodiment, the cell is from the genus Corynebacterium or Brevibacterium, or is selected from those strains set forth in Table 3.

Another aspect of the invention pertains to methods for modulating production of a molecule from a microorganism. Such methods include contacting the cell with an agent which modulates MCP protein activity or MCP nucleic acid expression such that a cell associated activity is altered relative to this same activity in the absence of the agent. In a preferred embodiment, the cell is modulated for one or more C. glutamicum MCP protein activities, such that the yield, production, and/or efficiency of production of a desired fine chemical by this microorganism is improved. The agent which modulates MCP protein activity can be an agent which stimulates MCP protein activity or MCP nucleic acid expression. Examples of agents which stimulate MCP protein activity or MCP nucleic acid expression include small molecules, active MCP proteins, and nucleic acids encoding MCP proteins that have been introduced into the cell. Examples of agents which inhibit MCP activity or expression include small molecules and antisense MCP nucleic acid molecules.

Another aspect of the invention pertains to methods for modulating yields, production, and/or efficiency of production of a desired compound from a cell, involving the introduction of a wild-type or mutant MCP gene into a cell, either maintained on a separate plasmid or integrated into the genome of the host cell. If integrated into the genome, such integration can be random, or it can take place by homologous recombination such that the native gene is replaced by the introduced copy, causing the production of the desired compound from the cell to be modulated. In a preferred embodiment, said yields are increased. In another preferred embodiment, said chemical is a fine chemical. In a particularly preferred embodiment, said fine chemical is an amino acid. In especially preferred embodiments, said amino acid is L-lysine.

DETAILED DESCRIPTION OF THE INVENTION

The present invention provides MCP nucleic acid and protein molecules. These MCP nucleic acid molecules may be utilized in the identification of Corynebacterium glutamicum or related organisms, in the mapping of the C. glutamicum genome (or a genome of a closely related organism), or in the identification of microorganisms which may be used to produce fine chemicals, e.g., by fermentation processes. The proteins encoded by these nucleic acids may be utilized in the direct or indirect modulation of the production or efficiency of production of one or more fine chemicals from C. glutamicum, as identifying markers for C. glutamicum or related organisms, in the oxidation of terpenoids or the degradation of hydrocarbons, or as targets for the development of therapeutic pharmaceutical compounds. Aspects of the invention are further explicated below.

I. Fine Chemicals

The term ‘fine chemical’ is art-recognized and includes molecules produced by an organism which have applications in various industries, such as, but not limited to, the pharmaceutical, agriculture, and cosmetics industries. Such compounds include organic acids, such as tartaric acid, itaconic acid, and diaminopimelic acid, both proteinogenic and non-proteinogenic amino acids, purine and pyrimidine bases, nucleosides, and nucleotides (as described e.g. in Kuninaka, A. (1996) Nucleotides and related compounds, p. 561-612, in Biotechnology vol. 6, Rehm et al., eds. VCH: Weinheim, and references contained therein), lipids, both saturated and unsaturated fatty acids (e.g., arachidonic acid), diols (e.g., propane diol, and butane diol), carbohydrates (e.g., hyaluronic acid and trehalose), aromatic compounds (e.g., aromatic amines, vanillin, and indigo), vitamins and cofactors (as described in Ullmann's Encyclopedia of Industrial Chemistry, vol. A27, “Vitamins”, p. 443-613 (1996) VCH: Weinheim and references therein; and Ong, A. S., Niki, E. & Packer, L. (1995) “Nutrition, Lipids, Health, and Disease” Proceedings of the UNESCO/Confederation of Scientific and Technological Associations in Malaysia, and the Society for Free Radical Research—Asia, held Sep. 1-3, 1994 at Penang, Malaysia, AOCS Press, (1995)), enzymes, polyketides (Cane et al. (1998) Science 282: 63-68), and all other chemicals described in Gutcho (1983) Chemicals by Fermentation, Noyes Data Corporation, ISBN: 0818805086 and references therein. The metabolism and uses of certain of these fine chemicals are further explicated below.

A. Amino Acid Metabolism and Uses

Amino acids comprise the basic structural units of all proteins, and as such are essential for normal cellular functioning in all organisms. The term “amino acid” is art-recognized. The proteinogenic amino acids, of which there are 20 species, serve as structural units for proteins, in which they are linked by peptide bonds, while the nonproteinogenic amino acids (hundreds of which are known) are not normally found in proteins (see Ulmann's Encyclopedia of Industrial Chemistry, vol. A2, p. 57-97 VCH: Weinheim (1985)). Amino acids may be in the D- or L-optical configuration, though L-amino acids are generally the only type found in naturally-occurring proteins. Biosynthetic and degradative pathways of each of the 20 proteinogenic amino acids have been well characterized in both prokaryotic and eukaryotic cells (see, for example, Stryer, L. Biochemistry, 3^(rd) edition, pages 578-590 (1988)). The ‘essential’ amino acids (histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine), so named because they are generally a nutritional requirement due to the complexity of their biosyntheses, are readily converted by simple biosynthetic pathways to the remaining 11 ‘nonessential’ amino acids (alanine, arginine, asparagine, aspartate, cysteine, glutamate, glutamine, glycine, proline, serine, and tyrosine). Higher animals do retain the ability to synthesize some of these amino acids, but the essential amino acids must be supplied from the diet in order for normal protein synthesis to occur.

Aside from their function in protein biosynthesis, these amino acids are interesting chemicals in their own right, and many have been found to have various applications in the food, feed, chemical, cosmetics, agriculture, and pharmaceutical industries. Lysine is an important amino acid in the nutrition not only of humans, but also of monogastric animals such as poultry and swine. Glutamate is most commonly used as a flavor additive (mono-sodium glutamate, MSG) and is widely used throughout the food industry, as are aspartate, phenylalanine, glycine, and cysteine. Glycine, L-methionine and tryptophan are all utilized in the pharmaceutical industry. Glutamine, valine, leucine, isoleucine, histidine, arginine, proline, serine and alanine are of use in both the pharmaceutical and cosmetics industries. Threonine, tryptophan, and D/L-methionine are common feed additives. (Leuchtenberger, W. (1996) Amino aids—technical production and use, p. 466-502 in Rehm et al. (eds.) Biotechnology vol. 6, chapter 14a, VCH: Weinheim). Additionally, these amino acids have been found to be useful as precursors for the synthesis of synthetic amino acids and proteins, such as N-acetylcysteine, S-carboxymethyl-L-cysteine, (S)-5-hydroxytryptophan, and others described in Ulmann's Encyclopedia of Industrial Chemistry, vol. A2, p. 57-97, VCH: Weinheim, 1985.

The biosynthesis of these natural amino acids in organisms capable of producing them, such as bacteria, has been well characterized (for review of bacterial amino acid biosynthesis and regulation thereof, see Umbarger, H. E. (1978) Ann. Rev. Biochem. 47: 533-606). Glutamate is synthesized by the reductive amination of α-ketoglutarate, an intermediate in the citric acid cycle. Glutamine, proline, and arginine are each subsequently produced from glutamate. The biosynthesis of serine is a three-step process beginning with 3-phosphoglycerate (an intermediate in glycolysis), and resulting in this amino acid after oxidation, transamination, and hydrolysis steps. Both cysteine and glycine are produced from serine; the former by the condensation of homocysteine with serine, and the latter by the transferal of the side-chain β-carbon atom to tetrahydrofolate, in a reaction catalyzed by serine transhydroxymethylase. Phenylalanine, and tyrosine are synthesized from the glycolytic and pentose phosphate pathway precursors erythrose 4-phosphate and phosphoenolpyruvate in a 9-step biosynthetic pathway that differ only at the final two steps after synthesis of prephenate. Tryptophan is also produced from these two initial molecules, but its synthesis is an 11-step pathway. Tyrosine may also be synthesized from phenylalanine, in a reaction catalyzed by phenylalanine hydroxylase. Alanine, valine, and leucine are all biosynthetic products of pyruvate, the final product of glycolysis. Aspartate is formed from oxaloacetate, an intermediate of the citric acid cycle. Asparagine, methionine, threonine, and lysine are each produced by the conversion of aspartate. Isoleucine is formed from threonine. A complex 9-step pathway results in the production of histidine from 5-phosphoribosyl-1-pyrophosphate, an activated sugar.

Amino acids in excess of the protein synthesis needs of the cell cannot be stored, and are instead degraded to provide intermediates for the major metabolic pathways of the cell (for review see Stryer, L. Biochemistry 3^(rd) ed. Ch. 21 “Amino Acid Degradation and the Urea Cycle” p. 495-516 (1988)). Although the cell is able to convert unwanted amino acids into useful metabolic intermediates, amino acid production is costly in terms of energy, precursor molecules, and the enzymes necessary to synthesize them. Thus it is not surprising that amino acid biosynthesis is regulated by feedback inhibition, in which the presence of a particular amino acid serves to slow or entirely stop its own production (for overview of feedback mechanisms in amino acid biosynthetic pathways, see Stryer, L. Biochemistry, 3^(rd) ed. Ch. 24: “Biosynthesis of Amino Acids and Heme” p. 575-600 (1988)). Thus, the output of any particular amino acid is limited by the amount of that amino acid present in the cell.

B. Vitamin, Cofactor, and Nutraceutical Metabolism and Uses

Vitamins, cofactors, and nutraceuticals comprise another group of molecules which the higher animals have lost the ability to synthesize and so must ingest, although they are readily synthesized by other organisms such as bacteria. These molecules are either bioactive substances themselves, or are precursors of biologically active substances which may serve as electron carriers or intermediates in a variety of metabolic pathways. Aside from their nutritive value, these compounds also have significant industrial value as coloring agents, antioxidants, and catalysts or other processing aids. (For an overview of the structure, activity, and industrial applications of these compounds, see, for example, Ullman's Encyclopedia of Industrial Chemistry, “Vitamins” vol. A27, p. 443-613, VCH: Weinheim, 1996.) The term “vitamin” is art-recognized, and includes nutrients which are required by an organism for normal functioning, but which that organism cannot synthesize by itself. The group of vitamins may encompass cofactors and nutraceutical compounds. The language “cofactor” includes nonproteinaceous compounds required for a normal enzymatic activity to occur. Such compounds may be organic or inorganic; the cofactor molecules of the invention are preferably organic. The term “nutraceutical” includes dietary supplements having health benefits in plants and animals, particularly humans. Examples of such molecules are vitamins, antioxidants, and also certain lipids (e.g., polyunsaturated fatty acids).

The biosynthesis of these molecules in organisms capable of producing them, such as bacteria, has been largely characterized (Ullman's Encyclopedia of Industrial Chemistry, “Vitamins” vol. A27, p. 443-613, VCH: Weinheim, 1996; Michal, G. (1999) Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, John Wiley & Sons; Ong, A. S., Niki, E. & Packer, L. (1995) “Nutrition, Lipids, Health, and Disease” Proceedings of the UNESCO/Confederation of Scientific and Technological Associations in Malaysia, and the Society for Free Radical Research—Asia, held Sep. 1-3, 1994 at Penang, Malaysia, AOCS Press: Champaign, Ill. X, 374 S).

Thiamin (vitamin B₁) is produced by the chemical coupling of pyrimidine and thiazole moieties. Riboflavin (vitamin B₂) is synthesized from guanosine-5′-triphosphate (GTP) and ribose-5′-phosphate. Riboflavin, in turn, is utilized for the synthesis of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). The family of compounds collectively termed ‘vitamin B₆’ (e.g., pyridoxine, pyridoxamine, pyridoxa-5′-phosphate, and the commercially used pyridoxin hydrochloride) are all derivatives of the common structural unit, 5-hydroxy-6-methylpyridine. Pantothenate (pantothenic acid, (R)-(+)-N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-O-alanine) can be produced either by chemical synthesis or by fermentation. The final steps in pantothenate biosynthesis consist of the ATP-driven condensation of O-alanine and pantoic acid. The enzymes responsible for the biosynthesis steps for the conversion to pantoic acid, to β-alanine and for the condensation to panthotenic acid are known. The metabolically active form of pantothenate is Coenzyme A, for which the biosynthesis proceeds in 5 enzymatic steps. Pantothenate, pyridoxal-5′-phosphate, cysteine and ATP are the precursors of Coenzyme A. These enzymes not only catalyze the formation of panthothante, but also the production of (R)-pantoic acid, (R)-pantolacton, (R)-panthenol (provitamin B₅), pantetheine (and its derivatives) and coenzyme A.

Biotin biosynthesis from the precursor molecule pimeloyl-CoA in microorganisms has been studied in detail and several of the genes involved have been identified. Many of the corresponding proteins have been found to also be involved in Fe-cluster synthesis and are members of the nifS class of proteins. Lipoic acid is derived from octanoic acid, and serves as a coenzyme in energy metabolism, where it becomes part of the pyruvate dehydrogenase complex and the α-ketoglutarate dehydrogenase complex. The folates are a group of substances which are all derivatives of folic acid, which is turn is derived from L-glutamic acid, p-amino-benzoic acid and 6-methylpterin. The biosynthesis of folic acid and its derivatives, starting from the metabolism intermediates guanosine-5′-triphosphate (GTP), L-glutamic acid and p-amino-benzoic acid has been studied in detail in certain microorganisms.

Corrinoids (such as the cobalamines and particularly vitamin B₁₂) and porphyrines belong to a group of chemicals characterized by a tetrapyrole ring system. The biosynthesis of vitamin B₁₂ is sufficiently complex that it has not yet been completely characterized, but many of the enzymes and substrates involved are now known. Nicotinic acid (nicotinate), and nicotinamide are pyridine derivatives which are also termed ‘niacin’. Niacin is the precursor of the important coenzymes NAD (nicotinamide adenine dinucleotide) and NADP (nicotinamide adenine dinucleotide phosphate) and their reduced forms.

The large-scale production of these compounds has largely relied on cell-free chemical syntheses, though some of these chemicals have also been produced by large-scale culture of microorganisms, such as riboflavin, Vitamin B₆, pantothenate, and biotin. Only Vitamin B₁₂ is produced solely by fermentation, due to the complexity of its synthesis. In vitro methodologies require significant inputs of materials and time, often at great cost.

C. Purine, Pyrimidine, Nucleoside and Nucleotide Metabolism and Uses

Purine and pyrimidine metabolism genes and their corresponding proteins are important targets for the therapy of tumor diseases and viral infections. The language “purine” or “pyrimidine” includes the nitrogenous bases which are constituents of nucleic acids, co-enzymes, and nucleotides. The term “nucleotide” includes the basic structural units of nucleic acid molecules, which are comprised of a nitrogenous base, a pentose sugar (in the case of RNA, the sugar is ribose; in the case of DNA, the sugar is D-deoxyribose), and phosphoric acid. The language “nucleoside” includes molecules which serve as precursors to nucleotides, but which are lacking the phosphoric acid moiety that nucleotides possess. By inhibiting the biosynthesis of these molecules, or their mobilization to form nucleic acid molecules, it is possible to inhibit RNA and DNA synthesis; by inhibiting this activity in a fashion targeted to cancerous cells, the ability of tumor cells to divide and replicate may be inhibited. Additionally, there are nucleotides which may serve as energy stores (e.g., ADP, ATP) or as coenzymes (i.e., FAD and NAD).

Several publications have described the use of these chemicals for these medical indications, by influencing purine and/or pyrimidine metabolism (e.g. Christopherson, R. I. and Lyons, S. D. (1990) “Potent inhibitors of de novo pyrimidine and purine biosynthesis as chemotherapeutic agents.” Med. Res. Reviews 10: 505-548). Studies of enzymes involved in purine and pyrimidine metabolism have been focused on the development of new drugs which can be used, for example, as immunosuppressants or anti-proliferants (Smith, J. L., (1995) “Enzymes in nucleotide synthesis.” Curr. Opin. Struct. Biol. 5: 752-757; (1995) Biochem Soc. Transact. 23: 877-902). However, purine and pyrimidine bases, nucleosides and nucleotides have other utilities: as intermediates in the biosynthesis of several fine chemicals (e.g., thiamine, S-adenosyl-methionine, folates, or riboflavin), as energy carriers for the cell (e.g., ATP or GTP), and for chemicals themselves, commonly used as flavor enhancers (e.g., IMP or GMP) or for several medicinal applications (see, for example, Kuninaka, A. (1996) Nucleotides and Related Compounds in Biotechnology vol. 6, Rehm et al., eds. VCH: Weinheim, p. 561-612). Also, enzymes involved in purine, pyrimidine, nucleoside, or nucleotide metabolism are increasingly serving as targets against which chemicals for crop protection, including fungicides, herbicides and insecticides, are developed.

The metabolism of these compounds in bacteria has been characterized (for reviews see, for example, Zalkin, H. and Dixon, J. E. (1992) “de novo purine nucleotide biosynthesis”, in: Progress in Nucleic Acid Research and Molecular Biology, vol. 42, Academic Press: p. 259-287; and Michal, G. (1999) “Nucleotides and Nucleosides”, Chapter 8 in: Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, Wiley: New York). Purine metabolism has been the subject of intensive research, and is essential to the normal functioning of the cell. Impaired purine metabolism in higher animals can cause severe disease, such as gout. Purine nucleotides are synthesized from ribose-5-phosphate, in a series of steps through the intermediate compound inosine-5′-phosphate (IMP), resulting in the production of guanosine-5′-monophosphate (GMP) or adenosine-5′-monophosphate (AMP), from which the triphosphate forms utilized as nucleotides are readily formed. These compounds are also utilized as energy stores, so their degradation provides energy for many different biochemical processes in the cell. Pyrimidine biosynthesis proceeds by the formation of uridine-5′-monophosphate (UMP) from ribose-5-phosphate. UMP, in turn, is converted to cytidine-5′-triphosphate (CTP). The deoxy-forms of all of these nucleotides are produced in a one step reduction reaction from the diphosphate ribose form of the nucleotide to the diphosphate deoxyribose form of the nucleotide. Upon phosphorylation, these molecules are able to participate in DNA synthesis.

D. Trehalose Metabolism and Uses

Trehalose consists of two glucose molecules, bound in α,α-1,1 linkage. It is commonly used in the food industry as a sweetener, an additive for dried or frozen foods, and in beverages. However, it also has applications in the pharmaceutical, cosmetics and biotechnology industries (see, for example, Nishimoto et al., (1998) U.S. Pat. No. 5,759,610; Singer, M. A. and Lindquist, S. (1998) Trends Biotech. 16: 460-467; Paiva, C. L. A. and Panek, A. D. (1996) Biotech. Ann. Rev. 2: 293-314; and Shiosaka, M. (1997) J. Japan 172: 97-102). Trehalose is produced by enzymes from many microorganisms and is naturally released into the surrounding medium, from which it can be collected using methods known in the art.

II. Elements and Methods of the Invention

The present invention is based, at least in part, on the discovery of novel molecules, referred to herein as MCP nucleic acid molecules. These MCP nucleic acid molecules are useful not only for the identification of C. glutamicum or related bacterial species, but also as markers for the mapping of the C. glutamicum genome and in the identification of bacteria useful for the production of fine chemicals by, e.g., fermentative processes. The present invention is also based, at least in part, on the MCP protein molecules encoded by these MCP nucleic acid molecules. These MCP proteins are capable of modulating the yield, production, and/or efficiency of production of one or more fine chemicals from C. glutamicum, of serving as identifying markers for C. glutamicum or related organisms, of degrading hydrocarbons, and of serving as targets for the development of therapeutic pharmaceutical compounds. In one embodiment, the MCP molecules of the invention directly or indirectly participate in one or more fine chemical metabolic pathways in C. glutamicum. In a preferred embodiment, the activity of the MCP molecules of the invention to indirectly or directly participate in such metabolic pathways has an impact on the production of a desired fine chemical by this microorganism. In a particularly preferred embodiment, the MCP molecules of the invention are modulated in activity, such that the C. glutamicum metabolic pathways in which the MCP proteins of the invention participate are modulated in efficiency or output, which either directly or indirectly modulates the production or efficiency of production of a desired fine chemical by C. glutamicum.

The language, “MCP protein” or “MCP polypeptide” includes proteins which are able to modulate the yield, production, and/or efficiency of production of one or more fine chemicals from C. glutamicum, to degrade hydrocarbons, to oxidize terpenoids, to serve as a target protein for drug screening or design, or to serve as identifying markers for C. glutamicum or related organisms. Examples of MCP proteins include those encoded by the MCP genes set forth in Table 1 and Appendix A. The terms “MCP gene” or “MCP nucleic acid sequence” include nucleic acid sequences encoding an MCP protein, which consist of a coding region and also corresponding untranslated 5′ and 3′ sequence regions. Examples of MCP genes include those set forth in Table 1. The terms “production” or “productivity” are art-recognized and include the concentration of the fermentation product (for example, the desired fine chemical) formed within a given time and a given fermentation volume (e.g., kg product per hour per liter). The term “efficiency of production” includes the time required for a particular level of production to be achieved (for example, how long it takes for the cell to attain a particular rate of output of a fine chemical). The term “yield” or “product/carbon yield” is art-recognized and includes the efficiency of the conversion of the carbon source into the product (i.e., fine chemical). This is generally written as, for example, kg product per kg carbon source. By increasing the yield or production of the compound, the quantity of recovered molecules, or of useful recovered molecules of that compound in a given amount of culture over a given amount of time is increased. The terms “biosynthesis” or a “biosynthetic pathway” are art-recognized and include the synthesis of a compound, preferably an organic compound, by a cell from intermediate compounds in what may be a multistep and highly regulated process. The terms “degradation” or a “degradation pathway” are art-recognized and include the breakdown of a compound, preferably an organic compound, by a cell to degradation products (generally speaking, smaller or less complex molecules) in what may be a multistep and highly regulated process. The language “metabolism” is art-recognized and includes the totality of the biochemical reactions that take place in an organism. The metabolism of a particular compound, then, (e.g., the metabolism of an amino acid such as glycine) comprises the overall biosynthetic, modification, and degradation pathways in the cell related to this compound.

In another embodiment, the MCP molecules of the invention are capable of modulating the production of a desired molecule, such as a fine chemical, in a microorganism such as C. glutamicum, either directly or indirectly. Using recombinant genetic techniques, one or more of the MCP proteins of the invention may be manipulated such that its function is modulated. Such modulation of function may result in the modulation of the yield, production, and/or efficiency of production of one or more fine chemicals from C. glutamicum.

For example, by modifying the activity of a protein involved in the biosynthesis or degradation of a fine chemical (i.e., through mutagenesis of the corresponding gene), one may directly modulate the ability of the cell to synthesize or to degrade this compound, thereby modulating the yield and/or efficiency of production of the fine chemical. Similarly, by modulating the activity of a protein which regulates a fine chemical metabolic pathway, one may directly influence whether the production of the desired compound is up- or down-regulated, either of which will modulate the yield or efficiency of production of the fine chemical from the cell.

Indirect modulation of fine chemical production may also result by modifying the activity of a protein of the invention (i.e., by mutagenesis of the corresponding gene) such that the overall ability of the cell to grow and divide or to remain viable and productive is increased. The production of fine chemicals from C. glutamicum is generally accomplished by the large-scale fermentative culture of these microorganisms, conditions which are frequently suboptimal for growth and cell division. By engineering a protein of the invention (e.g., a stress response protein, a cell wall protein, or proteins involved in the metabolism of compounds necessary for cell growth and division to occur, such as nucleotides and amino acids) such that it is better able to survive, grow, and multiply in such conditions, it may be possible to increase the number and productivity of such engineered C. glutamicum cells in large-scale culture, which in turn should result in increased yields and/or efficiency of production of one or more desired fine chemicals. Further, the metabolic pathways of any cell are necessarily interrelated and coregulated. By altering the activity or regulation of any one metabolic pathway in C. glutamicum (i.e., by altering the activity of one of the proteins of the invention which participates in such a pathway), it is possible to concomitantly alter the activity or regulation of other metabolic pathways in this microorganism, which may be directly involved in the synthesis or degradation of a fine chemical.

The isolated nucleic acid sequences of the invention are contained within the genome of a Corynebacterium glutamicum strain available through the American Type Culture Collection, given designation ATCC 13032. The nucleotide sequences of the isolated C. glutamicum MCP nucleic acid molecules and the predicted amino acid sequences of the C. glutamicum MCP proteins are shown in Appendices A and B, respectively. Computational analyses were performed which classified and/or identified many of these nucleotide sequences as sequences having homology to E. coli or Bacillus subtilis genes.

The present invention also pertains to proteins which have an amino acid sequence which is substantially homologous to an amino acid sequence of Appendix B. As used herein, a protein which has an amino acid sequence which is substantially homologous to a selected amino acid sequence is least about 50% homologous to the selected amino acid sequence, e.g., the entire selected amino acid sequence. A protein which has an amino acid sequence which is substantially homologous to a selected amino acid sequence can also be least about 50-60%, preferably at least about 60-70%, and more preferably at least about 70-80%, 80-90%, or 90-95%, and most preferably at least about 96%, 97%, 98%, 99% or more homologous to the selected amino acid sequence.

The MCP protein or a biologically active portion or fragment thereof of the invention is able to modulate the yield, production, and/or efficiency of production of one or more fine chemicals from C. glutamicum, to degrade hydrocarbons, to oxidize terpenoids, to serve as a target for drug development, or to serve as an identifying marker for C. glutamicum or related organisms.

Various aspects of the invention are described in further detail in the following subsections:

A. Isolated Nucleic Acid Molecules

One aspect of the invention pertains to isolated nucleic acid molecules that encode MCP polypeptides or biologically active portions thereof, as well as nucleic acid fragments sufficient for use as hybridization probes or primers for the identification or amplification of MCP-encoding nucleic acid (e.g., MCP DNA). These nucleic acid molecules may be used to identify C. glutamicum or related organisms, to map the genome of C. glutamicum or closely related bacteria, or to identify microorganisms useful for the production of fine chemicals, e.g., by fermentative processes. As used herein, the term “nucleic acid molecule” is intended to include DNA molecules (e.g., cDNA or genomic DNA) and RNA molecules (e.g., mRNA) and analogs of the DNA or RNA generated using nucleotide analogs. This term also encompasses untranslated sequence located at both the 3′ and 5′ ends of the coding region of the gene: at least about 100 nucleotides of sequence upstream from the 5′ end of the coding region and at least about 20 nucleotides of sequence downstream from the 3′end of the coding region of the gene. The nucleic acid molecule can be single-stranded or double-stranded, but preferably is double-stranded DNA. An “isolated” nucleic acid molecule is one which is separated from other nucleic acid molecules which are present in the natural source of the nucleic acid. Preferably, an “isolated” nucleic acid is free of sequences which naturally flank the nucleic acid (i.e., sequences located at the 5′ and 3′ ends of the nucleic acid) in the genomic DNA of the organism from which the nucleic acid is derived. For example, in various embodiments, the isolated MCP nucleic acid molecule can contain less than about 5 kb, 4 kb, 3 kb, 2 kb, 1 kb, 0.5 kb or 0.1 kb of nucleotide sequences which naturally flank the nucleic acid molecule in genomic DNA of the cell from which the nucleic acid is derived (e.g, a C. glutamicum cell). Moreover, an “isolated” nucleic acid molecule, such as a DNA molecule, can be substantially free of other cellular material, or culture medium when produced by recombinant techniques, or chemical precursors or other chemicals when chemically synthesized.

A nucleic acid molecule of the present invention, e.g., a nucleic acid molecule having a nucleotide sequence of Appendix A, or a portion thereof, can be isolated using standard molecular biology techniques and the sequence information provided herein. For example, a C. glutamicum MCP DNA can be isolated from a C. glutamicum library using all or portion of one of the sequences of Appendix A as a hybridization probe and standard hybridization techniques (e.g., as described in Sambrook, J., Fritsh, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual. 2nd, ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989). Moreover, a nucleic acid molecule encompassing all or a portion of one of the sequences of Appendix A can be isolated by the polymerase chain reaction using oligonucleotide primers designed based upon this sequence (e.g., a nucleic acid molecule encompassing all or a portion of one of the sequences of Appendix A can be isolated by the polymerase chain reaction using oligonucleotide primers designed based upon this same sequence of Appendix A). For example, mRNA can be isolated from normal endothelial cells (e.g., by the guanidinium-thiocyanate extraction procedure of Chirgwin et al. (1979) Biochemistry 18: 5294-5299) and DNA can be prepared using reverse transcriptase (e.g., Moloney MLV reverse transcriptase, available from Gibco/BRL, Bethesda, Md.; or AMV reverse transcriptase, available from Seikagaku America, Inc., St. Petersburg, Fla.) and random polynucleotide primers or oligonucleotide primers based upon one of the nucleotide sequences shown in Appendix A. Synthetic oligonucleotide primers for polymerase chain reaction amplification can be designed based upon one of the nucleotide sequences shown in Appendix A. A nucleic acid of the invention can be amplified using cDNA or, alternatively, genomic DNA, as a template and appropriate oligonucleotide primers according to standard PCR amplification techniques. The nucleic acid so amplified can be cloned into an appropriate vector and characterized by DNA sequence analysis. Furthermore, oligonucleotides corresponding to an MCP nucleotide sequence can be prepared by standard synthetic techniques, e.g., using an automated DNA synthesizer.

In a preferred embodiment, an isolated nucleic acid molecule of the invention comprises one of the nucleotide sequences shown in Appendix A. The sequences of Appendix A correspond to the Corynebacterium glutamicum MCP DNAs of the invention. This cDNA comprises sequences encoding MCP proteins (i.e., the “coding region”, indicated in each sequence in Appendix A), as well as 5′ untranslated sequences and 3′ untranslated sequences, also indicated in Appendix A. Alternatively, the nucleic acid molecule can comprise only the coding region of any of the sequences in Appendix A.

For the purposes of this application, it will be understood that each of the sequences set forth in Appendix A has an identifying RXA or RXN number having the designation “RXA” or “RXN” followed by 5 digits (i.e., RXA00003 or RXN00022). Each of these sequences comprises up to three parts: a 5′ upstream region, a coding region, and a downstream region. Each of these three regions is identified by the same RXA or RXN designation to eliminate confusion. The recitation “one of the sequences in Appendix A”, then, refers to any of the sequences in Appendix A, which may be distinguished by their differing RXA or RXN designations. The coding region of each of these sequences is translated into a corresponding amino acid sequence, which is set forth in Appendix B. The sequences of Appendix B are identified by the same RXA or RXN designations as Appendix A, such that they can be readily correlated. For example, the amino acid sequence in Appendix B designated RXA00003 is a translation of the coding region of the nucleotide sequence of nucleic acid molecule RXA00003 in Appendix A, and the amino acid sequence in Appendix B designated RXN0022 is a translation of the coding region of the nucleotide sequence of nucleic acid molecule RXN0022 in Appendix A. Each of the RXA and RXN nucleotide and amino acid sequences of the invention has also been assigned a SEQ ID NO, as indicated in Table 1.

Several of the genes of the invention are “F-designated genes”. An F-designated gene includes those genes set forth in Table 1 which have an ‘F’ in front of the RXA designation. For example, SEQ ID NO:3, designated, as indicated on Table 1, as “F RXA01638”, is an F-designated gene, as are SEQ ID NOs: 5, 9, and 11 (designated on Table 1 as “F RXA01639”, “F RXA01590”, and “F RXA01542”, respectively).

In one embodiment, the nucleic acid molecules of the present invention are not intended to include those compiled in Table 2.

In another preferred embodiment, an isolated nucleic acid molecule of the invention comprises a nucleic acid molecule which is a complement of one of the nucleotide sequences shown in Appendix A, or a portion thereof. A nucleic acid molecule which is complementary to one of the nucleotide sequences shown in Appendix A is one which is sufficiently complementary to one of the nucleotide sequences shown in Appendix A such that it can hybridize to one of the nucleotide sequences shown in Appendix A, thereby forming a stable duplex.

In still another preferred embodiment, an isolated nucleic acid molecule of the invention comprises a nucleotide sequence which is at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more homologous to a nucleotide sequence shown in Appendix A, or a portion thereof. Ranges and identity values intermediate to the above-recited ranges, (e.g., 70-90% identical or 80-95% identical) are also intended to be encompassed by the present invention. For example, ranges of identity values using a combination of any of the above values recited as upper and/or lower limits are intended to be included. In an additional preferred embodiment, an isolated nucleic acid molecule of the invention comprises a nucleotide sequence which hybridizes, e.g., hybridizes under stringent conditions, to one of the nucleotide sequences shown in Appendix A, or a portion thereof.

Moreover, the nucleic acid molecule of the invention can comprise only a portion of the coding region of one of the sequences in Appendix A, for example a fragment which can be used as a probe or primer or a fragment encoding a biologically active portion of an MCP protein. The nucleotide sequences determined from the cloning of the MCP genes from C. glutamicum allows for the generation of probes and primers designed for use in identifying and/or cloning MCP homologues in other cell types and organisms, as well as MCP homologues from other Corynebacteria or related species. The probe/primer typically comprises substantially purified oligonucleotide. The oligonucleotide typically comprises a region of nucleotide sequence that hybridizes under stringent conditions to at least about 12, preferably about 25, more preferably about 40, 50 or 75 consecutive nucleotides of a sense strand of one of the sequences set forth in Appendix A, an anti-sense sequence of one of the sequences set forth in Appendix A, or naturally occurring mutants thereof. Primers based on a nucleotide sequence of Appendix A can be used in PCR reactions to clone MCP homologues. Probes based on the MCP nucleotide sequences can be used to detect transcripts or genomic sequences encoding the same or homologous proteins. In preferred embodiments, the probe further comprises a label group attached thereto, e.g. the label group can be a radioisotope, a fluorescent compound, an enzyme, or an enzyme co-factor. Such probes can be used as a part of a diagnostic test kit for identifying cells which misexpress an MCP protein, such as by measuring a level of an MCP-encoding nucleic acid in a sample of cells, e.g., detecting MCP mRNA levels or determining whether a genomic MCP gene has been mutated or deleted.

In one embodiment, the nucleic acid molecule of the invention encodes a protein or portion thereof which includes an amino acid sequence which is sufficiently homologous to an amino acid sequence of Appendix B such that the protein or portion thereof maintains the ability to modulate the yield, production, and/or efficiency of production of one or more fine chemicals from C. glutamicum, to degrade hydrocarbons, to oxidize terpenoids, to serve as a target for drug development, or to serve as an identifying marker for C. glutamicum or related organisms. As used herein, the language “sufficiently homologous” refers to proteins or portions thereof which have amino acid sequences which include a minimum number of identical or equivalent (e.g., an amino acid residue which has a similar side chain as an amino acid residue in one of the sequences of Appendix B) amino acid residues to an amino acid sequence of Appendix B such that the protein or portion thereof is able to modulate the yield, production, and/or efficiency of production of one or more fine chemicals from C. glutamicum, to degrade hydrocarbons, to oxidize terpenoids, to serve as a target for drug development, or to serve as an identifying marker for C. glutamicum or related organisms. Examples of such activities are also described herein. Thus, “the function of an MCP protein” contributes to the overall regulation of one or more fine chemical metabolic pathways, or to the degradation of a hydrocarbon, or to the oxidation of a terpenoid.

In another embodiment, the protein is at least about 50-60%, preferably at least about 60-70%, and more preferably at least about 70-80%, 80-90%, 90-95%, and most preferably at least about 96%, 97%, 98%, 99% or more homologous to an entire amino acid sequence of Appendix B.

Portions of proteins encoded by the MCP nucleic acid molecules of the invention are preferably biologically active portions of one of the MCP proteins. As used herein, the term “biologically active portion of an MCP protein” is intended to include a portion, e.g., a domain/motif, of an MCP protein that modulates the yield, production, and/or efficiency of production of one or more fine chemicals from C. glutamicum, that degrades hydrocarbons, that oxidizes terpenoids, that may serve as a target for drug development, or that may serve as an identifying marker for C. glutamicum or related organisms. To determine whether an MCP protein or a biologically active portion thereof can modulate the yield, production, and/or efficiency of production of one or more fine chemicals from C. glutamicum, can degrade hydrocarbons, or can oxidize terpenoids, an assay of activity may be performed. Such assay methods are well known to those of ordinary skill in the art, as detailed in Example 8 of the Exemplification.

Additional nucleic acid fragments encoding biologically active portions of an MCP protein can be prepared by isolating a portion of one of the sequences in Appendix B, expressing the encoded portion of the MCP protein or peptide (e.g., by recombinant expression in vitro) and assessing the activity of the encoded portion of the MCP protein or peptide.

The invention further encompasses nucleic acid molecules that differ from one of the nucleotide sequences shown in Appendix A (and portions thereof) due to degeneracy of the genetic code and thus encode the same MCP protein as that encoded by the nucleotide sequences shown in Appendix A. In another embodiment, an isolated nucleic acid molecule of the invention has a nucleotide sequence encoding a protein having an amino acid sequence shown in Appendix B. In a still further embodiment, the nucleic acid molecule of the invention encodes a full length C. glutamicum protein which is substantially homologous to an amino acid sequence of Appendix B (encoded by an open reading frame shown in Appendix A).

It will be understood by one of ordinary skill in the art that in one embodiment the sequences of the invention are not meant to include the sequences of the prior art, such as those Genbank sequences set forth in Tables 2 or 4 which were available prior to the present invention. In one embodiment, the invention includes nucleotide and amino acid sequences having a percent identity to a nucleotide or amino acid sequence of the invention which is greater than that of a sequence of the prior art (e.g., a Genbank sequence (or the protein encoded by such a sequence) set forth in Tables 2 or 4). For example, the invention includes a nucleotide sequence which is greater than and/or at least 39% identical to the nucleotide sequence designated RXA00008 (SEQ ID NO:1549), a nucleotide sequence which is greater than and/or at least 42% identical to the nucleotide sequence designated RXA00059 (SEQ ID NO:1571), and a nucleotide sequence which is greater than and/or at least 39% identical to the nucleotide sequence designated RXA00096 (SEQ ID NO:93). One of ordinary skill in the art would be able to calculate the lower threshold of percent identity for any given sequence of the invention by examining the GAP-calculated percent identity scores set forth in Table 4 for each of the three top hits for the given sequence, and by subtracting the highest GAP-calculated percent identity from 100 percent. One of ordinary skill in the art will also appreciate that nucleic acid and amino acid sequences having percent identities greater than the lower threshold so calculated (e.g., at least 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more identical) are also encompassed by the invention.

In addition to the C. glutamicum MCP nucleotide sequences shown in Appendix A, it will be appreciated by those of ordinary skill in the art that DNA sequence polymorphisms that lead to changes in the amino acid sequences of MCP proteins may exist within a population (e.g., the C. glutamicum population). Such genetic polymorphism in the MCP gene may exist among individuals within a population due to natural variation. As used herein, the terms “gene” and “recombinant gene” refer to nucleic acid molecules comprising an open reading frame encoding an MCP protein, preferably a C. glutamicum MCP protein. Such natural variations can typically result in 1-5% variance in the nucleotide sequence of the MCP gene. Any and all such nucleotide variations and resulting amino acid polymorphisms in MCP that are the result of natural variation and that do not alter the functional activity of MCP proteins are intended to be within the scope of the invention.

Nucleic acid molecules corresponding to natural variants and non-C. glutamicum homologues of the C. glutamicum MCP DNA of the invention can be isolated based on their homology to the C. glutamicum MCP nucleic acid disclosed herein using the C. glutamicum DNA, or a portion thereof, as a hybridization probe according to standard hybridization techniques under stringent hybridization conditions. Accordingly, in another embodiment, an isolated nucleic acid molecule of the invention is at least 15 nucleotides in length and hybridizes under stringent conditions to the nucleic acid molecule comprising a nucleotide sequence of Appendix A. In other embodiments, the nucleic acid is at least 30, 50, 100, 250 or more nucleotides in length. As used herein, the term “hybridizes under stringent conditions” is intended to describe conditions for hybridization and washing under which nucleotide sequences at least 60% homologous to each other typically remain hybridized to each other. Preferably, the conditions are such that sequences at least about 65%, more preferably at least about 70%, and even more preferably at least about 75% or more homologous to each other typically remain hybridized to each other. Such stringent conditions are known to those of ordinary skill in the art and can be found in Current Protocols in Molecular Biology, John Wiley & Sons, N.Y. (1989), 6.3.1-6.3.6. A preferred, non-limiting example of stringent hybridization conditions are hybridization in 6× sodium chloride/sodium citrate (SSC) at about 45° C., followed by one or more washes in 0.2×SSC, 0.1% SDS at 50-65° C. Preferably, an isolated nucleic acid molecule of the invention that hybridizes under stringent conditions to a sequence of Appendix A corresponds to a naturally-occurring nucleic acid molecule. As used herein, a “naturally-occurring” nucleic acid molecule refers to an RNA or DNA molecule having a nucleotide sequence that occurs in nature (e.g., encodes a natural protein). In one embodiment, the nucleic acid encodes a natural C. glutamicum MCP protein.

In addition to naturally-occurring variants of the MCP sequence that may exist in the population, one of ordinary skill in the art will further appreciate that changes can be introduced by mutation into a nucleotide sequence of Appendix A, thereby leading to changes in the amino acid sequence of the encoded MCP protein, without altering the functional ability of the MCP protein. For example, nucleotide substitutions leading to amino acid substitutions at “non-essential” amino acid residues can be made in a sequence of Appendix A. A “non-essential” amino acid residue is a residue that can be altered from the wild-type sequence of one of the MCP proteins (Appendix B) without altering the activity of said MCP protein, whereas an “essential” amino acid residue is required for MCP protein activity. Other amino acid residues, however, (e.g., those that are not conserved or only semi-conserved in the domain having MCP activity) may not be essential for activity and thus are likely to be amenable to alteration without altering MCP activity.

Accordingly, another aspect of the invention pertains to nucleic acid molecules encoding MCP proteins that contain changes in amino acid residues that are not essential for MCP activity. Such MCP proteins differ in amino acid sequence from a sequence contained in Appendix B yet retain at least one of the MCP activities described herein. In one embodiment, the isolated nucleic acid molecule comprises a nucleotide sequence encoding a protein, wherein the protein comprises an amino acid sequence at least about 50% homologous to an amino acid sequence of Appendix B and is able to modulate the yield, production, and/or efficiency of production of one or more fine chemicals from C. glutamicum, to degrade hydrocarbons, to oxidize terpenoids, to serve as a target for drug development, or to serve as an identifying marker for C. glutamicum or related organisms. Preferably, the protein encoded by the nucleic acid molecule is at least about 50-60% homologous to one of the sequences in Appendix B, more preferably at least about 60-70% homologous to one of the sequences in Appendix B, even more preferably at least about 70-80%, 80-90%, 90-95% homologous to one of the sequences in Appendix B, and most preferably at least about 96%, 97%, 98%, or 99% homologous to one of the sequences in Appendix B.

To determine the percent homology of two amino acid sequences (e.g., one of the sequences of Appendix B and a mutant form thereof) or of two nucleic acids, the sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in the sequence of one protein or nucleic acid for optimal alignment with the other protein or nucleic acid). The amino acid residues or nucleotides at corresponding amino acid positions or nucleotide positions are then compared. When a position in one sequence (e.g., one of the sequences of Appendix B) is occupied by the same amino acid residue or nucleotide as the corresponding position in the other sequence (e.g., a mutant form of the sequence selected from Appendix B), then the molecules are homologous at that position (i.e., as used herein amino acid or nucleic acid “homology” is equivalent to amino acid or nucleic acid “identity”). The percent homology between the two sequences is a function of the number of identical positions shared by the sequences (i.e., % homology=# of identical positions/total # of positions×100).

An isolated nucleic acid molecule encoding an MCP protein homologous to a protein sequence of Appendix B can be created by introducing one or more nucleotide substitutions, additions or deletions into a nucleotide sequence of Appendix A such that one or more amino acid substitutions, additions or deletions are introduced into the encoded protein. Mutations can be introduced into one of the sequences of Appendix A by standard techniques, such as site-directed mutagenesis and PCR-mediated mutagenesis. Preferably, conservative amino acid substitutions are made at one or more predicted non-essential amino acid residues. A “conservative amino acid substitution” is one in which the amino acid residue is replaced with an amino acid residue having a similar side chain. Families of amino acid residues having similar side chains have been defined in the art. These families include amino acids with basic side chains (e.g., lysine, arginine, histidine), acidic side chains (e.g., aspartic acid, glutamic acid), uncharged polar side chains (e.g., glycine, asparagine, glutamine, serine, threonine, tyrosine, cysteine), nonpolar side chains (e.g., alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, tryptophan), beta-branched side chains (e.g., threonine, valine, isoleucine) and aromatic side chains (e.g., tyrosine, phenylalanine, tryptophan, histidine). Thus, a predicted nonessential amino acid residue in an MCP protein is preferably replaced with another amino acid residue from the same side chain family. Alternatively, in another embodiment, mutations can be introduced randomly along all or part of an MCP coding sequence, such as by saturation mutagenesis, and the resultant mutants can be screened for an MCP activity described herein to identify mutants that retain MCP activity. Following mutagenesis of one of the sequences of Appendix A, the encoded protein can be expressed recombinantly and the activity of the protein can be determined using, for example, assays described herein (see Example 8 of the Exemplification).

In addition to the nucleic acid molecules encoding MCP proteins described above, another aspect of the invention pertains to isolated nucleic acid molecules which are antisense thereto. An “antisense” nucleic acid comprises a nucleotide sequence which is complementary to a “sense” nucleic acid encoding a protein, e.g., complementary to the coding strand of a double-stranded cDNA molecule or complementary to an mRNA sequence. Accordingly, an antisense nucleic acid can hydrogen bond to a sense nucleic acid. The antisense nucleic acid can be complementary to an entire MCP coding strand, or to only a portion thereof. In one embodiment, an antisense nucleic acid molecule is antisense to a “coding region” of the coding strand of a nucleotide sequence encoding an MCP protein. The term “coding region” refers to the region of the nucleotide sequence comprising codons which are translated into amino acid residues (e.g., the entire coding region of SEQ ID NO. 1 (RXN01638) comprises nucleotides 1 to 900). In another embodiment, the antisense nucleic acid molecule is antisense to a “noncoding region” of the coding strand of a nucleotide sequence encoding MCP. The term “noncoding region” refers to 5′ and 3′ sequences which flank the coding region that are not translated into amino acids (i.e., also referred to as 5′ and 3′ untranslated regions).

Given the coding strand sequences encoding MCP disclosed herein (e.g., the sequences set forth in Appendix A), antisense nucleic acids of the invention can be designed according to the rules of Watson and Crick base pairing. The antisense nucleic acid molecule can be complementary to the entire coding region of MCP mRNA, but more preferably is an oligonucleotide which is antisense to only a portion of the coding or noncoding region of MCP mRNA. For example, the antisense oligonucleotide can be complementary to the region surrounding the translation start site of MCP mRNA. An antisense oligonucleotide can be, for example, about 5, 10, 15, 20, 25, 30, 35, 40, 45 or 50 nucleotides in length. An antisense nucleic acid of the invention can be constructed by chemical synthesis and enzymatic ligation reactions using procedures known in the art. For example, an antisense nucleic acid (e.g., an antisense oligonucleotide) can be chemically synthesized using naturally occurring nucleotides or variously modified nucleotides designed to increase the biological stability of the molecules or to increase the physical stability of the duplex formed between the antisense and sense nucleic acids, e.g., phosphorothioate derivatives and acridine substituted nucleotides can be used. Examples of modified nucleotides which can be used to generate the antisense nucleic acid include 5-fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xanthine, 4-acetylcytosine, 5-(carboxyhydroxylmethyl)uracil, 5-carboxymethylaminomethyl-2-thiouridine, 5-carboxymethylaminomethyluracil, dihydrouracil, beta-D-galactosylqueosine, inosine, N6-isopentenyladenine, 1-methylguanine, 1-methylinosine, 2,2-dimethylguanine, 2-methyladenine, 2-methylguanine, 3-methylcytosine, 5-methylcytosine, N6-adenine, 7-methylguanine, 5-methylaminomethyluracil, 5-methoxyaminomethyl-2-thiouracil, beta-D-mannosylqueosine, 5′-methoxycarboxymethyluracil, 5-methoxyuracil, 2-methylthio-N-6-isopentenyladenine, uracil-5-oxyacetic acid (v), wybutoxosine, pseudouracil, queosine, 2-thiocytosine, 5-methyl-2-thiouracil, 2-thiouracil, 4-thiouracil, 5-methyluracil, uracil-5-oxyacetic acid methylester, uracil-5-oxyacetic acid (v), 5-methyl-2-thiouracil, 3-(3-amino-3-N-2-carboxypropyl)uracil, (acp3)w, and 2,6-diaminopurine. Alternatively, the antisense nucleic acid can be produced biologically using an expression vector into which a nucleic acid has been subcloned in an antisense orientation (i.e., RNA transcribed from the inserted nucleic acid will be of an antisense orientation to a target nucleic acid of interest, described further in the following subsection).

The antisense nucleic acid molecules of the invention are typically administered to a cell or generated in situ such that they hybridize with or bind to cellular mRNA and/or genomic DNA encoding an MCP protein to thereby inhibit expression of the protein, e.g., by inhibiting transcription and/or translation. The hybridization can be by conventional nucleotide complementarity to form a stable duplex, or, for example, in the case of an antisense nucleic acid molecule which binds to DNA duplexes, through specific interactions in the major groove of the double helix. The antisense molecule can be modified such that it specifically binds to a receptor or an antigen expressed on a selected cell surface, e.g., by linking the antisense nucleic acid molecule to a peptide or an antibody which binds to a cell surface receptor or antigen. The antisense nucleic acid molecule can also be delivered to cells using the vectors described herein. To achieve sufficient intracellular concentrations of the antisense molecules, vector constructs in which the antisense nucleic acid molecule is placed under the control of a strong prokaryotic, viral, or eukaryotic promoter are preferred.

In yet another embodiment, the antisense nucleic acid molecule of the invention is an α-anomeric nucleic acid molecule. An α-anomeric nucleic acid molecule forms specific double-stranded hybrids with complementary RNA in which, contrary to the usual β-units, the strands run parallel to each other (Gaultier et al. (1987) Nucleic Acids. Res. 15:6625-6641). The antisense nucleic acid molecule can also comprise a 2′-o-methylribonucleotide (Inoue et al. (1987) Nucleic Acids Res. 15:6131-6148) or a chimeric RNA-DNA analogue (Inoue et al. (1987) FEBS Lett. 215:327-330).

In still another embodiment, an antisense nucleic acid of the invention is a ribozyme. Ribozymes are catalytic RNA molecules with ribonuclease activity which are capable of cleaving a single-stranded nucleic acid, such as an mRNA, to which they have a complementary region. Thus, ribozymes (e.g., hammerhead ribozymes (described in Haselhoff and Gerlach (1988) Nature 334:585-591)) can be used to catalytically cleave MCP mRNA transcripts to thereby inhibit translation of MCP mRNA. A ribozyme having specificity for an MCP-encoding nucleic acid can be designed based upon the nucleotide sequence of an MCP DNA disclosed herein (i.e., SEQ ID NO. 1 (RXN01368) in Appendix A). For example, a derivative of a Tetrahymena L-19 IVS RNA can be constructed in which the nucleotide sequence of the active site is complementary to the nucleotide sequence to be cleaved in an MCP-encoding mRNA. See, e.g., Cech et al. U.S. Pat. No. 4,987,071 and Cech et al U.S. Pat. No. 5,116,742. Alternatively, MCP mRNA can be used to select a catalytic RNA having a specific ribonuclease activity from a pool of RNA molecules. See, e.g., Bartel, D. and Szostak, J. W. (1993) Science 261:1411-1418.

Alternatively, MCP gene expression can be inhibited by targeting nucleotide sequences complementary to the regulatory region of an MCP nucleotide sequence (e.g., an MCP promoter and/or enhancers) to form triple helical structures that prevent transcription of an MCP gene in target cells. See generally, Helene, C. (1991) Anticancer Drug Des. 6(6):569-84; Helene, C. et al. (1992) Ann. N.Y. Acad. Sci. 660:27-36; and Maher, L. J. (1992) Bioassays 14(12):807-15.

B. Recombinant Expression Vectors and Host Cells

Another aspect of the invention pertains to vectors, preferably expression vectors, containing a nucleic acid encoding an MCP protein (or a portion thereof). As used herein, the term “vector” refers to a nucleic acid molecule capable of transporting another nucleic acid to which it has been linked. One type of vector is a “plasmid”, which refers to a circular double stranded DNA loop into which additional DNA segments can be ligated. Another type of vector is a viral vector, wherein additional DNA segments can be ligated into the viral genome. Certain vectors are capable of autonomous replication in a host cell into which they are introduced (e.g., bacterial vectors having a bacterial origin of replication and episomal mammalian vectors). Other vectors (e.g., non-episomal mammalian vectors) are integrated into the genome of a host cell upon introduction into the host cell, and thereby are replicated along with the host genome. Moreover, certain vectors are capable of directing the expression of genes to which they are operatively linked. Such vectors are referred to herein as “expression vectors”. In general, expression vectors of utility in recombinant DNA techniques are often in the form of plasmids. In the present specification, “plasmid” and “vector” can be used interchangeably as the plasmid is the most commonly used form of vector. However, the invention is intended to include such other forms of expression vectors, such as viral vectors (e.g., replication defective retroviruses, adenoviruses and adeno-associated viruses), which serve equivalent functions.

The recombinant expression vectors of the invention comprise a nucleic acid of the invention in a form suitable for expression of the nucleic acid in a host cell, which means that the recombinant expression vectors include one or more regulatory sequences, selected on the basis of the host cells to be used for expression, which is operatively linked to the nucleic acid sequence to be expressed. Within a recombinant expression vector, “operably linked” is intended to mean that the nucleotide sequence of interest is linked to the regulatory sequence(s) in a manner which allows for expression of the nucleotide sequence (e.g., in an in vitro transcription/translation system or in a host cell when the vector is introduced into the host cell). The term “regulatory sequence” is intended to include promoters, repressor binding sites, activator binding sites, enhancer regions and other expression control elements (e.g., terminators, other elements of mRNA secondary structure, or polyadenylation signals). Such regulatory sequences are described, for example, in Goeddel; Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, Calif. (1990). Regulatory sequences include those which direct constitutive expression of a nucleotide sequence in many types of host cell and those which direct expression of the nucleotide sequence only in certain host cells. Preferred regulatory sequences are, for example, promoters such as cos-, tac-, trp-, tet-, trp-tet-, lpp-, lac-, lpp-lac-, lacI^(q)-, T7-, T5-, T3-, gal-, trc-, ara-, SP6-, arny, SPO2, λ-P_(R)- or λP_(L), which are used preferably in bacteria. Additional regulatory sequences are, for example, promoters from yeasts and fungi, such as ADC1, MFα, AC, P-60, CYC1, GAPDH, TEF, rp28, ADH, promoters from plants such as CaMV/35S, SSU, OCS, lib4, usp, STLS1, B33, nos or ubiquitin- or phaseolin-promoters. It is also possible to use artificial promoters. It will be appreciated by those of ordinary skill in the art that the design of the expression vector can depend on such factors as the choice of the host cell to be transformed, the level of expression of protein desired, etc. The expression vectors of the invention can be introduced into host cells to thereby produce proteins or peptides, including fusion proteins or peptides, encoded by nucleic acids as described herein (e.g., MCP proteins, mutant forms of MCP proteins, fusion proteins, etc.).

The recombinant expression vectors of the invention can be designed for expression of MCP proteins in prokaryotic or eukaryotic cells. For example, MCP genes can be expressed in bacterial cells such as C. glutamicum, insect cells (using baculovirus expression vectors), yeast and other fungal cells (see Romanos, M. A. et al. (1992) “Foreign gene expression in yeast: a review”, Yeast 8: 423-488; van den Hondel, C. A. M. J. J. et al. (1991) “Heterologous gene expression in filamentous fungi” in: More Gene Manipulations in Fungi, J. W. Bennet & L. L. Lasure, eds., p. 396-428: Academic Press: San Diego; and van den Hondel, C. A. M. J. J. & Punt, P. J. (1991) “Gene transfer systems and vector development for filamentous fungi, in: Applied Molecular Genetics of Fungi, Peberdy, J. F. et al., eds., p. 1-28, Cambridge University Press: Cambridge), algae and multicellular plant cells (see Schmidt, R. and Willmitzer, L. (1988) High efficiency Agrobacterium tumefactiens-mediated transformation of Arabidopsis thaliana leaf and cotyledon explants” Plant Cell Rep.: 583-586), or mammalian cells. Suitable host cells are discussed further in Goeddel, Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, Calif. (1990). Alternatively, the recombinant expression vector can be transcribed and translated in vitro, for example using T7 promoter regulatory sequences and T7 polymerase.

Expression of proteins in prokaryotes is most often carried out with vectors containing constitutive or inducible promoters directing the expression of either fusion or non-fusion proteins. Fusion vectors add a number of amino acids to a protein encoded therein, usually to the amino terminus of the recombinant protein. Such fusion vectors typically serve three purposes: 1) to increase expression of recombinant protein; 2) to increase the solubility of the recombinant protein; and 3) to aid in the purification of the recombinant protein by acting as a ligand in affinity purification. Often, in fusion expression vectors, a proteolytic cleavage site is introduced at the junction of the fusion moiety and the recombinant protein to enable separation of the recombinant protein from the fusion moiety subsequent to purification of the fusion protein. Such enzymes, and their cognate recognition sequences, include Factor Xa, thrombin and enterokinase.

Typical fusion expression vectors include pGEX (Pharmacia Biotech Inc; Smith, D. B. and Johnson, K. S. (1988) Gene 67:31-40), pMAL (New England Biolabs, Beverly, Mass.) and pRIT5 (Pharmacia, Piscataway, N.J.) which fuse glutathione S-transferase (GST), maltose E binding protein, or protein A, respectively, to the target recombinant protein. In one embodiment, the coding sequence of the MCP protein is cloned into a pGEX expression vector to create a vector encoding a fusion protein comprising, from the N-terminus to the C-terminus, GST-thrombin cleavage site-X protein. The fusion protein can be purified by affinity chromatography using glutathione-agarose resin. Recombinant MCP protein unfused to GST can be recovered by cleavage of the fusion protein with thrombin.

Examples of suitable inducible non-fusion E. coli expression vectors include pTrc (Amann et al., (1988) Gene 69:301-315), pLG338, pACYC184, pBR322, pUC18, pUC19, pKC30, pRep4, pHS1, pHS2, pPLc236, pMBL24, pLG200, pUR290, pIN-III113-B1, λgt11, pBdC1, and pET 11d (Studier et al., Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, Calif. (1990) 60-89; and Pouwels et al., eds. (1985) Cloning Vectors. Elsevier: New York IBSN 0 444 904018). Target gene expression from the pTrc vector relies on host RNA polymerase transcription from a hybrid trp-lac fusion promoter. Target gene expression from the pET 11d vector relies on transcription from a T7 gn10-lac fusion promoter mediated by a coexpressed viral RNA polymerase (T7 gn1). This viral polymerase is supplied by host strains BL21(DE3) or HMS174(DE3) from a resident λ prophage harboring a T7 gn1 gene under the transcriptional control of the lacUV 5 promoter. For transformation of other varieties of bacteria, appropriate vectors may be selected. For example, the plasmids pIJ101, pIJ364, pIJ702 and pIJ361 are known to be useful in transforming Streptomyces, while plasmids pUB110, pC194, or pBD214 are suited for transformation of Bacillus species. Several plasmids of use in the transfer of genetic information into Corynebacterium include pHM1519, pBL1, pSA77, or pAJ667 (Pouwels et al., eds. (1985) Cloning Vectors. Elsevier: New York IBSN 0 444 904018).

One strategy to maximize recombinant protein expression is to express the protein in a host bacteria with an impaired capacity to proteolytically cleave the recombinant protein (Gottesman, S., Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, Calif. (1990) 119-128). Another strategy is to alter the nucleic acid sequence of the nucleic acid to be inserted into an expression vector so that the individual codons for each amino acid are those preferentially utilized in the bacterium chosen for expression, such as C. glutamicum (Wada et al. (1992) Nucleic Acids Res. 20:2111-2118). Such alteration of nucleic acid sequences of the invention can be carried out by standard DNA synthesis techniques.

In another embodiment, the MCP protein expression vector is a yeast expression vector. Examples of vectors for expression in yeast S. cerevisiae include pYepSec1 (Baldari, et al., (1987) Embo J. 6:229-234), 2μ, pAG-1, Yep6, Yep13, pEMBLYe23, pMFa (Kudjan and Herskowitz, (1982) Cell 30:933-943), pJRY88 (Schultz et al., (1987) Gene 54:113-123), and pYES2 (Invitrogen Corporation, San Diego, Calif.). Vectors and methods for the construction of vectors appropriate for use in other fungi, such as the filamentous fungi, include those detailed in: van den Hondel, C. A. M. J. J. & Punt, P. J. (1991) “Gene transfer systems and vector development for filamentous fungi, in: Applied Molecular Genetics of Fungi, J. F. Peberdy, et al., eds., p. 1-28, Cambridge University Press: Cambridge, and Pouwels et al., eds. (1985) Cloning Vectors. Elsevier: New York (IBSN 0 444 904018).

Alternatively, the MCP proteins of the invention can be expressed in insect cells using baculovirus expression vectors. Baculovirus vectors available for expression of proteins in cultured insect cells (e.g., Sf9 cells) include the pAc series (Smith et al. (1983) Mol. Cell Biol. 3:2156-2165) and the pVL series (Lucklow and Summers (1989) Virology 170:31-39).

In another embodiment, the MCP proteins of the invention may be expressed in unicellular plant cells (such as algae) or in plant cells from higher plants (e.g., the spermatophytes, such as crop plants). Examples of plant expression vectors include those detailed in: Becker, D., Kemper, E., Schell, J. and Masterson, R. (1992) “New plant binary vectors with selectable markers located proximal to the left border”, Plant Mol. Biol. 20: 1195-1197; and Bevan, M. W. (1984) “Binary Agrobacterium vectors for plant transformation”, Nucl. Acid. Res. 12: 8711-8721, and include pLGV23, pGHlac+, pBIN19, pAK2004, and pDH51 (Pouwels et al., eds. (1985) Cloning Vectors. Elsevier: New York IBSN 0 444 904018).

In yet another embodiment, a nucleic acid of the invention is expressed in mammalian cells using a mammalian expression vector. Examples of mammalian expression vectors include pCDM8 (Seed, B. (1987) Nature 329:840) and pMT2PC (Kaufman et al. (1987) EMBO J. 6:187-195). When used in mammalian cells, the expression vector's control functions are often provided by viral regulatory elements. For example, commonly used promoters are derived from polyoma, Adenovirus 2, cytomegalovirus and Simian Virus 40. For other suitable expression systems for both prokaryotic and eukaryotic cells see chapters 16 and 17 of Sambrook, J., Fritsh, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual. 2nd, ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989.

In another embodiment, the recombinant mammalian expression vector is capable of directing expression of the nucleic acid preferentially in a particular cell type (e.g., tissue-specific regulatory elements are used to express the nucleic acid). Tissue-specific regulatory elements are known in the art. Non-limiting examples of suitable tissue-specific promoters include the albumin promoter (liver-specific; Pinkert et al. (1987) Genes Dev. 1:268-277), lymphoid-specific promoters (Calame and Eaton (1988) Adv. Immunol. 43:235-275), in particular promoters of T cell receptors (Winoto and Baltimore (1989) EMBO J. 8:729-733) and immunoglobulins (Banerji et al. (1983) Cell 33:729-740; Queen and Baltimore (1983) Cell 33:741-748), neuron-specific promoters (e.g., the neurofilament promoter; Byrne and Ruddle (1989) PNAS 86:5473-5477), pancreas-specific promoters (Edlund et al. (1985) Science 230:912-916), and mammary gland-specific promoters (e.g., milk whey promoter; U.S. Pat. No. 4,873,316 and European Application Publication No. 264,166). Developmentally-regulated promoters are also encompassed, for example the murine hox promoters (Kessel and Gruss (1990) Science 249:374-379) and the α-fetoprotein promoter (Campes and Tilghman (1989) Genes Dev. 3:537-546).

The invention further provides a recombinant expression vector comprising a DNA molecule of the invention cloned into the expression vector in an antisense orientation. That is, the DNA molecule is operatively linked to a regulatory sequence in a manner which allows for expression (by transcription of the DNA molecule) of an RNA molecule which is antisense to MCP mRNA. Regulatory sequences operatively linked to a nucleic acid cloned in the antisense orientation can be chosen which direct the continuous expression of the antisense RNA molecule in a variety of cell types, for instance viral promoters and/or enhancers, or regulatory sequences can be chosen which direct constitutive, tissue specific or cell type specific expression of antisense RNA. The antisense expression vector can be in the form of a recombinant plasmid, phagemid or attenuated virus in which antisense nucleic acids are produced under the control of a high efficiency regulatory region, the activity of which can be determined by the cell type into which the vector is introduced. For a discussion of the regulation of gene expression using antisense genes see Weintraub, H. et al. (1986) “Antisense RNA as a molecular tool for genetic analysis”, Reviews—Trends in Genetics, Vol. 1(1).

Another aspect of the invention pertains to host cells into which a recombinant expression vector of the invention has been introduced. The terms “host cell” and “recombinant host cell” are used interchangeably herein. It is understood that such terms refer not only to the particular subject cell but to the progeny or potential progeny of such a cell. Because certain modifications may occur in succeeding generations due to either mutation or environmental influences, such progeny may not, in fact, be identical to the parent cell, but are still included within the scope of the term as used herein.

A host cell can be any prokaryotic or eukaryotic cell. For example, an MCP protein can be expressed in bacterial cells such as C. glutamicum, insect cells, yeast or mammalian cells (such as Chinese hamster ovary cells (CHO) or COS cells). Other suitable host cells are known to those of ordinary skill in the art. Microorganisms related to Corynebacterium glutamicum which may be conveniently used as host cells for the nucleic acid and protein molecules of the invention are set forth in Table 3.

Vector DNA can be introduced into prokaryotic or eukaryotic cells via conventional transformation or transfection techniques. As used herein, the terms “transformation”, “transfection”, “conjugation” and “transduction” are intended to refer to a variety of art-recognized techniques for introducing foreign nucleic acid (e.g., linear DNA or RNA (e.g., a linearized vector or a gene construct alone without a vector) or nucleic acid in the form of a vector (e.g., a plasmid, phage, phasmid, phagemid, transposon or other DNA) into a host cell, including using natural competence, chemical mediated transfer, calcium phosphate or calcium chloride co-precipitation, DEAE-dextran-mediated transfection, lipofection, or electroporation. Suitable methods for transforming or transfecting host cells can be found in Sambrook, et al. (Molecular Cloning: A Laboratory Manual. 2nd, ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989), and other laboratory manuals.

For stable transfection of mammalian cells, it is known that, depending upon the expression vector and transfection technique used, only a small fraction of cells may integrate the foreign DNA into their genome. In order to identify and select these integrants, a gene that encodes a selectable marker (e.g., resistance to antibiotics) is generally introduced into the host cells along with the gene of interest. Preferred selectable markers include those which confer resistance to drugs, such as G418, hygromycin and methotrexate. Nucleic acid encoding a selectable marker can be introduced into a host cell on the same vector as that encoding an MCP protein or can be introduced on a separate vector. Cells stably transfected with the introduced nucleic acid can be identified by, for example, drug selection (e.g., cells that have incorporated the selectable marker gene will survive, while the other cells die).

To create a homologous recombinant microorganism, a vector is prepared which contains at least a portion of an MCP gene into which a deletion, addition or substitution has been introduced to thereby alter, e.g., functionally disrupt, the MCP gene. Preferably, this MCP gene is a Corynebacterium glutamicum MCP gene, but it can be a homologue from a related bacterium or even from a mammalian, yeast, or insect source. In a preferred embodiment, the vector is designed such that, upon homologous recombination, the endogenous MCP gene is functionally disrupted (i.e., no longer encodes a functional protein; also referred to as a “knock out” vector). Alternatively, the vector can be designed such that, upon homologous recombination, the endogenous MCP gene is mutated or otherwise altered but still encodes functional protein (e.g., the upstream regulatory region can be altered to thereby alter the expression of the endogenous MCP protein). In the homologous recombination vector, the altered portion of the MCP gene is flanked at its 5′ and 3′ ends by additional nucleic acid of the MCP gene to allow for homologous recombination to occur between the exogenous MCP gene carried by the vector and an endogenous MCP gene in a microorganism. The additional flanking MCP nucleic acid is of sufficient length for successful homologous recombination with the endogenous gene. Typically, less than one kilobase of flanking DNA (both at the 5′ and 3′ ends) is included in the vector (see e.g., Thomas, K. R., and Capecchi, M. R. (1987) Cell 51: 503 for a description of homologous recombination vectors). The vector is introduced into a microorganism (e.g., by electroporation) and cells in which the introduced MCP gene has homologously recombined with the endogenous MCP gene are selected, using art-known techniques.

In another embodiment, recombinant microorganisms can be produced which contain selected systems which allow for regulated expression of the introduced gene. For example, inclusion of an MCP gene on a vector placing it under control of the lac operon permits expression of the MCP gene in the presence of IPTG. Such regulatory systems are well known in the art.

In another embodiment, an endogenous MCP gene in a host cell is disrupted (e.g., by homologous recombination or other genetic means known in the art) such that expression of its protein product does not occur. In another embodiment, an endogenous or introduced MCP gene in a host cell has been altered by one or more point mutations, deletions, or inversions, but still encodes a functional MCP protein. In still another embodiment, one or more of the regulatory regions (e.g., a promoter, repressor, or inducer) of an MCP gene in a microorganism has been altered (e.g., by deletion, truncation, inversion, or point mutation) such that the expression of the MCP gene is modulated. One of ordinary skill in the art will appreciate that host cells containing more than one of the described MCP gene and protein modifications may be readily produced using the methods of the invention, and are meant to be included in the present invention.

A host cell of the invention, such as a prokaryotic or eukaryotic host cell in culture, can be used to produce (i.e., express) an MCP protein. Accordingly, the invention further provides methods for producing MCP proteins using the host cells of the invention. In one embodiment, the method comprises culturing the host cell of invention (into which a recombinant expression vector encoding an MCP protein has been introduced, or into which genome has been introduced a gene encoding a wild-type or altered MCP protein) in a suitable medium until MCP protein is produced. In another embodiment, the method further comprises isolating MCP proteins from the medium or the host cell.

C. Isolated MCP Proteins

Another aspect of the invention pertains to isolated MCP proteins, and biologically active portions thereof. An “isolated” or “purified” protein or biologically active portion thereof is substantially free of cellular material when produced by recombinant DNA techniques, or chemical precursors or other chemicals when chemically synthesized. The language “substantially free of cellular material” includes preparations of MCP protein in which the protein is separated from cellular components of the cells in which it is naturally or recombinantly produced. In one embodiment, the language “substantially free of cellular material” includes preparations of MCP protein having less than about 30% (by dry weight) of non-MCP protein (also referred to herein as a “contaminating protein”), more preferably less than about 20% of non-MCP protein, still more preferably less than about 10% of non-MCP protein, and most preferably less than about 5% non-MCP protein. When the MCP protein or biologically active portion thereof is recombinantly produced, it is also preferably substantially free of culture medium, i.e., culture medium represents less than about 20%, more preferably less than about 10%, and most preferably less than about 5% of the volume of the protein preparation. The language “substantially free of chemical precursors or other chemicals” includes preparations of MCP protein in which the protein is separated from chemical precursors or other chemicals which are involved in the synthesis of the protein. In one embodiment, the language “substantially free of chemical precursors or other chemicals” includes preparations of MCP protein having less than about 30% (by dry weight) of chemical precursors or non-MCP chemicals, more preferably less than about 20% chemical precursors or non-MCP chemicals, still more preferably less than about 10% chemical precursors or non-MCP chemicals, and most preferably less than about 5% chemical precursors or non-MCP chemicals. In preferred embodiments, isolated proteins or biologically active portions thereof lack contaminating proteins from the same organism from which the MCP protein is derived. Typically, such proteins are produced by recombinant expression of, for example, a C. glutamicum MCP protein in a microorganism such as C. glutamicum.

An isolated MCP protein or a portion thereof of the invention is able to modulate the yield, production, and/or efficiency of production of one or more fine chemicals from C. glutamicum, to degrade hydrocarbons, to oxidize terpenoids, to serve as a target for drug development, or to serve as an identifying marker for C. glutamicum or related organisms. In preferred embodiments, the protein or portion thereof comprises an amino acid sequence which is sufficiently homologous to an amino acid sequence of Appendix B such that the protein or portion thereof maintains the ability to modulate the yield, production, and/or efficiency of production of one or more fine chemicals from C. glutamicum, to degrade hydrocarbons, to oxidize terpenoids, to serve as a target for drug development, or to serve as an identifying marker for C. glutamicum or related organisms. The portion of the protein is preferably a biologically active portion as described herein. In another preferred embodiment, an MCP protein of the invention has an amino acid sequence shown in Appendix B. In yet another preferred embodiment, the MCP protein has an amino acid sequence which is encoded by a nucleotide sequence which hybridizes, e.g., hybridizes under stringent conditions, to a nucleotide sequence of Appendix A. In still another preferred embodiment, the MCP protein has an amino acid sequence which is encoded by a nucleotide sequence that is at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more homologous to one of the nucleic acid sequences of Appendix A, or a portion thereof. Ranges and identity values intermediate to the above-recited values, (e.g., 70-90% identical or 80-95% identical) are also intended to be encompassed by the present invention. For example, ranges of identity values using a combination of any of the above values recited as upper and/or lower limits are intended to be included. The preferred MCP proteins of the present invention also preferably possess at least one of the MCP activities described herein. For example, a preferred MCP protein of the present invention includes an amino acid sequence encoded by a nucleotide sequence which hybridizes, e.g., hybridizes under stringent conditions, to a nucleotide sequence of Appendix A, and which is able to modulate the yield, production, and/or efficiency of production of one or more fine chemicals from C. glutamicum, to degrade hydrocarbons, to oxidize terpenoids, to serve as a target for drug development, or to serve as an identifying marker for C. glutamicum or related organisms.

In other embodiments, the MCP protein is substantially homologous to an amino acid sequence of Appendix B and retains the functional activity of the protein of one of the sequences of Appendix B yet differs in amino acid sequence due to natural variation or mutagenesis, as described in detail in subsection I above. Accordingly, in another embodiment, the MCP protein is a protein which comprises an amino acid sequence which is at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more homologous to an entire amino acid sequence of Appendix B and which has at least one of the MCP activities described herein. Ranges and identity values intermediate to the above-recited values, (e.g., 70-90% identical or 80-95% identical) are also intended to be encompassed by the present invention. For example, ranges of identity values using a combination of any of the above values recited as upper and/or lower limits are intended to be included. In another embodiment, the invention pertains to a full length C. glutamicum protein which is substantially homologous to an entire amino acid sequence of Appendix B.

Biologically active portions of an MCP protein include peptides comprising amino acid sequences derived from the amino acid sequence of an MCP protein, e.g., an amino acid sequence shown in Appendix B or the amino acid sequence of a protein homologous to an MCP protein, which include fewer amino acids than a full length MCP protein or the full length protein which is homologous to an MCP protein, and exhibit at least one activity of an MCP protein. Typically, biologically active portions (peptides, e.g., peptides which are, for example, 5, 10, 15, 20, 30, 35, 36, 37, 38, 39, 40, 50, 100 or more amino acids in length) comprise a domain or motif with at least one activity of an MCP protein. Moreover, other biologically active portions, in which other regions of the protein are deleted, can be prepared by recombinant techniques and evaluated for one or more of the activities described herein. Preferably, the biologically active portions of an MCP protein include one or more selected domains/motifs or portions thereof having biological activity.

MCP proteins are preferably produced by recombinant DNA techniques. For example, a nucleic acid molecule encoding the protein is cloned into an expression vector (as described above), the expression vector is introduced into a host cell (as described above) and the MCP protein is expressed in the host cell. The MCP protein can then be isolated from the cells by an appropriate purification scheme using standard protein purification techniques. Alternative to recombinant expression, an MCP protein, polypeptide, or peptide can be synthesized chemically using standard peptide synthesis techniques. Moreover, native MCP protein can be isolated from cells (e.g., endothelial cells, bacterial cells, fungal cells or other cells), for example using an anti-MCP antibody, which can be produced by standard techniques utilizing an MCP protein or fragment thereof of this invention.

The invention also provides MCP chimeric or fusion proteins. As used herein, an MCP “chimeric protein” or “fusion protein” comprises an MCP polypeptide operatively linked to a non-MCP polypeptide. An “MCP polypeptide” refers to a polypeptide having an amino acid sequence corresponding to an MCP protein, whereas a “non-MCP polypeptide” refers to a polypeptide having an amino acid sequence corresponding to a protein which is not substantially homologous to the MCP protein, e.g., a protein which is different from the MCP protein and which is derived from the same or a different organism. Within the fusion protein, the term “operatively linked” is intended to indicate that the MCP polypeptide and the non-MCP polypeptide are fused in-frame to each other. The non-MCP polypeptide can be fused to the N-terminus or C-terminus of the MCP polypeptide. For example, in one embodiment the fusion protein is a GST-MCP fusion protein in which the MCP sequences are fused to the C-terminus of the GST sequences. Such fusion proteins can facilitate the purification of recombinant MCP proteins. In another embodiment, the fusion protein is an MCP protein containing a heterologous signal sequence at its N-terminus. In certain host cells (e.g., mammalian host cells, bacterial host cells, fungal host cells), expression and/or secretion of an MCP protein can be increased through use of a heterologous signal sequence.

Preferably, an MCP chimeric or fusion protein of the invention is produced by standard recombinant DNA techniques. For example, DNA fragments coding for the different polypeptide sequences are ligated together in-frame in accordance with conventional techniques, for example by employing blunt-ended or stagger-ended termini for ligation, restriction enzyme digestion to provide for appropriate termini, filling-in of cohesive ends as appropriate, alkaline phosphatase treatment to avoid undesirable joining, and enzymatic ligation. In another embodiment, the fusion gene can be synthesized by conventional techniques including automated DNA synthesizers. Alternatively, PCR amplification of gene fragments can be carried out using anchor primers which give rise to complementary overhangs between two consecutive gene fragments which can subsequently be annealed and reamplified to generate a chimeric gene sequence (see, for example, Current Protocols in Molecular Biology, eds. Ausubel et al. John Wiley & Sons: 1992). Moreover, many expression vectors are commercially available that already encode a fusion moiety (e.g., a GST polypeptide). An MCP-encoding nucleic acid can be cloned into such an expression vector such that the fusion moiety is linked in-frame to the MCP protein.

Homologues of the MCP protein can be generated by mutagenesis, e.g., discrete point mutation or truncation of the MCP protein. As used herein, the term “homologue” refers to a variant form of the MCP protein which acts as an agonist or antagonist of the activity of the MCP protein. An agonist of the MCP protein can retain substantially the same, or a subset, of the biological activities of the MCP protein. An antagonist of the MCP protein can inhibit one or more of the activities of the naturally occurring form of the MCP protein, by, for example, competitively binding to a downstream or upstream member of a biochemical pathway which includes the MCP protein.

In an alternative embodiment, homologues of the MCP protein can be identified by screening combinatorial libraries of mutants, e.g., truncation mutants, of the MCP protein for MCP protein agonist or antagonist activity. In one embodiment, a variegated library of MCP variants is generated by combinatorial mutagenesis at the nucleic acid level and is encoded by a variegated gene library. A variegated library of MCP variants can be produced by, for example, enzymatically ligating a mixture of synthetic oligonucleotides into gene sequences such that a degenerate set of potential MCP sequences is expressible as individual polypeptides, or alternatively, as a set of larger fusion proteins (e.g., for phage display) containing the set of MCP sequences therein. There are a variety of methods which can be used to produce libraries of potential MCP homologues from a degenerate oligonucleotide sequence. Chemical synthesis of a degenerate gene sequence can be performed in an automatic DNA synthesizer, and the synthetic gene then ligated into an appropriate expression vector. Use of a degenerate set of genes allows for the provision, in one mixture, of all of the sequences encoding the desired set of potential MCP sequences. Methods for synthesizing degenerate oligonucleotides are known in the art (see, e.g., Narang, S. A. (1983) Tetrahedron 39:3; Itakura et al. (1984) Annu. Rev. Biochem. 53:323; Itakura et al. (1984) Science 198:1056; Ike et al. (1983) Nucleic Acid Res. 11:477.

In addition, libraries of fragments of the MCP protein coding can be used to generate a variegated population of MCP fragments for screening and subsequent selection of homologues of an MCP protein. In one embodiment, a library of coding sequence fragments can be generated by treating a double stranded PCR fragment of an MCP coding sequence with a nuclease under conditions wherein nicking occurs only about once per molecule, denaturing the double stranded DNA, renaturing the DNA to form double stranded DNA which can include sense/antisense pairs from different nicked products, removing single stranded portions from reformed duplexes by treatment with S1 nuclease, and ligating the resulting fragment library into an expression vector. By this method, an expression library can be derived which encodes N-terminal, C-terminal and internal fragments of various sizes of the MCP protein.

Several techniques are known in the art for screening gene products of combinatorial libraries made by point mutations or truncation, and for screening cDNA libraries for gene products having a selected property. Such techniques are adaptable for rapid screening of the gene libraries generated by the combinatorial mutagenesis of MCP homologues. The most widely used techniques, which are amenable to high through-put analysis, for screening large gene libraries typically include cloning the gene library into replicable expression vectors, transforming appropriate cells with the resulting library of vectors, and expressing the combinatorial genes under conditions in which detection of a desired activity facilitates isolation of the vector encoding the gene whose product was detected. Recrusive ensemble mutagenesis (REM), a new technique which enhances the frequency of functional mutants in the libraries, can be used in combination with the screening assays to identify MCP homologues (Arkin and Yourvan (1992) PNAS 89:7811-7815; Delgrave et al. (1993) Protein Engineering 6(3):327-331).

In another embodiment, cell based assays can be exploited to analyze a variegated MCP library, using methods well known in the art.

D. Uses and Methods of the Invention

The nucleic acid molecules, proteins, protein homologues, fusion proteins, primers, vectors, and host cells described herein can be used in one or more of the following methods: identification of C. glutamicum and related organisms; mapping of genomes of organisms related to C. glutamicum; identification and localization of C. glutamicum sequences of interest; evolutionary studies; determination of MCP protein regions required for function; modulation of an MCP protein activity; modulation of the activity of one or more metabolic pathways; and modulation of cellular production of a desired compound, such as a fine chemical.

The MCP nucleic acid molecules of the invention have a variety of uses. First, they may be used to identify an organism as being Corynebacterium glutamicum or a close relative thereof. Also, they may be used to identify the presence of C. glutamicum or a relative thereof in a mixed population of microorganisms. The invention provides the nucleic acid sequences of a number of C. glutamicum genes, and probes based thereon; by probing the extracted genomic DNA of a culture of a unique or mixed population of microorganisms under stringent conditions with a probe spanning a region of a C. glutamicum gene which is unique to this organism, one can ascertain whether this organism is present. Although Corynebacterium glutamicum itself is nonpathogenic, it is related to pathogenic species, such as Corynebacterium diphtheriae. Corynebacterium diphtheriae is the causative agent of diphtheria, a rapidly developing, acute, febrile infection which involves both local and systemic pathology. In this disease, a local lesion develops in the upper respiratory tract and involves necrotic injury to epithelial cells; the bacilli secrete toxin which is disseminated through this lesion to distal susceptible tissues of the body. Degenerative changes brought about by the inhibition of protein synthesis in these tissues, which include heart, muscle, peripheral nerves, adrenals, kidneys, liver and spleen, result in the systemic pathology of the disease. Diphtheria continues to have high incidence in many parts of the world, including Africa, Asia, Eastern Europe and the independent states of the former Soviet Union. An ongoing epidemic of diphtheria in the latter two regions has resulted in at least 5,000 deaths since 1990.

In one embodiment, the invention provides a method of identifying the presence or activity of Corynebacterium diphtheriae in a subject. This method includes detection of one or more of the nucleic acid or amino acid sequences of the invention (e.g., the sequences set forth in Appendix A or Appendix B) in a subject, thereby detecting the presence or activity of Corynebacterium diphtheriae in the subject. C. glutamicum and C. diphtheriae are related bacteria, and many of the nucleic acid and protein molecules in C. glutamicum are homologous to C. diphtheriae nucleic acid and protein molecules, and can therefore be used to detect C. diphtheriae in a subject.

To detect the presence of C. glutamicum in a sample, techniques well known in the art may be employed. Specifically, the cells in the sample may optionally first be cultured in a suitable liquid or on a suitable solid culture medium to increase the number of cells in the sample. These cells are lysed, and the total DNA content extracted and optionally purified to remove debris and protein material which may interfere with subsequent analysis. The polymerase chain reaction or a similar technique known in the art is performed (for general reference on methodologies commonly used for the amplification of nucleic acid sequences, see Mullis et al., U.S. Pat. No. 4,683,195, Mullis et al., U.S. Pat. No. 4,965,188, and Innis, M. A., and Gelfand, D. H., (1989) PCR Protocols, A guide to Methods and Applications, Academic Press, p. 3-12, and (1988) Biotechnology 6:1197, and International Patent Application No. WO89/01050) in which primers specific to an MCP nucleic acid molecule of the invention are incubated with the nucleic acid sample such that, if present in the sample, that particular MCP nucleic acid sequence will be amplified. The particular MCP nucleic acid to be amplified is selected based on its uniqueness to the C. glutamicum genome, or to the genomes of C. glutamicum and only a few closely related bacteria. The presence of the desired amplified product is thus indicative of the presence of C. glutamicum, or an organism closely related to C. glutamicum.

Further, the nucleic acid and protein molecules of the invention may serve as markers for specific regions of the genome. It is possible, using techniques well known in the art, to ascertain the physical location on the C. glutamicum genome of the MCP nucleic acid molecules of the invention, which in turn provides markers on the genome which can be used to aid in the placement of other nucleic acid molecules and genes on the genome map. Also, the nucleic acid molecules of the invention may be sufficiently homologous to the sequences of related bacterial species that these nucleic acid molecules may similarly permit the construction of a genomic map in such bacteria (e.g., Brevibacterium lactofermentum).

The nucleic acid molecules of the invention have utility not only in the mapping of the genome, but also for functional studies of C. glutamicum proteins. For example, to identify the region of the genome to which a particular C. glutamicum DNA-binding protein binds, the C. glutamicum genome could be digested, and the fragments incubated with the DNA-binding protein. Those which bind the protein may be additionally probed with the nucleic acid molecules of the invention, preferably with readily detectable labels; binding of such a nucleic acid molecule to the genome fragment enables the localization of the fragment to the genome map of C. glutamicum, and, when performed multiple times with different enzymes, facilitates a rapid determination of the nucleic acid sequence to which the protein binds.

The MCP nucleic acid molecules of the invention are also useful for evolutionary and protein structural studies. The metabolic processes in which the molecules of the invention participate are utilized by a wide variety of prokaryotic and eukaryotic cells; by comparing the sequences of the nucleic acid molecules of the present invention to those encoding similar enzymes from other organisms, the evolutionary relatedness of the organisms can be assessed. Similarly, such a comparison permits an assessment of which regions of the sequence are conserved and which are not, which may aid in determining those regions of the protein which are essential for the functioning of the enzyme. This type of determination is of value for protein engineering studies and may give an indication of what the protein can tolerate in terms of mutagenesis without losing function.

The MCP protein molecules of the invention may also be utilized as markers for the classification of an unknown bacterium as C. glutamicum, or for the identification of C. glutamicum or closely related bacteria in a sample. For example, using techniques well known in the art, cells in a sample may optionally be amplified (e.g., by culturing in an appropriate medium) to increase the sample size, and then may be lysed to release proteins contained therein. This sample may optionally be purified to remove debris and nucleic acid molecules which may interfere with subsequent analysis. Antibodies specific for a selected MCP protein of the invention may be incubated with the protein sample in a typical Western assay format (see, e.g., Ausubel et al., (1988) Current Protocols in Molecular Biology, Wiley: New York) in which the antibody will bind to its target protein if this protein is present in the sample. An MCP protein is selected for this type of assay if it is unique or nearly unique to C. glutamicum or C. glutamicum and bacteria very closely related to C. glutamicum. Proteins in the sample are then separated by gel electrophoresis, and transferred to a suitable matrix, such as nitrocellulose. An appropriate secondary antibody having a detectable label (e.g., chemiluminescent or calorimetric) is incubated with this matrix, followed by stringent washing. The presence or absence of the label is indicative of the presence or absence of the target protein in the sample. If the protein is present, then this is indicative of the presence of C. glutamicum. A similar process enables the classification of an unknown bacterium as C. glutamicum; if a panel of proteins specific to C. glutamicum are not detected in protein samples prepared from the unknown bacterium, then that bacterium is not likely to be C. glutamicum.

The invention provides methods for screening molecules which modulate the activity of an MCP protein, either by interacting with the protein itself or a substrate or binding partner of the MCP protein, or by modulating the transcription or translation of an MCP nucleic acid molecule of the invention. In such methods, a microorganism expressing one or more MCP proteins of the invention is contacted with one or more test compounds, and the effect of each test compound on the activity or level of expression of the MCP protein is assessed.

Genetic manipulation of the MCP nucleic acid molecules of the invention may result in the production of MCP proteins having functional differences from the wild-type MCP proteins. These proteins may be improved in efficiency or activity, may be present in greater numbers in the cell than is usual, or may be decreased in efficiency or activity.

Such changes in activity may directly modulate the yield, production, and/or efficiency of production of one or more fine chemicals from C. glutamicum. For example, by modifying the activity of a protein involved in the biosynthesis or degradation of a fine chemical (i.e., through mutagenesis of the corresponding gene), one may directly modulate the ability of the cell to synthesize or to degrade this compound, thereby modulating the yield and/or efficiency of production of the fine chemical. Similarly, by modulating the activity of a protein which regulates a fine chemical metabolic pathway, one may directly influence whether the production of the desired compound is up- or down-regulated, either of which will modulate the yield or efficiency of production of the fine chemical from the cell.

Indirect modulation of fine chemical production may also result by modifying the activity of a protein of the invention (i.e., by mutagenesis of the corresponding gene) such that the overall ability of the cell to grow and divide or to remain viable and productive is increased. The production of fine chemicals from C. glutamicum is generally accomplished by the large-scale fermentative culture of these microorganisms, conditions which are frequently suboptimal for growth and cell division. By engineering a protein of the invention (e.g., a stress response protein, a cell wall protein, or proteins involved in the metabolism of compounds necessary for cell growth and division to occur, such as nucleotides and amino acids) such that it is better able to survive, grow, and multiply in such conditions, it may be possible to increase the number and productivity of such engineered C. glutamicum cells in large-scale culture, which in turn should result in increased yields and/or efficiency of production of one or more desired fine chemicals. Further, the metabolic pathways of any cell are necessarily interrelated and coregulated. By altering the activity or regulation of any one metabolic pathway in C. glutamicum (i.e., by altering the activity of one of the proteins of the invention which participates in such a pathway), it is possible to concomitantly alter the activity or regulation of other metabolic pathways in this microorganism, which may be directly involved in the synthesis or degradation of a fine chemical.

The aforementioned mutagenesis strategies for MCP proteins to result in increased yields of a fine chemical from C. glutamicum are not meant to be limiting; variations on these strategies will be readily apparent to one of ordinary skill in the art. Using such strategies, and incorporating the mechanisms disclosed herein, the nucleic acid and protein molecules of the invention may be utilized to generate C. glutamicum or related strains of bacteria expressing mutated MCP nucleic acid and protein molecules such that the yield, production, and/or efficiency of production of a desired compound is improved. This desired compound may be any natural product of C. glutamicum, which includes the final products of biosynthesis pathways and intermediates of naturally-occurring metabolic pathways, as well as molecules which do not naturally occur in the metabolism of C. glutamicum, but which are produced by a C. glutamicum strain of the invention.

This invention is further illustrated by the following examples which should not be construed as limiting. The contents of all references, patent applications, patents, published patent applications, Tables, Appendices, and the sequence listing cited throughout this application are hereby incorporated by reference.

EXEMPLIFICATION Example 1 Preparation of Total Genomic DNA of Corynebacterium glutamicum ATCC 13032

A culture of Corynebacterium glutamicum (ATCC 13032) was grown overnight at 30° C. with vigorous shaking in BHI medium (Difco). The cells were harvested by centrifugation, the supernatant was discarded and the cells were resuspended in 5 ml buffer-I (5% of the original volume of the culture—all indicated volumes have been calculated for 100 ml of culture volume). Composition of buffer-I: 140.34 g/l sucrose, 2.46 g/l MgSO₄×7H₂O, 10 ml/l KH₂PO₄ solution (100 g/l, adjusted to pH 6.7 with KOH), 50 ml/l M12 concentrate (10 g/l (NH₄)₂SO₄, 1 g/l NaCl, 2 g/l MgSO₄×7H₂O, 0.2 g/l CaCl₂, 0.5 g/l yeast extract (Difco), 10 ml/l trace-elements-mix (200 mg/l FeSO₄×H₂O, 10 mg/l ZnSO₄×7H₂O, 3 mg/l MnCl₂×4H₂O, 30 mg/l H₃BO₃ 20 mg/l CoCl₂×6H₂O, 1 mg/l NiCl₂×6H₂O, 3 mg/l Na₂MoO₄×2H₂O, 500 mg/l complexing agent (EDTA or critic acid), 100 ml/l vitamins-mix (0.2 mg/l biotin, 0.2 mg/l folic acid, 20 mg/l p-amino benzoic acid, 20 mg/l riboflavin, 40 mg/l α-panthothenate, 140 mg/l nicotinic acid, 40 mg/l pyridoxole hydrochloride, 200 mg/l myo-inositol). Lysozyme was added to the suspension to a final concentration of 2.5 mg/ml. After an approximately 4 h incubation at 37° C., the cell wall was degraded and the resulting protoplasts are harvested by centrifugation. The pellet was washed once with 5 ml buffer-I and once with 5 ml TE-buffer (10 mM Tris-HCl, 1 mM EDTA, pH 8). The pellet was resuspended in 4 ml TE-buffer and 0.5 ml SDS solution (10%) and 0.5 ml NaCl solution (5 M) are added. After adding of proteinase K to a final concentration of 200 μg/ml, the suspension is incubated for ca.18 h at 37° C. The DNA was purified by extraction with phenol, phenol-chloroform-isoamylalcohol and chloroform-isoamylalcohol using standard procedures. Then, the DNA was precipitated by adding 1/50 volume of 3 M sodium acetate and 2 volumes of ethanol, followed by a 30 min incubation at −20° C. and a 30 min centrifugation at 12,000 rpm in a high speed centrifuge using a SS34 rotor (Sorvall). The DNA was dissolved in 1 ml TE-buffer containing 20 μg/ml RNaseA and dialysed at 4° C. against 1000 ml TE-buffer for at least 3 hours. During this time, the buffer was exchanged 3 times. To aliquots of 0.4 ml of the dialysed DNA solution, 0.4 ml of 2 M LiCl and 0.8 ml of ethanol are added. After a 30 min incubation at −20° C., the DNA was collected by centrifugation (13,000 rpm, Biofuge Fresco, Heraeus, Hanau, Germany). The DNA pellet was dissolved in TE-buffer. DNA prepared by this procedure could be used for all purposes, including southern blotting or construction of genomic libraries.

Example 2 Construction of Genomic Libraries in Escherichia coli of Corynebacterium glutamicum ATCC13032

Using DNA prepared as described in Example 1, cosmid and plasmid libraries were constructed according to known and well established methods (see e.g., Sambrook, J. et al. (1989) “Molecular Cloning: A Laboratory Manual”, Cold Spring Harbor Laboratory Press, or Ausubel, F. M. et al. (1994) “Current Protocols in Molecular Biology”, John Wiley & Sons.)

Any plasmid or cosmid could be used. Of particular use were the plasmids pBR322 (Sutcliffe, J. G. (1979) Proc. Natl. Acad. Sci. USA, 75:3737-3741); pACYC177 (Change & Cohen (1978) J. Bacteriol 134:1141-1156), plasmids of the pBS series (pBSSK+, pBSSK− and others; Stratagene, LaJolla, USA), or cosmids as SuperCos1 (Stratagene, LaJolla, USA) or Lorist6 (Gibson, T. J., Rosenthal A. and Waterson, R. H. (1987) Gene 53:283-286. Gene libraries specifically for use in C. glutamicum may be constructed using plasmid pSL109 (Lee, H.-S. and A. J. Sinskey (1994) J. Microbiol. Biotechnol. 4: 256-263).

Example 3 DNA Sequencing and Computational Functional Analysis

Genomic libraries as described in Example 2 were used for DNA sequencing according to standard methods, in particular by the chain termination method using AB1377 sequencing machines (see e.g., Fleischman, R. D. et al. (1995) “Whole-genome Random Sequencing and Assembly of Haemophilus Influenzae Rd., Science, 269:496-512). Sequencing primers with the following nucleotide sequences were used: 5′- GGAAACAGTATGACCATG-3′ (SEQ ID NO: 2933) or 5′- GTAAAACGACGGCCAGT-3′. (SEQ ID NO: 2934)

Example 4 In Vivo Mutagenesis

In vivo mutagenesis of Corynebacterium glutamicum can be performed by passage of plasmid (or other vector) DNA through E. coli or other microorganisms (e.g. Bacillus spp. or yeasts such as Saccharomyces cerevisiae) which are impaired in their capabilities to maintain the integrity of their genetic information. Typical mutator strains have mutations in the genes for the DNA repair system (e.g., mutHLS, mutD, mutT, etc.; for reference, see Rupp, W. D. (1996) DNA repair mechanisms, in: Escherichia coli and Salmonella, p. 2277-2294, ASM: Washington.) Such strains are well known to those of ordinary skill in the art. The use of such strains is illustrated, for example, in Greener, A. and Callahan, M. (1994) Strategies 7: 32-34.

Example 5 DNA Transfer Between Escherichia coli and Corynebacterium glutamicum

Several Corynebacterium and Brevibacterium species contain endogenous plasmids (as e.g., pHM1519 or pBL1) which replicate autonomously (for review see, e.g., Martin, J. F. et al. (1987) Biotechnology, 5:137-146). Shuttle vectors for Escherichia coli and Corynebacterium glutamicum can be readily constructed by using standard vectors for E. coli (Sambrook, J. et al. (1989), “Molecular Cloning: A Laboratory Manual”, Cold Spring Harbor Laboratory Press or Ausubel, F. M. et al. (1994) “Current Protocols in Molecular Biology”, John Wiley & Sons) to which a origin or replication for and a suitable marker from Corynebacterium glutamicum is added. Such origins of replication are preferably taken from endogenous plasmids isolated from Corynebacterium and Brevibacterium species. Of particular use as transformation markers for these species are genes for kanamycin resistance (such as those derived from the Tn5 or Tn903 transposons) or chloramphenicol (Winnacker, E. L. (1987) “From Genes to Clones—Introduction to Gene Technology, VCH, Weinheim). There are numerous examples in the literature of the construction of a wide variety of shuttle vectors which replicate in both E. coli and C. glutamicum, and which can be used for several purposes, including gene over-expression (for reference, see e.g., Yoshihama, M. et al. (1985) J. Bacteriol. 162:591-597, Martin J. F. et al. (1987) Biotechnology, 5:137-146 and Eikmanns, B. J. et al. (1991) Gene, 102:93-98).

Using standard methods, it is possible to clone a gene of interest into one of the shuttle vectors described above and to introduce such a hybrid vectors into strains of Corynebacterium glutamicum. Transformation of C. glutamicum can be achieved by protoplast transformation (Kastsumata, R. et al. (1984) J. Bacteriol. 159306-311), electroporation (Liebl, E. et al. (1989) FEMS Microbiol. Letters, 53:399-303) and in cases where special vectors are used, also by conjugation (as described e.g. in Schafer, A et al. (1990) J. Bacteriol. 172:1663-1666). It is also possible to transfer the shuttle vectors for C. glutamicum to E. coli by preparing plasmid DNA from C. glutamicum (using standard methods well-known in the art) and transforming it into E. coli. This transformation step can be performed using standard methods, but it is advantageous to use an Mcr-deficient E. coli strain, such as NM522 (Gough & Murray (1983) J. Mol. Biol. 166:1-19).

Genes may be overexpressed in C. glutamicum strains using plasmids which comprise pCG1 (U.S. Pat. No. 4,617,267) or fragments thereof, and optionally the gene for kanamycin resistance from TN903 (Grindley, N. D. and Joyce, C. M. (1980) Proc. Natl. Acad. Sci. USA 77(12): 7176-7180). In addition, genes may be overexpressed in C. glutamicum strains using plasmid pSL109 (Lee, H.-S. and A. J. Sinskey (1994) J. Microbiol. Biotechnol. 4: 256-263).

Aside from the use of replicative plasmids, gene overexpression can also be achieved by integration into the genome. Genomic integration in C. glutamicum or other Corynebacterium or Brevibacterium species may be accomplished by well-known methods, such as homologous recombination with genomic region(s), restriction endonuclease mediated integration (REMI) (see, e.g., DE Patent 19823834), or through the use of transposons. It is also possible to modulate the activity of a gene of interest by modifying the regulatory regions (e.g., a promoter, a repressor, and/or an enhancer) by sequence modification, insertion, or deletion using site-directed methods (such as homologous recombination) or methods based on random events (such as transposon mutagenesis or REMI). Nucleic acid sequences which function as transcriptional terminators may also be inserted 3′ to the coding region of one or more genes of the invention; such terminators are well-known in the art and are described, for example, in Winnacker, E. L. (1987) From Genes to Clones—Introduction to Gene Technology. VCH: Weinheim.

Example 6 Assessment of the Expression of the Mutant Protein

Observations of the activity of a mutated protein in a transformed host cell rely on the fact that the mutant protein is expressed in a similar fashion and in a similar quantity to that of the wild-type protein. A useful method to ascertain the level of transcription of the mutant gene (an indicator of the amount of mRNA available for translation to the gene product) is to perform a Northern blot (for reference see, for example, Ausubel et al. (1988) Current Protocols in Molecular Biology, Wiley: New York), in which a primer designed to bind to the gene of interest is labeled with a detectable tag (usually radioactive or chemiluminescent), such that when the total RNA of a culture of the organism is extracted, run on gel, transferred to a stable matrix and incubated with this probe, the binding and quantity of binding of the probe indicates the presence and also the quantity of mRNA for this gene. This information is evidence of the degree of transcription of the mutant gene. Total cellular RNA can be prepared from Corynebacterium glutamicum by several methods, all well-known in the art, such as that described in Bormann, E. R. et al. (1992) Mol. Microbiol. 6: 317-326.

To assess the presence or relative quantity of protein translated from this mRNA, standard techniques, such as a Western blot, may be employed (see, for example, Ausubel et al. (1988) Current Protocols in Molecular Biology, Wiley: New York). In this process, total cellular proteins are extracted, separated by gel electrophoresis, transferred to a matrix such as nitrocellulose, and incubated with a probe, such as an antibody, which specifically binds to the desired protein. This probe is generally tagged with a chemiluminescent or calorimetric label which may be readily detected. The presence and quantity of label observed indicates the presence and quantity of the desired mutant protein present in the cell.

Example 7 Growth of Genetically Modified Corynebacterium glutamicum—Media and Culture Conditions

Genetically modified Corynebacteria are cultured in synthetic or natural growth media. A number of different growth media for Corynebacteria are both well-known and readily available (Lieb et al. (1989) Appl. Microbiol. Biotechnol., 32:205-210; von der Osten et al. (1998) Biotechnology Letters, 11:11-16; Patent DE 4,120,867; Liebl (1992) “The Genus Corynebacterium, in: The Procaryotes, Volume II, Balows, A. et al., eds. Springer-Verlag). These media consist of one or more carbon sources, nitrogen sources, inorganic salts, vitamins and trace elements. Preferred carbon sources are sugars, such as mono-, di-, or polysaccharides. For example, glucose, fructose, mannose, galactose, ribose, sorbose, ribulose, lactose, maltose, sucrose, raffinose, starch or cellulose serve as very good carbon sources. It is also possible to supply sugar to the media via complex compounds such as molasses or other by-products from sugar refinement. It can also be advantageous to supply mixtures of different carbon sources. Other possible carbon sources are alcohols and organic acids, such as methanol, ethanol, acetic acid or lactic acid. Nitrogen sources are usually organic or inorganic nitrogen compounds, or materials which contain these compounds. Exemplary nitrogen sources include ammonia gas or ammonia salts, such as NH₄Cl or (NH₄)₂SO₄, NH₄OH, nitrates, urea, amino acids or complex nitrogen sources like corn steep liquor, soy bean flour, soy bean protein, yeast extract, meat extract and others.

Inorganic salt compounds which may be included in the media include the chloride-, phosphorous- or sulfate-salts of calcium, magnesium, sodium, cobalt, molybdenum, potassium, manganese, zinc, copper and iron. Chelating compounds can be added to the medium to keep the metal ions in solution. Particularly useful chelating compounds include dihydroxyphenols, like catechol or protocatechuate, or organic acids, such as citric acid. It is typical for the media to also contain other growth factors, such as vitamins or growth promoters, examples of which include biotin, riboflavin, thiamin, folic acid, nicotinic acid, pantothenate and pyridoxin. Growth factors and salts frequently originate from complex media components such as yeast extract, molasses, corn steep liquor and others. The exact composition of the media compounds depends strongly on the immediate experiment and is individually decided for each specific case. Information about media optimization is available in the textbook “Applied Microbiol. Physiology, A Practical Approach (eds. P. M. Rhodes, P. F. Stanbury, IRL Press (1997) pp. 53-73, ISBN 0 19 963577 3). It is also possible to select growth media from commercial suppliers, like standard 1 (Merck) or BHI (grain heart infusion, DIFCO) or others.

All medium components are sterilized, either by heat (20 minutes at 1.5 bar and 121° C.) or by sterile filtration. The components can either be sterilized together or, if necessary, separately. All media components can be present at the beginning of growth, or they can optionally be added continuously or batchwise.

Culture conditions are defined separately for each experiment. The temperature should be in a range between 15° C. and 45° C. The temperature can be kept constant or can be altered during the experiment. The pH of the medium should be in the range of 5 to 8.5, preferably around 7.0, and can be maintained by the addition of buffers to the media. An exemplary buffer for this purpose is a potassium phosphate buffer. Synthetic buffers such as MOPS, HEPES, ACES and others can alternatively or simultaneously be used. It is also possible to maintain a constant culture pH through the addition of NaOH or NH₄OH during growth. If complex medium components such as yeast extract are utilized, the necessity for additional buffers may be reduced, due to the fact that many complex compounds have high buffer capacities. If a fermentor is utilized for culturing the micro-organisms, the pH can also be controlled using gaseous ammonia.

The incubation time is usually in a range from several hours to several days. This time is selected in order to permit the maximal amount of product to accumulate in the broth. The disclosed growth experiments can be carried out in a variety of vessels, such as microtiter plates, glass tubes, glass flasks or glass or metal fermentors of different sizes. For screening a large number of clones, the microorganisms should be cultured in microtiter plates, glass tubes or shake flasks, either with or without baffles. Preferably 100 ml shake flasks are used, filled with 10% (by volume) of the required growth medium. The flasks should be shaken on a rotary shaker (amplitude 25 mm) using a speed-range of 100-300 rpm. Evaporation losses can be diminished by the maintenance of a humid atmosphere; alternatively, a mathematical correction for evaporation losses should be performed.

If genetically modified clones are tested, an unmodified control clone or a control clone containing the basic plasmid without any insert should also be tested. The medium is inoculated to an OD₆₀₀ of O.5-1.5 using cells grown on agar plates, such as CM plates (10 g/l glucose, 2.5 g/l NaCl, 2 g/l urea, 10 g/l polypeptone, 5 g/l yeast extract, 5 g/l meat extract, 22 g/l NaCl, 2 g/l urea, 10 g/l polypeptone, 5 g/l yeast extract, 5 g/l meat extract, 22 g/l agar, pH 6.8 with 2M NaOH) that had been incubated at 30° C. Inoculation of the media is accomplished by either introduction of a saline suspension of C. glutamicum cells from CM plates or addition of a liquid preculture of this bacterium.

Example 8 In Vitro Analysis of the Function of Mutant Proteins

The determination of activities and kinetic parameters of enzymes is well established in the art. Experiments to determine the activity of any given altered enzyme must be tailored to the specific activity of the wild-type enzyme, which is well within the ability of one of ordinary skill in the art. Overviews about enzymes in general, as well as specific details concerning structure, kinetics, principles, methods, applications and examples for the determination of many enzyme activities may be found, for example, in the following references: Dixon, M., and Webb, E. C., (1979) Enzymes. Longmans: London; Fersht, (1985) Enzyme Structure and Mechanism. Freeman: New York; Walsh, (1979) Enzymatic Reaction Mechanisms. Freeman: San Francisco; Price, N. C., Stevens, L. (1982) Fundamentals of Enzymology. Oxford Univ. Press: Oxford; Boyer, P. D., ed. (1983) The Enzymes, 3^(rd) ed. Academic Press: New York; Bisswanger, H., (1994) Enzymkinetik, 2^(nd) ed. VCH: Weinheim (ISBN 3527300325); Bergmeyer, H. U., Bergmeyer, J., Graβl, M., eds. (1983-1986) Methods of Enzymatic Analysis, 3^(rd) ed., vol. I-XII, Verlag Chemie: Weinheim; and Ullmann's Encyclopedia of Industrial Chemistry (1987) vol. A9, “Enzymes”. VCH: Weinheim, p. 352-363.

The activity of proteins which bind to DNA can be measured by several well-established methods, such as DNA band-shift assays (also called gel retardation assays). The effect of such proteins on the expression of other molecules can be measured using reporter gene assays (such as that described in Kolmar, H. et al. (1995) EMBO J. 14: 3895-3904 and references cited therein). Reporter gene test systems are well known and established for applications in both pro- and eukaryotic cells, using enzymes such as beta-galactosidase, green fluorescent protein, and several others.

The determination of activity of membrane-transport proteins can be performed according to techniques such as those described in Gennis, R. B. (1989) “Pores, Channels and Transporters”, in Biomembranes, Molecular Structure and Function, Springer: Heidelberg, p. 85-137; 199-234; and 270-322.

Example 9 Analysis of Impact of Mutant Protein on the Production of the Desired Product

The effect of the genetic modification in C. glutamicum on production of a desired compound (such as an amino acid) can be assessed by growing the modified microorganism under suitable conditions (such as those described above) and analyzing the medium and/or the cellular component for increased production of the desired product (i.e., an amino acid). Such analysis techniques are well known to one of ordinary skill in the art, and include spectroscopy, thin layer chromatography, staining methods of various kinds, enzymatic and microbiological methods, and analytical chromatography such as high performance liquid chromatography (see, for example, Ullman, Encyclopedia of Industrial Chemistry, vol. A2, p. 89-90 and p. 443-613, VCH: Weinheim (1985); Fallon, A. et al., (1987) “Applications of HPLC in Biochemistry” in: Laboratory Techniques in Biochemistry and Molecular Biology, vol. 17; Rehm et al. (1993) Biotechnology, vol. 3, Chapter III: “Product recovery and purification”, page 469-714, VCH: Weinheim; Belter, P. A. et al. (1988) Bioseparations: downstream processing for biotechnology, John Wiley and Sons; Kennedy, J. F. and Cabral, J. M. S. (1992) Recovery processes for biological materials, John Wiley and Sons; Shaeiwitz, J. A. and Henry, J. D. (1988) Biochemical separations, in: Ulmann's Encyclopedia of Industrial Chemistry, vol. B3, Chapter 11, page 1-27, VCH: Weinheim; and Dechow, F. J. (1989) Separation and purification techniques in biotechnology, Noyes Publications.)

In addition to the measurement of the final product of fermentation, it is also possible to analyze other components of the metabolic pathways utilized for the production of the desired compound, such as intermediates and side-products, to determine the overall efficiency of production of the compound. Analysis methods include measurements of nutrient levels in the medium (e.g., sugars, hydrocarbons, nitrogen sources, phosphate, and other ions), measurements of biomass composition and growth, analysis of the production of common metabolites of biosynthetic pathways, and measurement of gasses produced during fermentation. Standard methods for these measurements are outlined in Applied Microbial Physiology, A Practical Approach, P. M. Rhodes and P. F. Stanbury, eds., IRL Press, p. 103-129; 131-163; and 165-192 (ISBN: 0199635773) and references cited therein.

Example 10 Purification of the Desired Product from C. glutamicum Culture

Recovery of the desired product from the C. glutamicum cells or supernatant of the above-described culture can be performed by various methods well known in the art. If the desired product is not secreted from the cells, the cells can be harvested from the culture by low-speed centrifugation, the cells can be lysed by standard techniques, such as mechanical force or sonication. The cellular debris is removed by centrifugation, and the supernatant fraction containing the soluble proteins is retained for further purification of the desired compound. If the product is secreted from the C. glutamicum cells, then the cells are removed from the culture by low-speed centrifugation, and the supernate fraction is retained for further purification.

The supernatant fraction from either purification method is subjected to chromatography with a suitable resin, in which the desired molecule is either retained on a chromatography resin while many of the impurities in the sample are not, or where the impurities are retained by the resin while the sample is not. Such chromatography steps may be repeated as necessary, using the same or different chromatography resins. One of ordinary skill in the art would be well-versed in the selection of appropriate chromatography resins and in their most efficacious application for a particular molecule to be purified. The purified product may be concentrated by filtration or ultrafiltration, and stored at a temperature at which the stability of the product is maximized.

There are a wide array of purification methods known to the art and the preceding method of purification is not meant to be limiting. Such purification techniques are described, for example, in Bailey, J. E. & Ollis, D. F. Biochemical Engineering Fundamentals, McGraw-Hill: New York (1986).

The identity and purity of the isolated compounds may be assessed by techniques standard in the art. These include high-performance liquid chromatography (HPLC), spectroscopic methods, staining methods, thin layer chromatography, NIRS, enzymatic assay, or microbiologically. Such analysis methods are reviewed in: Patek et al. (1994) Appl. Environ. Microbiol. 60: 133-140; Malakhova et al. (1996) Biotekhnologiya 11: 27-32; and Schmidt et al. (1998) Bioprocess Engineer. 19: 67-70. Ulmann's Encyclopedia of Industrial Chemistry, (1996) vol. A27, VCH: Weinheim, p. 89-90, p. 521-540, p. 540-547, p. 559-566, 575-581 and p. 581-587; Michal, G. (1999) Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, John Wiley and Sons; Fallon, A. et al. (1987) Applications of HPLC in Biochemistry in: Laboratory Techniques in Biochemistry and Molecular Biology, vol. 17.

Example 11 Analysis of the Gene Sequences of the Invention

The comparison of sequences and determination of percent homology between two sequences are art-known techniques, and can be accomplished using a mathematical algorithm, such as the algorithm of Karlin and Altschul (1990) Proc. Natl. Acad. Sci. USA 87:2264-68, modified as in Karlin and Altschul (1993) Proc. Natl. Acad. Sci. USA 90:5873-77. Such an algorithm is incorporated into the NBLAST and XBLAST programs (version 2.0) of Altschul, et al. (1990) J. Mol. Biol. 215:403-10. BLAST nucleotide searches can be performed with the NBLAST program, score=100, wordlength=12 to obtain nucleotide sequences homologous to MCP nucleic acid molecules of the invention. BLAST protein searches can be performed with the XBLAST program, score=50, wordlength=3 to obtain amino acid sequences homologous to MCP protein molecules of the invention. To obtain gapped alignments for comparison purposes, Gapped BLAST can be utilized as described in Altschul et al., (1997) Nucleic Acids Res. 25(17):3389-3402. When utilizing BLAST and Gapped BLAST programs, one of ordinary skill in the art will know how to optimize the parameters of the program (e.g., XBLAST and NBLAST) for the specific sequence being analyzed.

Another example of a mathematical algorithm utilized for the comparison of sequences is the algorithm of Meyers and Miller ((1988) Comput. Appl. Biosci. 4: 11-17). Such an algorithm is incorporated into the ALIGN program (version 2.0) which is part of the GCG sequence alignment software package. When utilizing the ALIGN program for comparing amino acid sequences, a PAM120 weight residue table, a gap length penalty of 12, and a gap penalty of 4 can be used. Additional algorithms for sequence analysis are known in the art, and include ADVANCE and ADAM. described in Torelli and Robotti (1994) Comput. Appl. Biosci. 10:3-5; and FASTA, described in Pearson and Lipman (1988) P.N.A.S. 85:2444-8.

The percent homology between two amino acid sequences can also be accomplished using the GAP program in the GCG software package (available at the Accelrys™ website), using either a Blosum 62 matrix or a PAM250 matrix, and a gap weight of 12, 10, 8, 6, or 4 and a length weight of 2, 3, or 4. The percent homology between two nucleic acid sequences can be accomplished using the GAP program in the GCG software package, using standard parameters, such as a gap weight of 50 and a length weight of 3.

A comparative analysis of the gene sequences of the invention with those present in Genbank has been performed using techniques known in the art (see, e.g., Bexevanis and Ouellette, eds. (1998) Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins. John Wiley and Sons: New York). The gene sequences of the invention were compared to genes present in Genbank in a three-step process. In a first step, a BLASTN analysis (e.g., a local alignment analysis) was performed for each of the sequences of the invention against the nucleotide sequences present in Genbank, and the top 500 hits were retained for further analysis. A subsequent FASTA search (e.g., a combined local and global alignment analysis, in which limited regions of the sequences are aligned) was performed on these 500 hits. Each gene sequence of the invention was subsequently globally aligned to each of the top three FASTA hits, using the GAP program in the GCG software package (using standard parameters). In order to obtain correct results, the length of the sequences extracted from Genbank were adjusted to the length of the query sequences by methods well-known in the art. The results of this analysis are set forth in Table 4. The resulting data is identical to that which would have been obtained had a GAP (global) analysis alone been performed on each of the genes of the invention in comparison with each of the references in Genbank, but required significantly reduced computational time as compared to such a database-wide GAP (global) analysis. Sequences of the invention for which no alignments above the cutoff values were obtained are indicated on Table 4 by the absence of alignment information. It will further be understood by one of ordinary skill in the art that the GAP alignment homology percentages set forth in Table 4 under the heading “% homology (GAP)” are listed in the European numerical format, wherein a ‘,’ represents a decimal point. For example, a value of “40,345” in this column represents “40.345%”.

Example 12 Construction and Operation of DNA Microarrays

The sequences of the invention may additionally be used in the construction and application of DNA microarrays (the design, methodology, and uses of DNA arrays are well known in the art, and are described, for example, in Schena, M. et al. (1995) Science 270: 467-470; Wodicka, L. et al. (1997) Nature Biotechnology 15: 1359-1367; DeSaizieu, A. et al. (1998) Nature Biotechnology 16: 45-48; and DeRisi, J. L. et al. (1997) Science 278: 680-686).

DNA microarrays are solid or flexible supports consisting of nitrocellulose, nylon, glass, silicone, or other materials. Nucleic acid molecules may be attached to the surface in an ordered manner. After appropriate labeling, other nucleic acids or nucleic acid mixtures can be hybridized to the immobilized nucleic acid molecules, and the label may be used to monitor and measure the individual signal intensities of the hybridized molecules at defined regions. This methodology allows the simultaneous quantification of the relative or absolute amount of all or selected nucleic acids in the applied nucleic acid sample or mixture. DNA microarrays, therefore, permit an analysis of the expression of multiple (as many as 6800 or more) nucleic acids in parallel (see, e.g., Schena, M. (1996) BioEssays 18(5): 427-431).

The sequences of the invention may be used to design oligonucleotide primers which are able to amplify defined regions of one or more C. glutamicum genes by a nucleic acid amplification reaction such as the polymerase chain reaction. The choice and design of the 5′ or 3′ oligonucleotide primers or of appropriate linkers allows the covalent attachment of the resulting PCR products to the surface of a support medium described above (and also described, for example, Schena, M. et al. (1995) Science 270: 467-470).

Nucleic acid microarrays may also be constructed by in situ oligonucleotide synthesis as described by Wodicka, L. et al. (1997) Nature Biotechnology 15: 1359-1367. By photolithographic methods, precisely defined regions of the matrix are exposed to light. Protective groups which are photolabile are thereby activated and undergo nucleotide addition, whereas regions that are masked from light do not undergo any modification. Subsequent cycles of protection and light activation permit the synthesis of different oligonucleotides at defined positions. Small, defined regions of the genes of the invention may be synthesized on microarrays by solid phase oligonucleotide synthesis.

The nucleic acid molecules of the invention present in a sample or mixture of nucleotides may be hybridized to the microarrays. These nucleic acid molecules can be labeled according to standard methods. In brief, nucleic acid molecules (e.g., mRNA molecules or DNA molecules) are labeled by the incorporation of isotopically or fluorescently labeled nucleotides, e.g., during reverse transcription or DNA synthesis. Hybridization of labeled nucleic acids to microarrays is described (e.g., in Schena, M. et al. (1995) supra; Wodicka, L. et al. (1997), supra; and DeSaizieu A. et al. (1998), supra). The detection and quantification of the hybridized molecule are tailored to the specific incorporated label. Radioactive labels can be detected, for example, as described in Schena, M. et al. (1995) supra) and fluorescent labels may be detected, for example, by the method of Shalon et al. (1996) Genome Research 6: 639-645).

The application of the sequences of the invention to DNA microarray technology, as described above, permits comparative analyses of different strains of C. glutamicum or other Corynebacteria. For example, studies of inter-strain variations based on individual transcript profiles and the identification of genes that are important for specific and/or desired strain properties such as pathogenicity, productivity and stress tolerance are facilitated by nucleic acid array methodologies. Also, comparisons of the profile of expression of genes of the invention during the course of a fermentation reaction are possible using nucleic acid array technology.

Example 13 Analysis of the Dynamics of Cellular Protein Populations (Proteomics)

The genes, compositions, and methods of the invention may be applied to study the interactions and dynamics of populations of proteins, termed ‘proteomics’. Protein populations of interest include, but are not limited to, the total protein population of C. glutamicum (e.g., in comparison with the protein populations of other organisms), those proteins which are active under specific environmental or metabolic conditions (e.g., during fermentation, at high or low temperature, or at high or low pH), or those proteins which are active during specific phases of growth and development.

Protein populations can be analyzed by various well-known techniques, such as gel electrophoresis. Cellular proteins may be obtained, for example, by lysis or extraction, and may be separated from one another using a variety of electrophoretic techniques. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) separates proteins largely on the basis of their molecular weight. Isoelectric focusing polyacrylamide gel electrophoresis (IEF-PAGE) separates proteins by their isoelectric point (which reflects not only the amino acid sequence but also posttranslational modifications of the protein). Another, more preferred method of protein analysis is the consecutive combination of both IEF-PAGE and SDS-PAGE, known as 2-D-gel electrophoresis (described, for example, in Hermann et al. (1998) Electrophoresis 19: 3217-3221; Fountoulakis et al. (1998) Electrophoresis 19: 1193-1202; Langen et al. (1997) Electrophoresis 18: 1184-1192; Antelmann et al. (1997) Electrophoresis 18: 1451-1463). Other separation techniques may also be utilized for protein separation, such as capillary gel electrophoresis; such techniques are well known in the art.

Proteins separated by these methodologies can be visualized by standard techniques, such as by staining or labeling. Suitable stains are known in the art, and include Coomassie Brilliant Blue, silver stain, or fluorescent dyes such as Sypro Ruby (Molecular Probes). The inclusion of radioactively labeled amino acids or other protein precursors (e.g., ³⁵S-methionine, ³⁵S-cysteine, ¹⁴C-labelled amino acids, ¹⁵N-amino acids, ¹⁵NO₃ or ¹⁵NH₄ ⁺ or ¹³C-labelled amino acids) in the medium of C. glutamicum permits the labeling of proteins from these cells prior to their separation. Similarly, fluorescent labels may be employed. These labeled proteins can be extracted, isolated and separated according to the previously described techniques.

Proteins visualized by these techniques can be further analyzed by measuring the amount of dye or label used. The amount of a given protein can be determined quantitatively using, for example, optical methods and can be compared to the amount of other proteins in the same gel or in other gels. Comparisons of proteins on gels can be made, for example, by optical comparison, by spectroscopy, by image scanning and analysis of gels, or through the use of photographic films and screens. Such techniques are well-known in the art.

To determine the identity of any given protein, direct sequencing or other standard techniques may be employed. For example, N- and/or C-terminal amino acid sequencing (such as Edman degradation) may be used, as may mass spectrometry (in particular MALDI or ESI techniques (see, e.g., Langen. et al. (1997) Electrophoresis 18: 1184-1192)). The protein sequences provided herein can be used for the identification of C. glutamicum proteins by these techniques.

The information obtained by these methods can be used to compare patterns of protein presence, activity, or modification between different samples from various biological conditions (e.g., different organisms, time points of fermentation, media conditions, or different biotopes, among others). Data obtained from such experiments alone, or in combination with other techniques, can be used for various applications, such as to compare the behavior of various organisms in a given (e.g., metabolic) situation, to increase the productivity of strains which produce fine chemicals or to increase the efficiency of the production of fine chemicals.

EQUIVALENTS

Those of ordinary skill in the art will recognize, or will be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. Such equivalents are intended to be encompassed by the following claims. TABLE 1 GENES IN THE APPLICATION Nucleic Acid SEQ Amino Acid Identification NT NT ID NO SEQ ID NO Code Contig. Start Stop 1 2 RXN01638 VV0005 54646 55545 3 4 F RXA01638 GR00456 825 436 5 6 F RXA01639 GR00456 1334 897 7 8 RXN01590 VV0015 66740 60294 9 10 F RXA01590 GR00445 1710 427 11 12 F RX01542 GR00429 3 5063 13 14 RXN01539 VV0015 60006 57841 15 16 F RXA01539 GR00428 120 2042 17 18 RXN01422 VV0122 17001 16030 19 20 F RXA01422 GR00416 2003 1221 21 22 RXN01403 VV0126 4644 3997 23 24 F RXA01403 GR00409 4410 3997 25 26 RXN01326 VV0102 23923 24288 27 28 F RXA01326 GR00386 45 338 29 30 RXN01301 VV0068 8224 8748 31 32 F RXA01301 GR00375 1993 1589 33 34 RXN01276 VV0009 31190 31633 35 36 F RXA01276 GR00367 29993 30538 37 38 RXN01231 VV0020 30144 29902 39 40 F RXA01231 GR00356 1384 1887 41 42 RXN01210 VV0169 4230 5060 43 44 F RXA01210 GR00349 3 695 45 46 RXN01206 VV0268 303 4 47 48 F RXA01206 GR00346 593 853 49 50 RXN01121 VV0182 5808 6893 51 52 F RXA01121 GR00310 2479 3156 53 54 RXN01085 VV0093 16599 15721 55 56 F RXA01085 GR00303 960 4 57 58 RXN00022 VV0015 27262 28962 59 60 F RXA00022 GR00002 20563 21297 61 62 F RXA01921 GR00551 943 5 63 64 RXN00027 VV0127 60015 59650 65 66 F RXA00027 GR00003 5142 5507 67 68 RXN00028 VV0127 57099 59045 69 70 F RXA00028 GR00003 8058 6112 71 72 RXN00033 VV0127 51753 53087 73 74 RXN00056 VV0044 11980 12729 75 76 F RXA00056 GR00009 1463 714 77 78 RXN00067 VV0019 29740 29255 79 80 F RXA00067 GR00011 708 223 81 82 RXN00077 VV0154 4222 5583 83 84 F RXA00077 GR00012 4228 5589 85 86 RXN00080 VV0154 8446 6917 87 88 F RXA00080 GR00012 7342 6923 89 90 RXN00087 VV0048 204 731 91 92 F RXA00087 GR00013 3983 3456 93 94 RXN00096 VV0129 22302 22000 95 96 F RXA00096 GR00014 4746 5048 97 98 RXN00097 VV0129 21841 20666 99 100 F RXA00097 GR00014 5222 6382 101 102 RXN00114 VV0129 5849 6337 103 104 F RXA00014 GR00017 3420 3908 105 106 RXN00120 VV0142 2612 3451 107 108 F RXA00120 GR00019 2798 3451 109 110 RXN00128 VV0124 7960 9663 111 112 F RXA00128 GR00020 4709 3006 113 114 RXN00154 VV0167 3283 4125 115 116 F RXA00154 GR00023 8568 7726 117 118 RXN00162 VV0084 9489 9842 119 120 F RXA00162 GR00024 5438 5791 121 122 RXN00167 VV0232 4324 4821 123 124 F RXA00167 GR00025 4324 4584 125 126 RXN00171 VV0031 5311 5054 127 128 F RXA00171 GR00026 10316 10086 129 130 RXN00194 VV0115 4174 4614 131 132 F RXA00194 GR00030 290 6 133 134 RXN00197 VV0115 2733 1522 135 136 F RXA00197 GR00030 1731 2741 137 138 RXN00216 VV0096 16292 15303 139 140 RXN00222 VV0096 21079 22224 141 142 F RXA00222 GR00032 21073 22218 143 144 RXN00232 VV0214 601 92 145 146 F RXA00232 GR00035 527 18 147 148 RXN00236 VV0133 3300 2575 149 150 F RXA00236 GR00036 3300 2575 151 152 RXN00242 VV0133 7031 8308 153 154 F RXA00242 GR00036 7031 8233 155 156 RXN00247 VV0057 35082 34156 157 158 F RXA00247 GR00037 7097 6171 159 160 RXN00256 VV0015 3794 4564 161 162 F RXA00256 GR00039 968 1738 163 164 RXN00264 VV0123 14046 13669 165 166 F RXA00264 GR00040 2459 2836 167 168 RXN00267 VV0123 12366 12683 169 170 F RXA00267 GR00040 4091 3822 171 172 RXN00271 VV0019 4975 3986 173 174 F RXA00271 GR00041 3709 2720 175 176 RXN00272 VV0019 5686 6057 177 178 F RXA00272 GR00041 4420 4791 179 180 RXN00283 VV0127 33097 32066 181 182 F RXA00283 GR00045 142 1269 183 184 RXN00334 VV0197 3581 3246 185 186 F RXA00334 GR00057 16762 17097 187 188 RXN00338 VV0197 26797 25658 189 190 F RXA00338 GR00059 1 783 191 192 F RXA00318 GR00055 426 635 193 194 RXN00342 VV0049 1576 1148 195 196 F RXA00342 GR00061 73 501 197 198 RXN00344 VV0135 42719 43597 199 200 F RXA00344 GR00063 6 584 201 202 RXN00353 VV0135 32107 32799 203 204 F RXA00353 GR00068 988 1680 205 206 RXN00354 VV0135 33604 32792 207 208 RXN00362 VV0176 33334 34680 209 210 F RXA00362 GR00073 2 961 211 212 RXN00373 VV0226 6002 6340 213 214 F RXA00373 GR00079 342 4 215 216 RXN00390 VV0025 9834 9430 217 218 F RXA00390 GR00086 1437 1841 219 220 RXN00399 VV0025 13735 13421 221 222 F RXA00399 GR00087 830 1144 223 224 RXN00416 VV0181 1 225 226 F RXA00416 GR00093 1 327 227 228 F RXA00418 GR00094 1 1065 229 230 RXN00422 VV0112 3820 4713 231 232 F RXA00422 GR00097 428 6 233 234 RXN00447 VV0112 23325 22906 235 236 F RXA00447 GR00108 518 817 237 238 RXN00455 VV0076 5523 4774 239 240 F RXA00455 GR00113 2 619 241 242 RXN00473 VV0086 31493 32281 243 244 F RXA00473 GR00119 5799 6563 245 246 RXN00485 VV0086 51200 48906 247 248 F RXA00485 GR00119 25230 23188 249 250 RXN00496 VV0086 17452 18477 251 252 F RXA00496 GR00123 1776 2177 253 254 RXN00503 VV0086 11688 13409 255 256 RXN00504 VV0086 13486 13905 257 258 F RXA00504 GR00125 5007 5252 259 260 RXN00505 VV0086 5810 6304 261 262 F RXA00505 GR00126 1 252 263 264 RXN00507 VV0086 4606 3752 265 266 F RXA00507 GR00127 1098 244 267 268 RXN00510 VV0086 1924 3432 269 270 F RXA00509 GR00128 316 140 271 272 F RXA00510 GR00128 384 914 273 274 RXN00515 VV0144 3289 2588 275 276 F RXA00515 GR00131 3 482 277 278 F RXA00520 GR00132 599 796 279 280 RXN00527 VV0079 23845 25608 281 282 F RXA00527 GR00136 3123 1360 283 284 RXN00547 VV0079 33886 35283 285 286 F RXA00547 GR00142 641 1054 287 288 F RXA00546 GR00142 1 690 289 290 RXN00552 VV0079 27617 28552 291 292 F RXA00552 GR00145 2 718 293 294 RXN00555 VV0079 30437 29499 295 296 F RXA00555 GR00145 2555 1665 297 298 RXN00560 VV0103 7606 7980 299 300 F RXA00560 GR00149 256 492 301 302 RXN00574 VV0323 16133 15255 303 304 F RXA00574 GR00156 767 1645 305 306 RXN00589 VV0323 2680 2231 307 308 F RXA00589 GR00156 14220 14582 309 310 RXN00616 VV0054 5670 5326 311 312 F RXA00616 GR00162 3574 3918 313 314 RXN00647 VV0109 12861 12229 315 316 F RXA00647 GR00169 641 1273 317 318 RXN00653 VV0109 6578 7342 319 320 F RXA00653 GR00169 6924 6160 321 322 RXN00662 VV0142 7711 8979 323 324 F RXA00662 GR00172 2671 1403 325 326 RXN00666 VV0109 1566 2480 327 328 F RXA00666 GR00175 390 4 329 330 RXN00704 VV0005 9240 9866 331 332 F RXA00704 GR00183 2972 3484 333 334 RXN00712 VV0005 1195 500 335 336 F RXA00712 GR00187 1048 500 337 338 RXN00720 VV0232 4899 5564 339 340 F RXA00720 GR00188 7665 7000 341 342 RXN00722 VV0052 2 343 344 F RXA00722 GR00189 1015 512 345 346 RXN00729 VV0024 3903 2926 347 348 F RXA00729 GR00194 1 642 349 350 F RXA02867 GR10008 610 5 351 352 RXN00730 VV0024 2031 2837 353 354 F RXA00730 GR00194 1063 731 355 356 RXN00731 VV0133 8314 10809 357 358 F RXA00731 GR00195 2613 142 359 360 RXN00738 VV0254 3 361 362 F RXA00738 GR00201 78 365 363 364 RXN00750 VV0010 30086 30523 365 366 F RXA00750 GR00202 18937 19374 367 368 RXN00762 VV0103 16953 17828 369 370 RXN00768 VV0103 12997 11879 371 372 F RXA00768 GR00204 5956 6399 373 374 F RXA00767 GR00204 5280 5993 375 376 RXN00769 VV0103 11654 11442 377 378 F RXA00769 GR00204 6624 6836 379 380 RXN00771 VV0103 26639 27457 381 382 F RXA00771 GR00205 857 180 383 384 RXN00785 VV0321 2 658 385 386 F RXA00785 GR00207 625 5 387 388 RXN00795 VV0321 6259 5732 389 390 F RXA00795 GR00211 4228 4755 391 392 RXN00831 VV0180 4205 4906 393 394 F RXA00831 GR00224 1662 961 395 396 RXN00835 VV0138 12068 13021 397 398 F RXA00835 GR00226 3 692 399 400 RXN00836 VV0138 13126 14841 401 402 F RXA00836 GR00226 797 2467 403 404 RXN00840 VV0138 6220 6933 405 406 F RXA00840 GR00228 742 1455 407 408 RXN00841 VV0138 6944 7480 409 410 F RXA00841 GR00228 1466 2002 411 412 RXN00846 VV0138 2367 1498 413 414 F RXA00846 GR00230 391 5 415 416 RXN00850 VV0067 4148 3321 417 418 RXN00854 VV0067 371 159 419 420 F RXA00854 GR00231 4708 4920 421 422 RXN00855 VV0255 735 1019 423 424 F RXA00855 GR00232 526 242 425 426 RXN00869 VV0127 5599 4679 427 428 F RXA00869 GR00239 1 792 429 430 RXN00915 VV0238 886 257 431 432 F RXA00915 GR00251 514 5 433 434 RXN00917 VV0238 7202 4524 435 436 F RXA00917 GR00251 5534 4152 437 438 RXN00921 VV0373 1 513 439 440 F RXA00921 GR00252 4750 2852 441 442 RXN00943 VV0116 11376 12287 443 444 F RXA00943 GR00258 3 509 445 446 F RXA02423 GR00706 221 6 447 448 RXN00945 VV0107 1876 2847 449 450 RXN00946 VV0107 3034 3807 451 452 F RXA00946 GR00259 3034 3807 453 454 RXN00953 VV0260 1834 1082 455 456 RXN00959 VV0208 402 857 457 458 F RXA00959 GR00265 402 728 459 460 RXN00963 VV0249 1816 2652 461 462 F RXA00963 GR00269 442 5 463 464 RXN00971 VV0149 14706 14389 465 466 F RXA00971 GR00273 1421 1149 467 468 RXN00991 VV0210 4424 3045 469 470 RXN01004 VV0210 3045 1984 471 472 RXN01016 VV0209 14476 15123 473 474 F RXA01016 GR00290 1141 494 475 476 RXN01023 VV0143 2343 3320 477 478 F RXA01023 GR00292 1817 867 479 480 RXN01028 VV0015 29000 31048 481 482 F RXA01028 GR00295 3 626 483 484 F RXA01812 GR00514 3 1232 485 486 RXN01069 VV0030 986 273 487 488 F RXA01069 GR00299 606 4 489 490 RXN01071 VV0030 4879 2816 491 492 F RXA02898 GR10040 1631 6 493 494 F RXA01071 GR00299 2822 2436 495 496 RXN01075 VV0084 42045 41635 497 498 F RXA01075 GR00300 3269 2859 499 500 RXN01128 VV0157 2427 3440 501 502 F RXA01128 GR00314 1325 312 503 504 RXN01134 VV0077 774 4 505 506 F RXA01134 GR00317 2 460 507 508 RXN01140 VV0077 1642 710 509 510 F RXA01140 GR00318 3272 4057 511 512 RXN01148 VV0136 3147 3746 513 514 F RXA01148 GR00323 1452 2051 515 516 RXN01153 VV0265 546 4 517 518 F RXA01153 GR00325 546 4 519 520 RXN01154 VV0266 644 6 521 522 F RXA01154 GR00326 608 6 523 524 RXN01155 VV0225 252 1721 525 526 F RXA01155 GR00327 1370 6 527 528 RXN01167 VV0117 12777 13172 529 530 F RXA01167 GR00333 3 323 531 532 RXN01169 VV0117 5804 6799 533 534 F RXA01169 GR00334 1 567 535 536 RXN01173 VV0117 11085 10471 537 538 F RXA01173 GR00334 4853 4239 539 540 RXN01174 VV0117 12236 11487 541 542 F RXA01174 GR00334 6004 5255 543 544 RXN01229 VV0020 32482 31205 545 546 F RXA01229 GR00355 2806 3498 547 548 RXN01246 VV0104 2815 3321 549 550 F RXA01246 GR00360 1824 2462 551 552 RXN01249 VV0271 1 553 554 F RXA01249 GR00363 303 4 555 556 RXN01251 VV0219 13143 12835 557 558 F RXA01251 GR00365 228 536 559 560 RXN01263 VV0009 11816 12727 561 562 F RXA01263 GR00367 10720 11631 563 564 RXN01266 VV0009 15553 14519 565 566 F RXA01266 GR00367 14457 13423 567 568 RXN01275 VV0009 29514 30431 569 570 F RXA01275 GR00367 28418 29335 571 572 RXN01281 VV0212 4506 5267 573 574 F RXA01281 GR00369 3869 4630 575 576 RXN01296 VV0209 10462 9380 577 578 F RXA01296 GR00373 5836 4754 579 580 RXN01306 VV0148 8158 7151 581 582 F RXA01306 GR00376 5691 4684 583 584 RXN01324 VV0082 6588 6887 585 586 RXN01331 VV0005 39816 42212 587 588 F RXA01331 GR00387 1606 1031 589 590 F RXA00668 GR00176 797 6 591 592 F RXA00674 GR00177 755 6 593 594 RXN01337 VV0032 1925 3337 595 596 F RXA01337 GR00389 5065 3653 597 598 RXN01351 VV0123 2841 3425 599 600 RXN01362 VV0051 27040 23387 601 602 F RXA01362 GR00395 3 1397 603 604 F RXA01364 GR00396 1869 4 605 606 RXN01379 VV0091 10518 11459 607 608 F RXA01379 GR00402 926 6 609 610 RXN01390 VV0277 6654 7310 611 612 F RXA01390 GR00408 992 336 613 614 RXN01391 VV0277 5568 6257 615 616 F RXA01391 GR00408 2078 1389 617 618 RXN01400 VV0126 2988 1489 619 620 F RXA01400 GR00409 2988 1489 621 622 RXN01409 VV0278 5304 4483 623 624 F RXA01409 GR00410 5296 4481 625 626 RXN01434 VV0050 13792 10841 627 628 F RXA01434 GR00417 10228 9863 629 630 RXN01448 VV0089 9602 10768 631 632 F RXA01448 GR00418 19796 19017 633 634 RXN01459 VV0233 3311 4120 635 636 F RXA01459 GR00420 3311 4120 637 638 RXN01460 VV0233 4066 4359 639 640 F RXA01460 GR00420 4066 4359 641 642 RXN01471 VV0019 11467 10661 643 644 F RXA01471 GR00422 5243 4437 645 646 RXN01479 VV0019 18635 18874 647 648 F RXA01479 GR00422 12423 12650 649 650 RXN01484 VV0019 26292 25747 651 652 F RXA01484 GR00422 20068 19523 653 654 RXN01485 VV0019 26454 28505 655 656 F RXA01485 GR00422 20230 22281 657 658 RXN01492 VV0139 36004 36807 659 660 F RXA01492 GR00423 6133 5330 661 662 RXN01518 VV0008 23238 23711 663 664 F RXA01518 GR00424 23238 23711 665 666 RXN01549 VV0080 46 1704 667 668 F RXA01549 GR00430 8426 7566 669 670 F RXA02011 GR00603 46 363 671 672 RXN01557 VV0323 959 1774 673 674 F RXA01557 GR00433 959 1774 675 676 RXN01574 VV0009 48980 47946 677 678 F RXA01574 GR00438 6963 5929 679 680 RXN01589 VV0227 1216 197 681 682 RXN01592 VV0229 14706 13405 683 684 F RXA01592 GR00447 3 1295 685 686 RXN01597 VV0229 8480 7299 687 688 F RXA01597 GR00447 6220 7401 689 690 RXN01598 VV0229 7286 6324 691 692 F RXA01598 GR00447 7414 8376 693 694 RXN01618 VV0050 23629 23246 695 696 F RXA01618 GR00451 1387 1004 697 698 RXN01634 VV0050 43466 42915 699 700 F RXA01634 GR00454 4988 5539 701 702 RXN01635 VV0050 42879 42139 703 704 F RXA01635 GR00454 5575 6315 705 706 RXN01647 VV0005 43276 44445 707 708 F RXA01647 GR00456 12422 11535 709 710 RXN01658 VV0010 44183 42351 711 712 F RXA01658 GR00461 5 1489 713 714 RXN01659 VV0089 5059 5604 715 716 F RXA01659 GR00462 3 488 717 718 RXN01663 VV0089 4271 5128 719 720 F RXA01663 GR00463 438 4 721 722 RXN01669 VV0057 4529 5443 723 724 F RXA01669 GR00465 1002 271 725 726 RXN01672 VV0179 7849 8190 727 728 F RXA01672 GR00467 2 310 729 730 RXN01694 VV0139 13054 13953 731 732 F RXA01694 GR00474 3931 3032 733 734 RXN01696 VV0115 1381 203 735 736 F RXA01696 GR00475 799 203 737 738 RXN01697 VV0139 1581 625 739 740 F RXA01697 GR00476 761 1486 741 742 RXN01701 VV0162 375 4 743 744 F RXA01701 GR00478 196 528 745 746 RXN01703 VV0089 7108 8220 747 748 F RXA01703 GR00479 2118 1648 749 750 RXN01709 VV0022 847 416 751 752 F RXA01709 GR00483 745 416 753 754 RXN01711 VV0191 8153 6996 755 756 F RXA01711 GR00484 2007 850 757 758 RXN01721 VV0036 1026 4 759 760 RXN01734 VV0221 1251 1784 761 762 F RXA01734 GR00492 544 1077 763 764 RXN01742 VV0233 5246 4743 765 766 F RXA01742 GR00493 7614 8117 767 768 RXN01754 VV0127 38790 36850 769 770 F RXA01754 GR00497 4082 2142 771 772 RXN01761 VV0010 11968 7505 773 774 F RXA00739 GR00202 819 4 775 776 F RXA01587 GR00442 120 2102 777 778 F RXA01761 GR00499 7001 5484 779 780 RXN01765 VV0054 17190 18131 781 782 F RXA01765 GR00500 3144 4085 783 784 RXN01767 VV0015 55242 55706 785 786 F RXA01767 GR00501 341 6 787 788 RXN01769 VV0015 54296 54736 789 790 F RXA01769 GR00501 1275 847 791 792 RXN01771 VV0050 35063 35764 793 794 F RXA01771 GR00502 886 185 795 796 RXN01774 VV0015 1794 2519 797 798 F RXA01774 GR00503 634 1416 799 800 RXN01787 VV0039 256 948 801 802 F RXA01787 GR00506 2 355 803 804 RXN01796 VV0137 2070 2843 805 806 F RXA01796 GR00508 2 484 807 808 RXN01803 VV0216 3355 4314 809 810 F RXA01803 GR00509 5671 4712 811 812 RXN01809 VV0081 9171 10346 813 814 F RXA01062 GR00297 490 5 815 816 F RXA01809 GR00510 3 638 817 818 RXN01811 VV0146 1243 1923 819 820 RXN01813 VV0084 46618 45953 821 822 F RXA01813 GR00515 635 6 823 824 RXN01815 VV0084 49277 50068 825 826 F RXA01815 GR00515 3294 4085 827 828 RXN01825 VV0083 2847 2578 829 830 F RXA01825 GR00516 2847 2578 831 832 RXN01831 VV0083 10874 10413 833 834 F RXA01831 GR00516 10874 10413 835 836 RXN01834 VV0143 11244 11945 837 838 F RXA01834 GR00517 2478 1777 839 840 RXN01846 VV0010 287 6 841 842 F RXA01846 GR00523 261 4 843 844 RXN01847 VV0139 19018 18284 845 846 F RXA01847 GR00524 52 786 847 848 RXN01874 VV0248 352 5 849 850 F RXA01874 GR00535 2556 2903 851 852 RXN01875 VV0145 2894 2049 853 854 F RXA01875 GR00536 516 1313 855 856 F RXA02734 GR00762 6514 6897 857 858 RXN01877 VV0105 3493 2423 859 860 F RXA01877 GR00537 135 1199 861 862 RXN01879 VV0105 1505 573 863 864 F RXA01879 GR00537 2117 2704 865 866 F RXA01880 GR00537 2641 3048 867 868 RXN01896 VV0098 75888 76523 869 870 F RXA01896 GR00544 2 580 871 872 RXN01899 VV0098 77817 78602 873 874 F RXA01899 GR00544 1874 2659 875 876 RXN01902 VV0098 84095 83037 877 878 F RXA01902 GR00544 7957 7094 879 880 RXN01908 VV0187 4030 4875 881 882 F RXA01908 GR00545 4030 4512 883 884 RXN01909 VV0218 69 947 885 886 F RXA01909 GR00546 59 937 887 888 RXN01910 VV0218 1040 1885 889 890 F RXA01910 GR00546 1030 1875 891 892 RXN01911 VV0218 2209 3147 893 894 F RXA01911 GR00546 2199 3044 895 896 RXN01930 VV0127 46545 47495 897 898 F RXA01930 GR00555 3817 2867 899 900 RXN01944 VV0050 42128 41157 901 902 F RXA01944 GR00558 2 385 903 904 F RXA01636 GR00454 6326 6898 905 906 RXN01945 VV0050 41150 39159 907 908 F RXA01945 GR00558 392 1633 909 910 F RXA01627 GR00453 1 495 911 912 RXN01960 VV0200 2259 1942 913 914 F RXA01960 GR00565 187 504 915 916 RXN01985 VV0056 1331 282 917 918 RXN01987 VV0149 167 379 919 920 F RXA01987 GR00576 167 379 921 922 RXN01988 VV0149 887 462 923 924 F RXA01988 GR00576 779 462 925 926 RXN01991 VV0230 926 1798 927 928 F RXA01991 GR00581 926 1720 929 930 RXN01996 VV0174 28434 27898 931 932 F RXA01996 GR00585 88 624 933 934 RXN02007 VV0324 855 223 935 936 F RXA02007 GR00598 651 223 937 938 RXN02014 VV0137 8298 8804 939 940 F RXA02014 GR00607 935 540 941 942 RXN02019 VV0129 44705 44205 943 944 F RXA02019 GR00612 597 106 945 946 RXN02023 VV0160 3234 4001 947 948 F RXA02023 GR00613 3234 4001 949 950 RXN02032 VV0117 5181 5750 951 952 F RXA02032 GR00618 4160 4729 953 954 RXN02039 VV0190 1482 643 955 956 F RXA02039 GR00621 3 812 957 958 RXN02044 VV0025 17208 15826 959 960 RXN02045 VV0025 15823 15563 961 962 F RXA02045 GR00623 1913 2173 963 964 RXN02049 VV0009 35549 36157 965 966 F RXA02049 GR00624 1583 2029 967 968 RXN02050 VV0009 36003 36797 969 970 F RXA02050 GR00624 2462 2833 971 972 RXN02059 VV0222 10306 10800 973 974 F RXA02059 GR00625 4678 4184 975 976 RXN02066 VV0222 6187 6678 977 978 F RXA02066 GR00626 6187 6678 979 980 RXN02067 VV0222 6733 7188 981 982 F RXA02067 GR00626 6733 7188 983 984 RXN02075 VV0318 12990 13778 985 986 RXN02076 VV0318 13879 14412 987 988 F RXA02076 GR00628 6902 7435 989 990 RXN02094 VV0126 18268 18984 991 992 F RXA02094 GR00629 13282 13998 993 994 RXN02104 VV0318 7435 6314 995 996 F RXA02104 GR00631 5327 4908 997 998 F RXA02071 GR00628 458 6 999 1000 RXN02107 VV0123 21585 21244 1001 1002 F RXA02107 GR00632 1536 1877 1003 1004 RXN02108 VV0123 21217 20609 1005 1006 F RXA02108 GR00632 2077 2511 1007 1008 RXN02114 VV0180 3 1009 1010 F RXA02114 GR00634 615 130 1011 1012 RXN02121 VV0102 12833 12129 1013 1014 F RXA02121 GR00636 5813 5109 1015 1016 RXN02138 VV0300 4409 4750 1017 1018 F RXA02138 GR00639 4409 4750 1019 1020 RXN02151 VV0300 19913 21100 1021 1022 F RXA02151 GR00639 19913 21100 1023 1024 RXN02169 VV0100 3172 4017 1025 1026 F RXA02169 GR00641 3172 4017 1027 1028 RXN02180 VV0100 16813 15356 1029 1030 F RXA02180 GR00641 16813 15356 1031 1032 RXN02185 VV0100 20185 20763 1033 1034 F RXA02185 GR00641 20185 20763 1035 1036 RXN02186 VV0100 21192 20995 1037 1038 F RXA02186 GR00641 21213 20995 1039 1040 RXN02207 VV0302 802 5 1041 1042 F RXA02207 GR00646 10909 11667 1043 1044 RXN02223 VV0308 2732 3232 1045 1046 F RXA02223 GR00652 425 6 1047 1048 RXN02226 VV0068 1059 4 1049 1050 F RXA02226 GR00653 1059 4 1051 1052 RXN02238 VV0204 1345 1629 1053 1054 F RXA02238 GR00654 5241 5525 1055 1056 RXN02254 VV0202 2 1057 1058 F RXA02254 GR00654 21769 22449 1059 1060 RXN02271 VV0020 14281 14838 1061 1062 F RXA02271 GR00655 5406 5963 1063 1064 RXN02279 VV0020 236 1693 1065 1066 F RXA02279 GR00657 1 1404 1067 1068 RXN02296 VV0127 24138 24626 1069 1070 F RXA02296 GR00662 6978 7466 1071 1072 RXN02300 VV0127 28354 28022 1073 1074 F RXA02300 GR00662 11194 10862 1075 1076 RXN02301 VV0127 29070 28354 1077 1078 F RXA02301 GR00662 11910 11194 1079 1080 RXN02302 VV0127 29196 30074 1081 1082 F RXA02302 GR00662 12036 12800 1083 1084 RXN02303 VV0127 13326 14231 1085 1086 F RXA02303 GR00663 1 720 1087 1088 RXN02307 VV0127 12611 11991 1089 1090 F RXA02307 GR00664 395 6 1091 1092 RXN02314 VV0025 23092 23532 1093 1094 F RXA02314 GR00665 6379 5939 1095 1096 RXN02337 VV0141 4679 3357 1097 1098 F RXA02337 GR00672 2893 3816 1099 1100 RXN02339 VV0195 1 1101 1102 F RXA02339 GR00674 1 492 1103 1104 RXN02340 VV0195 1640 576 1105 1106 F RXA02338 GR00673 484 5 1107 1108 F RXA02340 GR00674 1214 576 1109 1110 RXN02341 VV0078 4279 4764 1111 1112 F RXA02341 GR00675 415 5 1113 1114 RXN02360 VV0051 14638 12206 1115 1116 F RXA02360 GR00685 3644 6076 1117 1118 RXN02361 VV0051 12122 11472 1119 1120 F RXA02361 GR00685 6160 6810 1121 1122 RXN02367 VV0102 4639 5247 1123 1124 F RXA02367 GR00687 2162 1554 1125 1126 RXN02368 VV0102 3883 4557 1127 1128 F RXA02368 GR00687 2918 2244 1129 1130 RXN02381 VV0213 3765 2743 1131 1132 F RXA02381 GR00691 1792 770 1133 1134 RXN02383 VV0213 639 4 1135 1136 F RXA02383 GR00692 608 6 1137 1138 RXN02387 VV0176 2729 3490 1139 1140 F RXA02387 GR00694 683 6 1141 1142 RXN02398 VV0176 12750 11149 1143 1144 F RXA02398 GR00698 2841 4370 1145 1146 RXN02406 VV0084 22016 22564 1147 1148 F RXA02406 GR00701 1322 774 1149 1150 RXN02407 VV0084 21758 21387 1151 1152 F RXA02407 GR00701 1580 1885 1153 1154 RXN02408 VV0084 20832 19921 1155 1156 F RXA02408 GR00702 832 5 1157 1158 RXN02409 VV0084 21371 20835 1159 1160 F RXA02409 GR00702 1248 835 1161 1162 RXN02428 VV0110 4585 3452 1163 1164 F RXA02428 GR00707 4585 3452 1165 1166 RXN02454 VV0196 2810 1569 1167 1168 F RXA02454 GR00711 3 815 1169 1170 RXN02457 VV0124 19193 18084 1171 1172 F RXA02457 GR00712 1295 2404 1173 1174 RXN02460 VV0124 14649 15152 1175 1176 F RXA02460 GR00712 5839 5336 1177 1178 RXN02464 VV0211 1990 3189 1179 1180 F RXA02464 GR00713 1107 1613 1181 1182 RXN02465 VV0211 3590 3192 1183 1184 F RXA02465 GR00713 2014 1616 1185 1186 RXN02466 VV0211 92 6 1187 1188 F RXA02466 GR00714 92 6 1189 1190 RXN02505 VV0007 23969 24139 1191 1192 F RXA02505 GR00720 18423 18593 1193 1194 RXN02510 VV0171 17467 16832 1195 1196 F RXA02510 GR00721 1983 2618 1197 1198 RXN02519 VV0183 2709 4337 1199 1200 F RXA02519 GR00724 1933 128 1201 1202 RXN02520 VV0183 2243 1560 1203 1204 F RXA02520 GR00724 2222 2905 1205 1206 RXN02534 VV0057 11192 11995 1207 1208 F RXA02534 GR00726 5536 6339 1209 1210 RXN02537 VV0057 14617 15078 1211 1212 F RXA02537 GR00726 8961 9422 1213 1214 RXN02538 VV0057 15078 15749 1215 1216 F RXA02538 GR00726 9422 10093 1217 1218 RXN02555 VV0101 5340 4738 1219 1220 F RXA02555 GR00731 1757 1155 1221 1222 RXN02564 VV0154 10016 9015 1223 1224 F RXA02564 GR00732 2543 3217 1225 1226 RXN02568 VV0245 1657 5 1227 1228 F RXA02568 GR00735 1363 5 1229 1230 RXN02593 VV0098 11073 11669 1231 1232 F RXA02593 GR00741 18693 18481 1233 1234 F RXA02594 GR00741 19077 18754 1235 1236 RXN02606 VV0098 34557 35927 1237 1238 F RXA02606 GR00742 13514 12144 1239 1240 RXN02610 VV0098 31620 30694 1241 1242 F RXA02610 GR00742 16452 17378 1243 1244 RXN02624 VV0129 29202 30497 1245 1246 F RXA02624 GR00746 5602 4889 1247 1248 RXN02626 VV0314 2012 1008 1249 1250 RXN02656 VV0090 15756 14917 1251 1252 RXN02673 VV0315 14030 13398 1253 1254 F RXA02673 GR00753 14030 13398 1255 1256 RXN02680 VV0098 64917 66200 1257 1258 F RXA02680 GR00754 6392 5109 1259 1260 F RXA02679 GR00754 5268 5693 1261 1262 F RXA02681 GR00754 5751 6194 1263 1264 RXN02693 VV0098 74100 75875 1265 1266 F RXA02693 GR00755 1650 4 1267 1268 RXN02696 VV0017 7946 7491 1269 1270 F RXA02696 GR00756 742 287 1271 1272 RXN02697 VV0017 31257 32783 1273 1274 F RXA02697 GR00757 1 699 1275 1276 F RXA02719 GR00758 19598 20245 1277 1278 RXN02720 VV0017 8727 8026 1279 1280 F RXA02720 GR00759 631 5 1281 1282 RXN02744 VV0074 893 1696 1283 1284 F RXA02744 GR00763 14460 13657 1285 1286 RXN02770 VV0171 4202 2637 1287 1288 F RXA02770 GR00772 3 1322 1289 1290 RXN02781 VV0084 14566 13376 1291 1292 F RXA02781 GR00774 1345 155 1293 1294 RXN02782 VV0093 7148 8446 1295 1296 F RXA02782 GR00775 204 875 1297 1298 RXN02812 VV0210 342 4 1299 1300 F RXA02812 GR00793 2 568 1301 1302 RXN02817 VV0346 403 5 1303 1304 F RXA02817 GR00798 403 5 1305 1306 RXN02818 VV0347 611 6 1307 1308 F RXA02818 GR00799 611 6 1309 1310 RXN02825 VV0082 3589 1751 1311 1312 F RXA01322 GR00385 443 6 1313 1314 F RXA02824 GR00805 531 4 1315 1316 F RXA02825 GR00806 565 182 1317 1318 RXN02838 VV0161 1 1319 1320 F RXA02838 GR00831 1 462 1321 1322 RXN02840 VV0365 488 339 1323 1324 F RXA02840 GR00835 488 339 1325 1326 RXN02841 VV0055 11788 12222 1327 1328 F RXA02841 GR00840 283 5 1329 1330 RXN02846 VV0127 30861 30112 1331 1332 F RXA02846 GR00845 578 6 1333 1334 RXN02847 VV0113 47 1135 1335 1336 F RXA02847 GR00847 598 5 1337 1338 RXN02849 VV0237 2 1339 1340 F RXA02849 GR00849 2 283 1341 1342 RXN02911 VV0135 24643 25101 1343 1344 RXN02914 VV0127 17305 16763 1345 1346 RXN02921 VV0213 1871 1401 1347 1348 RXN02924 VV0088 4557 5105 1349 1350 RXN02927 VV0082 18836 19303 1351 1352 RXN02928 VV0082 19511 20203 1353 1354 RXN02931 VV0090 25420 25644 1355 1356 RXN02932 VV0176 23391 24362 1357 1358 RXN02934 VV0103 14533 14838 1359 1360 RXN02936 VV0197 24360 24557 1361 1362 RXN02939 VV0008 33988 32387 1363 1364 F RXA01383 GR00406 1147 5 1365 1366 RXN02950 VV0224 7629 7306 1367 1368 RXN02951 VV0176 5739 5131 1369 1370 RXN02957 VV0020 30448 30158 1371 1372 RXN02967 VV0318 6614 6931 1373 1374 RXN02971 VV0210 951 640 1375 1376 RXN02978 VV0010 2191 683 1377 1378 RXN02995 VV0069 348 1913 1379 1380 RXN02997 VV0069 3709 2981 1381 1382 RXN03001 VV0170 422 874 1383 1384 RXN03005 VV0237 1101 334 1385 1386 RXN03009 VV0238 353 6 1387 1388 RXN03010 VV0238 7435 7199 1389 1390 RXN03011 VV0098 2984 3184 1391 1392 RXN03012 VV0241 2 571 1393 1394 RXN03017 VV0218 5720 7258 1395 1396 F RXA02753 GR00765 2630 138 1397 1398 RXN03018 VV0218 7221 8213 1399 1400 RXN03024 VV0003 6315 7730 1401 1402 RXN03025 VV0003 8668 7796 1403 1404 RXN03027 VV0008 17 151 1405 1406 RXN03029 VV0009 95 607 1407 1408 RXN03031 VV0011 1 789 1409 1410 RXN03032 VV0012 3652 3936 1411 1412 RXN03034 VV0013 2 661 1413 1414 F RXA00063 GR00010 1658 1374 1415 1416 RXN03037 VV0015 5364 5549 1417 1418 RXN03041 VV0018 1770 1273 1419 1420 F RXA02892 GR10035 1171 668 1421 1422 RXN03045 VV0019 33044 34039 1423 1424 RXN03046 VV0020 1 336 1425 1426 RXN03047 VV0020 25070 26485 1427 1428 F RXA00036 GR00004 7204 8619 1429 1430 RXN03048 VV0020 27423 26551 1431 1432 F RXA00037 GR00004 9557 8685 1433 1434 RXN03050 VV0021 6368 7333 1435 1436 RXN03053 VV0026 12 1535 1437 1438 F RXA02885 GR10021 1 1536 1439 1440 RXN03055 VV0026 3519 3947 1441 1442 F RXA00261 GR00039 11693 11265 1443 1444 F RXA02888 GR10024 326 754 1445 1446 RXN03059 VV0030 5373 4894 1447 1448 F RXA02899 GR10040 2125 1646 1449 1450 RXN03062 VV0035 525 4 1451 1452 RXN03066 VV0038 7298 6636 1453 1454 F RXA02876 GR10016 405 1067 1455 1456 RXN03067 VV0038 7493 7323 1457 1458 RXN03068 VV0038 7648 7529 1459 1460 RXN03073 VV0042 1573 944 1461 1462 F RXA02905 GR10044 477 4 1463 1464 RXN03085 VV0048 4511 4161 1465 1466 RXN03089 VV0053 1183 26 1467 1468 F RXA00071 GR00011 4013 5464 1469 1470 RXN03098 VV0064 2100 2723 1471 1472 RXN03099 VV0064 5576 6250 1473 1474 RXN03104 VV0071 401 577 1475 1476 RXN03106 VV0074 15930 16121 1477 1478 RXN03107 VV0076 232 432 1479 1480 RXN03113 VV0086 6541 8139 1481 1482 F RXA00506 GR00126 489 1829 1483 1484 RXN03115 VV0089 148 546 1485 1486 RXN03122 VV0104 3329 3475 1487 1488 RXN03134 VV0127 65312 65662 1489 1490 RXN03135 VV0127 66674 67402 1491 1492 F RXA02285 GR00660 1544 2272 1493 1494 RXN03138 VV0129 21194 21664 1495 1496 RXN03140 VV0131 4550 4302 1497 1498 RXN03141 VV0135 31144 31473 1499 1500 RXN03146 VV0143 25998 26468 1501 1502 RXN03147 VV0144 2726 2977 1503 1504 RXN03149 VV0146 969 1235 1505 1506 RXN03152 VV0166 264 536 1507 1508 RXN03153 VV0176 46481 47044 1509 1510 RXN03154 VV0179 1328 2239 1511 1512 RXN03156 VV0187 4908 5087 1513 1514 F RXA00176 GR00027 3475 3317 1515 1516 RXN03162 VV0195 909 1304 1517 1518 RXN03167 VV0327 633 4 1519 1520 F RXA02862 GR10006 1695 2330 1521 1522 RXN03170 VV0328 457 209 1523 1524 F RXA02856 GR10003 459 211 1525 1526 RXN03172 VV0329 1392 367 1527 1528 F RXA02858 GR10004 1392 367 1529 1530 RXN03173 VV0330 1340 243 1531 1532 F RXA02874 GR10015 1348 869 1533 1534 RXN03174 VV0331 461 6 1535 1536 F RXA02884 GR10020 1695 2156 1537 1538 RXN03177 VV0333 816 151 1539 1540 F RXA02881 GR10019 94 759 1541 1542 RXN03182 VV0339 276 4 1543 1544 RXN03184 VV0374 517 20 1545 1546 RXN03185 VV0375 311 123 1547 1548 RXA00003 GR00001 2279 3019 1549 1550 RXA00008 GR00002 606 115 1551 1552 RXA00015 GR00002 5999 6307 1553 1554 RXA00018 GR00002 12979 14277 1555 1556 RXA00020 GR00002 17142 16363 1557 1558 RXA00021 GR00002 18766 20538 1559 1560 RXA00025 GR00003 2211 3647 1561 1562 RXA00031 GR00003 10383 9982 1563 1564 RXA00049 GR00008 2270 2956 1565 1566 RXA00052 GR00008 7957 7247 1567 1568 RXA00054 GR00008 8557 11469 1569 1570 RXA00058 GR00009 7394 6831 1571 1572 RXA00059 GR00009 8301 8020 1573 1574 RXA00065 GR00010 4140 4412 1575 1576 RXA00068 GR00011 1305 724 1577 1578 RXA00079 GR00012 6599 6820 1579 1580 RXA00082 GR00012 9019 8456 1581 1582 RXA00083 GR00013 771 1070 1583 1584 RXA00093 GR00014 204 2426 1585 1586 RXA00101 GR00014 10514 10107 1587 1588 RXA00108 GR00015 546 4 1589 1590 RXA00110 GR00016 364 912 1591 1592 RXA00117 GR00019 791 201 1593 1594 RXA00118 GR00019 918 1172 1595 1596 RXA00119 GR00019 1704 2462 1597 1598 RXA00121 GR00019 3473 4183 1599 1600 RXA00122 GR00019 4220 5842 1601 1602 RXA00127 GR00020 2871 2416 1603 1604 RXA00134 GR00021 1648 1079 1605 1606 RXA00140 GR00022 3841 3656 1607 1608 RXA00141 GR00022 4307 3846 1609 1610 RXA00142 GR00022 4776 4300 1611 1612 RXA00150 GR00023 4085 4858 1613 1614 RXA00151 GR00023 4956 5552 1615 1616 RXA00153 GR00023 7656 7231 1617 1618 RXA00155 GR00023 8615 9397 1619 1620 RXA00159 GR00024 3868 2687 1621 1622 RXA00161 GR00024 4893 5354 1623 1624 RXA00169 GR00026 5222 3150 1625 1626 RXA00170 GR00026 9914 8061 1627 1628 RXA00173 GR00027 1716 1384 1629 1630 RXA00174 GR00027 2079 1795 1631 1632 RXA00175 GR00027 2732 2103 1633 1634 RXA00179 GR00028 1714 1256 1635 1636 RXA00180 GR00028 2334 1795 1637 1638 RXA00183 GR00028 7344 8195 1639 1640 RXA00185 GR00028 9418 12045 1641 1642 RXA00199 GR00031 2172 754 1643 1644 RXA00200 GR00031 2837 2535 1645 1646 RXA00207 GR00032 6430 6747 1647 1648 RXA00211 GR00032 10120 10782 1649 1650 RXA00218 GR00032 18104 19243 1651 1652 RXA00220 GR00032 20666 20163 1653 1654 RXA00230 GR00034 746 27 1655 1656 RXA00233 GR00036 420 4 1657 1658 RXA00234 GR00036 998 459 1659 1660 RXA00237 GR00036 3668 4045 1661 1662 RXA00238 GR00036 4186 4554 1663 1664 RXA00239 GR00036 5118 4534 1665 1666 RXA00240 GR00036 5342 5133 1667 1668 RXA00244 GR00037 1565 930 1669 1670 RXA00245 GR00037 3049 1565 1671 1672 RXA00248 GR00037 7843 7121 1673 1674 RXA00250 GR00038 6 221 1675 1676 RXA00252 GR00038 485 727 1677 1678 RXA00257 GR00039 1760 2215 1679 1680 RXA00258 GR00039 3219 3890 1681 1682 RXA00260 GR00039 9234 10409 1683 1684 RXA00273 GR00042 185 1297 1685 1686 RXA00274 GR00042 1556 4165 1687 1688 RXA00275 GR00042 4696 4238 1689 1690 RXA00276 GR00042 5016 4675 1691 1692 RXA00279 GR00043 4001 2616 1693 1694 RXA00282 GR00044 793 5 1695 1696 RXA00285 GR00046 3 515 1697 1698 RXA00286 GR00046 579 1142 1699 1700 RXA00294 GR00047 2761 3189 1701 1702 RXA00297 GR00048 2861 3772 1703 1704 RXA00320 GR00057 358 537 1705 1706 RXA00321 GR00057 2411 597 1707 1708 RXA00322 GR00057 3658 2555 1709 1710 RXA00325 GR00057 8594 9238 1711 1712 RXA00326 GR00057 9378 9857 1713 1714 RXA00336 GR00057 19461 19931 1715 1716 RXA00337 GR00058 530 6 1717 1718 RXA00339 GR00059 817 1533 1719 1720 RXA00349 GR00066 3 1061 1721 1722 RXA00355 GR00069 635 510 1723 1724 RXA00375 GR00080 549 49 1725 1726 RXA00380 GR00082 836 216 1727 1728 RXA00387 GR00084 1403 591 1729 1730 RXA00392 GR00086 3890 3027 1731 1732 RXA00394 GR00086 5322 4990 1733 1734 RXA00395 GR00086 5417 5716 1735 1736 RXA00396 GR00086 6653 6183 1737 1738 RXA00397 GR00086 7206 6667 1739 1740 RXA00398 GR00087 1 681 1741 1742 RXA00408 GR00091 642 1088 1743 1744 RXA00409 GR00091 1088 2500 1745 1746 RXA00411 GR00092 1685 1011 1747 1748 RXA00423 GR00097 909 457 1749 1750 RXA00424 GR00097 1379 909 1751 1752 RXA00425 GR00097 1433 1657 1753 1754 RXA00428 GR00098 2657 2025 1755 1756 RXA00429 GR00098 3063 2662 1757 1758 RXA00430 GR00098 3473 3063 1759 1760 RXA00433 GR00100 1446 1970 1761 1762 RXA00451 GR00110 816 325 1763 1764 RXA00457 GR00114 1451 372 1765 1766 RXA00462 GR00116 3023 1644 1767 1768 RXA00463 GR00116 4209 3388 1769 1770 RXA00468 GR00118 1282 464 1771 1772 RXA00469 GR00119 1647 472 1773 1774 RXA00472 GR00119 5449 4589 1775 1776 RXA00474 GR00119 6575 8152 1777 1778 RXA00475 GR00119 8822 8163 1779 1780 RXA00476 GR00119 8961 9821 1781 1782 RXA00481 GR00119 17636 18220 1783 1784 RXA00486 GR00120 1 702 1785 1786 RXA00490 GR00121 2676 1774 1787 1788 RXA00491 GR00122 1057 638 1789 1790 RXA00493 GR00123 3 326 1791 1792 RXA00519 GR00132 4 516 1793 1794 RXA00528 GR00136 3562 4650 1795 1796 RXA00529 GR00136 5274 4732 1797 1798 RXA00530 GR00136 6837 5557 1799 1800 RXA00535 GR00137 5155 5871 1801 1802 RXA00540 GR00139 2027 2269 1803 1804 RXA00549 GR00143 502 897 1805 1806 RXA00550 GR00143 935 1255 1807 1808 RXA00553 GR00145 742 1062 1809 1810 RXA00554 GR00145 1606 1136 1811 1812 RXA00563 GR00151 1 2739 1813 1814 RXA00564 GR00151 3744 4148 1815 1816 RXA00573 GR00156 117 767 1817 1818 RXA00576 GR00156 2916 2245 1819 1820 RXA00577 GR00156 2980 3327 1821 1822 RXA00578 GR00156 4087 3365 1823 1824 RXA00582 GR00156 9442 8924 1825 1826 RXA00585 GR00156 11894 11577 1827 1828 RXA00586 GR00156 12818 11937 1829 1830 RXA00587 GR00156 13008 13490 1831 1832 RXA00595 GR00159 3 332 1833 1834 RXA00597 GR00159 797 1066 1835 1836 RXA00598 GR00159 1070 1387 1837 1838 RXA00601 GR00159 3459 3749 1839 1840 RXA00602 GR00159 4907 4155 1841 1842 RXA00604 GR00159 5489 5779 1843 1844 RXA00610 GR00161 1193 2056 1845 1846 RXA00611 GR00161 3640 2165 1847 1848 RXA00613 GR00162 1652 1200 1849 1850 RXA00614 GR00162 1680 2594 1851 1852 RXA00617 GR00162 4002 5084 1853 1854 RXA00628 GR00165 1284 877 1855 1856 RXA00631 GR00166 172 1626 1857 1858 RXA00637 GR00167 2002 2754 1859 1860 RXA00646 GR00169 446 6 1861 1862 RXA00649 GR00169 2823 3278 1863 1864 RXA00652 GR00169 5449 5997 1865 1866 RXA00654 GR00169 7213 8478 1867 1868 RXA00656 GR00169 9495 9235 1869 1870 RXA00657 GR00169 10882 9980 1871 1872 RXA00661 GR00172 664 1353 1873 1874 RXA00667 GR00175 593 1177 1875 1876 RXA00676 GR00178 647 1393 1877 1878 RXA00678 GR00179 1037 303 1879 1880 RXA00691 GR00181 2152 1223 1881 1882 RXA00692 GR00181 3450 2317 1883 1884 RXA00693 GR00181 4303 3821 1885 1886 RXA00701 GR00182 427 801 1887 1888 RXA00707 GR00185 377 1348 1889 1890 RXA00713 GR00188 71 1033 1891 1892 RXA00714 GR00188 1809 1249 1893 1894 RXA00716 GR00188 3002 3514 1895 1896 RXA00719 GR00188 5283 6911 1897 1898 RXA00724 GR00191 811 164 1899 1900 RXA00726 GR00192 841 701 1901 1902 RXA00740 GR00202 1646 1068 1903 1904 RXA00741 GR00202 2986 2054 1905 1906 RXA00742 GR00202 5517 3868 1907 1908 RXA00743 GR00202 6652 6230 1909 1910 RXA00745 GR00202 13874 13341 1911 1912 RXA00746 GR00202 13755 14945 1913 1914 RXA00747 GR00202 15067 15654 1915 1916 RXA00748 GR00202 15917 16360 1917 1918 RXA00749 GR00202 17240 16542 1919 1920 RXA00751 GR00202 20245 19418 1921 1922 RXA00752 GR00202 21847 21419 1923 1924 RXA00757 GR00203 3119 4372 1925 1926 RXA00763 GR00204 1384 2166 1927 1928 RXA00765 GR00204 3283 3969 1929 1930 RXA00781 GR00206 2682 2395 1931 1932 RXA00788 GR00209 910 686 1933 1934 RXA00804 GR00215 438 881 1935 1936 RXA00805 GR00215 2057 2938 1937 1938 RXA00808 GR00217 1029 352 1939 1940 RXA00812 GR00219 287 1345 1941 1942 RXA00814 GR00219 2463 3236 1943 1944 RXA00815 GR00219 3236 3808 1945 1946 RXA00816 GR00219 4382 4678 1947 1948 RXA00826 GR00223 567 37 1949 1950 RXA00830 GR00224 266 988 1951 1952 RXA00853 GR00231 3775 3173 1953 1954 RXA00861 GR00235 6 431 1955 1956 RXA00862 GR00236 580 17 1957 1958 RXA00874 GR00241 758 1846 1959 1960 RXA00876 GR00241 4208 2454 1961 1962 RXA00881 GR00242 8057 8434 1963 1964 RXA00882 GR00242 8788 9465 1965 1966 RXA00883 GR00242 10060 9542 1967 1968 RXA00887 GR00242 13544 14266 1969 1970 RXA00889 GR00242 15341 15928 1971 1972 RXA00893 GR00244 789 193 1973 1974 RXA00895 GR00244 2578 1988 1975 1976 RXA00904 GR00246 1457 702 1977 1978 RXA00908 GR00247 1611 2168 1979 1980 RXA00916 GR00251 4108 518 1981 1982 RXA00926 GR00253 466 104 1983 1984 RXA00930 GR00253 3841 3089 1985 1986 RXA00932 GR00253 5068 5541 1987 1988 RXA00933 GR00253 6047 5586 1989 1990 RXA00940 GR00257 129 524 1991 1992 RXA00949 GR00259 5400 6047 1993 1994 RXA00969 GR00273 1 147 1995 1996 RXA00973 GR00274 2272 1670 1997 1998 RXA00978 GR00276 217 831 1999 2000 RXA00986 GR00280 60 401 2001 2002 RXA00987 GR00280 875 411 2003 2004 RXA00988 GR00280 1371 949 2005 2006 RXA01005 GR00286 520 1365 2007 2008 RXA01007 GR00287 2572 866 2009 2010 RXA01008 GR00287 2719 4659 2011 2012 RXA01011 GR00288 2089 857 2013 2014 RXA01017 GR00290 2175 1567 2015 2016 RXA01021 GR00291 1759 2280 2017 2018 RXA01029 GR00295 1338 1826 2019 2020 RXA01031 GR00295 3182 3847 2021 2022 RXA01032 GR00295 3974 4348 2023 2024 RXA01033 GR00295 4363 4698 2025 2026 RXA01034 GR00295 5177 4824 2027 2028 RXA01035 GR00295 5818 6423 2029 2030 RXA01036 GR00295 6513 6965 2031 2032 RXA01037 GR00295 7000 7527 2033 2034 RXA01038 GR00295 7530 8276 2035 2036 RXA01039 GR00295 9540 8965 2037 2038 RXA01040 GR00295 9711 10613 2039 2040 RXA01041 GR00295 10780 10932 2041 2042 RXA01042 GR00295 11088 12365 2043 2044 RXA01043 GR00295 12774 13346 2045 2046 RXA01044 GR00295 14024 15280 2047 2048 RXA01045 GR00295 15407 17230 2049 2050 RXA01046 GR00295 17441 19219 2051 2052 RXA01047 GR00295 19244 19717 2053 2054 RXA01058 GR00296 8566 8246 2055 2056 RXA01063 GR00297 828 499 2057 2058 RXA01066 GR00298 605 1330 2059 2060 RXA01068 GR00298 2184 3254 2061 2062 RXA01074 GR00300 2811 2107 2063 2064 RXA01076 GR00300 4374 3355 2065 2066 RXA01078 GR00300 6043 6876 2067 2068 RXA01083 GR00302 1777 1502 2069 2070 RXA01088 GR00304 3083 1902 2071 2072 RXA01091 GR00305 546 76 2073 2074 RXA01092 GR00305 702 881 2075 2076 RXA01092 GR00305 702 881 2077 2078 RXA01096 GR00306 4341 3643 2079 2080 RXA01102 GR00306 10018 8774 2081 2082 RXA01103 GR00306 10316 10092 2083 2084 RXA01107 GR00306 13612 14811 2085 2086 RXA01108 GR00306 15562 14912 2087 2088 RXA01109 GR00306 16281 15640 2089 2090 RXA01119 GR00310 1068 139 2091 2092 RXA01122 GR00311 557 36 2093 2094 RXA01123 GR00311 1090 644 2095 2096 RXA01127 GR00314 2 280 2097 2098 RXA01129 GR00314 1461 3326 2099 2100 RXA01131 GR00315 445 1311 2101 2102 RXA01137 GR00318 1101 1460 2103 2104 RXA01156 GR00327 1588 1388 2105 2106 RXA01158 GR00328 2580 1639 2107 2108 RXA01159 GR00328 3089 2775 2109 2110 RXA01160 GR00328 4187 3213 2111 2112 RXA01163 GR00331 710 6 2113 2114 RXA01165 GR00332 2155 1583 2115 2116 RXA01166 GR00332 3005 2523 2117 2118 RXA01170 GR00334 638 1120 2119 2120 RXA01171 GR00334 1714 2406 2121 2122 RXA01176 GR00335 1980 1477 2123 2124 RXA01177 GR00335 2121 4106 2125 2126 RXA01178 GR00335 4106 4555 2127 2128 RXA01184 GR00338 1489 17 2129 2130 RXA01186 GR00338 3742 2645 2131 2132 RXA01186 GR00338 3742 2645 2133 2134 RXA01187 GR00338 3850 4308 2135 2136 RXA01195 GR00343 1413 1859 2137 2138 RXA01196 GR00343 1889 2578 2139 2140 RXA01197 GR00343 3333 2881 2141 2142 RXA01198 GR00343 3422 3724 2143 2144 RXA01207 GR00347 126 773 2145 2146 RXA01213 GR00351 1508 282 2147 2148 RXA01218 GR00353 1078 1506 2149 2150 RXA01234 GR00357 633 250 2151 2152 RXA01237 GR00358 2751 2311 2153 2154 RXA01267 GR00367 16799 15486 2155 2156 RXA01268 GR00367 19365 18526 2157 2158 RXA01271 GR00367 23467 21656 2159 2160 RXA01273 GR00367 26475 25042 2161 2162 RXA01282 GR00369 5444 4665 2163 2164 RXA01294 GR00373 3537 2872 2165 2166 RXA01295 GR00373 3764 4738 2167 2168 RXA01304 GR00376 1982 2467 2169 2170 RXA01310 GR00380 803 477 2171 2172 RXA01313 GR00381 1116 172 2173 2174 RXA01315 GR00382 1394 744 2175 2176 RXA01316 GR00382 1855 1553 2177 2178 RXA01317 GR00382 2296 1877 2179 2180 RXA01318 GR00382 3616 2315 2181 2182 RXA01330 GR00387 569 1024 2183 2184 RXA01333 GR00389 1231 227 2185 2186 RXA01336 GR00389 3640 3038 2187 2188 RXA01342 GR00389 11296 12807 2189 2190 RXA01348 GR00392 261 752 2191 2192 RXA01349 GR00392 1531 755 2193 2194 RXA01357 GR00393 4357 4659 2195 2196 RXA01359 GR00393 6857 8038 2197 2198 RXA01366 GR00397 1369 980 2199 2200 RXA01367 GR00397 1518 1919 2201 2202 RXA01370 GR00398 1875 2225 2203 2204 RXA01372 GR00399 1 591 2205 2206 RXA01378 GR00401 1281 4 2207 2208 RXA01380 GR00403 2 2017 2209 2210 RXA01384 GR00406 3238 1523 2211 2212 RXA01396 GR00408 6475 6218 2213 2214 RXA01397 GR00408 6894 6475 2215 2216 RXA01401 GR00409 3193 3453 2217 2218 RXA01402 GR00409 3508 3981 2219 2220 RXA01405 GR00410 1844 1389 2221 2222 RXA01413 GR00412 854 1453 2223 2224 RXA01414 GR00412 1628 2134 2225 2226 RXA01417 GR00414 645 49 2227 2228 RXA01421 GR00416 1215 829 2229 2230 RXA01425 GR00417 1701 2585 2231 2232 RXA01429 GR00417 5651 6268 2233 2234 RXA01439 GR00418 5949 6494 2235 2236 RXA01440 GR00418 7496 6489 2237 2238 RXA01441 GR00418 8542 7514 2239 2240 RXA01445 GR00418 15083 14091 2241 2242 RXA01447 GR00418 17885 18733 2243 2244 RXA01452 GR00419 2363 2641 2245 2246 RXA01456 GR00420 898 1419 2247 2248 RXA01457 GR00420 1499 2173 2249 2250 RXA01463 GR00421 2493 1330 2251 2252 RXA01469 GR00422 2091 3122 2253 2254 RXA01470 GR00422 4112 3687 2255 2256 RXA01472 GR00422 5783 5328 2257 2258 RXA01473 GR00422 6596 5832 2259 2260 RXA01474 GR00422 6678 7223 2261 2262 RXA01475 GR00422 7651 7226 2263 2264 RXA01476 GR00422 7847 8188 2265 2266 RXA01488 GR00423 2179 1349 2267 2268 RXA01494 GR00423 8515 7520 2269 2270 RXA01497 GR00424 262 1179 2271 2272 RXA01501 GR00424 8130 7843 2273 2274 RXA01504 GR00424 10710 11318 2275 2276 RXA01505 GR00424 11318 11815 2277 2278 RXA01506 GR00424 11815 12225 2279 2280 RXA01507 GR00424 12239 12661 2281 2282 RXA01519 GR00424 23725 24471 2283 2284 RXA01520 GR00424 24784 25167 2285 2286 RXA01523 GR00424 27951 28901 2287 2288 RXA01525 GR00424 32301 30580 2289 2290 RXA01527 GR00425 5126 2616 2291 2292 RXA01536 GR00427 4066 2825 2293 2294 RXA01540 GR00428 3083 2382 2295 2296 RXA01543 GR00430 2802 37 2297 2298 RXA01544 GR00430 3496 2897 2299 2300 RXA01545 GR00430 4838 3588 2301 2302 RXA01546 GR00430 5584 4889 2303 2304 RXA01547 GR00430 6371 5709 2305 2306 RXA01548 GR00430 7432 6425 2307 2308 RXA01552 GR00431 6122 5145 2309 2310 RXA01554 GR00432 3719 1578 2311 2312 RXA01560 GR00435 767 438 2313 2314 RXA01575 GR00438 8024 7005 2315 2316 RXA01577 GR00438 8811 9185 2317 2318 RXA01579 GR00439 671 1054 2319 2320 RXA01585 GR00441 1226 600 2321 2322 RXA01586 GR00441 1597 1229 2323 2324 RXA01595 GR00447 3326 4285 2325 2326 RXA01600 GR00447 10460 11128 2327 2328 RXA01602 GR00447 13591 12062 2329 2330 RXA01605 GR00448 960 2474 2331 2332 RXA01610 GR00449 4343 3615 2333 2334 RXA01611 GR00449 4832 4476 2335 2336 RXA01612 GR00449 5235 4891 2337 2338 RXA01619 GR00451 2407 1433 2339 2340 RXA01622 GR00452 1908 2510 2341 2342 RXA01623 GR00452 2514 3224 2343 2344 RXA01624 GR00452 3220 3564 2345 2346 RXA01628 GR00453 866 1879 2347 2348 RXA01630 GR00454 341 1417 2349 2350 RXA01641 GR00456 5182 6552 2351 2352 RXA01642 GR00456 6557 7798 2353 2354 RXA01643 GR00456 8374 7949 2355 2356 RXA01645 GR00456 10574 9969 2357 2358 RXA01646 GR00456 11513 10695 2359 2360 RXA01656 GR00460 1548 2444 2361 2362 RXA01665 GR00463 2152 1433 2363 2364 RXA01671 GR00466 854 1468 2365 2366 RXA01673 GR00467 1807 773 2367 2368 RXA01675 GR00467 2824 3234 2369 2370 RXA01676 GR00467 4179 3424 2371 2372 RXA01677 GR00467 5043 4300 2373 2374 RXA01681 GR00467 10681 11313 2375 2376 RXA01685 GR00470 1488 910 2377 2378 RXA01686 GR00470 2026 1586 2379 2380 RXA01693 GR00474 1553 2974 2381 2382 RXA01714 GR00485 985 371 2383 2384 RXA01715 GR00485 1267 1962 2385 2386 RXA01729 GR00489 2636 3154 2387 2388 RXA01731 GR00491 109 807 2389 2390 RXA01738 GR00493 3971 4684 2391 2392 RXA01741 GR00493 7535 6738 2393 2394 RXA01748 GR00495 3681 4460 2395 2396 RXA01749 GR00495 4633 6249 2397 2398 RXA01750 GR00496 1878 3518 2399 2400 RXA01752 GR00497 557 6 2401 2402 RXA01753 GR00497 2095 557 2403 2404 RXA01760 GR00498 5095 5376 2405 2406 RXA01768 GR00501 827 450 2407 2408 RXA01770 GR00501 5134 1370 2409 2410 RXA01773 GR00503 34 444 2411 2412 RXA01775 GR00504 178 741 2413 2414 RXA01776 GR00504 838 2289 2415 2416 RXA01777 GR00504 2319 2777 2417 2418 RXA01778 GR00504 2912 4048 2419 2420 RXA01779 GR00504 4246 5664 2421 2422 RXA01780 GR00504 5721 6095 2423 2424 RXA01781 GR00504 6052 6312 2425 2426 RXA01782 GR00504 6384 6779 2427 2428 RXA01783 GR00504 6842 7078 2429 2430 RXA01785 GR00505 729 1304 2431 2432 RXA01788 GR00506 361 801 2433 2434 RXA01789 GR00506 875 1516 2435 2436 RXA01790 GR00506 1672 1731 2437 2438 RXA01791 GR00506 1885 2247 2439 2440 RXA01792 GR00506 2310 2582 2441 2442 RXA01793 GR00506 2916 3149 2443 2444 RXA01794 GR00506 3194 3427 2445 2446 RXA01799 GR00509 377 1570 2447 2448 RXA01800 GR00509 2292 1573 2449 2450 RXA01804 GR00509 6117 5797 2451 2452 RXA01805 GR00509 6515 6186 2453 2454 RXA01806 GR00509 6595 7074 2455 2456 RXA01816 GR00515 4210 4941 2457 2458 RXA01817 GR00515 4941 5573 2459 2460 RXA01820 GR00515 8360 9733 2461 2462 RXA01842 GR00522 1397 480 2463 2464 RXA01844 GR00522 1950 1771 2465 2466 RXA01845 GR00522 1919 2326 2467 2468 RXA01856 GR00527 225 770 2469 2470 RXA01857 GR00527 939 1589 2471 2472 RXA01858 GR00529 578 6 2473 2474 RXA01870 GR00534 2123 2797 2475 2476 RXA01871 GR00534 2797 3759 2477 2478 RXA01903 GR00545 3 281 2479 2480 RXA01904 GR00545 762 340 2481 2482 RXA01905 GR00545 1074 1604 2483 2484 RXA01906 GR00545 2322 2786 2485 2486 RXA01907 GR00545 3176 3787 2487 2488 RXA01923 GR00552 1311 1739 2489 2490 RXA01931 GR00555 4913 5566 2491 2492 RXA01941 GR00557 995 1429 2493 2494 RXA01942 GR00557 3526 2927 2495 2496 RXA01957 GR00564 389 850 2497 2498 RXA01958 GR00564 910 1416 2499 2500 RXA01959 GR00564 1639 2019 2501 2502 RXA01961 GR00565 521 1000 2503 2504 RXA01962 GR00565 1022 1591 2505 2506 RXA01963 GR00565 1757 2440 2507 2508 RXA01964 GR00566 1329 4 2509 2510 RXA01965 GR00566 1935 1375 2511 2512 RXA01966 GR00567 47 703 2513 2514 RXA01968 GR00567 3295 2138 2515 2516 RXA01969 GR00567 5689 5216 2517 2518 RXA01973 GR00570 2 583 2519 2520 RXA01974 GR00570 658 2109 2521 2522 RXA01976 GR00571 3742 2222 2523 2524 RXA01977 GR00571 4547 3972 2525 2526 RXA01982 GR00573 3001 1844 2527 2528 RXA01990 GR00581 1 999 2529 2530 RXA01992 GR00583 709 260 2531 2532 RXA01999 GR00589 2384 2854 2533 2534 RXA02001 GR00590 700 152 2535 2536 RXA02004 GR00594 3 209 2537 2538 RXA02006 GR00597 498 4 2539 2540 RXA02009 GR00601 127 5 2541 2542 RXA02013 GR00607 553 5 2543 2544 RXA02021 GR00613 2008 1061 2545 2546 RXA02036 GR00619 3441 3821 2547 2548 RXA02040 GR00621 1452 925 2549 2550 RXA02046 GR00623 2680 2943 2551 2552 RXA02051 GR00624 3186 3683 2553 2554 RXA02053 GR00624 5484 6062 2555 2556 RXA02057 GR00625 2972 3502 2557 2558 RXA02058 GR00625 4051 3500 2559 2560 RXA02069 GR00627 1116 1694 2561 2562 RXA02070 GR00627 1733 2830 2563 2564 RXA02080 GR00628 11017 10211 2565 2566 RXA02081 GR00628 12307 13935 2567 2568 RXA02084 GR00629 2920 2576 2569 2570 RXA02089 GR00629 8431 8901 2571 2572 RXA02090 GR00629 9764 8964 2573 2574 RXA02091 GR00629 10512 9862 2575 2576 RXA02097 GR00630 184 3555 2577 2578 RXA02102 GR00631 4479 3322 2579 2580 RXA02103 GR00631 4510 4905 2581 2582 RXA02109 GR00632 3460 2540 2583 2584 RXA02117 GR00636 1056 1529 2585 2586 RXA02123 GR00636 6558 7928 2587 2588 RXA02124 GR00636 7956 9911 2589 2590 RXA02125 GR00637 739 1539 2591 2592 RXA02129 GR00637 5906 6139 2593 2594 RXA02132 GR00638 737 1375 2595 2596 RXA02137 GR00639 4166 3369 2597 2598 RXA02141 GR00639 8457 8864 2599 2600 RXA02146 GR00639 14742 15368 2601 2602 RXA02152 GR00640 237 638 2603 2604 RXA02163 GR00640 10072 10824 2605 2606 RXA02164 GR00640 10824 12398 2607 2608 RXA02165 GR00640 12388 12999 2609 2610 RXA02166 GR00640 13048 13224 2611 2612 RXA02168 GR00641 2894 81 2613 2614 RXA02170 GR00641 4798 4025 2615 2616 RXA02172 GR00641 6919 6581 2617 2618 RXA02177 GR00641 12683 13615 2619 2620 RXA02178 GR00641 13628 14497 2621 2622 RXA02181 GR00641 17168 17845 2623 2624 RXA02183 GR00641 18663 19187 2625 2626 RXA02187 GR00641 21249 23447 2627 2628 RXA02199 GR00646 2591 3160 2629 2630 RXA02203 GR00646 7469 7092 2631 2632 RXA02206 GR00646 9927 10862 2633 2634 RXA02211 GR00648 2537 2989 2635 2636 RXA02212 GR00649 964 467 2637 2638 RXA02216 GR00651 2 307 2639 2640 RXA02217 GR00651 968 306 2641 2642 RXA02218 GR00651 1299 1565 2643 2644 RXA02219 GR00651 1578 2963 2645 2646 RXA02221 GR00651 6720 8081 2647 2648 RXA02227 GR00653 1236 1853 2649 2650 RXA02230 GR00653 4156 3620 2651 2652 RXA02231 GR00653 5111 4356 2653 2654 RXA02244 GR00654 12058 13590 2655 2656 RXA02255 GR00654 22507 23442 2657 2658 RXA02266 GR00655 653 1165 2659 2660 RXA02267 GR00655 2053 1181 2661 2662 RXA02280 GR00658 2 754 2663 2664 RXA02286 GR00660 3285 3833 2665 2666 RXA02287 GR00660 4071 4622 2667 2668 RXA02294 GR00662 5992 5618 2669 2670 RXA02295 GR00662 6842 6063 2671 2672 RXA02297 GR00662 7502 8638 2673 2674 RXA02298 GR00662 10310 8652 2675 2676 RXA02304 GR00663 1613 723 2677 2678 RXA02308 GR00664 939 511 2679 2680 RXA02324 GR00668 1548 2633 2681 2682 RXA02325 GR00668 4314 3445 2683 2684 RXA02331 GR00671 396 761 2685 2686 RXA02336 GR00672 2731 2552 2687 2688 RXA02347 GR00677 509 189 2689 2690 RXA02349 GR00678 394 5 2691 2692 RXA02352 GR00681 2 556 2693 2694 RXA02356 GR00684 761 1756 2695 2696 RXA02358 GR00685 1239 1529 2697 2698 RXA02362 GR00685 7045 10743 2699 2700 RXA02374 GR00688 1626 2246 2701 2702 RXA02390 GR00695 1500 832 2703 2704 RXA02393 GR00697 168 449 2705 2706 RXA02395 GR00698 2 733 2707 2708 RXA02396 GR00698 1309 1031 2709 2710 RXA02403 GR00700 896 1660 2711 2712 RXA02412 GR00703 2043 2522 2713 2714 RXA02417 GR00705 4755 2632 2715 2716 RXA02421 GR00705 7237 6428 2717 2718 RXA02425 GR00707 1 630 2719 2720 RXA02427 GR00707 3447 3061 2721 2722 RXA02430 GR00707 7498 7683 2723 2724 RXA02433 GR00708 2981 3580 2725 2726 RXA02437 GR00709 1661 2470 2727 2728 RXA02443 GR00709 6818 7771 2729 2730 RXA02444 GR00709 7836 9113 2731 2732 RXA02452 GR00710 5271 5092 2733 2734 RXA02459 GR00712 4341 5075 2735 2736 RXA02461 GR00712 6252 5845 2737 2738 RXA02467 GR00714 643 419 2739 2740 RXA02472 GR00715 5435 5725 2741 2742 RXA02473 GR00715 6664 5924 2743 2744 RXA02475 GR00715 9595 8441 2745 2746 RXA02478 GR00716 1245 10 2747 2748 RXA02482 GR00718 914 105 2749 2750 RXA02483 GR00718 1813 1001 2751 2752 RXA02484 GR00718 2317 1817 2753 2754 RXA02486 GR00718 3441 4076 2755 2756 RXA02488 GR00719 1 369 2757 2758 RXA02489 GR00719 373 996 2759 2760 RXA02495 GR00720 9002 6435 2761 2762 RXA02496 GR00720 10025 9219 2763 2764 RXA02498 GR00720 11016 11819 2765 2766 RXA02500 GR00720 13460 13558 2767 2768 RXA02506 GR00720 19484 18603 2769 2770 RXA02514 GR00723 1 837 2771 2772 RXA02518 GR00723 3464 3874 2773 2774 RXA02521 GR00724 2924 4366 2775 2776 RXA02524 GR00725 2405 3094 2777 2778 RXA02525 GR00725 3113 3490 2779 2780 RXA02540 GR00726 12438 12001 2781 2782 RXA02544 GR00726 16715 18142 2783 2784 RXA02545 GR00726 18749 18192 2785 2786 RXA02546 GR00726 19927 18824 2787 2788 RXA02549 GR00728 1331 6 2789 2790 RXA02552 GR00730 924 130 2791 2792 RXA02554 GR00731 1050 427 2793 2794 RXA02569 GR00736 82 831 2795 2796 RXA02570 GR00736 837 1478 2797 2798 RXA02573 GR00739 594 151 2799 2800 RXA02575 GR00739 1907 3064 2801 2802 RXA02576 GR00740 1569 148 2803 2804 RXA02577 GR00740 2463 1579 2805 2806 RXA02584 GR00741 8925 8575 2807 2808 RXA02585 GR00741 9917 8937 2809 2810 RXA02588 GR00741 13037 12354 2811 2812 RXA02591 GR00741 15780 17609 2813 2814 RXA02598 GR00742 2576 3166 2815 2816 RXA02600 GR00742 5027 3630 2817 2818 RXA02601 GR00742 5258 7246 2819 2820 RXA02602 GR00742 7239 7742 2821 2822 RXA02604 GR00742 8800 10875 2823 2824 RXA02609 GR00742 16197 16445 2825 2826 RXA02617 GR00745 1404 1910 2827 2828 RXA02619 GR00746 204 1103 2829 2830 RXA02620 GR00746 1192 1845 2831 2832 RXA02639 GR00749 511 1344 2833 2834 RXA02647 GR00751 4155 4616 2835 2836 RXA02649 GR00752 1284 283 2837 2838 RXA02652 GR00752 2973 3551 2839 2840 RXA02655 GR00752 9313 8330 2841 2842 RXA02662 GR00753 1461 1724 2843 2844 RXA02665 GR00753 6497 6018 2845 2846 RXA02670 GR00753 10199 10780 2847 2848 RXA02672 GR00753 12303 13400 2849 2850 RXA02678 GR00754 3858 4775 2851 2852 RXA02683 GR00754 7742 7065 2853 2854 RXA02685 GR00754 10058 9402 2855 2856 RXA02688 GR00754 12256 12924 2857 2858 RXA02689 GR00754 13405 13064 2859 2860 RXA02690 GR00754 14502 13405 2861 2862 RXA02700 GR00757 3507 4742 2863 2864 RXA02701 GR00757 4838 6145 2865 2866 RXA02712 GR00758 13067 12273 2867 2868 RXA02714 GR00758 14754 14326 2869 2870 RXA02715 GR00758 15847 15458 2871 2872 RXA02721 GR00759 1373 636 2873 2874 RXA02725 GR00760 1478 867 2875 2876 RXA02727 GR00760 6287 5376 2877 2878 RXA02735 GR00763 777 73 2879 2880 RXA02736 GR00763 1753 797 2881 2882 RXA02751 GR00764 6393 5920 2883 2884 RXA02756 GR00766 3851 2961 2885 2886 RXA02757 GR00766 4475 3930 2887 2888 RXA02765 GR00769 3552 2794 2889 2890 RXA02766 GR00770 986 594 2891 2892 RXA02774 GR00773 3 473 2893 2894 RXA02775 GR00773 744 968 2895 2896 RXA02776 GR00773 1713 1372 2897 2898 RXA02777 GR00773 4626 5732 2899 2900 RXA02778 GR00773 10095 10319 2901 2902 RXA02779 GR00773 10617 10895 2903 2904 RXA02780 GR00773 10954 11280 2905 2906 RXA02783 GR00775 845 1393 2907 2908 RXA02784 GR00775 1751 1936 2909 2910 RXA02786 GR00777 2 808 2911 2912 RXA02789 GR00777 5237 5782 2913 2914 RXA02793 GR00777 9385 8684 2915 2916 RXA02796 GR00778 1648 1100 2917 2918 RXA02798 GR00778 2842 4266 2919 2920 RXA02799 GR00780 182 454 2921 2922 RXA02815 GR00796 3 554 2923 2924 RXA02823 GR00804 275 6 2925 2926 RXA02827 GR00812 428 6 2927 2928 RXA02842 GR00841 356 15 2929 2930 RXA02845 GR00844 2 616 2931 2932 RXA02848 GR00848 113 511

TABLE 2 GENES IDENTIFIED FROM GENBANK GenBank ™ Accession Gene Gene No. Name Function Reference A09073 ppg Phosphoenol pyruvate carboxylase Bachmann, B. et al. “DNA fragment coding for phosphoenolpyruvat corboxylase, recombinant DNA carrying said fragment, strains carrying the recombinant DNA and method for producing L-aminino acids using said strains,” Patent: EP 0358940-A 3 Mar. 21, 1990 A45579, Threonine dehydratase Moeckel, B. et al. “Production of L-isoleucine by means of recombinant A45581, micro-organisms with deregulated threonine dehydratase,” Patent: WO A45583, 9519442-A 5 Jul. 20, 1995 A45585 A45587 AB003132 murC; Kobayashi, M. et al. “Cloning, sequencing, and characterization of the ftsZ ftsQ; gene from coryneform bacteria,” Biochem. Biophys. Res. Commun., ftsZ 236(2): 383-388 (1997) AB015023 murC; Wachi, M. et al. “A murC gene from Coryneform bacteria,” Appl. Microbiol. ftsQ Biotechnol., 51(2): 223-228 (1999) AB018530 dtsR Kimura, E. et al. “Molecular cloning of a novel gene, dtsR, which rescues the detergent sensitivity of a mutant derived from Brevibacterium lactofermentum,” Biosci. Biotechnol. Biochem., 60(10): 1565-1570 (1996) AB018531 dtsR1; dtsR2 AB020624 murI D-glutamate racemase AB023377 tkt transketolase AB024708 gltB; gltD Glutamine 2-oxoglutarate aminotransferase large and small subunits AB025424 acn aconitase AB027714 rep Replication protein AB027715 rep; aad Replication protein; aminoglycoside adenyltransferase AF005242 argC N-acetylglutamate-5-semialdehyde dehydrogenase AF005635 glnA Glutamine synthetase AF030405 hisF cyclase AF030520 argG Argininosuccinate synthetase AF031518 argF Ornithine carbamolytransferase AF036932 aroD 3-dehydroquinate dehydratase AF038548 pyc Pyruvate carboxylase AF038651 dciAE; Dipeptide-binding protein; adenine Wehmeier, L. et al. “The role of the Corynebacterium glutamicum rel gene in apt; rel phosphoribosyltransferase; GTP (p)ppGpp metabolism,” Microbiology, 144: 1853-1862 (1998) pyrophosphokinase AF041436 argR Arginine repressor AF045998 impA Inositol monophosphate phosphatase AF048764 argH Argininosuccinate lyase AF049897 argC; N-acetylglutamylphosphate reductase; argJ; ornithine acetyltransferase; N- argB; acetylglutamate kinase; acetylornithine argD; transminase; ornithine argF; carbamoyltransferase; arginine repressor; argR; argininosuccinate synthase; argG; argininosuccinate lyase argH AF050109 inhA Enoyl-acyl carrier protein reductase AF050166 hisG ATP phosphoribosyltransferase AF051846 hisA Phosphoribosylformimino-5-amino-1- phosphoribosyl-4-imidazolecarboxamide isomerase AF052652 metA Homoserine O-acetyltransferase Park, S. et al. “Isolation and analysis of metA, a methionine biosynthetic gene encoding homoserine acetyltransferase in Corynebacterium glutamicum,” Mol. Cells., 8(3): 286-294 (1998) AF053071 aroB Dehydroquinate synthetase AF060558 hisH Glutamine amidotransferase AF086704 hisE Phosphoribosyl-ATP- pyrophosphohydrolase AF114233 aroA 5-enolpyruvylshikimate 3-phosphate synthase AF116184 panD L-aspartate-alpha-decarboxylase precursor Dusch, N. et al. “Expression of the Corynebacterium glutamicum panD gene encoding L-aspartate-alpha-decarboxylase leads to pantothenate overproduction in Escherichia coli,” Appl. Environ. Microbiol., 65(4)1530-1539 (1999) AF124518 aroD; 3-dehydroquinase; shikimate aroE dehydrogenase AF124600 aroC; Chorismate synthase; shikimate kinase; 3- aroK; dehydroquinate synthase; putative aroB; cytoplasmic peptidase pepQ AF145897 inhA AF145898 inhA AJ001436 ectP Transport of ectoine, glycine betaine, Peter, H. et al. “Corynebacterium glutamicum is equipped with four secondary proline carriers for compatible solutes: Identification, sequencing, and characterization of the proline/ectoine uptake system, ProP, and the ectoine/proline/glycine betaine carrier, EctP,” J. Bacteriol., 180(22): 6005-6012 (1998) AJ004934 dapD Tetrahydrodipicolinate succinylase Wehrmann, A. et al. “Different modes of diaminopimelate synthesis and their (incomplete^(i)) role in cell wall integrity: A study with Corynebacterium glutamicum,” J. Bacteriol., 180(12): 3159-3165 (1998) AJ007732 ppc; Phosphoenolpyruvate-carboxylase; ?; high secG; amt; affinity ammonium uptake protein; ocd; soxA putative ornithine-cyclodecarboxylase; sarcosine oxidase AJ010319 ftsY, Involved in cell division; PII protein; Jakoby, M. et al. “Nitrogen regulation in Corynebacterium glutamicum; glnB, uridylyltransferase (uridylyl-removing Isolation of genes involved in biochemical characterization of corresponding glnD; enzmye); signal recognition particle; low proteins,” FEMS Microbiol., 173(2): 303-310 (1999) srp; amtP affinity ammonium uptake protein AJ132968 cat Chloramphenicol aceteyl transferase AJ224946 mqo L-malate: quinone oxidoreductase Molenaar, D. et al. “Biochemical and genetic characterization of the membrane-associated malate dehydrogenase (acceptor) from Corynebacterium glutamicum,” Eur. J. Biochem., 254(2): 395-403 (1998) AJ238250 ndh NADH dehydrogenase AJ238703 porA Porin Lichtinger, T. et al. “Biochemical and biophysical characterization of the cell wall porin of Corynebacterium glutamicum: The channel is formed by a low molecular mass polypeptide,” Biochemistry, 37(43): 15024-15032 (1998) D17429 Transposable element IS31831 Vertes, A. A. et al. “Isolation and characterization of IS31831, a transposable element from Corynebacterium glutamicum,” Mol. Microbiol., 11(4): 739-746 (1994) D84102 odhA 2-oxoglutarate dehydrogenase Usuda, Y. et al. “Molecular cloning of the Corynebacterium glutamicum (Brevibacterium lactofermentum AJ12036) odhA gene encoding a novel type of 2-oxoglutarate dehydrogenase,” Microbiology, 142: 3347-3354 (1996) E01358 hdh; hk Homoserine dehydrogenase; homoserine Katsumata, R. et al. “Production of L-thereonine and L-isoleucine,” Patent: JP kinase 1987232392-A 1 Oct. 12, 1987 E01359 Upstream of the start codon of homoserine Katsumata, R. et al. “Production of L-thereonine and L-isoleucine,” Patent: JP kinase gene 1987232392-A 2 Oct. 12, 1987 E01375 Tryptophan operon E01376 trpL; trpE Leader peptide; anthranilate synthase Matsui, K. et al. “Tryptophan operon, peptide and protein coded thereby, utilization of tryptophan operon gene expression and production of tryptophan,” Patent: JP 1987244382-A 1 Oct. 24, 1987 E01377 Promoter and operator regions of Matsui, K. et al. “Tryptophan operon, peptide and protein coded 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1 Dec. 27, 1993 E06111 Mutated Prephenate dehydratase Kikuchi, T. et al. “Production of L-phenylalanine by fermentation method,” Patent: JP 1993344881-A 1 Dec. 27, 1993 E06146 Acetohydroxy acid synthetase Inui, M. et al. “Gene capable of coding Acetohydroxy acid synthetase and its use,” Patent: JP 1993344893-A 1 Dec. 27, 1993 E06825 Aspartokinase Sugimoto, M. et al. “Mutant aspartokinase gene,” patent: JP 1994062866-A 1 Mar. 08, 1994 E06826 Mutated aspartokinase alpha subunit Sugimoto, M. et al. “Mutant aspartokinase gene,” patent: JP 1994062866-A 1 Mar. 08, 1994 E06827 Mutated aspartokinase alpha subunit Sugimoto, M. et al. “Mutant aspartokinase gene,” patent: JP 1994062866-A 1 Mar. 08, 1994 E07701 secY Honno, N. et al. “Gene DNA participating in integration of membraneous protein to membrane,” Patent: JP 1994169780-A 1 Jun. 21, 1994 E08177 Aspartokinase Sato, Y. et al. “Genetic DNA capable of coding Aspartokinase released from feedback inhibition and its utilization,” Patent: JP 1994261766-A 1 Sep. 20, 1994 E08178, Feedback inhibition-released Sato, Y. et al. “Genetic DNA capable of coding Aspartokinase released from E08179, Aspartokinase feedback inhibition and its utilization,” Patent: JP 1994261766-A 1 Sep. 20, 1994 E08180, E08181, E08182 E08232 Acetohydroxy-acid isomeroreductase Inui, M. et al. “Gene DNA coding acetohydroxy acid isomeroreductase,” Patent: JP 1994277067-A 1 Oct. 04, 1994 E08234 secE Asai, Y. et al. “Gene DNA coding for translocation machinery of protein,” Patent: JP 1994277073-A 1 Oct. 04, 1994 E08643 FT aminotransferase and desthiobiotin Hatakeyama, K. et al. “DNA fragment having promoter function in synthetase promoter region coryneform bacterium,” Patent: JP 1995031476-A 1 Feb. 03, 1995 E08646 Biotin synthetase Hatakeyama, K. et al. “DNA fragment having promoter function in coryneform bacterium,” Patent: JP 1995031476-A 1 Feb. 03, 1995 E08649 Aspartase Kohama, K. et al “DNA fragment having promoter function in coryneform bacterium,” Patent: JP 1995031478-A 1 Feb. 03, 1995 E08900 Dihydrodipicolinate reductase Madori, M. et al. “DNA fragment containing gene coding Dihydrodipicolinate acid reductase and utilization thereof,” Patent: JP 1995075578-A 1 Mar. 20, 1995 E08901 Diaminopimelic acid decarboxylase Madori, M. et al. “DNA fragment containing gene coding Diaminopimelic acid decarboxylase and utilization thereof,” Patent: JP 1995075579-A 1 Mar. 20, 1995 E12594 Serine hydroxymethyltransferase Hatakeyama, K. et al. “Production of L-trypophan,” Patent: JP 1997028391-A 1 Feb. 04, 1997 E12760, transposase Moriya, M. et al. “Amplification of gene using artificial transposon,” Patent: E12759, JP 1997070291-A Mar. 18, 1997 E12758 E12764 Arginyl-tRNA synthetase; diaminopimelic Moriya, M. et al. “Amplification of gene using artificial transposon,” Patent: acid decarboxylase JP 1997070291-A Mar. 18, 1997 E12767 Dihydrodipicolinic acid synthetase Moriya, M. et al. “Amplification of gene using artificial transposon,” Patent: JP 1997070291-A Mar. 18, 1997 E12770 aspartokinase Moriya, M. et al. “Amplification of gene using artificial transposon,” Patent: JP 1997070291-A Mar. 18, 1997 E12773 Dihydrodipicolinic acid reductase Moriya, M. et al. “Amplification of gene using artificial transposon,” Patent: JP 1997070291-A Mar. 18, 1997 E13655 Glucose-6-phosphate dehydrogenase Hatakeyama, K. et al. “Glucose-6-phosphate dehydrogenase and DNA capable of coding the same,” Patent: JP 1997224661-A 1 Sep. 02, 1997 L01508 IlvA Threonine dehydratase Moeckel, B. et al. “Functional and structural analysis of the threonine dehydratase of Corynebacterium glutamicum,” J. Bacteriol., 174: 8065-8072 (1992) L07603 EC 3-deoxy-D-arabinoheptulosonate-7- Chen, C. et al. “The cloning and nucleotide sequence of Corynebacterium 4.2.1.15 phosphate synthase glutamicum 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase gene,” FEMS Microbiol. Lett., 107: 223-230 (1993) L09232 IlvB; Acetohydroxy acid synthase large subunit; Keilhauer, C. et al. “Isoleucine synthesis in Corynebacterium glutamicum: ilvN; Acetohydroxy acid synthase small subunit; molecular analysis of the ilvB-ilvN-ilvC operon,” J. Bacteriol., ilvC Acetohydroxy acid isomeroreductase 175(17): 5595-5603 (1993) L18874 PtsM Phosphoenolpyruvate sugar Fouet, A et al. “Bacillus subtilis sucrose-specific enzyme II of the phosphotransferase phosphotransferase system: expression in Escherichia coli and homology to enzymes II from enteric bacteria,” PNAS USA, 84(24): 8773-8777 (1987); Lee, J. K. et al. “Nucleotide sequence of the gene encoding the Corynebacterium glutamicum mannose enzyme II and analyses of the deduced protein sequence,” FEMS Microbiol. Lett., 119(1-2): 137-145 (1994) L27123 aceB Malate synthase Lee, H-S. et al. “Molecular characterization of aceB, a gene encoding malate synthase in Corynebacterium glutamicum,” J. Microbiol. Biotechnol., 4(4): 256-263 (1994) L27126 Pyruvate kinase Jetten, M. S. et al. “Structural and functional analysis of pyruvate kinase from Corynebacterium glutamicum,” Appl. Environ. Microbiol., 60(7): 2501-2507 (1994) L28760 aceA Isocitrate lyase L35906 dtxr Diphtheria toxin repressor Oguiza, J. A. et al. “Molecular cloning, DNA sequence analysis, and characterization of the Corynebacterium diphtheriae dtxR from Brevibacterium lactofermentum,” J. Bacteriol., 177(2): 465-467 (1995) M13774 Prephenate dehydratase Follettie, M. T. et al. “Molecular cloning and nucleotide sequence of the Corynebacterium glutamicum pheA gene,” J. Bacteriol., 167: 695-702 (1986) M16175 5S rRNA Park, Y-H. et al. “Phylogenetic analysis of the coryneform bacteria by 56 rRNA sequences,” J. Bacteriol., 169: 1801-1806 (1987) M16663 trpE Anthranilate synthase, 5′ end Sano, K. et al. “Structure and function of the trp operon control regions of Brevibacterium lactofermentum, a glutamic-acid-producing bacterium,” Gene, 52: 191-200 (1987) M16664 trpA Tryptophan synthase, 3′end Sano, K. et al. “Structure and function of the trp operon control regions of Brevibacterium lactofermentum, a glutamic-acid-producing bacterium,” Gene, 52: 191-200 (1987) M25819 Phosphoenolpyruvate carboxylase O'Regan, M. et al. “Cloning and nucleotide sequence of the Phosphoenolpyruvate carboxylase-coding gene of Corynebacterium glutamicum ATCC13032,” Gene, 77(2): 237-251 (1989) M85106 23S rRNA gene insertion sequence Roller, C. et al. “Gram-positive bacteria with a high DNA G + C content are characterized by a common insertion within their 23S rRNA genes,” J. Gen. Microbiol., 138: 1167-1175 (1992) M85107, 23S rRNA gene insertion sequence Roller, C. et al. “Gram-positive bacteria with a high DNA G + C content are M85108 characterized by a common insertion within their 23S rRNA genes,” J. Gen. Microbiol., 138: 1167-1175 (1992) M89931 aecD; Beta C-S lyase; branched-chain Rossol, I. et al. “The Corynebacterium glutamicum aecD gene encodes a C-S brnQ; amino acid uptake carrier; lyase with alpha, beta-elimination activity that degrades aminoethylcysteine,” yhbw hypothetical protein yhbw J. Bacteriol., 174(9): 2968-2977 (1992); Tauch, A. et al. “Isoleucine uptake in Corynebacterium glutamicum ATCC 13032 is directed by the brnQ gene product,” Arch. Microbiol., 169(4): 303-312 (1998) S59299 trp Leader gene (promoter) Herry, D. M. et al. “Cloning of the trp gene cluster from a tryptophan- hyperproducing strain of Corynebacterium glutamicum: identification of a mutation in the trp leader sequence,” Appl. Environ. Microbiol., 59(3): 791-799 (1993) U11545 trpD Anthranilate phosphoribosyltransferase O'Gara, J. P. and Dunican, L. K. (1994) Complete nucleotide sequence of the Corynebacterium glutamicum ATCC 21850 tpD gene.” Thesis, Microbiology Department, University College Galway, Ireland. U13922 cglIM; Putative type II 5-cytosoine Schafer, A. et al. “Cloning and characterization of a DNA region encoding a cglIR; methyltransferase; putative type II stress-sensitive restriction system from Corynebacterium glutamicum ATCC clgIIR restriction endonuclease; putative type I or 13032 and analysis of its role in intergeneric conjugation with Escherichia type III restriction endonuclease coli,” J. Bacteriol., 176(23): 7309-7319 (1994); Schafer, A. et al. “The Corynebacterium glutamicum cglIM gene encoding a 5-cytosine in an McrBC- deficient Escherichia coli strain,” Gene, 203(2): 95-101 (1997) U14965 recA U31224 ppx Ankri, S. et al. “Mutations in the Corynebacterium glutamicumproline biosynthetic pathway: A natural bypass of the proA step,” J. Bacteriol., 178(15): 4412-4419 (1996) U31225 proC L-proline: NADP+ 5-oxidoreductase Ankri, S. et al. “Mutations in the Corynebacterium glutamicumproline biosynthetic pathway: A natural bypass of the proA step,” J. Bacteriol., 178(15): 4412-4419 (1996) U31230 obg; proB; ?; gamma glutamyl kinase; similar to D- Ankri, S. et al. “Mutations in the Corynebacterium glutamicumproline unkdh isomer specific 2-hydroxyacid biosynthetic pathway: A natural bypass of the proA step,” J. Bacteriol., dehydrogenases 178(15): 4412-4419 (1996) U31281 bioB Biotin synthase Serebriiskii, I. G., “Two new members of the bio B superfamily: Cloning, sequencing and expression of bio B genes of Methylobacillus flagellatum and Corynebacterium glutamicum,” Gene, 175: 15-22 (1996) U35023 thtR; Thiosulfate sulfurtransferase; acyl CoA Jager, W. et al. “A Corynebacterium glutamicum gene encoding a two-domain accBC carboxylase protein similar to biotin carboxylases and biotin-carboxyl-carrier proteins,” Arch. Microbiol., 166(2); 76-82 (1996) U43535 cmr Multidrug resistance protein Jager, W. et al. “A Corynebacterium glutamicum gene conferring multidrug resistance in the heterologous host Escherichia coli,” J. Bacteriol., 179(7): 2449-2451 (1997) U43536 clpB Heat shock ATP-binding protein U53587 aphA-3 3′5″-aminoglycoside phosphotransferase U89648 Corynebacterium glutamicum unidentified sequence involved in histidine biosynthesis, partial sequence X04960 trpA; Tryptophan operon Matsui, K. et al. “Complete nucleotide and deduced amino acid sequences of trpB; the Brevibacterium lactofermentum tryptophan operon,” Nucleic Acids Res., trpC; 14(24): 10113-10114 (1986) trpD; trpE; trpG; trpL X07563 lys A DAP decarboxylase Yeh, P. et al. “Nucleic sequence of the lysA gene of Corynebacterium (meso-diaminopimelate glutamicum and possible mechanisms for modulation of its expression,” Mol. decarboxylase, EC 4.1.1.20) Gen. Genet., 212(1): 112-119 (1988) X14234 EC Phosphoenolpyruvate carboxylase Eikmanns, B. J. et al. “The Phosphoenolpyruvate carboxylase gene of 4.1.1.31 Corynebacterium glutamicum: Molecular cloning, nucleotide sequence, and expression,” Mol. Gen. Genet., 218(2): 330-339 (1989); Lepiniec, L. et al. “Sorghum Phosphoenolpyruvate carboxylase gene family: structure, function and molecular evolution,” Plant. Mol. Biol., 21 (3): 487-502 (1993) X17313 fda Fructose-bisphosphate aldolase Von der Osten, C. H. et al. “Molecular cloning, nucleotide sequence and fine- structural analysis of the Corynebacterium glutamicum fda gene: structural comparison of C. glutamicum fructose-1, 6-biphosphate aldolase to class I and class II aldolases,” Mol. Microbiol., X53993 dapA L-2, 3-dihydrodipicolinate synthetase (EC Bonnassie, S. et al. “Nucleic sequence of the dapA gene from 4.2.1.52) Corynebacterium glutamicum,” Nucleic Acids Res., 18(21): 6421 (1990) X54223 AttB-related site Cianciotto, N. et al. “DNA sequence homology between att B-related sites of Corynebacterium diphtheriae, Corynebacterium ulcerans, Corynebacterium glutamicum, and the attP site of lambdacorynephage,” FEMS. Microbiol, Lett., 66: 299-302 (1990) X54740 argS; lysA Arginyl-tRNA synthetase; Marcel, T. et al. “Nucleotide sequence and organization of the upstream region Diaminopimelate of the Corynebacterium glutamicum lysA gene,” Mol. Microbiol., decarboxylase 4(11): 1819-1830 (1990) X55994 trpL; trpE Putative leader peptide; anthranilate Heery, D. M. et al. “Nucleotide sequence of the Corynebacterium glutamicum synthase component 1 trpE gene,” Nucleic Acids Res., 18(23): 7138 (1990) X56037 thrC Threonine synthase Han, K. S. et al. “The molecular structure of the Corynebacterium glutamicum threonine synthase gene,” Mol. Microbiol., 4(10): 1693-1702 (1990) X56075 attB- Attachment site Cianciotto, N. et al. “DNA sequence homology between att B-related sites of related Corynebacterium diphtheriae, Corynebacterium ulcerans, Corynebacterium site glutamicum, and the attP site of lambdacorynephage,” FEMS. Microbiol, Lett., 66: 299-302 (1990) X57226 lysC- Aspartokinase-alpha subunit; Kalinowski, J. et al. “Genetic and biochemical analysis of the Aspartokinase alpha; Aspartokinase-beta subunit; aspartate beta from Corynebacterium glutamicum,” Mol. Microbiol., 5(5): 1197-1204 (1991); lysC- semialdehyde dehydrogenase Kalinowski, J. et al. “Aspartokinase genes lysC alpha and lysC beta overlap beta; asd and are adjacent to the aspertate beta-semialdehyde dehydrogenase gene asd in Corynebacterium glutamicum,” Mol. Gen. Genet., 224(3): 317-324 (1990) X59403 gap; Glyceraldehyde-3-phosphate; Eikmanns, B. J. “Identification, sequence analysis, and expression of a pgk; tpi phosphoglycerate kinase; triosephosphate Corynebacterium glutamicum gene cluster encoding the three glycolytic isomerase enzymes glyceraldehyde-3-phosphate dehydrogenase, 3-phosphoglycerate kinase, and triosephosphate isomeras,” J. Bacteriol., 174(19): 6076-6086 (1992) X59404 gdh Glutamate dehydrogenase Bormann, E. R. et al. “Molecular analysis of the Corynebacterium glutamicum gdh gene encoding glutamate dehydrogenase,” Mol. Microbiol., 6(3): 317-326 (1992) X60312 lysI L-lysine permease Seep-Feldhaus, A. H. et al. “Molecular analysis of the Corynebacterium glutamicum lysl gene involved in lysine uptake,” Mol. Microbiol., 5(12): 2995-3005 (1991) X66078 cop1 Ps1 protein Joliff, G. et al. “Cloning and nucleotide sequence of the csp1 gene encoding PS1, one of the two major secreted proteins of Corynebacterium glutamicum: The deduced N-terminal region of PS1 is similar to the Mycobacterium antigen 85 complex,” Mol. Microbiol., 6(16): 2349-2362 (1992) X66112 glt Citrate synthase Eikmanns, B. J. et al. “Cloning sequence, expression and transcriptional analysis of the Corynebacterium glutamicum gltA gene encoding citrate synthase,” Microbiol., 140: 1817-1828 (1994) X67737 dapB Dihydrodipicolinate reductase X69103 csp2 Surface layer protein PS2 Peyret, J. L. et al. “Characterization of the cspB gene encoding PS2, an ordered surface-layer protein in Corynebacterium glutamicum,” Mol. Microbiol., 9(1): 97-109 (1993) X69104 IS3 related insertion element Bonamy, C. et al. “Identification of IS1206, a Corynebacterium glutamicum IS3-related insertion sequence and phylogenetic analysis,” Mol. Microbiol., 14(3): 571-581 (1994) X70959 leuA Isopropylmalate synthase Patek, M. et al. “Leucine synthesis in Corynebacterium glutamicum: enzyme activities, structure of leuA, and effect of leuA inactivation on lysine synthesis,” Appl. Environ. Microbiol., 60(1): 133-140 (1994) X71489 icd Isocitrate dehydrogenase (NADP+) Eikmanns, B. J. et al. “Cloning sequence analysis, expression, and inactivation of the Corynebacterium glutamicum icd gene encoding isocitrate dehydrogenase and biochemical characterization of the enzyme,” J. Bacteriol., 177(3): 774-782 (1995) X72855 GDHA Glutamate dehydrogenase (NADP+) X75083, mtrA 5-methyltryptophan resistance Heery, D. M. et al. “A sequence from a tryptophan-hyperproducing strain of X70584 Corynebacterium glutamicum encoding resistance to 5-methyltryptophan,” Biochem. Biophys. Res. Commun., 201(3): 1255-1262 (1994) X75085 recA Fitzpatrick, R. et al. “Construction and characterization of recA mutant strains of Corynebacterium glutamicum and Brevibacterium lactofermentum,” Appl. Microbiol. Biotechnol., 42(4): 575-580 (1994) X75504 aceA; thiX Partial Isocitrate lyase; ? Reinscheid, D. J. et al. “Characterization of the isocitrate lyase gene from Corynebacterium glutamicum and biochemical analysis of the enzyme,” J. Bacteriol., 176(12): 3474-3483 (1994) X76875 ATPase beta-subunit Ludwig, W. et al. “Phylogenetic relationships of bacteria based on comparative sequence analysis of elongation factor Tu and ATP-synthase beta-subunit genes,” Antonie Van Leeuwenhoek, 64: 285-305 (1993) X77034 tuf Elongation factor Tu Ludwig, W. et al. “Phylogenetic relationships of bacteria based on comparative sequence analysis of elongation factor Tu and ATP-synthase beta-subunit genes,” Antonie Van Leeuwenhoek, 64: 285-305 (1993) X77384 recA Billman-Jacobe, H. “Nucleotide sequence of a recA gene from Corynebacterium glutamicum,” DNA Seq., 4(6): 403-404 (1994) X78491 aceB Malate synthase Reinscheid, D. J. et al. “Malate synthase from Corynebacterium glutamicum pta-ack operon encoding phosphotransacetylase: sequence analysis,” Microbiology, 140: 3099-3108 (1994) X80629 16S rDNA 16S ribosomal RNA Rainey, F. A. et al. “Phylogenetic analysis of the genera Rhodococcus and Norcardia and evidence for the evolutionary origin of the genus Norcardia from within the radiation of Rhodococcus species,” Microbiol., 141: 523-528 (1995) X81191 gluA; Glutamate uptake system Kronemeyer, W. et al. “Structure of the gluABCD cluster encoding the gluB; glutamate uptake system of Corynebacterium glutamicum,” J. Bacteriol., gluC; 177(5): 1152-1158 (1995) gluD X81379 dapE Succinyldiaminopimelate desuccinylase Wehrmann, A. et al. “Analysis of different DNA fragments of Corynebacterium glutamicum complementing dapE of Escherichia coli,” Microbiology, 40: 3349-56 (1994) X82061 16S rDNA 16S ribosomal RNA Ruimy, R. et al. “Phylogeny of the genus Corynebacterium deduced from analyses of small-subunit ribosomal DNA sequences,” Int. J. Syst. Bacteriol., 45(4): 740-746 (1995) X82928 asd; lysC Aspartate-semialdehyde dehydrogenase; ? Serebrijski, I. et al. “Multicopy suppression by asd gene and osmotic stress- dependent complementation by heterologous proA in proA mutants,” J. Bacteriol., 177(24): 7255-7260 (1995) X82929 proA Gamma-glutamyl phosphate reductase Serebrijski, I. et al. “Multicopy suppression by asd gene and osmotic stress- dependent complementation by heterologous proA in proA mutants,” J. Bacteriol., 177(24): 7255-7260 (1995) X84257 16S rDNA 16S ribosomal RNA Pascual, C. et al. “Phylogenetic analysis of the genus Corynebacterium based on 16S rRNA gene sequences,” Int. J. Syst. Bacteriol., 45(4): 724-728 (1995) X85965 aroP; Aromatic amino acid permease; ? Wehrmann, A. et al. “Functional analysis of sequences adjacent to dapE of dapE Corynebacterium glutamicumproline reveals the presence of aroP, which encodes the aromatic amino acid transporter,” J. Bacteriol., 177(20): 5991-5993 (1995) X86157 argB; Acetylglutamate kinase; N-acetyl-gamma- Sakanyan, V. et al. “Genes and enzymes of the acetyl cycle of arginine argC; glutamyl-phosphate reductase; biosynthesis in Corynebacterium glutamicum: enzyme evolution in the early argD; acetylornithine aminotransferase; ornithine steps of the arginine pathway,” Microbiology, 142: 99-108 (1996) argF; argJ carbamoyltransferase; glutamate N- acetyltransferase X89084 pta; ackA Phosphate acetyltransferase; acetate kinase Reinscheid, D. J. et al. “Cloning, sequence analysis, expression and inactivation of the Corynebacterium glutamicum pta-ack operon encoding phosphotransacetylase and acetate kinase,” Microbiology, 145: 503-513 (1999) X89850 attB Attachment site Le Marrec, C. et al. “Genetic characterization of site-specific integration functions of phi AAU2 infecting “Arthrobacter aureus C70,” J. Bacteriol., 178(7): 1996-2004 (1996) X90356 Promoter fragment F1 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90357 Promoter fragment F2 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90358 Promoter fragment F10 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90359 Promoter fragment F13 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90360 Promoter fragment F22 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90361 Promoter fragment F34 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90362 Promoter fragment F37 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90363 Promoter fragment F45 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90364 Promoter fragment F64 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90365 Promoter fragment F75 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90366 Promoter fragment PF101 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90367 Promoter fragment PF104 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90368 Promoter fragment PF109 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X93513 amt Ammonium transport system Siewe, R. M. et al. “Functional and genetic characterization of the (methyl) ammonium uptake carrier of Corynebacterium glutamicum,” J. Biol. Chem., 271(10): 5398-5403 (1996) X93514 betP Glycine betaine transport system Peter, H. et al. “Isolation, characterization, and expression of the Corynebacterium glutamicum betP gene, encoding the transport system for the compatible solute glycine betaine,” J. Bacteriol., 178(17): 5229-5234 (1996) X95649 orf4 Patek, M. et al. “Identification and transcriptional analysis of the dapB-ORF2- dapA-ORF4 operon of Corynebacterium glutamicum, encoding two enzymes involved in L-lysine synthesis,” Biotechnol. Lett., 19: 1113-1117 (1997) X96471 lysE; lysG Lysine exporter protein; Lysine export Vrljic, M. et al. “A new type of transporter with a new type of cellular regulator protein function: L-lysine export from Corynebacterium glutamicum,” Mol. Microbiol., 22(5): 815-826 (1996) X96580 panB; 3-methyl-2-oxobutanoate Sahm, H. et al. “D-pantothenate synthesis in Corynebacterium glutamicum and panC; hydroxymethyltransferase; pantoate-beta- use of panBC and genes encoding L-valine synthesis for D-pantothenate xylB alanine ligase; xylulokinase overproduction,” Appl. Environ. Microbiol., 65(5): 1973-1979 (1999) X96962 Insertion sequence IS1207 and transposase X99289 Elongation factor P Ramos, A. et al. “Cloning, sequencing and expression of the gene encoding elongation factor P in the amino-acid producer Brevibacterium lactofermentum (Corynebacterium glutamicum ATCC 13869),” Gene, 198: 217-222 (1997) Y00140 thrB Homoserine kinase Mateos, L. M. et al. “Nucleotide sequence of the homoserine kinase (thrB) gene of the Brevibacterium lactofermentum,” Nucleic Acids Res., 15(9): 3922 (1987) Y00151 ddh Meso-diaminopimelate D-dehydrogenase Ishino, S. et al. “Nucleotide sequence of the meso-diaminopimelate D- (EC 1.4.1.16) dehydrogenase gene from Corynebacterium glutamicum,” Nucleic Acids Res., 15(9): 3917 (1987) Y00476 thrA Homoserine dehydrogenase Mateos, L. M. et al. “Nucleotide sequence of the homoserine dehydrogenase (thrA) gene of the Brevibacterium lactofermentum,” Nucleic Acids Res., 15(24): 10598 (1987) Y00546 hom; thrB Homoserine dehydrogenase; homoserine Peoples, O. P. et al. “Nucleotide sequence and fine structural analysis of the kinase Corynebacterium glutamicum hom-thrB operon,” Mol. Microbiol., 2(1): 63-72 (1988) Y08964 murC; UPD-N-acetylmuramate-alanine ligase; Honrubia, M. P. et al. “Identification, characterization, and chromosomal ftsQ/divD; division initiation protein or cell division organization of the ftsZ gene from Brevibacterium lactofermentum,” Mol. Gen. ftsZ protein; cell division protein Genet., 259(1): 97-104 (1998) Y09163 putP High affinity proline transport system Peter, H. et al. “Isolation of the putP gene of Corynebacterium glutamicumproline and characterization of a low-affinity uptake system for compatible solutes,” Arch. Microbiol., 168(2): 143-151 (1997) Y09548 pyc Pyruvate carboxylase Peters-Wendisch, P. G. et al. “Pyruvate carboxylase from Corynebacterium glutamicum: characterization, expression and inactivation of the pyc gene,” Microbiology, 144: 915-927 (1998) Y09578 leuB 3-isopropylmalate dehydrogenase Patek, M. et al. “Analysis of the leuB gene from Corynebacterium glutamicum,” Appl. Microbiol. Biotechnol., 50(1): 42-47 (1998) Y12472 Attachment site bacteriophage Phi-16 Moreau, S. et al. “Site-specific integration of corynephage Phi-16: The construction of an integration vector,” Microbiol., 145: 539-548 (1999) Y12537 proP Proline/ectoine uptake system protein Peter, H. et al. “Corynebacterium glutamicum is equipped with four secondary carriers for compatible solutes: Identification, sequencing, and characterization of the proline/ectoine uptake system, ProP, and the ectoine/proline/glycine betaine carrier, EctP,” J. Bacteriol., 180(22): 6005-6012 (1998) Y13221 glnA Glutamine synthetase I Jakoby, M. et al. “Isolation of Corynebacterium glutamicum glnA gene encoding glutamine synthetase I,” FEMS Microbiol. Lett., 154(1): 81-88 (1997) Y16642 lpd Dihydrolipoamide dehydrogenase Y18059 Attachment site Corynephage 304L Moreau, S. et al. “Analysis of the integration functions of &phi; 304L: An integrase module among corynephages,” Virology, 255(1): 150-159 (1999) Z21501 argS; lysA Arginyl-tRNA synthetase; Oguiza, J. A. et al. “A gene encoding arginyl-tRNA synthetase is located in the diaminopimelate upstream region of the lysA gene in Brevibacterium lactofermentum: decarboxylase (partial) Regulation of argS-lysA cluster expression by arginine,” J. Bacteriol., 175(22): 7356-7362 (1993) Z21502 dapA; Dihydrodipicolinate synthase; Pisabarro, A. et al. “A cluster of three genes (dapA, orf2, and dapB) of dapB dihydrodipicolinate reductase Brevibacterium lactofermentum encodes dihydrodipicolinate reductase, and a third polypeptide of unknown function,” J. Bacteriol., 175(9): 2743-2749 (1993) Z29563 thrC Threonine synthase Malumbres, M. et al. “Analysis and expression of the thrC gene of the encoded threonine synthase,” Appl. Environ. Microbiol., 60(7)2209-2219 (1994) Z46753 16S rDNA Gene for 16S ribosomal RNA Z49822 sigA SigA sigma factor Oguiza, J. A. et al “Multiple sigma factor genes in Brevibacterium lactofermentum: Characterization of sigA and sigB,” J. Bacteriol., 178(2): 550-553 (1996) Z49823 galE; dtxR Catalytic activity UDP-galactose 4- Oguiza, J. A. et al “The galE gene encoding the UDP-galactose 4-epimerase of epimerase; diphtheria toxin regulatory Brevibacterium lactofermentum is coupled transcriptionally to the dmdR protein gene,” Gene, 177: 103-107 (1996) Z49824 orfl; sigB ?; SigB sigma factor Oguiza, J. A. et al. “Multiple sigma factor genes in Brevibacterium lactofermentum: Characterization of sigA and sigB,” J. Bacteriol., 178(2): 550-553 (1996) Z66534 Transposase Correia, A. et al. “Cloning and characterization of an IS-like element present in the genome of Brevibacterium lactofermentum ATCC 13869,” Gene, 170(1): 91-94 (1996) ¹A sequence for this gene was published in the indicated reference. However, the sequence obtained by the inventors of the present application is significantly longer than the published version. It is believed that the published version relied on an incorrect start codon, and thus represents only a fragment of the actual coding region.

TABLE 3 Corynebacterium and Brevibacterium Strains Which May be Used in the Practice of the Invention Genus species ATCC FERM NRRL CECT NCIMB CBS NCTC DSMZ Brevibacterium ammoniagenes 21054 Brevibacterium ammoniagenes 19350 Brevibacterium ammoniagenes 19351 Brevibacterium ammoniagenes 19352 Brevibacterium ammoniagenes 19353 Brevibacterium ammoniagenes 19354 Brevibacterium ammoniagenes 19355 Brevibacterium ammoniagenes 19356 Brevibacterium ammoniagenes 21055 Brevibacterium ammoniagenes 21077 Brevibacterium ammoniagenes 21553 Brevibacterium ammoniagenes 21580 Brevibacterium ammoniagenes 39101 Brevibacterium butanicum 21196 Brevibacterium divaricatum 21792 P928 Brevibacterium flavum 21474 Brevibacterium flavum 21129 Brevibacterium flavum 21518 Brevibacterium flavum B11474 Brevibacterium flavum B11472 Brevibacterium flavum 21127 Brevibacterium flavum 21128 Brevibacterium flavum 21427 Brevibacterium flavum 21475 Brevibacterium flavum 21517 Brevibacterium flavum 21528 Brevibacterium flavum 21529 Brevibacterium flavum B11477 Brevibacterium flavum B11478 Brevibacterium flavum 21127 Brevibacterium flavum B11474 Brevibacterium healii 15527 Brevibacterium ketoglutamicum 21004 Brevibacterium ketoglutamicum 21089 Brevibacterium ketosoreductum 21914 Brevibacterium lactofermentum 70 Brevibacterium lactofermentum 74 Brevibacterium lactofermentum 77 Brevibacterium lactofermentum 21798 Brevibacterium lactofermentum 21799 Brevibacterium lactofermentum 21800 Brevibacterium lactofermentum 21801 Brevibacterium lactofermentum B11470 Brevibacterium lactofermentum B11471 Brevibacterium lactofermentum 21086 Brevibacterium lactofermentum 21420 Brevibacterium lactofermentum 21086 Brevibacterium lactofermentum 31269 Brevibacterium linens 9174 Brevibacterium linens 19391 Brevibacterium linens 8377 Brevibacterium paraffinolyticum 11160 Brevibacterium spec. 717.73 Brevibacterium spec. 717.73 Brevibacterium spec. 14604 Brevibacterium spec. 21860 Brevibacterium spec. 21864 Brevibacterium spec. 21865 Brevibacterium spec. 21866 Brevibacterium spec. 19240 Corynebacterium acetoacidophilum 21476 Corynebacterium acetoacidophilum 13870 Corynebacterium acetoglutamicum B11473 Corynebacterium acetoglutamicum B11475 Corynebacterium acetoglutamicum 15806 Corynebacterium acetoglutamicum 21491 Corynebacterium acetoglutamicum 31270 Corynebacterium acetophilum B3671 Corynebacterium ammoniagenes 6872 2399 Corynebacterium ammoniagenes 15511 Corynebacterium fujiokense 21496 Corynebacterium glutamicum 14067 Corynebacterium glutamicum 39137 Corynebacterium glutamicum 21254 Corynebacterium glutamicum 21255 Corynebacterium glutamicum 31830 Corynebacterium glutamicum 13032 Corynebacterium glutamicum 14305 Corynebacterium glutamicum 15455 Corynebacterium glutamicum 13058 Corynebacterium glutamicum 13059 Corynebacterium glutamicum 13060 Corynebacterium glutamicum 21492 Corynebacterium glutamicum 21513 Corynebacterium glutamicum 21526 Corynebacterium glutamicum 21543 Corynebacterium glutamicum 13287 Corynebacterium glutamicum 21851 Corynebacterium glutamicum 21253 Corynebacterium glutamicum 21514 Corynebacterium glutamicum 21516 Corynebacterium glutamicum 21299 Corynebacterium glutamicum 21300 Corynebacterium glutamicum 39684 Corynebacterium glutamicum 21488 Corynebacterium glutamicum 21649 Corynebacterium glutamicum 21650 Corynebacterium glutamicum 19223 Corynebacterium glutamicum 13869 Corynebacterium glutamicum 21157 Corynebacterium glutamicum 21158 Corynebacterium glutamicum 21159 Corynebacterium glutamicum 21355 Corynebacterium glutamicum 31808 Corynebacterium glutamicum 21674 Corynebacterium glutamicum 21562 Corynebacterium glutamicum 21563 Corynebacterium glutamicum 21564 Corynebacterium glutamicum 21565 Corynebacterium glutamicum 21566 Corynebacterium glutamicum 21567 Corynebacterium glutamicum 21568 Corynebacterium glutamicum 21569 Corynebacterium glutamicum 21570 Corynebacterium glutamicum 21571 Corynebacterium glutamicum 21572 Corynebacterium glutamicum 21573 Corynebacterium glutamicum 21579 Corynebacterium glutamicum 19049 Corynebacterium glutamicum 19050 Corynebacterium glutamicum 19051 Corynebacterium glutamicum 19052 Corynebacterium glutamicum 19053 Corynebacterium glutamicum 19054 Corynebacterium glutamicum 19055 Corynebacterium glutamicum 19056 Corynebacterium glutamicum 19057 Corynebacterium glutamicum 19058 Corynebacterium glutamicum 19059 Corynebacterium glutamicum 19060 Corynebacterium glutamicum 19185 Corynebacterium glutamicum 13286 Corynebacterium glutamicum 21515 Corynebacterium glutamicum 21527 Corynebacterium glutamicum 21544 Corynebacterium glutamicum 21492 Corynebacterium glutamicum B8183 Corynebacterium glutamicum B8182 Corynebacterium glutamicum B12416 Corynebacterium glutamicum B12417 Corynebacterium glutamicum B12418 Corynebacterium glutamicum B11476 Corynebacterium glutamicum 21608 Corynebacterium lilium P973 Corynebacterium nitrilophilus 21419 11594 Corynebacterium spec. P4445 Corynebacterium spec. P4446 Corynebacterium spec. 31088 Corynebacterium spec. 31089 Corynebacterium spec. 31090 Corynebacterium spec. 31090 Corynebacterium spec. 31090 Corynebacterium spec. 15954 20145 Corynebacterium spec. 21857 Corynebacterium spec. 21862 Corynebacterium spec. 21863 ATCC: American Type Culture Collection, Rockville, MD, USA FERM: Fermentation Research Institute, Chiba, Japan NRRL: ARS Culture Collection, Northern Regional Research Laboratory, Peoria, IL, USA CECT: Coleccion Espanola de Cultivos Tipo, Valencia, Spain NCIMB: National Collection of Industrial and Marine Bacteria Ltd., Aberdeen, UK CBS: Centraalbureau voor Schimmelcultures, Baarn, NL NCTC: National Collection of Type Cultures, London, UK DSMZ: Deutsche Sammlung von Mikroorganismen und Zellkulturen, Braunschweig, Germany For reference see Sugawara, H. et al. (1993) World directory of collections of cultures of microorganisms: Bacteria, fungi and yeasts (4^(th) edn), World federation for culture collections world data center on microorganisms, Saimata, Japen.

TABLE 4 ALIGNMENT RESULTS % length homology ID # (NT) Genbank Hit Length Accession Name of Genbank Hit Source of Genbank Hit (GAP) Date of Deposit rxa00003 864 GB_BA2: MPAE000013 10328 AE000013 Mycoplasma pneumoniae section 13 of 63 of the complete genome. Mycoplasma pneumoniae 37,409 18-Nov-96 GB_BA2: MPAE000013 10328 AE000013 Mycoplasma pneumoniae section 13 of 63 of the complete genome. Mycoplasma pneumoniae 36,768 18-Nov-96 rxa00008 615 GB_HTG2: AC007356 185382 AC007356 Drosophila melanogaster chromosome 2 clone BACR24H09 (D595) RPCI-98 24.H.9 Drosophila melanogaster 39,203 2-Aug-99 map 49A-49B strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 13 unordered pieces. GB_HTG2: AC007356 185382 AC007356 Drosophila melanogaster chromosome 2 clone BACR24H09 (D595) RPCI-98 24.H.9 Drosophila melanogaster 39,203 2-Aug-99 map 49A-49B strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 13 unordered pieces. GB_EST36: AV194293 380 AV194293 AV194293 Yuji Kohara unpublished cDNA: Strain N2 hermaphrodite embryo Caenorhabditis elegans 38,947 22-Jul-99 Caenorhabditis elegans cDNA clone yk627f12 5′, mRNA sequence. rxa00015 432 GB_GSS4: AQ684785 671 AQ684785 HS_5481_B2_H06_SP6E RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 41,388 28-Jun-99 genomic clone Plate = 1057 Col = 12 Row = P, genomic survey sequence. GB_PR2: HS217O16 87552 AL031771 Human DNA sequence from clone 217O16 on chromosome 6q24 Contains Homo sapiens 37,471 23-Nov-99 GSS, complete sequence. GB_EST15: AA528550 335 AA528550 nf01f01.s1 NCI_CGAP_Kid1 Homo sapiens cDNA clone IMAGE: 912505, Homo sapiens 40,789 19-Aug-97 mRNA sequence. rxa00018 1422 GB_VI: HS5MCP 4320 M25411 Human cytomegalovirus major capsid protein (MCP) gene, complete cds. human herpesvirus 5 38,231 30-OCT-1994 GB_BA2: AE001270 12448 AE001270 Treponema pallidum section 86 of 87 of the complete genome. Treponema pallidum 37,130 16-Jul-98 GB_IN1: LMFL2385 22004 AL034389 Leishmania major Friedlin cosmid L2385, complete sequence. Leishmania major 37,518 15-MAR-1999 rxa00020 903 GB_PR4: AC006960 179757 AC006960 Homo sapiens clone UWGC: djs58 from 7p14-15, complete sequence. Homo sapiens 36,618 05-MAR-1999 GB_HTG3: AC008266 178972 AC008266 Homo sapiens clone DJ1145A24, *** SEQUENCING IN PROGRESS ***, Homo sapiens 35,419 21-Aug-99 3 unordered pieces. GB_HTG3: AC008266 178972 AC008266 Homo sapiens clone DJ1145A24, *** SEQUENCING IN PROGRESS ***, Homo sapiens 35,419 21-Aug-99 3 unordered pieces. rxa00021 1896 GB_EST15: AA496164 429 AA496164 zu67e09.r1 Soares_testis_NHT Homo sapiens cDNA clone IMAGE: 743080 5′, Homo sapiens 35,526 11-Aug-97 mRNA sequence. GB_EST30: AI660039 443 AI660039 we65d06.x1 Soares_thymus_NHFTh Homo sapiens cDNA clone IMAGE: 2345963 Homo sapiens 42,574 10-MAY-1999 3′, mRNA sequence. GB_EST37: AI953059 522 AI953059 wq49g06.x1 NCI_CGAP_GC6 Homo sapiens cDNA clone IMAGE: 2474650 3′, Homo sapiens 39,198 6-Sep-99 mRNA sequence. rxa00022 1824 GB_EST15: AA496164 429 AA496164 zu67e09.r1 Soares_testis_NHT Homo sapiens cDNA clone IMAGE: 743080 5′, Homo sapiens 41,141 11-Aug-97 mRNA sequence. GB_PR3: AF022141 43473 AF022141 Homo sapiens chromosome 21q22.2 cosmid Q13F10, complete sequence. Homo sapiens 37,262 21-Jan-98 GB_EST18: AA678649 538 AA678649 ah07c05.s1 Gessler Wilms tumor Homo sapiens cDNA clone IMAGE: 1155944 Homo sapiens 38,104 02-DEC-1997 3′ similar to gb: X16869 ELONGATION FACTOR 1-ALPHA 1 (HUMAN);, mRNA sequence. rxa00025 1560 GB_PL2: AC009978 97554 AC009978 Genomic sequence for Arabidopsis thaliana BAC T23E18 from chromosome I, Arabidopsis thaliana 34,173 15-Nov-99 complete sequence. GB_HTG2: AC005958 216706 AC005958 Homo sapiens, *** SEQUENCING IN PROGRESS ***, 40 unordered pieces. Homo sapiens 35,374 11-Nov-98 GB_HTG2: AC005958 216706 AC005958 Homo sapiens, *** SEQUENCING IN PROGRESS ***, 40 unordered pieces. Homo sapiens 35,374 11-Nov-98 rxa00027 489 GB_PR3: HSDJ247C2 98358 AL049713 Human DNA sequence from clone 247C2 on chromosome 11p13, complete sequence. Homo sapiens 33,056 23-Nov-99 rxa00028 GB_PR3: HSDJ247C2 98358 AL049713 Human DNA sequence from clone 247C2 on chromosome 11p13, complete sequence. Homo sapiens 37,988 23-Nov-99 rxa00031 525 GB_PL1: SPBC725 37949 AL034352 S. pombe chromosome II cosmid c725. Schizosaccharomyces 36,084 29-MAR-1999 pombe GB_EST5: N22565 435 N22565 yw30f05.s1 Morton Fetal Cochlea Homo sapiens cDNA clone IMAGE: 253761 3′, Homo sapiens 41,570 20-DEC-1995 mRNA sequence. GB_EST21: AA993042 464 AA993042 ot92f07.s1 Soares_total_fetus_Nb2HF8_9w Homo sapiens cDNA clone IMAGE: Homo sapiens 41,499 27-Aug-98 1624261 3′, mRNA sequence. rxa00049 810 GB_HTG2: HSJ749H19 253387 AL117380 Homo sapiens chromosome 20 clone RP4-749H19 map q13.11-13.33, Homo sapiens 37,132 03-DEC-1999 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG2: HSJ749H19 253387 AL117380 Homo sapiens chromosome 20 clone RP4-749H19 map q13.11-13.33, Homo sapiens 37,132 03-DEC-1999 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG4: AC010137 155817 AC010137 Homo sapiens clone NH0169D01, *** SEQUENCING IN PROGRESS ***, Homo sapiens 40,052 17-OCT-1999 4 unordered pieces. rxa00052 834 GB_EST37: AI962012 382 AI962012 wt41e06.x1 NCI_CGAP_Pan1 Homo sapiens cDNA clone IMAGE: 2510050 Homo sapiens 40,486 20-Aug-99 3′ similar to SW: ALC2_HUMAN P01877 IG ALPHA-2 CHAIN C REGION.;, mRNA sequence. GB_GSS13: AQ454792 450 AQ454792 HS_5195_B2_H04_SP6E RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 40,991 21-Apr-99 genomic clone Plate = 771 Col = 8 Row = P, genomic survey sequence. GB_GSS13: AQ454792 450 AQ454792 HS_5195_B2_H04_SP6E RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 40,278 21-Apr-99 genomic clone Plate = 771 Col = 8 Row = P, genomic survey sequence. rxa00054 3036 GB_GSS5: AQ773786 459 AQ773786 HS_2222_A1_E07_MR CIT Approved Human Genomic Sperm Library D Homo sapiens 40,087 29-Jul-99 Homo sapiens genomic clone Plate = 2222 Col = 13 Row = I, genomic survey sequence. GB_GSS5: AQ773786 459 AQ773786 HS_2222_A1_E07_MR CIT Approved Human Genomic Sperm Library D Homo sapiens 40,087 29-Jul-99 Homo sapiens genomic clone Plate = 2222 Col = 13 Row = I, genomic survey sequence. rxa00056 873 GB_IN1: CEF56H9 28291 Z74473 Caenorhabditis elegans cosmid F56H9, Caenorhabditis elegans 35,301 23-Nov-98 complete sequence. GB_IN1: CEF56H9 28291 Z74473 Caenorhabditis elegans cosmid F56H9, complete sequence. Caenorhabditis elegans 38,941 23-Nov-98 rxa00058 687 GB_HTG6: AC011647 141830 AC011647 Homo sapiens clone RP11-15D18, *** SEQUENCING IN PROGRESS ***, Homo sapiens 39,939 04-DEC-1999 29 unordered pieces. GB_HTG6: AC011647 141830 AC011647 Homo sapiens clone RP11-15D18, *** SEQUENCING IN PROGRESS ***, Homo sapiens 37,537 04-DEC-1999 29 unordered pieces. rxa00059 405 GB_GSS6: AQ825754 463 AQ825754 HS_5441_A2_G02_SP6E RPCI-11 Human Male BAC Library Homo sapiens 34,444 27-Aug-99 Homo sapiens genomic clone Plate = 1017 Col = 4 Row = M, genomic survey sequence. GB_PAT: I32939 30001 I32939 Sequence 1 from patent U.S. Pat. No. 5589385. Unknown. 42,049 6-Feb-97 GB_PAT: AR031772 30001 AR031772 Sequence 1 from patent U.S. Pat. No. 5866410. Unknown. 42,049 29-Sep-99 rxa00065 396 GB_PAT: E16763 2517 E16763 gDNA encoding aspartate transferase (AAT). Corynebacterium 98,765 28-Jul-99 glutamicum GB_EST32: AU050556 813 AU050556 AU050556 Paralichthys olivaceus library (Aoki T) Paralichthys olivaceus Paralichthys olivaceus 35,638 8-Jun-99 cDNA clone WF7-19, mRNA sequence. GB_EST32: AU050215 733 AU050215 AU050215 Paralichthys olivaceus library (Aoki T) Paralichthys olivaceus Paralichthys olivaceus 35,638 8-Jun-99 cDNA clone WB1-12, mRNA sequence. rxa00067 609 GB_HTG3: AC008289 115120 AC008289 Drosophila melanogaster chromosome 2 clone BACR04E05 (D1055) RPCI-98 04.E.5 Drosophila melanogaster 30,397 17-Aug-99 map 57B-57B strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 100 unordered pieces. GB_IN2: AC004433 85862 AC004433 Drosophila melanogaster, chromosome 2R, region 57B1-57B6, P1 clone DS03659, Drosophila melanogaster 35,501 01-DEC-1998 complete sequence. GB_HTG3: AC008289 115120 AC008289 Drosophila melanogaster chromosome 2 clone BACR04E05 (D1055) RPCI-98 04.E.5 Drosophila melanogaster 30,397 17-Aug-99 map 57B-57B strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 100 unordered pieces. rxa00068 705 GB_PL2: ATAC006201 87947 AC006201 Arabidopsis thaliana chromosome II BAC T27K22 genomic sequence, Arabidopsis thaliana 39,099 12-MAR-1999 complete sequence. GB_HTG5: AC010146 271437 AC010146 Homo sapiens clone NH0355I13, WORKING DRAFT SEQUENCE, Homo sapiens 34,237 12-Nov-99 1 unordered pieces. GB_GSS3: B85079 307 B85079 RPCI11-29O9.TP RPCI-11 Homo sapiens genomic clone RPCI-11-29O9, Homo sapiens 39,560 9-Apr-99 genomic survey sequence. rxa00077 1485 GB_PR4: AC007157 152937 AC007157 Homo sapiens, clone hRPK.78_A_1, complete sequence. Homo sapiens 37,661 27-Apr-99 GB_HTG1: CEY43C5 149571 AL021449 Caenorhabditis elegans chromosome IV clone Y43C5, *** SEQUENCING Caenorhabditis elegans 25,242 23-Jan-98 IN PROGRESS ***, in unordered pieces. GB_HTG1: CEY43C5 149571 AL021449 Caenorhabditis elegans chromosome IV clone Y43C5, *** SEQUENCING Caenorhabditis elegans 38,258 23-Jan-98 IN PROGRESS ***, in unordered pieces. rxa00079 345 GB_IN1: CTAJ2763 1097 AJ002763 Chironomus tentans mRNA for P23 protein (23 kDa). Chironomus tentans 36,176 26-Jan-98 GB_IN1: CTHRP23 752 AJ003820 Chironomus tentans mRNA for hnRNP protein, hrp23. Chironomus tentans 36,176 02-DEC-1998 GB_EST17: AA650674 540 AA650674 30788 Lambda-PRL2 Arabidopsis thaliana cDNA clone 277G7T7, mRNA sequence. Arabidopsis thaliana 36,965 31-OCT-1997 rxa00080 1653 GB_EST38: AW039986 564 AW039986 EST282477 tomato mixed elicitor, BTI Lycopersicon esculentum cDNA Lycopersicon esculentum 38,078 18-OCT-1999 clone cLET19F23, mRNA sequence. GB_EST33: AI778332 378 AI778332 EST259211 tomato susceptible, Cornell Lycopersicon esculentum Lycopersicon esculentum 38,298 29-Jun-99 cDNA clone cLES5A13, mRNA sequence. GB_EST38: AW039988 564 AW039988 EST282479 tomato mixed elicitor, BTI Lycopersicon esculentum Lycopersicon esculentum 38,078 18-OCT-1999 cDNA clone cLET19F23, mRNA sequence. rxa00082 687 GB_PR1: HSS171 333303 AJ011930 Homo sapiens chromosome 21q22.3, PAC clones 314N7, 225L15, BAC Homo sapiens 36,111 10-Nov-98 clone 7B7, complete sequence bases 1..333303. GB_PR1: HSS171 333303 AJ011930 Homo sapiens chromosome 21q22.3, PAC clones 314N7, 225L15, BAC Homo sapiens 35,432 10-Nov-98 clone 7B7, complete sequence bases 1..333303. GB_PR3: AC004000 128117 AC004000 Human PAC clone DJ404F18 from Xq23, complete sequence. Homo sapiens 38,750 15-Jan-98 rxa00083 423 GB_HTG1: CNS018OY 168868 AL109769 Homo sapiens chromosome 14 clone R-501E21, *** SEQUENCING IN Homo sapiens 33,806 15-OCT-1999 PROGRESS ***, in ordered pieces. GB_HTG1: CNS018OY 168868 AL109769 Homo sapiens chromosome 14 clone R-501E21, *** SEQUENCING IN Homo sapiens 33,806 15-OCT-1999 PROGRESS ***, in ordered pieces. GB_PR3: HS516C23 116685 Z93021 Human DNA sequence from clone 516C23 on chromosome 6q12 Contains CA Homo sapiens 38,562 23-Nov-99 repeat (D6S402) and GSSs, complete sequence. rxa00087 651 GB_BA1: PSEBPHABC 6780 M83673 P. pseudoalcaligenes dioxygenase (bphABC) gene cluster, complete cds. Pseudomonas 39,564 26-Apr-93 pseudoalcaligenes GB_BA1: PSEBPHA 5700 M86348 Pseudomonas sp. LB400 biphenyl dioxygenase (bphA), biphenyl dioxygenase Burkholderia sp. LB400 39,564 18-Jul-97 (bphE), biphenyl dioxygenase (bphF) and biphenyl dioxygenase (bphG)s, complete cds, and dihydrodiol dehydrogenase (bphB), partial cds. GB_PAT: E04215 4721 E04215 Benzene dioxygenase gene. Pseudomonas aeruginosa 45,814 29-Sep-97 rxa00093 2346 GB_HTG2: AC007361 36465 AC007361 Homo sapiens clone NH0144P23, *** SEQUENCING IN PROGRESS ***, Homo sapiens 37,179 23-Apr-99 1 unordered pieces. GB_PR4: AC006043 189036 AC006043 Homo sapiens BAC clone NH0538D15 from 7q11.23-q21.1, complete sequence. Homo sapiens 37,060 20-Feb-99 GB_HTG2: AC007361 36465 AC007361 Homo sapiens clone NH0144P23, *** SEQUENCING IN PROGRESS ***, Homo sapiens 37,179 23-Apr-99 1 unordered pieces. rxa00096 426 GB_EST15: AA533064 534 AA533064 nj60d06.s1 NCI_CGAP_Pr9 Homo sapiens cDNA clone IMAGE: 996875, Homo sapiens 39,024 21-Aug-97 mRNA sequence. GB_IN1: CELF01G12 34671 U53342 Caenorhabditis elegans cosmid F01G12. Caenorhabditis elegans 38,060 5-Apr-96 GB_PR3: AC004511 45005 AC004511 Homo sapiens chromosome 5, P1 clone 792C12 (LBNL H22), complete sequence. Homo sapiens 39,163 31-MAR-1998 rxa00097 1299 GB_OM: CFU60590 6726 U60590 Canis familiaris TTX-resistant sodium channel mRNA, complete cds. Canis familiaris 39,528 8-Jan-98 GB_GSS15: AQ664394 485 AQ664394 HS_5480_B1_B02_SP6E RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 39,666 23-Jun-99 genomic clone Plate = 1056 Col = 3 Row = D, genomic survey sequence. GB_BA2: RSAF000233 5984 AF000233 Rhodobacter sphaeroides nitric oxide reductase operon: norC, norB, norQ, Rhodobacter sphaeroides 37,500 6-Jun-97 norD, nnrT and nnrU genes, complete cds. rxa00101 rxa00108 643 GB_PR4: AC007115 180821 AC007115 Homo sapiens chromosome 12 clone 917O5, complete sequence. Homo sapiens 35,165 17-Aug-99 GB_PR3: AC004080 129354 AC004080 Homo sapiens PAC clone DJ0170O19 from 7p15-p21, complete sequence. Homo sapiens 38,560 29-Jan-98 GB_HTG1: HSAJ9613 45302 AJ009613 Homo sapiens chromosome 17 clone cosmid 5L5 map p11, *** SEQUENCING IN Homo sapiens 39,274 11-Nov-98 PROGRESS ***, in unordered pieces. rxa00110 672 GB_PL1: MIATGENB 166924 Y08502 A. thaliana mitochondrial genome, part B. Mitochondrion Arabidopsis 36,391 13-Nov-98 thaliana GB_PL2: AC010718 87684 AC010718 Arabidopsis thaliana chromosome I BAC F28O16 genomic sequence, Arabidopsis thaliana 36,622 30-OCT-1999 complete sequence. GB_PL2: AC007729 106639 AC007729 Arabidopsis thaliana chromosome II BAC T18C6 genomic sequence, Arabidopsis thaliana 35,053 5-Jun-99 complete sequence. rxa00114 612 GB_OM: BTMICSD1 362 Z27071 B. taurus (cos1E3) microsatellite DNA (362 bp). Bos taurus 37,117 10-Aug-95 GB_OM: BTMICSD1 362 Z27071 B. taurus (cos1E3) microsatellite DNA (362 bp). Bos taurus 36,486 10-Aug-95 rxa00117 714 GB_PL2: AF080249 3194 AF080249 Arabidopsis thaliana kinesin-like heavy chain (KATD) mRNA, complete cds. Arabidopsis thaliana 37,846 14-Apr-99 GB_PL2: IG002P16 110946 AF007270 Arabidopsis thaliana BAC IG002P16. Arabidopsis thaliana 37,110 12-Jun-97 GB_PL2: AF080249 3194 AF080249 Arabidopsis thaliana kinesin-like heavy chain (KATD) mRNA, complete cds. Arabidopsis thaliana 36,506 14-Apr-99 rxa00118 378 GB_HTG2: AC008043 124844 AC008043 Drosophila melanogaster chromosome 3 clone BACR05A08 (D750) RPCI-98 05.A.8 Drosophila melanogaster 33,780 2-Aug-99 map 94A-94A strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 86 unordered pieces. GB_HTG2: AC008043 124844 AC008043 Drosophila melanogaster chromosome 3 clone BACR05A08 (D750) RPCI-98 05.A.8 Drosophila melanogaster 33,780 2-Aug-99 map 94A-94A strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 86 unordered pieces. GB_PR3: AC004827 129690 AC004827 Homo sapiens PAC clone DJ044L15 from Xq23, complete sequence. Homo sapiens 32,320 17-OCT-1998 rxa00119 882 GB_PR4: HSU34879 46610 U34879 Human 17-beta-hydroxysteroid dehydrogenase (EDH17B2) gene, complete cds. Homo sapiens 36,671 14-Jan-99 GB_PR4: HSU34879 46610 U34879 Human 17-beta-hydroxysteroid dehydrogenase (EDH17B2) gene, complete cds. Homo sapiens 38,345 14-Jan-99 GB_EST37: AW005997 702 AW005997 wz91c01.x1 NCI_CGAP_Brn25 Homo sapiens cDNA clone IMAGE: 2566176 Homo sapiens 40,774 10-Sep-99 3′ similar to TR: O08609 O08609 TRANSCRIPTION FACTOR-LIKE PROTEIN 4.;, mRNA sequence. rxa00120 963 GB_BA1: TRU80216 1936 U80216 Thermomicrobium roseum 70 kDa heat shock protein Hsp70 (DnaK) gene, Thermomicrobium roseum 38,000 1-Feb-97 complete cds. GB_HTG1: HS791K14 155318 AL035685 Homo sapiens chromosome 20 clone RP4-791K14, *** SEQUENCING IN Homo sapiens 37,277 23-Nov-99 PROGRESS ***, in unordered pieces. GB_HTG1: HS791K14 155318 AL035685 Homo sapiens chromosome 20 clone RP4-791K14, *** SEQUENCING IN Homo sapiens 37,277 23-Nov-99 PROGRESS ***, in unordered pieces. rxa00121 834 GB_HTG1: HSBA298O6 198847 AL118525 Homo sapiens chromosome 20 clone RP11-298O6, *** SEQUENCING IN Homo sapiens 36,199 24-Nov-99 PROGRESS ***, in unordered pieces. GB_HTG1: HS791K14 155318 AL035685 Homo sapiens chromosome 20 clone RP4-791K14, *** SEQUENCING IN Homo sapiens 36,983 23-Nov-99 PROGRESS ***, in unordered pieces. GB_HTG1: HS791K14 155318 AL035685 Homo sapiens chromosome 20 clone RP4-791K14, *** SEQUENCING IN Homo sapiens 36,983 23-Nov-99 PROGRESS ***, in unordered pieces. rxa00122 1746 GB_PL1: MZECPN60A 6575 L21007 Corn nuclear-encoded mitochondrial chaperonin 60 (cpn60I) gene, Zea mays 36,098 26-Jul-93 complete cds. GB_PL1: ZMCPNAGA 2247 Z12114 Z. mays CPNA gene encoding mitochondrial chaperonin-60. Zea mays 37,702 01-OCT-1992 GB_PL1: ZMCHHSP60 2138 Z11546 Z. mays mRNA for mitochondrial chaperonin hsp60. Zea mays 37,721 11-Jun-92 rxa00127 588 GB_PR4: AC005193 108400 AC005193 Homo sapiens clone DJ0655N24, complete sequence. Homo sapiens 37,500 1-Jul-99 GB_PR4: AC005193 108400 AC005193 Homo sapiens clone DJ0655N24, complete sequence. Homo sapiens 36,796 1-Jul-99 rxa00128 1827 GB_GSS11: AQ299024 449 AQ299024 HS_3178_B1_B06_T7 CIT Approved Human Genomic Sperm Library D Homo sapiens 40,757 15-DEC-1998 Homo sapiens genomic clone Plate = 3178 Col = 11 Row = D, genomic survey sequence. GB_GSS11: AQ299024 449 AQ299024 HS_3178_B1_B06_T7 CIT Approved Human Genomic Sperm Library D Homo sapiens 40,443 15-DEC-1998 Homo sapiens genomic clone Plate = 3178 Col = 11 Row = D, genomic survey sequence. rxa00134 693 GB_GSS10: AQ177172 393 AQ177172 HS_3225_A2_E10_MR CIT Approved Human Genomic Sperm Library D Homo sapiens 50,000 17-OCT-1998 Homo sapiens genomic clone Plate = 3225 Col = 20 Row = I, genomic survey sequence. GB_PR3: AC005726 185215 AC005726 Homo sapiens chromosome 17, clone hRPK.192_H_23, complete sequence. Homo sapiens 37,778 30-OCT-1998 GB_PR3: AC005726 185215 AC005726 Homo sapiens chromosome 17, clone hRPK.192_H_23, complete sequence. Homo sapiens 38,710 30-OCT-1998 rxa00140 309 GB_VI: OPU75930 131993 U75930 Orgyia pseudotsugata nuclear polyhedrosis virus complete genome. Orgyia pseudotsugata 39,007 06-MAR-1998 nuclear polyhedrosis virus GB_HTG2: AC006319 156299 AC006319 Homo sapiens clone DJ0837C09, *** SEQUENCING IN PROGRESS ***, Homo sapiens 31,773 23-Apr-99 1 unordered pieces. GB_HTG2: AC006319 156299 AC006319 Homo sapiens clone DJ0837C09, *** SEQUENCING IN PROGRESS ***, Homo sapiens 31,773 23-Apr-99 1 unordered pieces. rxa00141 585 GB_VI: OPU75930 131993 U75930 Orgyia pseudotsugata nuclear polyhedrosis virus complete genome. Orgyia pseudotsugata 38,079 06-MAR-1998 nuclear polyhedrosis virus GB_PR4: AC004526 297898 AC004526 Homo sapiens chromosome 17, Neurofibromatosis 1 locus, complete sequence. Homo sapiens 37,336 25-Feb-99 GB_PR2: HUMNEUROF 100849 L05367 Human oligodendrocyte myelin glycoprotein (OMG) exons 1-2; neurofibromatosis 1 Homo sapiens 37,336 20-Sep-95 (NF1) exons 28-49; ecotropic viral integration site 2B (EVI2B) exons 1-2; ecotropic viral integration site 2A (EVI2A) exons 1-2; adenylate kinase (AK3) exons 1-2. rxa00142 600 GB_PR4: HUAC002331 139480 AC002331 Homo sapiens Chromosome 16 BAC clone CIT987SK-A-A-218C7, Homo sapiens 38,898 23-Nov-99 complete sequence. GB_PR3: AF064861 133965 AF064861 Homo sapiens PAC 128M19 derived from chromosome 21q22.3, containing Homo sapiens 37,182 2-Jun-98 the HMG-14 and CHD5 genes, complete cds, complete sequence. GB_HTG3: AC009451 165302 AC009451 Homo sapiens chromosome 17 clone 2286_H_12 map 17, *** SEQUENCING IN Homo sapiens 33,167 22-Aug-99 PROGRESS ***, 26 unordered pieces. rxa00150 897 GB_PR4: AF130343 292721 AF130343 Homo sapiens chromosome 8 clone PAC 87.2 map 8q24.1, complete sequence. Homo sapiens 36,032 9-Jul-99 GB_HTG4: AC008578 98891 AC008578 Homo sapiens chromosome 5 clone CIT-HSPC_558D4, *** SEQUENCING IN Homo sapiens 38,129 31-OCT-1999 PROGRESS ***, 143 unordered pieces. GB_HTG4: AC008578 98891 AC008578 Homo sapiens chromosome 5 clone CIT-HSPC_558D4, *** SEQUENCING IN Homo sapiens 38,129 31-OCT-1999 PROGRESS ***, 143 unordered pieces. rxa00151 720 GB_PL2: AF058914 111767 AF058914 Arabidopsis thaliana BAC F21E10. Arabidopsis thaliana 36,068 15-Apr-98 GB_PR1: AB019440 200000 AB019440 Homo sapiens DNA for immunoglobulin heavy-chain variable region, Homo sapiens 36,517 24-Feb-99 complete sequence, 4 of 5. GB_PR2: AP000098 100000 AP000098 Homo sapiens genomic DNA of 21q22.1, GART and AML related, Q78C10-149C3 Homo sapiens 39,224 25-Sep-99 region, segment 1/20, complete sequence. rxa00153 549 GB_PR4: AC006265 177707 AC006265 Homo sapiens chromosome 17, clone hRPK.566_B_16, complete sequence. Homo sapiens 34,862 28-Jan-99 GB_HTG2: AC007389 207188 AC007389 Homo sapiens clone NH0418H16, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,044 5-Jun-99 6 unordered pieces. GB_HTG2: AC007389 207188 AC007389 Homo sapiens clone NH0418H16, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,044 5-Jun-99 6 unordered pieces. rxa00154 rxa00155 906 GB_BA2: AE001707 19518 AE001707 Thermotoga maritima section 19 of 136 of the complete genome. Thermotoga maritima 36,854 2-Jun-99 GB_PR2: HS1126I14 19544 AL078589 Human DNA sequence from clone 1126I14 on chromosome 6q16.1-16.3. Homo sapiens 36,723 23-Nov-99 Contains an STS and GSSs, complete sequence. GB_BA1: MTCY01B2 35938 Z95554 Mycobacterium tuberculosis H37Rv complete genome; segment 72/162. Mycobacterium 40,435 17-Jun-98 tuberculosis rxa00159 1305 GB_EST38: AW048718 475 AW048718 UI-M-BH1-amy-d-01-0-UI.s1 NIH_BMAP_M_S2 Mus musculus cDNA clone Mus musculus 39,789 18-Sep-99 UI-M-BH1-amy-d-01-0-UI 3′, mRNA sequence. GB_EST21: AA993450 381 AA993450 ot32h09.s1 Soares_testis_NHT Homo sapiens cDNA clone IMAGE: 1618529 3′, Homo sapiens 38,684 27-Aug-98 mRNA sequence. GB_BA1: AB007009 363 AB007009 Cytophaga sp. 16S rRNA gene, partial sequence. Cytophaga sp. 39,039 13-OCT-1997 rxa00161 585 GB_HTG3: AC009708 25123 AC009708 Homo sapiens chromosome 8 clone 318_G_5 map 8, LOW-PASS Homo sapiens 37,108 28-Aug-99 SEQUENCE SAMPLING. GB_HTG3: AC009708 25123 AC009708 Homo sapiens chromosome 8 clone 318_G_5 map 8, LOW-PASS Homo sapiens 37,108 28-Aug-99 SEQUENCE SAMPLING. GB_PR3: HSN104C4 40203 Z83855 Human DNA sequence from clone N104C4 on chromosome 22 Contains Homo sapiens 37,634 23-Nov-99 GSSs, complete sequence. rxa00162 477 GB_HTG1: CEY94A7 41009 Z99294 Caenorhabditis elegans chromosome V clone Y94A7, *** SEQUENCING IN Caenorhabditis elegans 41,502 18-Sep-97 PROGRESS ***, in unordered pieces. GB_HTG1: CEY94A7 41009 Z99294 Caenorhabditis elegans chromosome V clone Y94A7, *** SEQUENCING IN Caenorhabditis elegans 41,502 18-Sep-97 PROGRESS ***, in unordered pieces. GB_BA2: AE001182 11228 AE001182 Borrelia burgdorferi (section 68 of 70) of the complete genome. Borrelia burgdorferi 39,655 15-DEC-1997 rxa00167 621 GB_HTG7: AC007937 206265 AC007937 Mus musculus chromosome 10 clone RP21-536F4 map 10, *** SEQUENCING IN Mus musculus 37,092 09-DEC-1999 PROGRESS ***, 6 unordered pieces. GB_RO: MMU6590 6429 AJ006590 Mus musculus mRNA for GANP protein. Mus musculus 38,678 2-Jun-99 GB_HTG3: AC008852 116219 AC008852 Homo sapiens chromosome 5 clone CITB-H1_2176I21, *** SEQUENCING IN Homo sapiens 35,691 3-Aug-99 PROGRESS ***, 13 unordered pieces. rxa00169 2196 GB_GSS3: B11032 896 B11032 T17F10-T7 TAMU Arabidopsis thaliana genomic clone T17F10, genomic Arabidopsis thaliana 42,024 14-MAY-1997 survey sequence. GB_GSS3: B10120 909 B10120 T27N10-Sp6.1 TAMU Arabidopsis thaliana genomic clone T27N10, genomic Arabidopsis thaliana 41,581 14-MAY-1997 survey sequence. GB_GSS3: B09409 916 B09409 T27M2-Sp6 TAMU Arabidopsis thaliana genomic clone T27M2, genomic Arabidopsis thaliana 41,356 14-MAY-1997 survey sequence. rxa00170 1977 GB_GSS8: AQ027582 456 AQ027582 CIT-HSP-2325M20.TR CIT-HSP Homo sapiens genomic clone 2325M20, Homo sapiens 40,749 30-Jun-98 genomic survey sequence. GB_GSS6: AQ833529 484 AQ833529 HS_5304_B2_C02_T7A RPCI-11 Human Male BAC Library Homo sapiens 38,017 27-Aug-99 Homo sapiens genomic clone Plate = 880 Col = 4 Row = F, genomic survey sequence. GB_PR2: HSM800174 2326 AL049389 Homo sapiens mRNA; cDNA DKFZp586O0118 (from clone DKFZp586O0118). Homo sapiens 37,556 21-MAY-1999 rxa00171 281 GB_EST38: AL118463 279 AL118463 w9112a43 Beddington mouse dissected endoderm Mus musculus cDNA clone Mus musculus 50,000 23-Sep-99 528_12E22 5′, mRNA sequence. GB_EST15: AA499834 419 AA499834 vg05e06.r1 Soares mouse NbMH Mus musculus cDNA clone IMAGE: 860482 5′, Mus musculus 39,801 1-Jul-97 mRNA sequence. GB_EST24: AI211527 431 AI211527 p0h01a1.r1 Aspergillus nidulans 24 hr asexual developmental and vegetative Emericella nidulans 41,584 19-OCT-1998 cDNA lambda zap library Emericella nidulans cDNA clone p0h01a1 5′, mRNA sequence. rxa00173 456 GB_PR3: AC004400 33367 AC004400 Homo sapiens chromosome 19, cosmid F24069, complete sequence. Homo sapiens 38,902 12-MAR-1998 GB_PL1: VFU14956 1474 U14956 Vicia faba ferredoxin NADP+ reductase precursor (fnr) mRNA, complete cds. Vicia faba 38,753 28-Sep-94 GB_PR3: AC004400 33367 AC004400 Homo sapiens chromosome 19, cosmid F24069, complete sequence. Homo sapiens 40,515 12-MAR-1998 rxa00174 408 GB_PL2: AF075293 4332 AF075293 Candida albicans strain 1161 agglutinin-like protein 6 (ALS6) gene, complete cds. Candida albicans 41,235 2-Jul-99 GB_PL2: JSPCHS1 1525 X94995 Juglans nigra x Juglans regia mRNA for chalcone synthase (CHS1). Juglans nigra x Juglans 39,558 19-Nov-99 regia GB_PL2: JSPCHS2 1534 X94706 Juglans nigra x Juglans regia mRNA for chalcone synthase (CHS2). Juglans nigra x Juglans 38,821 19-Nov-99 regia rxa00175 rxa00179 582 GB_BA1: CGPUTP 3791 Y09163 C. glutamicum putP gene. Corynebacterium 100,000 8-Sep-97 glutamicum GB_IN2: L76038 2421 L76038 Anopheles gambiae prophenoloxidase mRNA, complete cds. Anopheles gambiae 35,751 23-Jul-98 GB_IN2: AF031626 8486 AF031626 Anopheles gambiae prophenoloxidase (AgProPO) gene, complete cds. Anopheles gambiae 36,395 5-Jan-99 rxa00180 663 GB_BA1: CGPUTP 3791 Y09163 C. glutamicum putP gene. Corynebacterium 100,000 8-Sep-97 glutamicum GB_HTG1: HS120G22 57021 AL031847 Homo sapiens chromosome 1 clone RP1-120G22, *** SEQUENCING IN Homo sapiens 35,976 23-Nov-99 PROGRESS ***, in unordered pieces. GB_HTG1: HS120G22 57021 AL031847 Homo sapiens chromosome 1 clone RP1-120G22, *** SEQUENCING IN Homo sapiens 35,976 23-Nov-99 PROGRESS ***, in unordered pieces. rxa00183 975 GB_IN2: AF049132 16005 AF049132 Florometra serratissima mitochondrion, complete genome. Mitochondrion Florometra 33,710 15-Jan-99 serratissima GB_IN1: MTCE 13794 X54252 C. elegans complete mitochondrial genome. Mitochondrion 35,036 30-Nov-97 Caenorhabditis elegans GB_IN2: AF049132 16005 AF049132 Florometra serratissima mitochondrion, complete genome. Mitochondrion Florometra 36,021 15-Jan-99 serratissima rxa00185 2751 GB_EST31: AI693167 500 AI693167 wd68c11.x1 NCI_CGAP_Lu24 Homo sapiens cDNA clone IMAGE: 2336756 Homo sapiens 37,800 2-Jun-99 3′ similar to SW: HIOM_BOVIN P10950 HYDROXYINDOLE O-METHYLTRANSFERASE;, mRNA sequence. GB_GSS1: CNS010IZ 1000 AL099029 Drosophila melanogaster genome survey sequence SP6 end of BAC BACN04K17 Drosophila melanogaster 35,158 26-Jul-99 of DrosBAC library from Drosophila melanogaster (fruit fly), genomic survey sequence. GB_EST31: AI693167 500 AI693167 wd68c11.x1 NCI_CGAP_Lu24 Homo sapiens cDNA clone IMAGE: 2336756 Homo sapiens 39,052 2-Jun-99 3′ similar to SW: HIOM_BOVIN P10950 HYDROXYINDOLE O-METHYLTRANSFERASE;, mRNA sequence. rxa00194 564 GB_GSS10: AQ192671 396 AQ192671 HS_2251_B2_A04_MF CIT Approved Human Genomic Sperm Library D Homo sapiens 44,240 4-Nov-98 Homo sapiens genomic clone Plate = 2251 Col = 8 Row = B, genomic survey sequence. GB_GSS8: AQ044307 644 AQ044307 CIT-HSP-2331N9.TR CIT-HSP Homo sapiens genomic clone 2331N9, Homo sapiens 36,150 14-Jul-98 genomic survey sequence. GB_EST36: AI925874 564 AI925874 wo20d11.x1 NCI_CGAP_Pan1 Homo sapiens cDNA clone IMAGE: 2455893 Homo sapiens 45,588 2-Sep-99 3′ similar to TR: O67849 O67849 GTP-BINDING PROTEIN.;, mRNA sequence. rxa00197 1335 GB_GSS12: AQ399208 436 AQ399208 mgxb0001M23f CUGI Rice Blast BAC Library Magnaporthe grisea genomic Magnaporthe grisea 63,529 06-MAR-1999 clone mgxb0001M23f, genomic survey sequence. GB_GSS12: AQ398449 472 AQ398449 mgxb0001P11f CUGI Rice Blast BAC Library Magnaporthe grisea genomic Magnaporthe grisea 49,580 06-MAR-1999 clone mgxb0001P11f, genomic survey sequence. GB_OM: BTMMP9 2350 X78324 B. taurus bmmp9 mRNA for matrix metalloproteinase. Bos taurus 40,440 30-MAR-1995 rxa00199 1542 GB_BA1: AB024708 8734 AB024708 Corynebacterium glutamicum gltB and gltD genes for glutamine 2-oxoglutarate Corynebacterium 36,237 13-MAR-1999 aminotransferase large and small subunits, complete cds. glutamicum GB_HTG2: AC007837 103949 AC007837 Drosophila melanogaster chromosome 2 clone BACR04I07 (D644) RPCI-98 04.I.7 Drosophila melanogaster 36,045 2-Aug-99 map 57B2-B3 strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 49 unordered pieces. GB_HTG2: AC007837 103949 AC007837 Drosophila melanogaster chromosome 2 clone BACR04I07 (D644) RPCI-98 04.I.7 Drosophila melanogaster 36,045 2-Aug-99 map 57B2-B3 strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 49 unordered pieces. rxa00200 3561 GB_BA2: MSU46844 16951 U46844 Mycobacterium smegmatis catalase-peroxidase (katG), putative arabinosyl Mycobacterium smegmatis 53,937 12-MAY-1997 transferase (embC, embA, embB), genes complete cds and putative propionyl-coA carboxylase beta chain (pccB) genes, partial cds. GB_BA2: MAU66560 7853 U66560 Mycobacterium avium EmbR (embR), EmbA (embA) and EmbB (embB) genes, Mycobacterium avium 52,241 8-Nov-96 complete cds. GB_BA1: MTY13D12 37085 Z80343 Mycobacterium tuberculosis H37Rv complete genome; segment 156/162. Mycobacterium 52,812 17-Jun-98 tuberculosis rxa00207 441 GB_PR3: HTCRBCHR9 216293 AF029308 Homo sapiens chromosome 9 duplication of the T cell receptor beta locus and Homo sapiens 39,286 13-Apr-98 trypsinogen gene families. GB_PR3: HTCRBCHR9 216293 AF029308 Homo sapiens chromosome 9 duplication of the T cell receptor beta locus and Homo sapiens 37,116 13-Apr-98 trypsinogen gene families. rxa00211 786 GB_PR2: HSU81831 38674 U81831 Human cosmid LL12NCO1-67C6, ETV6 gene, intron 1A, partial sequence. Homo sapiens 35,509 3-Jan-97 GB_RO: MUSKROX2S2 2868 M28845 Mus musculus zinc finger protein (Krox-24) gene, exon 2. Mus musculus 40,566 21-MAY-1996 GB_HTG2: AC007440 120642 AC007440 Drosophila melanogaster chromosome 2 clone BACR37I09 (D593) RPCI-98 37.I.9 Drosophila melanogaster 36,753 2-Aug-99 map 49A-49B strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 103 unordered pieces. rxa00218 rxa00220 627 GB_BA1: ASU04436 4668 U04436 Anabaena sp. PCC 7120 putative polyketide synthase gene, complete cds. Anabaena sp. 33,766 21-DEC-1993 GB_RO: AF068199 3490 AF068199 Mus musculus D-dopachrome tautomerase gene, complete cds. Mus musculus 38,833 26-Aug-98 GB_RO: AF068199 3490 AF068199 Mus musculus D-dopachrome tautomerase gene, complete cds. Mus musculus 34,776 26-Aug-98 rxa00222 1269 GB_PL1: AB011477 78181 AB011477 Arabidopsis thaliana genomic DNA, chromosome 5, P1 clone: MHK7, Arabidopsis thaliana 36,766 20-Nov-99 complete sequence. GB_EST17: AA615900 427 AA615900 vo91b05.r1 Barstead mouse irradiated colon MPLRB7 Mus musculus cDNA Mus musculus 39,782 07-OCT-1997 clone IMAGE: 1066449 5′ similar to SW: MUCL_RAT P98089 INTESTINAL MUCIN-LIKE PROTEIN;, mRNA sequence. GB_EST38: AW039188 486 AW039188 EST281423 tomato mixed elicitor, BTI Lycopersicon esculentum cDNA Lycopersicon esculentum 41,286 18-OCT-1999 clone cLET9F17, mRNA sequence. rxa00230 843 GB_PR3: AC005255 94343 AC005255 Homo sapiens chromosome 19, CIT-HSP-146e8, complete sequence. Homo sapiens 35,990 6-Jul-98 GB_PR3: AC005255 94343 AC005255 Homo sapiens chromosome 19, CIT-HSP-146e8, complete sequence. Homo sapiens 38,175 6-Jul-98 rxa00232 633 GB_HTG2: AC007118 200000 AC007118 Homo sapiens chromosome 4, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,772 19-MAR-1999 45 unordered pieces. GB_HTG2: AC007118 200000 AC007118 Homo sapiens chromosome 4, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,772 19-MAR-1999 45 unordered pieces. GB_GSS1: CNS004WZ 978 AL055537 Drosophila melanogaster genome survey sequence TET3 end of BAC # BACR11G02 Drosophila melanogaster 34,518 3-Jun-99 of RPCI-98 library from Drosophila melanogaster (fruit fly), genomic survey sequence. rxa00233 517 GB_BA1: AB006206 7443 AB006206 Streptomyces griseus AmfR, AmfA and AmfB genes and 4 ORFs, complete cds. Streptomyces griseus 38,690 5-Feb-99 GB_PR4: AC006999 112878 AC006999 Homo sapiens clone NH0462A19, complete sequence. Homo sapiens 40,244 17-Jul-99 GB_HTG2: AC007042 132400 AC007042 Homo sapiens clone NH0399H17, *** SEQUENCING IN PROGRESS ***, Homo sapiens 40,244 06-MAR-1999 5 unordered pieces. rxa00234 663 GB_PAT: E13059 3480 E13059 gDNA encoding cytochrome b5. unidentified 40,091 24-Jun-98 GB_PL1: AB022444 2104 AB022444 Mortierella alpina gene for cytochrome b5, complete cds. Mortierella alpina 42,314 14-Jul-99 GB_GSS9: AQ112619 443 AQ112619 CIT-HSP-2371D11.TR CIT-HSP Homo sapiens genomic clone 2371D11, Homo sapiens 39,623 29-Aug-98 genomic survey sequence. rxa00236 849 GB_BA1: CGPROMF34 60 X90361 C. glutamicum DNA for promoter fragment F34. Corynebacterium 98,333 4-Nov-96 glutamicum GB_IN1: CEF56G4 38062 Z81552 Caenorhabditis elegans cosmid F56G4, complete sequence. Caenorhabditis elegans 36,190 08-OCT-1999 GB_EST16: C51159 370 C51159 C51159 Yuji Kohara unpublished cDNA: Strain N2 hermaphrodite embryo Caenorhabditis elegans 41,096 18-OCT-1999 Caenorhabditis elegans cDNA clone yk491h3 5′, mRNA sequence. rxa00237 501 GB_GSS9: AQ148605 511 AQ148605 HS_3137_B2_A11_T7 CIT Approved Human Genomic Sperm Library D Homo sapiens 37,959 08-OCT-1998 Homo sapiens genomic clone Plate = 3137 Col = 22 Row = B, genomic survey sequence. GB_GSS11: AQ274889 622 AQ274889 RPCI-5-1111N8T7 RPCI-5 Homo sapiens genomic clone RPCI-5-1111N8T7, Homo sapiens 44,628 10-Nov-98 genomic survey sequence. GB_GSS11: AQ274889 622 AQ274889 RPCI-5-1111N8T7 RPCI-5 Homo sapiens genomic clone RPCI-5-1111N8T7, Homo sapiens 37,321 10-Nov-98 genomic survey sequence. rxa00238 492 GB_PL2: PBU91560 2605 U91560 Paracoccidioides brasiliensis heat shock protein 70 (Hsp70) gene, complete cds. Paracoccidioides 37,137 12-MAR-1999 brasiliensis GB_HTG6: AC007957 212658 AC007957 Homo sapiens, *** SEQUENCING IN PROGRESS ***, 2 ordered pieces. Homo sapiens 38,285 26-Nov-99 GB_PR4: AC009288 140876 AC009288 Homo sapiens, complete sequence. Homo sapiens 36,575 19-Nov-99 rxa00239 708 GB_PL2: PBU91560 2605 U91560 Paracoccidioides brasiliensis heat shock protein 70 (Hsp70) gene, complete cds. Paracoccidioides 45,545 12-MAR-1999 brasiliensis GB_BA2: CJU96452 1450 U96452 Campylobacter jejuni major outer membrane porin gene, complete cds. Campylobacter jejuni 37,197 02-DEC-1998 GB_RO: RATPF4 1675 M15254 Rat platelet factor 4 (PF4) gene. Rattus norvegicus 35,014 27-Apr-93 rxa00240 333 GB_BA1: CGLYSI 4232 X60312 C. glutamicum lysI gene for L-lysine permease. Corynebacterium 46,207 30-Jan-92 glutamicum GB_PR3: AC005358 184886 AC005358 Homo sapiens chromosome 17, clone hRPK.746_E_8, complete sequence. Homo sapiens 35,843 29-Aug-98 GB_BA1: CGLYSI 4232 X60312 C. glutamicum lysI gene for L-lysine permease. Corynebacterium 42,025 30-Jan-92 glutamicum rxa00242 1401 GB_BA1: CGLYSI 4232 X60312 C. glutamicum lysI gene for L-lysine permease. Corynebacterium 100,000 30-Jan-92 glutamicum GB_PR3: HSJ514B11 100494 AL049554 Human DNA sequence from clone 514B11 on chromosome 6q16.1-21 Contains an Homo sapiens 37,010 23-Nov-99 EST, STSs and GSSs, complete sequence. GB_HTG3: AC009393 137353 AC009393 Drosophila melanogaster chromosome 3 clone BACR17F05 (D977) RPCI-98 17.F.5 Drosophila melanogaster 39,600 27-Aug-99 map 87D-87D strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 111 unordered pieces. rxa00244 759 GB_HTG4: AC011290 148409 AC011290 Homo sapiens clone NH0064I02, *** SEQUENCING IN PROGRESS ***, Homo sapiens 38,102 15-OCT-1999 3 unordered pieces. GB_HTG4: AC011290 148409 AC011290 Homo sapiens clone NH0064I02, *** SEQUENCING IN PROGRESS ***, Homo sapiens 38,102 15-OCT-1999 3 unordered pieces. GB_EST23: AI077162 527 AI077162 TENU3384 T. cruzi epimastigote normalized cDNA Library Trypanosoma cruzi cDNA Trypanosoma cruzi 38,847 10-Aug-98 clone 28o6 5′ similar to TRANSPLANTATION ANTIGEN P35B sp|P23591|TUM3_MOUSE, mRNA sequence. rxa00245 1608 GB_HTG2: AC007644 141048 AC007644 Homo sapiens chromosome 17 clone hRPK.19_F_16 map 17, Homo sapiens 36,929 23-MAY-1999 *** SEQUENCING IN PROGRESS ***, 17 unordered pieces. GB_HTG2: AC007644 141048 AC007644 Homo sapiens chromosome 17 clone hRPK.19_F_16 map 17, Homo sapiens 36,929 23-MAY-1999 *** SEQUENCING IN PROGRESS ***, 17 unordered pieces. GB_HTG2: AC007644 141048 AC007644 Homo sapiens chromosome 17 clone hRPK.19_F_16 map 17, Homo sapiens 34,025 23-MAY-1999 *** SEQUENCING IN PROGRESS ***, 17 unordered pieces. rxa00247 1050 GB_PR2: AP000119 100000 AP000119 Homo sapiens genomic DNA of 21q22.1, GART and AML related, Homo sapiens 36,187 25-Sep-99 SLC5A3-f4A4 region, segment 2/8, complete sequence. GB_PR2: AP000051 100000 AP000051 Homo sapiens genomic DNA, chromosome 21q22.1, segment 22/28, Homo sapiens 36,187 20-Nov-99 complete sequence. GB_PR2: AP000166 100000 AP000166 Homo sapiens genomic DNA, chromosome 21q22.1, D21S226-AML region, Homo sapiens 37,942 20-Nov-99 clone B2344F14-f50E8, segment 2/9, complete sequence. rxa00248 846 GB_PR4: AC006464 99908 AC006464 Homo sapiens BAC clone NH0436C12 from 2, complete sequence. Homo sapiens 36,797 22-OCT-1999 GB_PR4: AC006238 211945 AC006238 Homo sapiens chromosome 18, clone hRPK.474_N_24, complete sequence. Homo sapiens 32,896 31-Jan-99 GB_PR4: AC006238 211945 AC006238 Homo sapiens chromosome 18, clone hRPK.474_N_24, complete sequence. Homo sapiens 34,438 31-Jan-99 rxa00250 870 GB_GSS10: AQ244736 469 AQ244736 HS_2056_B1_F03_T7 CIT Approved Human Genomic Sperm Library D Homo sapiens 36,310 03-OCT-1998 Homo sapiens genomic clone Plate = 2056 Col = 5 Row = L, genomic survey sequence. GB_PAT: I07323 340 I07323 Sequence 5 from Patent EP 0331961. Unknown. 38,125 02-DEC-1994 GB_PR1: HS11Q13RP 10777 Y12377 H. sapiens FGF/int-2 gene upstream flanking region. Homo sapiens 36,155 17-Apr-97 rxa00252 366 GB_BA1: MTCY20G9 37218 Z77162 Mycobacterium tuberculosis H37Rv complete genome; segment 25/162. Mycobacterium 39,554 17-Jun-98 tuberculosis GB_BA1: MTV004 69350 AL009198 Mycobacterium tuberculosis H37Rv complete genome; segment 144/162. Mycobacterium 40,443 18-Jun-98 tuberculosis GB_BA1: MTV004 69350 AL009198 Mycobacterium tuberculosis H37Rv complete genome; segment 144/162. Mycobacterium 41,803 18-Jun-98 tuberculosis rxa00256 894 GB_PR4: AC005343 137213 AC005343 Homo sapiens Chromosome 12p13.3 BAC RPCI11-21K20 (Roswell Park Homo sapiens 36,436 2-Apr-99 Cancer Institute Human BAC Library) complete sequence. GB_PR3: AC003005 45084 AC003005 Human DNA from chromosome 19-specific cosmid F25419 containing ZNF Homo sapiens 36,395 22-OCT-1997 gene family members, genomic sequence, complete sequence. GB_HTG3: AC007930 67668 AC007930 Drosophila melanogaster chromosome 2 clone BACR49A06 (D772) RPCI-98 49.A.6 Drosophila melanogaster 32,503 20-Sep-99 map 43B-43B strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 40 unordered pieces. rxa00257 579 GB_PR4: AC005343 137213 AC005343 Homo sapiens Chromosome 12p13.3 BAC RPCI11-21K20 (Roswell Park Cancer Homo sapiens 37,063 2-Apr-99 Institute Human BAC Library) complete sequence. GB_HTG1: HS1096J16 194423 AL121721 Homo sapiens chromosome 20 clone RP5-1096J16, *** SEQUENCING IN Homo sapiens 37,217 23-Nov-99 PROGRESS ***, in unordered pieces. GB_HTG1: HS1096J16 194423 AL121721 Homo sapiens chromosome 20 clone RP5-1096J16, *** SEQUENCING IN Homo sapiens 37,217 23-Nov-99 PROGRESS ***, in unordered pieces. rxa00258 795 GB_PR3: HSJ747H23 114201 AL049699 Human DNA sequence from clone 747H23 on chromosome 6q13-15. Contains the 3′ Homo sapiens 36,469 23-Nov-99 part of the ME1 gene for malic enzyme 1, soluble (NADP-dependent malic enzyme, malate oxidoreductase, EC 1.1.1.40), a novel gene and the 5′ part of the gene for N-acetylglucosamine-phosphate mutase. Contains ESTs, STSs, GSSs and two putative CpG islands, complete sequence. GB_HTG2: HSJ202D23 175496 AL121716 Homo sapiens chromosome 6 clone RP1-202D23 map q14.1-15, *** SEQUENCING Homo sapiens 36,469 03-DEC-1999 IN PROGRESS ***, in unordered pieces. GB_HTG2: HSJ202D23 175496 AL121716 Homo sapiens chromosome 6 clone RP1-202D23 map q14.1-15, *** SEQUENCING Homo sapiens 36,469 03-DEC-1999 IN PROGRESS ***, in unordered pieces. rxa00260 1299 GB_PR3: HS360B4 23388 AL031716 Human DNA sequence from clone 360B4 on chromosome 16. Contains part Homo sapiens 36,145 23-Nov-99 of a gene for a PUTATIVE novel protein similar to predicted bacterial and worm proteins and ESTs, complete sequence. GB_EST19: AA741904 423 AA741904 LmLv39p3/71A Leishmania major promastigote full length cDNA library from early Leishmania major 39,192 10-DEC-1998 logarithmic stage (day 3) Leishmania major cDNA clone 71A 5′, mRNA sequence. GB_PR3: HS360B4 23388 AL031716 Human DNA sequence from clone 360B4 on chromosome 16. Contains part Homo sapiens 39,494 23-Nov-99 of a gene for a PUTATIVE novel protein similar to predicted bacterial and worm proteins and ESTs, complete sequence. rxa00264 rxa00267 441 GB_GSS10: AQ258013 761 AQ258013 nbxb0019H05f CUGI Rice BAC Library Oryza sativa genomic clone nbxb0019H05f, Oryza sativa 52,033 23-OCT-1998 sequence. GB_EST10: AA167894 552 AA167894 CpEST.021 uniZAPCpIOWAsporoLib1 Cryptosporidium parvum cDNA 5′ Cryptosporidium parvum 40,462 19-DEC-1996 similar to lactate dehydrogenase, mRNA sequence. GB_HTG3: AC011591 129431 AC011591 Homo sapiens chromosome 17 clone 118_B_18 map 17, *** SEQUENCING Homo sapiens 35,469 07-OCT-1999 IN PROGRESS ***, 25 unordered pieces. rxa00271 1113 GB_PL1: CHTRP1 3480 X70035 C. heterostrophus gene for trifunctional tryptophan synthase. Cochliobolus 41,636 31-OCT-1996 heterostrophus GB_VI: FLU47643 1492 U47643 Feline leukemia virus Notch2 gene, clone FeLV/Notch2-AP (subgenomic), partial cds. Feline leukemia virus 37,869 25-OCT-1996 GB_VI: FLU47644 1641 U47644 Feline leukemia virus Notch2 gene, clone FeLV/Notch2-B, partial cds. Feline leukemia virus 36,441 25-OCT-1996 rxa00272 495 GB_GSS8: AQ041841 373 AQ041841 CIT-HSP-2335L1.TR CIT-HSP Homo sapiens genomic clone 2335L1, genomic Homo sapiens 45,455 14-Jul-98 survey sequence. GB_GSS13: AQ429301 591 AQ429301 CITBI-E1-2562H16.TR CITBI-E1 Homo sapiens genomic clone 2562H16, Homo sapiens 63,636 24-MAR-1999 genomic survey sequence. GB_GSS10: AQ237541 667 AQ237541 RPCI11-61O21.TJB.1 RPCI-11 Homo sapiens genomic clone RPCI-11-61O21, Homo sapiens 62,222 21-Apr-99 genomic survey sequence. rxa00273 1236 GB_BA1: CGBETPGEN 2339 X93514 C. glutamicum betP gene. Corynebacterium 44,056 8-Sep-97 glutamicum GB_PR2: HS142F18 141672 AL031073 Human DNA sequence from clone 142F18 on chromosome Xq26.3-27.2 Contains Homo sapiens 44,643 23-Nov-99 part of a gene similar to melanoma-associated antigen, EST, GSS and an inverted repeat, complete sequence. GB_IN2: AC007177 101320 AC007177 Drosophila melanogaster, chromosome 2R, region 59C1-59C5, P1 clones Drosophila melanogaster 36,721 27-MAR-1999 DS06621 and DS02186, complete sequence. rxa00274 2733 GB_HTG3: AC011675 98026 AC011675 Homo sapiens clone 10_J_17, LOW-PASS SEQUENCE SAMPLING. Homo sapiens 35,405 10-OCT-1999 GB_HTG3: AC011675 98026 AC011675 Homo sapiens clone 10_J_17, LOW-PASS SEQUENCE SAMPLING. Homo sapiens 35,405 10-OCT-1999 GB_HTG3: AC010598 174019 AC010598 Homo sapiens chromosome 5 clone CIT-HSPC_560O9, *** SEQUENCING Homo sapiens 36,908 16-Sep-99 IN PROGRESS ***, 50 unordered pieces. rxa00275 582 GB_GSS14: AQ574926 666 AQ574926 nbxb0086K14f CUGI Rice BAC Library Oryza sativa genomic clone nbxb0086K14f, Oryza sativa 33,830 2-Jun-99 genomic survey sequence. GB_HTG2: AC004396 43686 AC004396 Homo sapiens , *** SEQUENCING IN PROGRESS ***, 2 unordered pieces. Homo sapiens 38,298 19-Jul-99 GB_HTG2: AC004396 43686 AC004396 Homo sapiens , *** SEQUENCING IN PROGRESS ***, 2 unordered pieces. Homo sapiens 38,298 19-Jul-99 rxa00276 465 GB_PL1: SC9952X 29286 Z49212 S. cerevisiae chromosome XIII cosmid 9952. Saccharomyces cerevisiae 37,118 11-Aug-97 GB_PL1: S45357 4017 S45357 PSE-1 = protein secretion enhancer [Saccharomyces cerevisiae, Genomic, 4017 nt]. Saccharomyces cerevisiae 41,394 08-MAY-1993 GB_PL1: SCPSE1G 4017 Z11538 S. cerevisiae PSE-1 gene. Saccharomyces cerevisiae 41,394 13-Aug-96 rxa00279 1509 GB_HTG3: AC009911 99707 AC009911 Drosophila melanogaster chromosome 2 clone BACR01N17 (D1036) RPCI-98 Drosophila melanogaster 33,023 05-OCT-1999 01.N.17 map 38A-38A strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 69 unordered pieces. GB_HTG3: AC009911 99707 AC009911 Drosophila melanogaster chromosome 2 clone BACR01N17 (D1036) RPCI-98 Drosophila melanogaster 33,023 05-OCT-1999 01.N.17 map 38A-38A strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 69 unordered pieces. GB_HTG4: AC008397 230451 AC008397 Homo sapiens chromosome 19 clone CIT-HSPC_251H24, *** SEQUENCING Homo sapiens 37,432 31-OCT-1999 IN PROGRESS ***, 81 unordered pieces. rxa00282 889 GB_PR3: HSB11B7 37290 Z82171 Human DNA sequence from cosmid B11B7 on chromosome 22 contains ESTs. Homo sapiens 35,845 23-Nov-99 GB_PR3: HSB11B7 37290 Z82171 Human DNA sequence from cosmid B11B7 on chromosome 22 contains ESTs. Homo sapiens 37,126 23-Nov-99 GB_RO: RATMTA 4197 L39264 Rattus norvegicus beta-2 adrenergic receptor gene, complete cds and promoter region. Rattus norvegicus 41,259 23-Feb-96 rxa00283 1155 GB_GSS8: AQ030327 411 AQ030327 HS_2177_B1_H06_MF CIT Approved Human Genomic Sperm Library D Homo sapiens 37,656 1-Jul-98 Homo sapiens genomic clone Plate = 2177 Col = 11 Row = P, genomic survey sequence. GB_PR3: HSL118GB 27858 Z68883 Human DNA sequence from cosmid L118G10, Huntington's Disease Region, Homo sapiens 37,412 23-Nov-99 chromosome 4p16.3. GB_PR3: HSJ513G18 110770 AL109760 Human DNA sequence from clone 513G18 on chromosome 4, complete sequence. Homo sapiens 37,412 23-Nov-99 rxa00286 687 GB_EST10: AA157040 414 AA157040 zo51c05.r1 Stratagene endothelial cell 937223 Homo sapiens cDNA clone IMAGE: Homo sapiens 37,136 11-DEC-1996 590408 5′ similar to gb: M84711 40S RIBOSOMAL PROTEIN S3A (HUMAN);, mRNA sequence. GB_EST11: AA213935 629 AA213935 zn57a04.r1 Stratagene muscle 937209 Homo sapiens cDNA clone IMAGE: Homo sapiens 34,219 1-Aug-97 562254 5′ similar to gb: M84711 40S RIBOSOMAL PROTEIN S3A (HUMAN);, mRNA sequence. GB_STS: BLYBG 459 L43987 Hordeum vulgare (clone ABG380) chromosome 4H, 6H, 7H STS mRNA, Hordeum vulgare 37,786 27-Jul-95 sequence tagged site. rxa00294 552 GB_PR2: HSAC000121 93163 AC000121 Human BAC clone RG249A12 from 7q22, complete sequence. Homo sapiens 36,735 31-Jan-97 GB_BA2: CGU31281 1614 U31281 Corynebacterium glutamicum biotin synthase (bioB) gene, complete cds. Corynebacterium 100,000 21-Nov-96 glutamicum GB_PR2: HSAC000121 93163 AC000121 Human BAC clone RG249A12 from 7q22, complete sequence. Homo sapiens 37,662 31-Jan-97 rxa00297 1035 GB_HTG2: AC006938 82665 AC006938 Drosophila melanogaster chromosome 2 clone DS01630 (D506) map 60C7-60C8 Drosophila melanogaster 37,241 2-Aug-99 strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 9 unordered pieces. GB_HTG2: AC007116 25478 AC007116 Drosophila melanogaster chromosome 2 clone DS04467 (D447) map 60C6-60C8 Drosophila melanogaster 38,630 30-Jul-99 strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 5 unordered pieces. GB_HTG2: AC006938 82665 AC006938 Drosophila melanogaster chromosome 2 clone DS01630 (D506) map 60C7-60C8 Drosophila melanogaster 37,241 2-Aug-99 strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 9 unordered pieces. rxa00320 303 GB_GSS14: AQ585202 564 AQ585202 RPCI-11-451L11.TJ RPCI-11 Homo sapiens genomic clone RPCI-11-451L11, Homo sapiens 37,319 7-Jun-99 genomic survey sequence. GB_BA1: NGPILC1 3144 Y13022 N. gonorrhoeae pilC1 gene, strain 640. Neisseria gonorrhoeae 38,667 07-OCT-1997 GB_BA1: NGPILC1 3144 Y13022 N. gonorrhoeae pilC1 gene, strain 640. Neisseria gonorrhoeae 36,000 07-OCT-1997 rxa00321 rxa00322 1227 GB_HTG2: AC007533 153053 AC007533 Homo sapiens chromosome 16 clone 474B12, *** SEQUENCING IN Homo sapiens 39,469 12-MAY-1999 PROGRESS ***, 5 ordered pieces. GB_HTG2: AC007533 153053 AC007533 Homo sapiens chromosome 16 clone 474B12, *** SEQUENCING IN Homo sapiens 39,469 12-MAY-1999 PROGRESS ***, 5 ordered pieces. GB_PR2: HUM133K23 82512 AC000061 Human BAC clone 133K23 from 7q31.2, complete sequence. Homo sapiens 38,950 14-Nov-96 rxa00325 768 GB_BA2: CDU73860 1273 U73860 Corynebacterium diphtheriae heme oxygenase homolog (hmuO) gene, complete cds. Corynebacterium 52,604 7-Feb-97 diphtheriae GB_BA1: AB019621 652 AB019621 Corynebacterium diphtheriae mRNA for Heme oxygenase, complete cds. Corynebacterium 55,675 31-Jul-99 diphtheriae GB_EST23: AI096171 554 AI096171 28 EcoRI Rice Etiolated Leaf cDNA Library Oryza sativa cDNA clone RZ513, Oryza sativa 38,536 19-Aug-98 mRNA sequence. rxa00326 603 GB_PH: MYP4CG 11624 X51522 Bacteriophage P4 complete DNA genome. Bacteriophage P4 40,577 17-Feb-97 GB_PH: MYP4ALPH 3063 X05623 Bacteriophage P4 alpha gene and cis replication region crr. Bacteriophage P4 38,640 12-Sep-93 GB_IN1: CEF22B3 30480 Z68336 Caenorhabditis elegans cosmid F22B3, complete sequence. Caenorhabditis elegans 39,012 2-Sep-99 rxa00334 459 GB_BA1: CGGLNA 3686 Y13221 Corynebacterium glutamicum glnA gene. Corynebacterium 37,640 28-Aug-97 glutamicum GB_GSS10: AQ248516 259 AQ248516 T5J22-Sp6 TAMU Arabidopsis thaliana genomic clone T5J22, genomic Arabidopsis thaliana 38,525 06-OCT-1998 survey sequence. GB_BA1: CGGLNA 3686 Y13221 Corynebacterium glutamicum glnA gene. Corynebacterium 40,487 28-Aug-97 glutamicum rxa00336 594 GB_BA1: CGGLNA 3686 Y13221 Corynebacterium glutamicum glnA gene. Corynebacterium 34,797 28-Aug-97 glutamicum GB_OV: XLFIMB1GN 7026 X95549 X. laevis FIM-B.1 gene. Xenopus laevis 33,217 13-Feb-97 GB_BA1: CGGLNA 3686 Y13221 Corynebacterium glutamicum glnA gene. Corynebacterium 37,371 28-Aug-97 glutamicum rxa00337 1173 GB_BA1: CGU43536 3464 U43536 Corynebacterium glutamicum heat shock, ATP-binding protein (clpB) gene, Corynebacterium 36,406 13-MAR-1997 complete cds. glutamicum GB_BA1: CGAJ4934 1160 AJ004934 Corynebacterium glutamicum dapD gene, complete CDS. Corynebacterium 39,734 17-Jun-98 glutamicum GB_EST37: AI944838 396 AI944838 bs06a08.y1 Drosophila melanogaster adult testis library Drosophila melanogaster Drosophila melanogaster 37,626 17-Aug-99 cDNA clone bs06a08 5′, mRNA sequence. rxa00338 1263 GB_BA1: BLTRP 7725 X04960 Brevibacterium lactofermentum tryptophan operon. Corynebacterium 39,790 10-Feb-99 glutamicum GB_PAT: E01688 7725 E01688 Genomic DNA of trp operon of prepibacterium latophelmentamn. unidentified 39,871 29-Sep-97 GB_PAT: E01375 7726 E01375 DNA sequence of tryptophan operon. Corynebacterium 39,871 29-Sep-97 glutamicum rxa00339 840 GB_VI: OPU75930 131993 U75930 Orgyia pseudotsugata nuclear polyhedrosis virus complete genome. Orgyia pseudotsugata 38,264 06-MAR-1998 nuclear polyhedrosis virus GB_VI: OPU75930 131993 U75930 Orgyia pseudotsugata nuclear polyhedrosis virus complete genome. Orgyia pseudotsugata 38,620 06-MAR-1998 nuclear polyhedrosis virus GB_HTG3: AC008340 126593 AC008340 Drosophila melanogaster chromosome 2 clone BACR07J20 (D918) RPCI-98 Drosophila melanogaster 38,193 6-Aug-99 07.J.20 map 42D-42E strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 92 unordered pieces. rxa00342 552 GB_EST34: AI794353 636 AI794353 fc43d12.y1 Zebrafish WashU MPIMG EST Danio rerio cDNA 5′ similar to TR: Danio rerio 40,283 2-Jul-99 Q62868 Q62868 ROK-ALPHA.;, mRNA sequence. GB_PR2: U73635 33676 U73635 Human Chromosome 11 Cosmid cSRL156b6, complete sequence. Homo sapiens 39,366 25-Jul-97 GB_PR2: U73635 33676 U73635 Human Chromosome 11 Cosmid cSRL156b6, complete sequence. Homo sapiens 37,970 25-Jul-97 rxa00344 1002 GB_HTG2: HS312E8 33595 AL032819 Homo sapiens chromosome 16 clone LA16-312E8, *** SEQUENCING IN Homo sapiens 40,415 03-DEC-1999 PROGRESS ***, in unordered pieces. GB_HTG2: HS312E8 33595 AL032819 Homo sapiens chromosome 16 clone LA16-312E8, *** SEQUENCING IN Homo sapiens 40,415 03-DEC-1999 PROGRESS ***, in unordered pieces. GB_OM: BOVINOPHOS 1573 M55916 Bovine inositol polyphosphate 1-phosphatase (inositol polyphosphate Bos taurus 38,420 27-Apr-93 1-phosphatase gene) mRNA, complete cds. rxa00349 1590 GB_PR3: HS353E16 189765 AL031591 Human DNA sequence from clone 353E16 on chromosome 22q11.22-12.3, Homo sapiens 34,766 23-Nov-99 complete sequence. GB_HTG2: AC005059 170128 AC005059 Homo sapiens clone RG074A24, *** SEQUENCING IN PROGRESS ***, 25 Homo sapiens 37,011 13-MAR-1999 unordered pieces. GB_HTG2: AC005059 170128 AC005059 Homo sapiens clone RG074A24, *** SEQUENCING IN PROGRESS ***, 25 Homo sapiens 37,011 13-MAR-1999 unordered pieces. rxa00353 816 GB_BA1: D87976 2352 D87976 Brevibacterium lactofermentum DNA for D-2-hydroxyisocaproate dehydrogenase Corynebacterium 39,290 7-Feb-99 (ddh), complete cds. glutamicum GB_BA1: CGDDH 1829 Y00151 Corynebacterium glutamicum ddh gene for meso-diaminopimelate Corynebacterium 39,342 12-Sep-93 D-dehydrogenase (EC 1.4.1.16). glutamicum GB_BA1: CGDDH 1829 Y00151 Corynebacterium glutamicum ddh gene for meso-diaminopimelate Corynebacterium 38,624 12-Sep-93 D-dehydrogenase (EC 1.4.1.16). glutamicum rxa00355 1143 GB_BA1: CGDDH 1829 Y00151 Corynebacterium glutamicum ddh gene for meso-diaminopimelate Corynebacterium 100,000 12-Sep-93 D-dehydrogenase (EC 1.4.1.16). glutamicum GB_BA1: D87976 2352 D87976 Brevibacterium lactofermentum DNA for D-2-hydroxyisocaproate Corynebacterium 98,411 7-Feb-99 dehydrogenase (ddh), complete cds. glutamicum GB_PAT: E14511 1034 E14511 DNA encoding Brevibacterium diaminopimelic acid dehydrogenase. Corynebacterium 100,000 28-Jul-99 glutamicum rxa00362 1470 GB_HTG4: AC009043 170748 AC009043 Homo sapiens chromosome 16 clone RPCI-11_184F14, *** SEQUENCING IN Homo sapiens 37,337 31-OCT-1999 PROGRESS ***, 122 unordered pieces. GB_HTG4: AC009043 170748 AC009043 Homo sapiens chromosome 16 clone RPCI-11_184F14, *** SEQUENCING IN Homo sapiens 37,337 31-OCT-1999 PROGRESS ***, 122 unordered pieces. GB_PR4: HSZO2TJP09 811 AF177521 Homo sapiens tight junction protein ZO-2 (TJP2) gene, exons 8 and 9. Homo sapiens 40,758 28-Sep-99 rxa00373 439 GB_PAT: AR004983 2277 AR004983 Sequence 5 from patent U.S. Pat. No. 5747317. Unknown. 41,638 04-DEC-1998 GB_EST37: AI967505 380 AI967505 Ljirnpest03-215-c10 Ljirnp Lambda HybriZap two-hybrid library Lotus japonicus Lotus japonicus 45,882 24-Aug-99 cDNA clone LP215-03-c10 5′ similar to 60S ribosomal protein L39, mRNA sequence. GB_EST27: AI399460 670 AI399460 NCSP4F6T7 Subtracted Perithecial Neurospora crassa cDNA clone SP4F6 3′, Neurospora crassa 38,571 8-Feb-99 mRNA sequence. rxa00375 624 GB_IN2: AC004445 61852 AC004445 Drosophila metanogaster DNA sequence (P1 DS00445 (D93)), complete sequence. Drosophila melanogaster 37,236 01-MAY-1998 GB_HTG6: AC011694 160557 AC011694 Homo sapiens clone RP11-19D19, *** SEQUENCING IN PROGRESS ***, 33 Homo sapiens 34,087 03-DEC-1999 unordered pieces. GB_HTG6: AC011694 160557 AC011694 Homo sapiens clone RP11-19D19, *** SEQUENCING IN PROGRESS ***, 33 Homo sapiens 40,523 03-DEC-1999 unordered pieces. rxa00380 744 GB_BA1: COXHSPAB 2302 M20482 C. burnetii heat shock operon encoding two heat shock proteins (htpA and htpB), Coxiella burnetii 37,788 26-Apr-93 complete cds. GB_RO: CBGPIMR 1735 Z37977 C. barabensis (griseus) mRNA for glucose Cricetulus griseus 37,823 14-Sep-95 phosphate isomerase. GB_GSS10: AQ172617 505 AQ172617 HS_3197_A2_G09_T7 CIT Approved Human Genomic Sperm Library D Homo sapiens 37,580 17-OCT-1998 Homo sapiens genomic clone Plate = 3197 Col = 18 Row = M, genomic survey sequence. rxa00387 978 GB_BA1: MTY25D10 40838 Z95558 Mycobacterium tuberculosis H37Rv complete genome; segment 28/162. Mycobacterium 60,477 17-Jun-98 tuberculosis GB_BA1: MSGY224 40051 AD000004 Mycobacterium tuberculosis sequence from clone y224. Mycobacterium 60,270 03-DEC-1996 tuberculosis GB_BA1: U00018 42991 U00018 Mycobacterium leprae cosmid B2168. Mycobacterium leprae 37,913 01-MAR-1994 rxa00390 528 GB_IN1: DMU29153 8230 U29153 Drosophila melanogaster nudel (ndl) mRNA, complete cds. Drosophila melanogaster 36,190 08-DEC-1995 GB_IN1: DMU29153 8230 U29153 Drosophila melanogaster nudel (ndl) mRNA, complete cds. Drosophila melanogaster 37,202 08-DEC-1995 rxa00392 987 GB_IN2: AE001274 268984 AE001274 Leishmania major chromosome 1, complete sequence. Leishmania major 37,885 24-MAR-1999 GB_EST11: AA270543 516 AA270543 va68h06.r1 Soares mouse 3NME12 5 Mus musculus cDNA clone IMAGE: Mus musculus 40,546 26-MAR-1997 736571 5′, mRNA sequence. GB_IN2: AE001274 268984 AE001274 Leishmania major chromosome 1, complete sequence. Leishmania major 36,103 24-MAR-1999 rxa00394 456 GB_GSS9: AQ158990 728 AQ158990 nbxb0012L11r CUGI Rice BAC Library Oryza sativa genomic clone nbxb0012L11r, Oryza sativa 41,463 12-Sep-98 genomic survey sequence. GB_GSS12: AQ342952 761 AQ342952 RPCI11-122O15.TV RPCI-11 Homo sapiens genomic clone RPCI-11-122O15, Homo sapiens 37,556 07-MAY-1999 genomic survey sequence. GB_GSS9: AQ158990 728 AQ158990 nbxb0012L11r CUGI Rice BAC Library Oryza sativa genomic clone nbxb0012L11r, Oryza sativa 37,923 12-Sep-98 genomic survey sequence. rxa00395 423 GB_PR2: HS1052M9 134245 AL022718 Human DNA sequence from clone 1052M9 on chromosome Xq25. Contains Homo sapiens 43,564 23-Nov-99 the SH2D1A gene for SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome) (DSHP), part of a 60S Acidic Ribosomal protein 1 (RPLP1) LIKE gene and part of a mouse DOC4 LIKE gene. Contains ESTs and GSSs, complete sequence. GB_BA2: RCPHSYNG 45959 Z11165 R. capsulatus complete photosynthesis gene cluster. Rhodobacter capsulatus 36,930 2-Sep-99 GB_PR2: HS1052M9 134245 AL022718 Human DNA sequence from clone 1052M9 on chromosome Xq25. Contains Homo sapiens 33,981 23-Nov-99 the SH2D1A gene for SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome) (DSHP), part of a 60S Acidic Ribosomal protein 1 (RPLP1) LIKE gene and part of a mouse DOC4 LIKE gene. Contains ESTs and GSSs, complete sequence. rxa00396 594 GB_PL2: AC002311 85855 AC002311 Arabidopsis thaliana chromosome I BAC T26J12 genomic sequence, Arabidopsis thaliana 38,957 4-Feb-98 complete sequence. GB_PL2: AC002311 85855 AC002311 Arabidopsis thaliana chromosome I BAC T26J12 genomic sequence, Arabidopsis thaliana 36,300 4-Feb-98 complete sequence. rxa00397 924 GB_PL1: HASMT 27694 D31785 Hansenula wingei mitochondrial DNA, complete sequence. Mitochondrion Pichia 33,985 10-Jun-99 canadensis GB_PL1: HASMT 27694 D31785 Hansenula wingel mitochondrial DNA, complete sequence. Mitochondrion Pichia 33,775 10-Jun-99 canadensis rxa00398 873 GB_HTG1: CNS01DRT 222150 AL118557 Homo sapiens chromosome 14 clone R-1033H12, *** SEQUENCING IN Homo sapiens 35,417 25-Sep-99 PROGRESS ***, in ordered pieces. GB_HTG1: CNS01DRT 222150 AL118557 Homo sapiens chromosome 14 clone R-1033H12, *** SEQUENCING IN Homo sapiens 35,417 25-Sep-99 PROGRESS ***, in ordered pieces. GB_HTG1: CNS01DRT 222150 AL118557 Homo sapiens chromosome 14 clone R-1033H12, *** SEQUENCING IN Homo sapiens 38,005 25-Sep-99 PROGRESS ***, in ordered pieces. rxa00399 438 GB_IN1: CELC32B5 42545 U80843 Caenorhabditis elegans cosmid C32B5. Caenorhabditis elegans 36,468 05-DEC-1996 GB_IN1: CELC32B5 42545 U80843 Caenorhabditis elegans cosmid C32B5. Caenorhabditis elegans 40,000 05-DEC-1996 rxa00408 570 GB_PR4: AC005940 158414 AC005940 Homo sapiens chromosome 17, clone hRPK.167_N_20, complete sequence. Homo sapiens 35,219 18-MAR-1999 GB_PR1: HSSERCA11 3050 Y15726 Homo sapiens SERCA3 gene, exons 11-14. Homo sapiens 35,036 30-Jun-98 GB_PR4: AC005940 158414 AC005940 Homo sapiens chromosome 17, clone hRPK.167_N_20, complete sequence. Homo sapiens 36,926 18-MAR-1999 rxa00409 1536 GB_PR1: HSSERCA11 3050 Y15726 Homo sapiens SERCA3 gene, exons 11-14. Homo sapiens 38,555 30-Jun-98 GB_PR4: AC005940 158414 AC005940 Homo sapiens chromosome 17, clone hRPK.167_N_20, complete sequence. Homo sapiens 36,370 18-MAR-1999 GB_PR3: HS591B8 142552 AL035410 Human DNA sequence from clone 591B8 on chromosome 1p13.1, complete sequence. Homo sapiens 35,891 23-Nov-99 rxa00411 798 GB_BA1: AP000003 233000 AP000003 Pyrococcus horikoshii OT3 genomic DNA, 544001-777000 nt. position (3/7). Pyrococcus horikoshii 36,849 8-Feb-99 GB_PL2: F25A4 115721 AC008263 Arabidopsis thaliana chromosome 1 BAC F25A4 sequence, complete sequence. Arabidopsis thaliana 37,628 15-Sep-99 GB_PR3: HS413H6 142599 AL022724 Human DNA sequence from clone 413H6 on chromosome 6p22.3-24.3. Homo sapiens 36,755 23-Nov-99 Contains a hamster Androgen-dependent Expressed Protein like protein gene, ESTs and GSSs, complete sequence. rxa00416 1673 GB_EST8: C10137 360 C10137 C10137 Yuji Kohara unpublished cDNA: Strain N2 hermaphrodite embryo Caenorhabditis elegans 35,574 18-OCT-1999 Caenorhabditis elegans cDNA clone yk188a1 5′, mRNA sequence. GB_EST36: AV186952 376 AV186952 AV186952 Yuji Kohara unpublished cDNA: Strain N2 hermaphrodite embryo Caenorhabditis elegans 36,702 22-Jul-99 Caenorhabditis elegans cDNA clone yk506a5 5′, mRNA sequence. GB_EST16: C48235 383 C48235 C48235 Yuji Kohara unpublished cDNA: Strain N2 hermaphrodite embryo Caenorhabditis elegans 42,440 18-OCT-1999 Caenorhabditis elegans cDNA clone yk459h10 5′, mRNA sequence. rxa00422 1017 GB_BA1: MTCY227 35946 Z77724 Mycobacterium tuberculosis H37Rv complete genome; segment 114/162. Mycobacterium 39,822 17-Jun-98 tuberculosis GB_BA1: MTV023 47852 AL022022 Mycobacterium tuberculosis H37Rv complete genome; segment 148/162. Mycobacterium 39,841 17-Jun-98 tuberculosis GB_PR3: AC003091 137817 AC003091 Human BAC clone RG326G04 from 7p21, complete sequence. Homo sapiens 36,653 6-Nov-97 rxa00423 576 GB_BA1: AP000063 185300 AP000063 Aeropyrum pernix genomic DNA, section 6/7. Aeropyrum pernix 38,908 22-Jun-99 GB_IN1: LDHSP100 7726 Z94053 L. donovani hsp100 gene. Leishmania donovani 39,646 28-Apr-97 GB_GSS11: AQ274393 572 AQ274393 nbxb0035G12r CUGI Rice BAC Library Oryza sativa genomic clone nbxb0035G12r, Oryza sativa 35,714 3-Nov-98 genomic survey sequence. rxa00424 594 GB_BA1: AP000063 185300 AP000063 Aeropyrum pernix genomic DNA, section 6/7. Aeropyrum pernix 38,225 22-Jun-99 GB_BA1: AP000063 185300 AP000063 Aeropyrum pernix genomic DNA, section 6/7. Aeropyrum pernix 36,735 22-Jun-99 GB_IN1: LDHSP100 7726 Z94053 L. donovani hsp100 gene. Leishmania donovani 35,125 28-Apr-97 rxa00425 348 GB_EST30: AV021214 281 AV021214 AV021214 Mus musculus 18-day embryo C57BL/6J Mus musculus cDNA clone Mus musculus 35,849 28-Aug-99 1190021P08, mRNA sequence. GB_HTG3: AC009278 164119 AC009278 Homo sapiens clone 44_J_4, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,705 12-Aug-99 14 unordered pieces. GB_HTG3: AC009278 164119 AC009278 Homo sapiens clone 44_J_4, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,705 12-Aug-99 14 unordered pieces. rxa00428 756 GB_BA2: AF127082 10847 AF127082 Myxococcus xanthus ATP-dependent protease proteolytic subunit ClpP Myxococcus xanthus 40,995 18-MAY-1999 (clpP), ATP-dependent protease ATPase subunit ClpX (clpX), prolyl endopeptidase precursor Pep (pep), ATP-dependent protease LonV(lonV), oligopeptide permease homolog OppA (oppA), oligopeptide permease homolog OppB (oppB), and oligopeptide permease homolog OppC (oppC) genes, complete cds. GB_PL1: AB017080 653 AB017080 Porphyra sp, DNA, internal transcribed spacer 1 (ITS1). Porphyra sp. 38,491 10-Sep-99 GB_EST27: AI442425 541 AI442425 sa26g05.y1 Gm-c1004 Glycine max cDNA clone GENOME SYSTEMS CLONE ID: Glycine max 40,000 01-DEC-1999 Gm-c1004-465 5′similar to SW: NDC1_RABIT Q28615 RENAL SODIUM/DICARBOXYLATE COTRANSPORTER;, mRNA sequence. rxa00429 525 GB_EST3: R33129 440 R33129 yh81c08.s1 Soares placenta Nb2HP Homo sapiens cDNA clone IMAGE: Homo sapiens 37,216 28-Apr-95 136142 3′ similar to gb: X53742_rna1 FIBULIN 1, ISOFORM B PRECURSOR (HUMAN);, mRNA sequence. GB_PH: AF115103 40739 AF115103 Streptococcus thermophilus bacteriophage Sfi21, complete genome. Streptococcus 36,069 18-Jul-99 thermophilus bacteriophage Sfi21 GB_PH: AF115102 37370 AF115102 Streptococcus thermophilus bacteriophage Sfi19, complete genome. Streptococcus 36,260 18-Jul-99 thermophilus bacteriophage Sfi19 rxa00430 534 GB_BA1: MSGY126 37164 AD000012 Mycobacterium tuberculosis sequence from clone y126. Mycobacterium 55,491 10-DEC-1996 tuberculosis GB_BA1: MTY13D12 37085 Z80343 Mycobacterium tuberculosis H37Rv complete genome; segment 156/162. Mycobacterium 55,491 17-Jun-98 tuberculosis GB_BA1: MSGB971CS 37566 L78821 Mycobacterium leprae cosmid B971 DNA sequence. Mycobacterium leprae 36,905 15-Jun-96 rxa00433 648 GB_PR2: AP000073 100000 AP000073 Homo sapiens genomic DNA, chromosome 8p11.2, senescence gene Homo sapiens 38,043 20-Nov-99 region, section 9/19, complete sequence. GB_IN1: CELF29G9 42751 AF016440 Caenorhabditis elegans cosmid F29G9. Caenorhabditis elegans 35,474 7-Aug-97 GB_BA1: MSGY414A 40121 AD000007 Mycobacterium tuberculosis sequence from clone y414a. Mycobacterium 36,809 03-DEC-1996 tuberculosis rxa00447 rxa00451 615 GB_EST26: AI389267 643 AI389267 GH20396.5prime GH Drosophila melanogaster head pOT2 Drosophila Drosophila melanogaster 41,085 28-Jan-99 melanogaster cDNA clone GH20396 5prime, mRNA sequence. GB_EST37: AI945493 574 AI945493 bs13e05.y1 Drosophila melanogaster adult testis library Drosophila Drosophila melanogaster 44,040 17-Aug-99 melanogaster cDNA clone bs13e05 5′, mRNA sequence. GB_GSS11: AQ288118 630 AQ288118 nbxb0032I18r CUGI Rice BAC Library Oryza sativa genomic clone nbxb0032I18r, Oryza sativa 37,885 03-DEC-1998 genomic survey sequence. rxa00455 873 GB_IN1: DMOVO 6655 X59772 D. melanogaster ovo gene required for female germ line development. Drosophila melanogaster 35,104 24-Feb-99 GB_EST14: AA390588 513 AA390588 LD09657.5prime LD Drosophila melanogaster embryo BlueScript Drosophila Drosophila melanogaster 39,759 28-Nov-98 melanogaster cDNA clone LD09657 5prime, mRNA sequence. GB_EST19: AA801874 621 AA801874 GM03519.5prime GM Drosophila melanogaster ovary BlueScript Drosophila Drosophila melanogaster 35,437 25-Nov-98 melanogaster cDNA clone GM03519 5prime similar to U11383: ovo FBgn0003028 PID: g520527 SWISS-PROT: P51521, mRNA sequence. rxa00457 1203 GB_GSS8: AQ000125 398 AQ000125 CIT-HSP-2282P3.TF CIT-HSP Homo sapiens genomic clone 2282P3, genomic Homo sapiens 41,730 26-Jun-98 survey sequence. GB_IN1: DROADDLIKE 4209 L14330 Drosophila melanogaster adducin-like protein, complete cds. Drosophila melanogaster 37,795 11-Jun-93 GB_IN1: DROHTSC 3922 L05016 Drosophila melanogaster hu-li tai shao (hts) mRNA, complete cds. Drosophila melanogaster 37,081 26-Apr-93 rxa00462 1503 GB_HTG3: AC009210 103814 AC009210 Drosophila melanogaster chromosome 2 clone BACR01I06 (D1054) RPCI-98 Drosophila melanogaster 33,356 20-Aug-99 01.I.6 map 55D-55D strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 86 unordered pieces. GB_HTG3: AC009210 103814 AC009210 Drosophila melanogaster chromosome 2 clone BACR01I06 (D1054) RPCI-98 Drosophila melanogaster 33,356 20-Aug-99 01.I.6 map 55D-55D strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 86 unordered pieces. GB_BA1: SCE9 37730 AL049841 Streptomyces coelicolor cosmid E9. Streptomyces coelicolor 37,308 19-MAY-1999 rxa00463 945 GB_BA2: AF052652 2096 AF052652 Corynebacterium glutamicum homoserine O-acetyltransferase (metA) Corynebacterium 99,481 19-MAR-1998 gene, complete cds. glutamicum GB_GSS12: AQ407770 500 AQ407770 HS_5069_B1_F03_T7A RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 40,081 17-MAR-1999 genomic clone Plate = 645 Col = 5 Row = L, genomic survey sequence. GB_GSS15: AQ596209 358 AQ596209 HS_5482_A2_H10_SP6E RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 40,000 8-Jun-99 genomic clone Plate = 1058 Col = 20 Row = O, genomic survey sequence. rxa00468 942 GB_EST32: AI763196 341 AI763196 wi65h04.x1 NCI_CGAP_Kid12 Homo sapiens cDNA clone IMAGE: 2398231 3′, Homo sapiens 38,824 24-Jun-99 mRNA sequence. GB_EST17: AA652964 329 AA652964 ns62e02.s1 NCI_CGAP_Pr22 Homo sapiens cDNA clone IMAGE: 1188218 3′, Homo sapiens 41,104 13-Nov-97 mRNA sequence. GB_EST20: AA864303 411 AA864303 oh54d02.s1 NCI_CGAP_GC4 Homo sapiens cDNA clone IMAGE: 1470435 3′, Homo sapiens 41,422 13-MAY-1998 mRNA sequence. rxa00469 1299 GB_PR4: AC005988 173126 AC005988 Homo sapiens chromosome 17, clone hRPK.299_G_24, complete sequence. Homo sapiens 34,699 15-Jan-99 GB_PR4: AC005988 173126 AC005988 Homo sapiens chromosome 17, clone hRPK.299_G_24, complete sequence. Homo sapiens 35,725 15-Jan-99 GB_HTG3: AC009116 186292 AC009116 Homo sapiens chromosome 16 clone RPCI-11_477D3, *** SEQUENCING IN Homo sapiens 36,222 3-Aug-99 PROGRESS ***, 47. unordered pieces. rxa00472 942 GB_HTG3: AC007882 214882 AC007882 Homo sapiens clone NH0499D05, *** SEQUENCING IN PROGRESS ***, Homo sapiens 38,245 8-Sep-99 2 unordered pieces. GB_HTG3: AC007882 214882 AC007882 Homo sapiens clone NH0499D05, *** SEQUENCING IN PROGRESS ***, Homo sapiens 38,245 8-Sep-99 2 unordered pieces. GB_PR2: HUAC002038 161973 AC002038 Homo sapiens chromosome 2 clone 101B6 map 2p11, complete sequence. Homo sapiens 37,961 30-Jun-97 rxa00473 912 GB_HTG3: AC011445 144370 AC011445 Homo sapiens chromosome 19 clone CIT-HSPC_246B18, *** SEQUENCING Homo sapiens 38,470 07-OCT-1999 IN PROGRESS ***, 31 unordered pieces. GB_HTG3: AC011445 144370 AC011445 Homo sapiens chromosome 19 clone CIT-HSPC_246B18, *** SEQUENCING Homo sapiens 38,470 07-OCT-1999 IN PROGRESS ***, 31 unordered pieces. GB_RO: AB026437 2097 AB026437 Mus musculus DNA, 5′ flanking region of interleukin 12 receptor beta 1. Mus musculus 40,000 02-OCT-1999 rxa00474 1701 GB_GSS10: AQ223838 543 AQ223838 HS_2218_A1_H03_MR CIT Approved Human Genomic Sperm Library D Homo sapiens 40,189 20-Sep-98 Homo sapiens genomic clone Plate = 2218 Col = 5 Row = O, genomic survey sequence. GB_GSS10: AQ223838 543 AQ223838 HS_2218_A1_H03_MR CIT Approved Human Genomic Sperm Library D Homo sapiens 37,944 20-Sep-98 Homo sapiens genomic clone Plate = 2218 Col = 5 Row = O, genomic survey sequence. rxa00475 783 GB_PL2: GMAKHSDH2 10535 AF049708 Glycine max aspartokinase-homoserine dehydrogenase (AK-HSDH) gene, partial cds. Glycine max 36,446 7-Jul-99 GB_EST14: AA386651 351 AA386651 vb54b04.r1 Ko mouse embryo 11 5dpc Mus musculus cDNA clone IMAGE: Mus musculus 41,311 23-Apr-97 760783 5′, mRNA sequence. GB_EST14: AA386603 498 AA386603 vb53c02.r1 Ko mouse embryo 11 5dpc Mus musculus cDNA clone IMAGE: 760706 Mus musculus 40,644 23-Apr-97 5′ similar to TR: G56689 G56689 DIMETHYLGLYCINE DEHYDROGENASE.;, mRNA sequence. rxa00476 984 GB_GSS5: AQ770769 554 AQ770769 HS_5357_B2_H01_T7A RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 35,560 28-Jul-99 genomic clone Plate = 933 Col = 2 Row = P, genomic survey sequence. GB_IN1: CEM162 39977 Z82278 Caenorhabditis elegans cosmid M162, complete sequence. Caenorhabditis elegans 34,224 19-Nov-99 GB_IN1: CEM162 39977 Z82278 Caenorhabditis elegans cosmid M162, complete sequence. Caenorhabditis elegans 33,777 19-Nov-99 rxa00481 708 GB_PR4: AC005013 195910 AC005013 Homo sapiens BAC clone GS165L15 from 7p15, complete sequence. Homo sapiens 35,755 28-Nov-98 GB_HTG1: PFMAL4P4 224448 AL035477 Plasmodium falciparum chromosome 4 strain 3D7, *** SEQUENCING IN Plasmodium falciparum 37,213 11-Aug-99 PROGRESS ***, in unordered pieces. GB_HTG1: PFMAL4P4 224448 AL035477 Plasmodium falciparum chromosome 4 strain 3D7, *** SEQUENCING IN Plasmodium falciparum 37,213 11-Aug-99 PROGRESS ***, in unordered pieces. rxa00485 2418 GB_EST30: AV017239 238 AV017239 AV017239 Mus musculus 18-day embryo C57BL/6J Mus musculus cDNA Mus musculus 39,916 28-Aug-99 clone 1110069G23, mRNA sequence. GB_EST33: AV093875 254 AV093875 AV093875 Mus musculus C57BL/6J ES cell Mus musculus cDNA clone Mus musculus 38,189 22-Nov-99 2400006D21, mRNA sequence. GB_EST33: AV084536 287 AV084536 AV084536 Mus musculus tongue C57BL/6J adult Mus musculus cDNA clone Mus musculus 37,282 25-Jun-99 2310007K01, mRNA sequence. rxa00486 1032 GB_RO: MUSP3VPR2 1089 AF098867 Mus sp. 129SV V3/V1b vasopressin receptor gene, exon 2 and complete cds. Mus musculus 38,163 28-Apr-99 GB_GSS9: AQ166448 407 AQ166448 HS_3137_B2_A06_MR CIT Approved Human Genomic Sperm Library D Homo sapiens 40,250 16-OCT-1998 Homo sapiens genomic clone Plate = 3137 Col = 12 Row = B, genomic survey sequence. GB_GSS15: AQ614261 505 AQ614261 HS_5123_B1_F11_SP6E RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 37,905 15-Jun-99 genomic clone Plate = 699 Col = 21 Row = L, genomic survey sequence. rxa00490 1026 GB_EST15: AA463205 282 AA463205 zx71c06.s1 Soares_total_fetus_Nb2HF8_9w Homo sapiens cDNA clone IMAGE: Homo sapiens 39,502 10-Jun-97 796906 3′, mRNA sequence. GB_BA1: SLLINC 36270 X79146 S. lincolnensis (78-11) Lincomycin production genes. Streptomyces lincolnensis 37,278 15-MAY-1996 GB_GSS3: B10984 646 B10984 F22I8-Sp6 IGF Arabidopsis thaliana genomic clone F22I8, genomic survey sequence. Arabidopsis thaliana 39,205 14-MAY-1997 rxa00491 543 GB_HTG1: CEY87G2 330612 AL022597 Caenorhabditis elegans chromosome I clone Y87G2, *** SEQUENCING IN Caenorhabditis elegans 37,405 26-OCT-1999 PROGRESS ***, in unordered pieces. GB_HTG1: CEY87G2 330612 AL022597 Caenorhabditis elegans chromosome I clone Y87G2, *** SEQUENCING IN Caenorhabditis elegans 37,405 26-OCT-1999 PROGRESS ***, in unordered pieces. GB_HTG1: CEY6B3 253516 Z92865 Caenorhabditis elegans chromosome I clone Y6B3, *** SEQUENCING IN Caenorhabditis elegans 38,213 30-Jul-98 PROGRESS ***, in unordered pieces. rxa00493 1737 GB_BA1: SC6G4 41055 AL031317 Streptomyces coelicolor cosmid 6G4. Streptomyces coelicolor 61,649 20-Aug-98 GB_BA2: U00015 42325 U00015 Mycobacterium leprae cosmid B1620. Mycobacterium leprae 38,567 01-MAR-1994 GB_BA1: U00020 36947 U00020 Mycobacterium leprae cosmid B229. Mycobacterium leprae 38,567 01-MAR-1994 rxa00496 1149 GB_VI: TVRNAP 6404 X68414 Toscana Virus genomic RNA for RNA-dependent RNA polymerase. Toscana virus 35,428 27-OCT-1992 GB_IN2: DMU09808 9239 U09808 Drosophila melanogaster twisted gastrulation (tsg) and serine protease (gd) genes, Drosophila melanogaster 36,837 25-Jun-98 complete cds. GB_IN2: DMU09808 9239 U09808 Drosophila melanogaster twisted gastrulation (tsg) and serine protease (gd) genes, Drosophila melanogaster 37,782 25-Jun-98 complete cds. rxa00504 543 GB_BA1: MTCY159 33818 Z83863 Mycobacterium tuberculosis H37Rv complete genome; segment 111/162. Mycobacterium 36,961 17-Jun-98 tuberculosis GB_PR1: HUMHM145 2214 D10925 Human mRNA for HM145. Homo sapiens 36,066 3-Feb-99 GB_EST14: AA415083 332 AA415083 Mg0017 RCW Lambda Zap Express Library Pyricularia grisea cDNA clone Pyricularia grisea 40,181 09-DEC-1999 RCW17 5′, mRNA sequence. rxa00505 618 GB_PAT: I92047 551 I92047 Sequence 14 from patent U.S. Pat. No. 5726299. Unknown. 46,250 01-DEC-1998 GB_PAT: I78759 549 I78759 Sequence 15 from patent U.S. Pat. No. 5693781. Unknown. 44,813 3-Apr-98 GB_PAT: I92048 549 I92048 Sequence 15 from patent U.S. Pat. No. 5726299. Unknown. 44,813 01-DEC-1998 rxa00507 978 GB_PR2: HS1063B2 114596 AL035683 Human DNA sequence from clone 1063B2 on chromosome 20q13.1-13.2. Homo sapiens 36,449 23-Nov-99 Contains the 3′ part of the gene for Beta-1,4-galactosyltransferase, ESTs, STSs and GSSs, complete sequence. GB_HTG2: AC007225 218892 AC007225 Homo sapiens chromosome 16 clone 480G7, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,646 6-Apr-99 38 unordered pieces. GB_HTG2: AC007225 218892 AC007225 Homo sapiens chromosome 16 clone 480G7, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,646 6-Apr-99 38 unordered pieces. rxa00510 1632 GB_GSS4: AQ707590 499 AQ707590 HS_5560_B1_H02_SP6E RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 37,275 7-Jul-99 genomic clone Plate = 1136 Col = 3 Row = P, genomic survey sequence. GB_GSS4: AQ707590 499 AQ707590 HS_5560_B1_H02_SP6E RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 37,275 7-Jul-99 genomic clone Plate = 1136 Col = 3 Row = P, genomic survey sequence. rxa00515 825 GB_BA1: CGICD 3595 X71489 C. glutamicum icd gene for monomeric isocitrate dehydrogenase. Corynebacterium 100,000 17-Feb-95 glutamicum GB_BA1: CGICD 3595 X71489 C. glutamicum icd gene for monomeric isocitrate dehydrogenase. Corynebacterium 38,150 17-Feb-95 glutamicum GB_GSS13: AQ451896 509 AQ451896 HS_5184_B1_C03_SP6E RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 36,638 21-Apr-99 genomic clone Plate = 760 Col = 5 Row = F, genomic survey sequence. rxa00519 2337 GB_BA1: CGICD 3595 X71489 C. glutamicum icd gene for monomeric isocitrate dehydrogenase. Corynebacterium 100,000 17-Feb-95 glutamicum GB_BA2: AF127018 2560 AF127018 Streptomyces coelicolor isocitrate dehydrogenase (idh) gene, idh-B allele, Streptomyces coelicolor 66,667 1-Jun-99 complete cds. GB_BA1: AVIICD 3550 D73443 Azotobacter vinelandii icd gene for isocitrate dehydrogenase, complete cds. Azotobacter vinelandii 63,652 4-Feb-99 rxa00527 1887 GB_PAT: I92049 2248 I92049 Sequence 16 from patent U.S. Pat. No. 5726299. Unknown. 39,250 01-DEC-1998 GB_PAT: I92053 2213 I92053 Sequence 20 from patent U.S. Pat. No. 5726299. Unknown. 70,635 01-DEC-1998 GB_BA1: MTCY98 31225 Z83860 Mycobacterium tuberculosis H37Rv complete genome; segment 103/162. Mycobacterium 37,741 17-Jun-98 tuberculosis rxa00528 1212 GB_BA1: MSGY219 38721 AD000013 Mycobacterium tuberculosis sequence from clone y219. Mycobacterium 68,672 10-DEC-1996 tuberculosis GB_BA1: MTCY21D4 20760 Z80775 Mycobacterium tuberculosis H37Rv complete genome; segment 3/262. Mycobacterium 39,762 24-Jun-99 tuberculosis GB_BA1: SCH24 41625 AL049826 Streptomyces coelicolor cosmid H24. Streptomyces coelicolor 40,411 11-MAY-1999 rxa00529 666 GB_PR2: HSAC000109 41122 AC000109 Human Cosmid g0771a222 from 7q31.3, complete sequence. Homo sapiens 37,462 11-Sep-97 GB_PR2: HSAC000110 45508 AC000110 Human Cosmid g0771a233, complete sequence. Homo sapiens 37,462 30-Jan-97 GB_PR2: HSAC000109 41122 AC000109 Human Cosmid g0771a222 from 7q31.3, complete sequence. Homo sapiens 39,724 11-Sep-97 rxa00530 1404 GB_PR3: HS435C23 151798 Z92844 Human DNA sequence from PAC 435C23 on chromosome X. Contains ESTs. Homo sapiens 36,482 23-Nov-99 GB_PR3: HS435C23 151798 Z92844 Human DNA sequence from PAC 435C23 on chromosome X. Contains ESTs. Homo sapiens 37,918 23-Nov-99 GB_PL1: YSCADE3 4883 M12878 Saccharomyces cerevisiae C-1-tetrahydrofolate synthase (ADE3) gene, complete cds. Saccharomyces cerevisiae 37,034 11-MAY-1995 rxa00535 840 GB_BA1: CGLEUA 3492 X70959 C. glutamicum gene leuA for isopropylmalate synthase. Corynebacterium 100,000 10-Feb-99 glutamicum GB_BA1: CORASKD 2957 L16848 Corynebacterium flavum aspartokinase (ask), and aspartate- Corynebacterium 43,750 11-Jun-93 semialdehyde dehydrogenase (asd) genes, complete cds. flavescens GB_GSS10: AQ193141 515 AQ193141 HS_3060_B1_F11_MF CIT Approved Human Genomic Homo sapiens 44,773 4-Nov-98 Sperm Library D Homo sapiens genomic clone Plate = 3060 Col = 21 Row = L, genomic survey sequence. rxa00540 366 GB_PAT: I92052 2115 I92052 Sequence 19 from patent U.S. Pat. No. 5726299. Unknown. 74,795 01-DEC-1998 GB_HTG2: AC008095 126322 AC008095 Drosophila melanogaster chromosome 2 clone BACR11H16 (D932) Drosophila melanogaster 41,899 2-Aug-99 RPCI-98 11.H.16 map 52A-52A strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 95 unordered pieces. GB_HTG2: AC008095 126322 AC008095 Drosophila melanogaster chromosome 2 clone BACR11H16 (D932) RPCI-98 Drosophila melanogaster 41,899 2-Aug-99 11.H.16 map 52A-52A strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 95 unordered pieces. rxa00547 1521 GB_BA1: MSGY219 38721 AD000013 Mycobacterium tuberculosis sequence from clone y219. Mycobacterium 36,910 10-DEC-1996 tuberculosis GB_BA1: MTCY21D4 20760 Z80775 Mycobacterium tuberculosis H37Rv complete genome; segment 3/262. Mycobacterium 51,125 24-Jun-99 tuberculosis GB_EST27: AI415174 292 AI415174 mc05c02.x1 Soares mouse p3NMF19.5 Mus musculus cDNA clone IMAGE: Mus musculus 39,384 9-Feb-99 338018 3′, mRNA sequence. rxa00549 1797 GB_PL2: ATAC007135 27313 AC007135 Arabidopsis thaliana chromosome II BAC F9C22 genomic Arabidopsis thaliana 35,584 26-MAY-1999 sequence, complete sequence. GB_PL2: ATAC006921 76042 AC006921 Arabidopsis thaliana chromosome II BAC F2H17 genomic Arabidopsis thaliana 36,581 23-MAR-1999 sequence, complete sequence. GB_PL2: ATAC007135 27313 AC007135 Arabidopsis thaliana chromosome II BAC F9C22 genomic Arabidopsis thaliana 35,827 26-MAY-1999 sequence, complete sequence. rxa00550 rxa00552 1059 GB_BA1: D90742 19201 D90742 Escherichia coli genomic DNA. (23.8-24.2 min). Escherichia coli 46,072 7-Feb-99 GB_BA1: ECHTRB 3129 X61000 E. coli K12 HtrB gene. Escherichia coli 39,164 30-Jun-93 GB_BA2: AE000207 11148 AE000207 Escherichia coli K-12 MG1655 section 97 of 400 of the complete genome. Escherichia coli 46,072 12-Nov-98 rxa00553 444 GB_EST18: AB009093 479 AB009093 AB009093 Chlamydomonas W80 lambda ZAP II Chlamydomonas sp. cDNA Chlamydomonas sp. 41,808 05-DEC-1997 similar to photosystem II 10 kDa protein, mRNA sequence. GB_EST30: AI640954 641 AI640954 AEMTAP02 Aedes aegypti MT pSPORT Library Aedes aegypti Aedes aegypti 38,991 28-Apr-99 cDNA clone AP02 5′, mRNA sequence. GB_GSS13: AQ467517 206 AQ467517 HS_5219_A2_F02_SP6E RPCI-11 Human Male BAC Library Homo sapiens 45,255 23-Apr-99 Homo sapiens genomic clone Plate = 795 Col = 4 Row = K, genomic survey sequence. rxa00554 594 GB_EST6: W04418 364 W04418 za43c06.r1 Soares fetal liver spleen 1NFLS Homo sapiens cDNA clone Homo sapiens 39,688 22-Apr-96 IMAGE: 295306 5′, mRNA sequence. GB_EST35: AL041829 564 AL041829 DKFZp434C0318_s1 434 (synonym: htes3) Homo sapiens cDNA Homo sapiens 40,433 29-Sep-99 clone DKFZp434C0318 3′, mRNA sequence. GB_EST35: AL041828 386 AL041828 DKFZp434C0318_r1 434 (synonym: htes3) Homo sapiens cDNA clone Homo sapiens 39,688 29-Sep-99 DKFZp434C0318 5′, mRNA sequence. rxa00555 rxa00560 498 GB_BA1: MTCY7H7A 10451 Z95618 Mycobacterium tuberculosis H37Rv complete genome; segment 39/162. Mycobacterium 52,727 17-Jun-98 tuberculosis GB_BA1: BAPURF 1885 X91252 B. ammoniagenes purF gene. Corynebacterium 61,092 5-Jun-97 ammoniagenes GB_PL1: YSCMET10A 3650 L26504 Saccharomyces carlsbergensis assimilatory sulfite reductase Saccharomyces 41,273 7-Feb-95 (MET10) gene, complete cds. pastorianus rxa00563 2762 GB_BA1: BAFASAA 10549 X64795 B. ammoniagenes FAS gene. Corynebacterium 66,910 14-OCT-1997 ammoniagenes GB_BA1: MTCY159 33818 Z83863 Mycobacterium tuberculosis H37Rv complete genome; segment 111/162. Mycobacterium 40,066 17-Jun-98 tuberculosis GB_BA1: MBU36763 8391 U36763 Mycobacterium bovis fatty acid synthase gene, complete cds. Mycobacterium bovis 61,178 15-Jul-96 rxa00564 528 GB_PR3: HS833B7 86574 AL008637 Human DNA sequence from clone 833B7 on chromosome 22q12.3-13.2 Homo sapiens 39,015 23-Nov-99 Contains genes for NCF4 (P40PHOX) protein, cytokine receptor common beta chain precursor CSF2RB (partial), ESTs, CA repeat, STS, GSS, complete sequence. GB_HTG3: AC008543 278334 AC008543 Homo sapiens chromosome 19 clone CIT-HSPC_499B15, *** SEQUENCING Homo sapiens 36,328 2-Sep-99 IN PROGRESS ***, 134 unordered pieces. GB_HTG3: AC008543 278334 AC008543 Homo sapiens chromosome 19 clone CIT-HSPC_499B15, *** SEQUENCING Homo sapiens 36,328 2-Sep-99 IN PROGRESS ***, 134 unordered pieces. rxa00573 rxa00574 1002 GB_GSS11: AQ301816 481 AQ301816 HS_3174_A1_B04_T7 CIT Approved Human Genomic Sperm Library Homo sapiens 43,137 16-DEC-1998 D Homo sapiens genomic clone Plate = 3174 Col = 7 Row = C, genomic survey sequence. GB_PR3: AC004537 88872 AC004537 Homo sapiens PAC clone DJ0872F07 from 7q31, complete sequence. Homo sapiens 34,712 9-Apr-98 GB_EST29: AI563059 339 AI563059 EST00183 watermelon lambda zap library Citrullus lanatus cDNA clone Citrullus lanatus 37,758 26-MAR-1999 WMLS355 5′ similar to unknown protein, mRNA sequence. rxa00576 795 GB_EST37: AI947508 533 AI947508 603022E09.x1 603 - stressed root cDNA library from Wang/Bohnert lab Zea mays 38,728 19-Aug-99 Zea mays cDNA, mRNA sequence. GB_GSS11: AQ296770 347 AQ296770 HS_3087_A2_B12_MF CIT Approved Human Genomic Sperm Library Homo sapiens 40,058 15-DEC-1998 D Homo sapiens genomic clone Plate = 3087 Col = 24 Row = C, genomic survey sequence. GB_GSS13: AQ503769 589 AQ503769 RPCI-11-282O13.TV RPCI-11 Homo sapiens genomic clone RPCI- Homo sapiens 37,993 29-Apr-99 11-282O13, genomic survey sequence. rxa00577 471 GB_GSS14: AQ533027 638 AQ533027 RPCI-11-351M24.TJ RPCI-11 Homo sapiens genomic clone RPCI- Homo sapiens 34,944 18-MAY-1999 11-351M24, genomic survey sequence. GB_PR3: HS440B3 28047 AL022331 Homo sapiens DNA sequence from clone 440B3 on chromosome 22q12.1-3 Homo sapiens 33,626 23-Nov-99 Contains a pseudogene similar to 60S Ribosomal protein L17. Contains ESTs and an STS (genomic marker D22S1176), complete sequence. GB_PL2: ZEU19267 1230 U19267 Zinnia elegans cysteine proteinase mRNA, complete cds. Zinnia elegans 35,456 26-Aug-96 rxa00578 rxa00582 642 GB_BA1: CORAHPS 2570 L07603 Corynebacterium gutamicum 3-deoxy-D-arabinoheptulosonate-7- Corynebacterium 98,901 26-Apr-93 phosphate synthase gene, complete cds. glutamicum GB_PR3: AC005389 120359 AC005389 Homo sapiens chromosome 17, clone hRPK.601_N_13, complete sequence. Homo sapiens 38,315 14-Aug-98 GB_HTG6: AC008002 126629 AC008002 Drosophila melanogaster chromosome 2 clone BACR48E08 (D843) Drosophila melanogaster 32,437 07-DEC-1999 RPCI-98 48.E.8 map 21D-21E strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 85 unordered pieces. rxa00585 441 GB_BA1: CORAHPS 2570 L07603 Corynebacterium gutamicum 3-deoxy-D-arabinoheptulosonate- Corynebacterium 98,039 26-Apr-93 7-phosphate synthase gene, complete cds. glutamicum GB_PR4: AC004970 149951 AC004970 Homo sapiens BAC clone DJ1122F04 from 7q11.23-q21.2, complete sequence. Homo sapiens 39,900 27-Aug-99 GB_PR2: HS102G20 99207 Z99127 Human DNA sequence from PAC 102G20 on chromosome 1q24-q25. Homo sapiens 41,509 23-Nov-99 Contains ESTS, STSs and a predicted CpG island. rxa00586 1005 GB_BA1: MTV017 67200 AL021897 Mycobacterium tuberculosis H37Rv complete genome; segment 48/162. Mycobacterium 56,219 24-Jun-99 tuberculosis GB_BA1: MLU15183 36800 U15183 Mycobacterium leprae cosmid B1740. Mycobacterium leprae 55,622 09-MAR-1995 GB_BA1: MTV017 67200 AL021897 Mycobacterium tuberculosis H37Rv complete genome; segment 48/162. Mycobacterium 37,838 24-Jun-99 tuberculosis rxa00587 459 GB_EST37: AI993539 514 AI993539 701496589 A. thaliana, Ohio State clone set Arabidopsis thaliana Arabidopsis thaliana 40,153 8-Sep-99 cDNA clone 701496589, mRNA sequence. GB_GSS10: AQ224941 511 AQ224941 HS_2009_B1_B06_T7 CIT Approved Human Genomic Sperm Homo sapiens 43,750 20-Sep-98 Library D Homo sapiens genomic clone Plate = 2009 Col = 11 Row = D, genomic survey sequence. GB_EST23: AI099719 475 AI099719 33872 Lambda-PRL2 Arabidopsis thaliana cDNA clone Arabidopsis thaliana 36,752 21-Aug-98 120M10XP 3′, mRNA sequence. rxa00589 573 GB_PL2: ATAC003673 70575 AC003673 Arabidopsis thaliana chromosome II BAC F19F24 genomic Arabidopsis thaliana 39,785 1-Apr-98 sequence, complete sequence. GB_PR3: HS427A4 149466 Z98049 Human DNA sequence from PAC 427A4 on chromosome 6q26-q27. Homo sapiens 35,145 23-Nov-99 Contains ribosomal protein S6 kinase, RSK3, ESTs, CpG island. rxa00595 GB_PL2: ATAC005724 86671 AC005724 Arabidopsis thaliana chromosome II P1 MSF3 genomic sequence, complete sequence. Arabidopsis thaliana 39,785 24-Jan-99 rxa00597 393 GB_PR3: AC004659 129577 AC004659 Homo sapiens chromosome 19, CIT-HSP-87m17 BAC clone, complete sequence. Homo sapiens 39,459 02-MAY-1998 GB_GSS14: AQ575039 927 AQ575039 nbxb0086L01r CUGI Rice BAC Library Oryza sativa genomic clone Oryza sativa 37,786 2-Jun-99 nbxb0086L01r, genomic survey sequence. GB_BA1: NMRRNA 5209 X72495 N. magadii rRNA operon. Natrialba magadii 39,788 10-Feb-95 rxa00598 rxa00601 414 GB_BA2: AF175719 1368 AF175719 Porphyromonas gingivalis strain W50 immunoreactive 51 kD Porphyromonas gingivalis 35,331 23-Aug-99 antigen PG52 gene, complete cds. GB_GSS9: AQ140775 464 AQ140775 HS_3128_A1_B11_MR CIT Approved Human Genomic Sperm Homo sapiens 40,431 24-Sep-98 Library D Homo sapiens genomic clone Plate = 3128 Col = 21 Row = C, genomic survey sequence. GB_EST8: AA018824 542 AA018824 ze57e09.s1 Soares retina N2b4HR Homo sapiens cDNA clone Homo sapiens 40,590 30-Jan-97 IMAGE: 363112 3′, mRNA sequence. rxa00602 876 GB_EST30: AI642687 479 AI642687 vw02h03.x1 Soares mouse mammary gland NbMMG Mus musculus cDNA clone Mus musculus 40,042 29-Apr-99 IMAGE: 1230773 3′, mRNA sequence. GB_EST20: AA879989 412 AA879989 vw03a05.r1 Soares mouse mammary gland NbMMG Mus musculus cDNA clone Mus musculus 39,948 26-MAR-1998 IMAGE: 1230800 5′, mRNA sequence. GB_EST28: AI481047 438 AI481047 vf91a05.x1 Soares mouse mammary gland NbMMG Mus musculus cDNA clone Mus musculus 38,128 09-MAR-1999 IMAGE: 851120 3′, mRNA sequence. rxa00604 414 GB_HTG2: AC008205 131658 AC008205 Drosophila melanogaster chromosome 3 clone BACR33F18 (D764) RPCI-98 Drosophila melanogaster 33,907 2-Aug-99 33.F.18 map 96A-96B strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 118 unordered pieces. GB_HTG2: AC008205 131658 AC008205 Drosophila melanogaster chromosome 3 clone BACR33F18 (D764) Drosophila melanogaster 33,907 2-Aug-99 RPCI-98 33.F.18 map 96A-96B strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 118 unordered pieces. GB_IN1: DMBR7C10 56820 AL121804 Drosophila melanogaster clone BACR7C10. Drosophila melanogaster 44,267 10-OCT-1999 rxa00610 987 GB_BA1: SME242575 1403 AJ242575 Sinorhibium meliloti partial oxi1 and dehydrogenase genes, isolate lpu119. Sinorhizobium meliloti 41,760 26-MAY-1999 GB_PR3: AC004655 134929 AC004655 Homo sapiens Xp22-140-141 BAC GSHB-128G5 (Genome Systems Homo sapiens 38,422 17-Sep-98 Human BAC library) complete sequence. GB_PR3: HS598F2 99886 AL021579 Human DNA sequence from clone 598F2 on chromosome Homo sapiens 38,351 23-Nov-99 1q23.1-24.3 Contains ESTs, STS and GSS, complete sequence. rxa00611 1599 GB_HTG2: AC007108 190000 AC007108 Homo sapiens chromosome 4, *** SEQUENCING IN Homo sapiens 17,451 17-MAR-1999 PROGRESS ***, 24 unordered pieces. GB_HTG2: AC007108 190000 AC007108 Homo sapiens chromosome 4, *** SEQUENCING IN Homo sapiens 17,451 17-MAR-1999 PROGRESS ***, 24 unordered pieces. GB_HTG4: AC010893 176178 AC010893 Homo sapiens chromosome unknown clone NH0480A20, Homo sapiens 35,819 29-OCT-1999 WORKING DRAFT SEQUENCE, in unordered pieces. rxa00613 576 GB_IN2: AC004361 87747 AC004361 Drosophila melanogaster DNA sequence (P1 DS07851 (D49)), complete sequence. Drosophila melanogaster 35,081 29-MAY-1998 GB_PL2: AC006268 105420 AC006268 Arabidopsis thaliana BAC T24G23 from chromosome IV Arabidopsis thaliana 43,682 1-Jan-99 near 21 cM, complete sequence. GB_BA1: MLCB596 38426 AL035472 Mycobacterium leprae cosmid B596. Mycobacterium leprae 35,026 27-Aug-99 rxa00614 1038 GB_BA1: MTV025 121125 AL022121 Mycobacterium tuberculosis H37Rv complete genome; segment 155/162. Mycobacterium 53,061 24-Jun-99 tuberculosis GB_BA1: SCH66 9153 AL049731 Streptomyces coelicolor cosmid H66. Streptomyces coelicolor 52,817 29-Apr-99 GB_EST14: AA446728 411 AA446728 zw84f03.r1 Soares_total_fetus_Nb2HF8_9w Homo sapiens cDNA Homo sapiens 36,548 3-Jun-97 clone IMAGE: 783677 5′, mRNA sequence. rxa00616 rxa00617 351 GB_PL1: AB009030 2589 AB009030 Panax ginseng OSCPNY1 mRNA for beta-Amyrin Synthase, complete cds. Panax ginseng 39,048 03-OCT-1998 GB_PR3: HS905G11 122469 AL035045 Human DNA sequence from clone 905G11 on chromosome Homo sapiens 39,255 23-Nov-99 20p11.2-12.1. Contains STSs, GSSs and genomic marker D20S182, complete sequence. GB_RO: MMT1CPS 8147 X15147 Mouse Tla region T1c pseudogene for class I antigen Mus musculus 36,311 19-Feb-90 major histocompatibility complex. rxa00628 531 GB_HTG5: AC010674 220575 AC010674 Homo sapiens chromosome 15 clone RP11-430B1 map 15q21, Homo sapiens 37,714 5-Nov-99 *** SEQUENCING IN PROGRESS ***, 46 ordered pieces. GB_HTG5: AC010674 220575 AC010674 Homo sapiens chromosome 15 clone RP11-430B1 map 15q21, *** SEQUENCING Homo sapiens 39,293 5-Nov-99 IN PROGRESS ***, 46 ordered pieces. rxa00631 1578 GB_BA1: BRLBIOAD 2272 D14083 Brevibacterium flavum genes for 7,8-diaminopelargonic acid Corynebacterium 47,368 3-Feb-99 aminotransferase and dethiobiotin synthetase, complete cds. glutamicum GB_PAT: E04041 675 E04041 DNA sequence coding for desthiobiotinsynthetase. Corynebacterium 46,552 29-Sep-97 glutamicum GB_EST20: AA820386 453 AA820386 LD23968.5prime LD Drosophila melanogaster embryo Drosophila melanogaster 45,679 25-Feb-99 pOT2 Drosophila melanogaster cDNA clone LD23968 5prime, mRNA sequence. rxa00637 876 GB_HTG2: AC007589 134659 AC007589 Drosophila melanogaster chromosome 3 clone BACR20D10 Drosophila melanogaster 32,102 2-Aug-99 (D667) RPCI-98 20.D.10 map 82D-82E strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 73 unordered pieces. GB_HTG2: AC007589 134659 AC007589 Drosophila melanogaster chromosome 3 clone BACR20D10 Drosophila melanogaster 32,102 2-Aug-99 (D667) RPCI-98 20.D.10 map 82D-82E strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 73 unordered pieces. GB_HTG3: AC009212 125452 AC009212 Drosophila melanogaster chromosome 3 clone BACR01A18 Drosophila melanogaster 37,126 23-Aug-99 (D669) RPCI-98 01.A.18 map 82E-82F strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 119 unordered pieces. rxa00646 541 GB_HTG1: AP000488 123363 AP000488 Homo sapiens chromosome 11 clone B759H8 map 11q23, *** SEQUENCING Homo sapiens 38,264 13-Sep-99 IN PROGRESS ***, in unordered pieces. GB_HTG1: AP000488 123363 AP000488 Homo sapiens chromosome 11 clone B759H8 map 11q23, *** SEQUENCING Homo sapiens 38,264 13-Sep-99 IN PROGRESS ***, in unordered pieces. GB_HTG1: AP000488 123363 AP000488 Homo sapiens chromosome 11 clone B759H8 map 11q23, *** SEQUENCING Homo sapiens 36,484 13-Sep-99 IN PROGRESS ***, in unordered pieces. rxa00647 756 GB_GSS13: AQ431426 536 AQ431426 HS_5140_A2_E01_T7A RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 35,635 31-MAR-1999 genomic clone Plate = 716 Col = 2 Row = I, genomic survey sequence. GB_OV: CHKP4HA 3149 M26217 Chicken prolyl 4-hydroxylase alpha subunit gene, 3′ end. Gallus gallus 40,655 28-Apr-93 GB_HTG2: AC008271 168302 AC008271 Homo sapiens clone NH0123E16, *** SEQUENCING IN Homo sapiens 37,417 31-Jul-99 PROGRESS ***, 2 unordered pieces. rxa00649 579 GB_PR2: AC002563 136436 AC002563 Human PAC clone 127H14 from 12q, complete sequence. Homo sapiens 37,937 26-Sep-97 GB_HTG3: AC011466 165953 AC011466 Homo sapiens chromosome 19 clone CIT-HSPC_453G23, *** SEQUENCING Homo sapiens 38,179 07-OCT-1999 IN PROGRESS ***, 74 unordered pieces. GB_HTG3: AC011466 165953 AC011466 Homo sapiens chromosome 19 clone CIT-HSPC_453G23, *** SEQUENCING Homo sapiens 38,179 07-OCT-1999 IN PROGRESS ***, 74 unordered pieces. rxa00652 rxa00653 rxa00654 1389 GB_EST1: Z34080 271 Z34080 ATTS3128 Grenoble-B Arabidopsis thaliana cDNA Arabidopsis thaliana 40,370 6-Jun-94 clone GBGe328 5′, mRNA sequence. GB_PR3: AC004460 113803 AC004460 Homo sapiens PAC clone DJ1086D14, complete sequence. Homo sapiens 36,150 24-MAR-1998 GB_GSS6: AQ835185 571 AQ835185 HS_4832_A1_E02_T7A CIT Approved Human Genomic Sperm Homo sapiens 39,429 27-Aug-99 Library D Homo sapiens genomic clone Plate = 4832 Col = 3 Row = I, genomic survey sequence. rxa00656 384 GB_HTG3: AC009948 172463 AC009948 Homo sapiens clone NH0065L03, *** SEQUENCING Homo sapiens 43,164 25-Sep-99 IN PROGRESS ***, 2 unordered pieces. GB_HTG3: AC009948 172463 AC009948 Homo sapiens clone NH0065L03, *** SEQUENCING IN Homo sapiens 43,164 25-Sep-99 PROGRESS ***, 2 unordered pieces. GB_GSS13: AQ462899 522 AQ462899 HS_5212_A1_C09_T7A RPCI-11 Human Male BAC Library Homo sapiens 42,529 23-Apr-99 Homo sapiens genomic clone Plate = 788 Col = 17 Row = E, genomic survey sequence. rxa00657 1026 GB_BA2: AF064700 3481 AF064700 Rhodococcus sp. NO1-1 CprS and CprR genes, complete cds. Rhodococcus sp. NO1-1 40,558 15-Jul-98 GB_PR3: AC005346 38849 AC005346 Homo sapiens chromosome 16, cosmid clone 2H2 (LANL), complete sequence. Homo sapiens 35,553 31-Jul-98 GB_HTG3: AC008905 129915 AC008905 Homo sapiens chromosome 5 clone CITB-H1_2259I14, *** SEQUENCING Homo sapiens 37,179 3-Aug-99 IN PROGRESS ***, 40 unordered pieces. rxa00661 813 GB_PL2: AC006193 118335 AC006193 Arabidopsis thaliana Arabidopsis thaliana 35,513 11-Jun-99 chromosome I BAC F13O11 genomic sequence, complete sequence. GB_RO: MMFABPE 6593 AJ223066 Mus musculus Fabpe gene. Mus musculus 37,500 27-Jul-98 GB_PL2: AC006193 118335 AC006193 Arabidopsis thaliana chromosome I BAC F13O11 genomic sequence, complete sequence. Arabidopsis thaliana 33,552 11-Jun-99 rxa00662 1392 GB_EST29: AI551960 718 AI551960 vi48d09.y1 Beddington mouse embryonic region Mus musculus Mus musculus 39,972 23-MAR-1999 cDNA clone IMAGE: 907025 5′ similar to gb: D10576 Mouse mRNA for ubiquitin activating enzyme E1 (MOUSE);, mRNA sequence. GB_BA2: AE000633 19734 AE000633 Helicobacter pylori 26695 section 111 of 134 of the complete genome. Helicobacter pylori 26695 36,606 6-Apr-99 GB_GSS10: AQ216730 529 AQ216730 HS_2262_A1_G06_MR CIT Approved Human Genomic Homo sapiens 32,703 19-Sep-98 Sperm Library D Homo sapiens genomic clone Plate = 2262 Col = 11 Row = M, genomic survey sequence. rxa00666 1038 GB_HTG3: AC009205 113482 AC009205 Drosophila melanogaster chromosome 2 clone BACR04C20 Drosophila melanogaster 36,713 17-Sep-99 (D1035) RPCI-98 04.C.20 map 36E-37C strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 101 unordered pieces. GB_EST25: AI259480 626 AI259480 LP02903.5prime LP Drosophila melanogaster larval-early pupal pOT2 Drosophila melanogaster 37,173 17-Nov-98 Drosophila melanogaster cDNA clone LP02903 5prime, mRNA sequence. GB_HTG3: AC009205 113482 AC009205 Drosophila melanogaster chromosome 2 clone BACR04C20 (D1035) Drosophila melanogaster 36,713 17-Sep-99 RPCI-98 04.C.20 map 36E-37C strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 101 unordered pieces. rxa00667 1137 GB_PAT: AR048317 2627 AR048317 Sequence 3 from patent U.S. Pat. No. 5821090. Unknown. 39,805 29-Sep-99 GB_PAT: A46560 2627 A46560 Sequence 3 from Patent WO9526406. Eremothecium gossypii 39,805 07-MAR-1997 GB_VI: HEHCMVCG 229354 X17403 Human cytomegalovirus strain AD169 complete genome. human herpesvirus 5 39,854 10-Feb-99 rxa00676 870 GB_HTG1: CEY38F1 178443 Z98861 Caenorhabditis elegans chromosome II clone Y38F1, *** SEQUENCING Caenorhabditis elegans 35,880 03-DEC-1998 IN PROGRESS ***, in unordered pieces. GB_HTG1: CEY38F1 178443 Z98861 Caenorhabditis elegans chromosome II clone Y38F1, *** SEQUENCING Caenorhabditis elegans 35,880 03-DEC-1998 IN PROGRESS ***, in unordered pieces. GB_PR3: HS934G17 107603 AL021155 Homo sapiens DNA sequence from PAC 934G17 on Homo sapiens 38,489 23-Nov-99 chromosome 1p36.21. Contains the alternatively spliced CLCN6 gene for chloride chanel proteins CLC-6A (KIAA0046) -B, -C and -D, the alternatively spliced NPPA gene coding for Atrial Natriuretic Factor ANF precursor (Atrial Natriuretic peptide ANP, Prepronatriodilatin), the NPPB gene for Brain Natriuretic Protein BNP, and a pseudogene similar to SBF1 (and other Myotubularin- related protein genes). Contains ESTs, STSs and the genomic marker D1S2740, complete sequence. rxa00678 858 GB_PR2: CNS00004 205573 AL049778 Human chromosome 14 DNA sequence *** IN PROGRESS *** BAC Homo sapiens 33,138 17-Jun-99 R-643C12 of RPCI-11 library from chromosome 14 of Homo sapiens (Human), complete sequence. GB_GSS1: AG000894 723 AG000894 Homo sapiens genomic DNA, 21q region, clone: 64E11X19, Homo sapiens 37,391 6-Feb-99 genomic survey sequence. GB_IN1: TSMIEXRNA 481 X90847 Trypanosoma simiae mini-exon DNA. Trypanosoma simiae 35,135 15-Feb-99 rxa00691 1053 GB_EST26: AA899042 505 AA899042 UI-R-E0-bz-a-06-0-UI.s2 UI-R-E0 Rattus norvegicus cDNA clone Rattus norvegicus 41,400 4-Jul-99 UI-R-E0-bz-a-06-0-UI 3′ similar to gi|485266| gb|U09256|RNU09256 Rattus norvegicus Sprague-Dawley transketolase mRNA, complete cds, mRNA sequence. GB_RO: RNU09256 2098 U09256 Rattus norvegicus Sprague-Dawley transketolase mRNA, complete cds. Rattus norvegicus 39,652 11-MAY-1994 GB_EST29: AI599628 510 AI599628 EST251331 Normalized rat embryo, Bento Soares Rattus sp. Rattus sp. 39,096 21-Apr-99 cDNA clone REMEH65 3′ end, mRNA sequence. rxa00692 1257 GB_PL2: SPU66305 8226 U66305 Schizosaccharomyces pombe ABC transporter (mam1) gene, complete cds. Schizosaccharomyces 36,842 30-Jul-97 pombe GB_PL1: SPBC25B2 26016 AL031853 S. pombe chromosome II cosmid c25B2. Schizosaccharomyces 36,803 09-OCT-1998 pombe GB_PL1: SPBC2G5 23645 AL033385 S. pombe chromosome II cosmid c2G5. Schizosaccharomyces 36,803 04-DEC-1998 pombe rxa00693 606 GB_BA2: RRU65510 16259 U65510 Rhodospirillum rubrum CO-induced hydrogenase operon Rhodospirillum rubrum 41,970 9-Apr-97 (cooM, cooK, cooL, cooX, cooU, cooH) genes, iron sulfur protein (cooF) gene, carbon monoxide dehydrogenase (cooS) gene, carbon monoxide dehydrogenase accessory proteins (cooC, cooT, cooJ) genes, putative transcriptional activator (cooA) gene, nicotinate- nucleotide pyrophosphorylase (nadC) gene, complete cds, L-aspartate oxidase (nadB) gene, and alkyl hydroperoxide reductase (ahpC) gene, partial cds. GB_PL1: LETHM27 1152 X95296 L. esculentum mRNA for THM27 protein. Lycopersicon esculentum 38,919 10-Jun-96 GB_EST38: AW033855 646 AW033855 EST277426 tomato callus, TAMU Lycopersicon esculentum Lycopersicon esculentum 35,945 15-Sep-99 cDNA clone cLEC29F6 similar to transcription factor, myb-related, mRNA sequence. rxa00701 498 GB_EST34: AI785570 454 AI785570 uj44d03.x1 Sugano mouse liver mlia Mus musculus Mus musculus 37,565 2-Jul-99 cDNA clone IMAGE: 1922789 3′ similar to gb: Z28407 60S RIBOSOMAL PROTEIN L8 (HUMAN);, mRNA sequence. GB_EST25: AI256147 684 AI256147 ui95e12.x1 Sugano mouse liver mlia Mus musculus cDNA clone Mus musculus 41,232 12-Nov-98 IMAGE: 1890190 3′ similar to gb: Z28407 60S RIBOSOMAL PROTEIN L8 (HUMAN);, mRNA sequence. GB_BA1: CARCG12 2079 X14979 C. aurantiacus reaction center genes 1 and 2. Chloroflexus aurantiacus 36,943 23-Apr-91 rxa00704 750 GB_EST15: AA497266 456 AA497266 fa04f08.s1 Zebrafish ICRFzfls Danio rerio cDNA clone 3A13 3′, mRNA sequence. Danio rerio 38,631 30-Jun-97 GB_EST36: AI884217 515 AI884217 fc75e10.x1 Zebrafish WashU MPIMG EST Danio rerio cDNA 3′, mRNA sequence. Danio rerio 38,012 26-Jul-99 GB_HTG1: CEY43F8_1 110000 Z95393 Caenorhabditis elegans chromosome V clone Y43F8, *** SEQUENCING Caenorhabditis elegans 37,889 Z95393 IN PROGRESS ***, in unordered pieces. rxa00707 906 GB_GSS8: AQ013755 715 AQ013755 RPCI11-23F24.TKBF RPCI-11 Homo sapiens genomic clone Homo sapiens 41,724 14-Apr-99 RPCI-11-23F24, genomic survey sequence. GB_GSS3: B86449 434 B86449 RPCI11-23F24.TV RPCI-11 Homo sapiens genomic clone Homo sapiens 42,936 9-Apr-99 RPCI-11-23F24, genomic survey sequence. GB_GSS5: AQ797072 449 AQ797072 nbxb0071D10f CUGI Rice BAC Library Oryza sativa genomic clone Oryza sativa 39,101 4-Aug-99 nbxb0071D10f, genomic survey sequence. rxa00712 819 GB_BA2: AF011544 7527 AF011544 Bacillus subtilis phosphoribosylaminoimidazole-carboxamide formyltransferase Bacillus subtilis 36,927 06-OCT-1997 (purH-J) gene, partial cds, phosphoribosylglycinamide synthetase (purD), YecA (yecA), putative adenine deaminase (yecB), YecC (yecC), and YecD (yecD) genes, complete cds, and putative glutamate synthase (yecE) gene, partial cds. GB_BA2: AF011544 7527 AF011544 Bacillus subtilis phosphoribosylaminoimidazole-carboxamide Bacillus subtilis 39,752 06-OCT-1997 formyltransferase (purH-J) gene, partial cds, phosphoribosylglycinamide synthetase (purD), YecA (yecA), putative adenine deaminase (yecB), YecC (yecC), and YecD (yecD) genes, complete cds, and putative glutamate synthase (yecE) gene, partial cds. rxa00713 1056 GB_PAT: I92037 241 I92037 Sequence 4 from patent U.S. Pat. No. 5726299. Unknown. 99,048 01-DEC-1998 GB_PAT: I78748 241 I78748 Sequence 4 from patent U.S. Pat. No. 5693781. Unknown. 99,048 3-Apr-98 GB_HTG3: AC009281 221178 AC009281 Homo sapiens chromosome 15 clone 8_C_22 map 15, *** SEQUENCING Homo sapiens 36,255 12-Aug-99 IN PROGRESS ***, 49 unordered pieces. rxa00714 684 GB_PL1: CCR5839 871 AJ005839 Cyclotella cryptica mRNA for fucoxanthin chlorophyll a/c binding protein, fcp12. Cyclotella cryptica 36,364 30-Jul-98 GB_PR2: HS1002M8 111768 AL035454 Human DNA sequence from clone 1002M8 on Homo sapiens 36,444 23-Nov-99 chromosome 20p11.21-11.23, complete sequence. GB_PR2: HS1002M8 111768 AL035454 Human DNA sequence from clone 1002M8 on Homo sapiens 34,894 23-Nov-99 chromosome 20p11.21-11.23, complete sequence. rxa00716 636 GB_PAT: I78753 1187 I78753 Sequence 9 from patent U.S. Pat. No. 5693781. Unknown. 36,022 3-Apr-98 GB_PAT: I92042 1187 I92042 Sequence 9 from patent U.S. Pat. No. 5726299. Unknown. 36,022 01-DEC-1998 GB_HTG3: AC005769 200000 AC005769 Homo sapiens chromosome 4, *** SEQUENCING Homo sapiens 36,745 21-Aug-99 IN PROGRESS ***, 5 unordered pieces. rxa00719 1752 GB_BA2: U32687 11847 U32687 Haemophilus influenzae Rd section 2 of 163 of the complete genome. Haemophilus influenzae Rd 36,937 29-MAY-1998 GB_EST13: AA333602 357 AA333602 EST37710 Embryo, 8 week I Homo sapiens cDNA 5′ end similar to guanine Homo sapiens 45,938 21-Apr-97 nucleotide-binding protein rap2, ras-oncogene related, mRNA sequence. GB_BA2: U32687 11847 U32687 Haemophilus influenzae Rd section 2 of 163 of the complete genome. Haemophilus influenzae Rd 36,390 29-MAY-1998 rxa00720 789 GB_EST1: M61974 437 M61974 EST00024 Fetal brain, Stratagene (cat#936206) Homo sapiens Homo sapiens 40,138 26-MAY-1992 cDNA clone HFBA87, mRNA sequence. GB_EST3: R73776 389 R73776 yi55h07.r1 Soares placenta Nb2HP Homo sapiens cDNA Homo sapiens 41,818 5-Jun-95 clone IMAGE: 143197 5′, mRNA sequence. GB_EST35: AL043192 793 AL043192 DKFZp434G0723_r1 434 (synonym: htes3) Homo sapiens Homo sapiens 38,571 29-Sep-99 cDNA clone DKFZp434G0723 5′, mRNA sequence. rxa00722 1088 GB_HTG3: AC008573 205755 AC008573 Homo sapiens chromosome 5 clone CIT-HSPC_551I11, *** SEQUENCING Homo sapiens 38,506 3-Aug-99 IN PROGRESS ***, 95 unordered pieces. GB_HTG3: AC008573 205755 AC008573 Homo sapiens chromosome 5 clone CIT-HSPC_551I11, *** SEQUENCING Homo sapiens 38,506 3-Aug-99 IN PROGRESS ***, 95 unordered pieces. GB_BA1: MTV014 58280 AL021646 Mycobacterium tuberculosis H37Rv complete genome; segment 137/162. Mycobacterium 41,392 18-Jun-98 tuberculosis rxa00724 2100 GB_BA1: SC7A1 32039 AL034447 Streptomyces coelicolor cosmid 7A1. Streptomyces coelicolor 54,858 15-DEC-1998 GB_BA1: BSY13937 27779 Y13937 Bacillus subtilis genomic DNA from the spoVM region. Bacillus subtilis 47,010 30-MAR-1998 GB_BA2: L78127 1225 L78127 Enterococcus faecium genomic DNA fragment. Enterococcus faecium 36,880 18-Aug-99 rxa00726 614 GB_BA1: BACJH642 282700 D84432 Bacillus subtilis DNA, 283 Kb region containing skin element. Bacillus subtilis 56,694 6-Feb-99 GB_BA1: BSUB0013 218470 Z99116 Bacillus subtilis complete genome (section 13 of 21): from 2395261 to 2613730. Bacillus subtilis 36,513 26-Nov-97 GB_BA1: SC4H8 15560 AL020958 Streptomyces coelicolor cosmid 4H8. Streptomyces coelicolor 35,073 10-DEC-1997 rxa00729 rxa00730 930 GB_HTG3: AC010758 145821 AC010758 Homo sapiens clone 1_B_18, *** SEQUENCING Homo sapiens 35,738 22-Sep-99 IN PROGRESS ***, 20 unordered pieces. GB_HTG3: AC010758 145821 AC010758 Homo sapiens clone 1_B_18, *** SEQUENCING Homo sapiens 35,738 22-Sep-99 IN PROGRESS ***, 20 unordered pieces. GB_GSS13: AQ469090 414 AQ469090 CITBI-E1-2596D12.TF CITBI-E1 Homo sapiens genomic clone Homo sapiens 36,842 23-Apr-99 2596D12, genomic survey sequence. rxa00731 2619 GB_BA1: CGLYSI 4232 X60312 C. glutamicum lysi gene for L-lysine permease. Corynebacterium 100,000 30-Jan-92 glutamicum GB_BA1: CGLYSI 4232 X60312 C. glutamicum lysi gene for L-lysine permease. Corynebacterium 37,645 30-Jan-92 glutamicum rxa00738 386 GB_BA1: MTCY10G2 38970 Z92539 Mycobacterium tuberculosis H37Rv complete genome; segment 47/162. Mycobacterium 54,427 17-Jun-98 tuberculosis GB_HTG1: HSJ564F22 106277 AL080249 Homo sapiens chromosome 20 clone RP4-564F22, *** SEQUENCING Homo sapiens 44,000 23-Nov-99 IN PROGRESS ***, in unordered pieces. GB_HTG1: HSJ564F22 106277 AL080249 Homo sapiens chromosome 20 clone RP4-564F22, *** SEQUENCING Homo sapiens 44,000 23-Nov-99 IN PROGRESS ***, in unordered pieces. rxa00740 702 GB_PL2: AF100167 1557 AF100167 Glycine max unknown mRNA. Glycine max 35,823 4-Nov-98 GB_EST28: AI465702 268 AI465702 vw83g01.y1 Stratagene mouse skin (#937313) Mus musculus Mus musculus 43,226 09-MAR-1999 cDNA clone IMAGE: 1261584 5′, mRNA sequence. GB_EST20: AA856157 359 AA856157 vw83g01.r1 Stratagene mouse skin (#937313) Mus musculus Mus musculus 43,226 06-MAR-1998 cDNA clone IMAGE: 1261584 5′, mRNA sequence. rxa00741 1056 GB_HTG2: AC007185 199340 AC007185 Drosophila melanogaster chromosome 2 clone BACR44N04 Drosophila melanogaster 39,583 2-Aug-99 (D545) RPCI-98 44.N.4 map 36A-36A strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 50 unordered pieces. GB_HTG2: AC007185 199340 AC007185 Drosophila melanogaster chromosome 2 clone BACR44N04 (D545) Drosophila melanogaster 39,583 2-Aug-99 RPCI-98 44.N.4 map 36A-36A strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 50 unordered pieces. GB_PL2: F17123 134784 AF160182 Arabidopsis thaliana BAC F17I23. Arabidopsis thaliana 37,788 20-Jun-99 rxa00742 1773 GB_IN1: CEC05C10 26263 Z48178 Caenorhabditis elegans cosmid C05C10, complete sequence. Caenorhabditis elegans 39,243 2-Sep-99 GB_IN1: CEC05C10 26263 Z48178 Caenorhabditis elegans cosmid C05C10, complete sequence. Caenorhabditis elegans 38,041 2-Sep-99 rxa00743 546 GB_GSS9: AQ093649 320 AQ093649 HS_3022_A1_E06_MR CIT Approved Human Genomic Homo sapiens 34,277 27-Aug-98 Sperm Library D Homo sapiens genomic clone Plate = 3022 Col = 11 Row = I, genomic survey sequence. GB_GSS9: AQ093649 320 AQ093649 HS_3022_A1_E06_MR CIT Approved Human Genomic Homo sapiens 34,277 27-Aug-98 Sperm Library D Homo sapiens genomic clone Plate = 3022 Col = 11 Row = I, genomic survey sequence. rxa00745 657 GB_HTG2: AC008195 130309 AC008195 Drosophila melanogaster chromosome 3 clone BACR42I20 (D748) Drosophila melanogaster 38,095 2-Aug-99 RPCI-98 42.I.20 map 93F-93F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 77 unordered pieces. GB_IN2: DMU53190 3477 U53190 Drosophila melanogaster Camguk (cmg) mRNA, complete cds. Drosophila melanogaster 39,623 30-Nov-98 GB_HTG2: AC008195 130309 AC008195 Drosophila melanogaster chromosome 3 clone BACR42I20 (D748) RPCI-98 42.I.20 Drosophila melanogaster 38,095 2-Aug-99 map 93F-93F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 77 unordered pieces. rxa00746 1314 GB_HTG3: AC010076 148614 AC010076 Homo sapiens chromosome 15 clone BAC 64K10 map 14q25, LOW-PASS Homo sapiens 36,336 11-Sep-99 SEQUENCE SAMPLING. GB_HTG3: AC010076 148614 AC010076 Homo sapiens chromosome 15 clone BAC 64K10 map 14q25, LOW-PASS Homo sapiens 36,336 11-Sep-99 SEQUENCE SAMPLING. GB_PR3: HS402G11 177241 AL022328 Human DNA sequence from clone 402G11 on chromosome 22q13.31-13.33 Contains Homo sapiens 38,752 23-Nov-99 genes for SAPK3 (stress-activated protein kinase 3), PRKM11 (protein kinase mitogen-activated 11), KIAA0315, ESTs, GSSs and CpG islands, complete sequence. rxa00747 711 GB_HTG4: AC010081 176777 AC010081 Homo sapiens clone NH0065E07, *** SEQUENCING IN PROGRESS ***, Homo sapiens 37,016 29-OCT-1999 1 unordered pieces. GB_HTG4: AC010081 176777 AC010081 Homo sapiens clone NH0065E07, *** SEQUENCING IN PROGRESS ***, Homo sapiens 37,016 29-OCT-1999 1 unordered pieces. GB_HTG3: AC011194 196098 AC011194 Mus musculus chromosome 11 clone 196_F_5 map 11, *** SEQUENCING Mus musculus 38,735 01-OCT-1999 IN PROGRESS ***, 32 unordered pieces. rxa00748 567 GB_GSS13: AQ457887 478 AQ457887 HS_5189_B2_B06_SP6E RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 37,844 23-Apr-99 genomic clone Plate = 765 Col = 12 Row = D, genomic survey sequence. GB_IN1: EHEXRIDRI 170 X58630 E. histolytica extrachromosomal ribosomal DNA for DRA I repeat unit. Entamoeba histolytica 42,353 13-Aug-91 GB_IN1: EHEXRDNA 3699 X61182 E. histolytica extrachromosomal ribosomal DNA downstream of rRNA genes. Entamoeba histolytica 38,905 2-Sep-96 rxa00749 822 GB_BA1: BSUB0003 209100 Z99106 Bacillus subtilis complete genome (section 3 of 21): from 402751 to 611850. Bacillus subtilis 37,238 26-Nov-97 GB_BA1: AB001488 148068 AB001488 Bacillus subtilis genome sequence, 148 kb sequence of the region between Bacillus subtilis 37,238 13-Feb-99 35 and 47 degree. rxa00750 GB_HTG3: AC008060 161486 AC008060 Homo sapiens clone DJ0912I13, *** SEQUENCING IN PROGRESS ***, Homo sapiens 39,474 13-Aug-99 4 unordered pieces. rxa00751 951 GB_PR4: AC006449 286758 AC006449 Homo sapiens chromosome 17, clone Homo sapiens 38,223 23-OCT-1999 hCIT.58_E_17, complete sequence. GB_HTG2: AC002118 170891 AC002118 Homo sapiens chromosome 17 clone 303_E_14, Homo sapiens 37,112 13-Feb-98 *** SEQUENCING IN PROGRESS ***, 20 unordered pieces. GB_HTG2: AC002118 170891 AC002118 Homo sapiens chromosome 17 clone 303_E_14, Homo sapiens 37,112 13-Feb-98 *** SEQUENCING IN PROGRESS ***, 20 unordered pieces. rxa00752 552 GB_PL2: F5K24 109786 AF128395 Arabidopsis thaliana BAC F5K24. Arabidopsis thaliana 38,899 03-MAR-1999 GB_BA1: MBHRDED 6300 Y09870 M. barkeri hdrE & hdrD genes, ORF1, ORF2, ORF3 & ORF4. Methanosarcina barkeri 40,609 04-DEC-1998 GB_PL1: SC9920 23498 Z48639 S. cerevisiae chromosome XIII cosmid 9920. Saccharomyces cerevisiae 35,754 11-Aug-97 rxa00757 1377 GB_PAT: E13655 2260 E13655 gDNA encoding glucose-6-phosphate dehydrogenase. Corynebacterium 46,045 24-Jun-98 glutamicum GB_GSS9: AQ103710 369 AQ103710 HS_3092_B1_C01_MF CIT Approved Human Genomic Sperm Library D Homo sapiens 36,339 27-Aug-98 Homo sapiens genomic clone Plate = 3092 Col = 1 Row = F, genomic survey sequence. GB_HTG3: AC009305 167705 AC009305 Homo sapiens clone NH0153B21, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,691 13-Aug-99 3 unordered pieces. rxa00763 906 GB_BA1: SC7B7 13800 AL009199 Streptomyces coelicolor cosmid 7B7. Streptomyces coelicolor 39,013 02-DEC-1997 GB_HTG2: HSJ473J16 203460 AL109942 Homo sapiens chromosome 6 clone RP3-473J16 map q25.3-26, Homo sapiens 38,192 03-DEC-1999 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG2: HSJ473J16 203460 AL109942 Homo sapiens chromosome 6 clone RP3-473J16 map q25.3-26, Homo sapiens 38,192 03-DEC-1999 *** SEQUENCING IN PROGRESS ***, in unordered pieces. rxa00765 810 GB_BA1: MTV043 68848 AL022004 Mycobacterium tuberculosis H37Rv complete genome; segment 40/162. Mycobacterium 38,568 24-Jun-99 tuberculosis GB_BA2: PAU93274 8008 U93274 Pseudomonas aeruginosa YafE (yafE), LeuB (leuB), Asd (asd), FimV (fimV), and Pseudomonas aeruginosa 37,656 23-Jun-98 HisT (hisT) genes, complete cds; TrpF (trpF) gene, partial cds; and unknown gene. GB_BA1: MTCY31 37630 Z73101 Mycobacterium tuberculosis H37Rv complete genome; segment 41/162. Mycobacterium 38,209 17-Jun-98 tuberculosis rxa00768 1242 GB_HTG5: AC008194 194555 AC008194 Drosophila melanogaster chromosome X clone BACR49A05 (D745) Drosophila melanogaster 34,078 15-Nov-99 RPCI-98 49.A.5 map 18A-18A strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 90 unordered pieces. GB_HTG5: AC008194 194555 AC008194 Drosophila melanogaster chromosome X clone BACR49A05 (D745) RPCI-98 49.A.5 Drosophila melanogaster 31,194 15-Nov-99 map 18A-18A strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 90 unordered pieces. GB_BA2: AF044495 9599 AF044495 Agrobacterium tumefaciens chemotaxis operon, complete sequence. Agrobacterium tumefaciens 40,165 2-Jul-98 rxa00769 336 GB_PR3: AC003068 42184 AC003068 Human Cosmid g5129z059 from 7q31.3, complete sequence. Homo sapiens 35,152 6-Nov-97 GB_PR2: HSAC000374 41585 AC000374 Human cosmid g1980a170, complete sequence. Homo sapiens 35,152 12-MAR-1997 GB_PR3: AC003068 42184 AC003068 Human Cosmid g5129z059 from 7q31.3, complete sequence. Homo sapiens 37,309 6-Nov-97 rxa00771 942 GB_PR2: HS172K2 131234 Z84814 Human DNA sequence from PAC 172K2 on chromosome 6 contains HLA CLASS Homo sapiens 34,719 23-Nov-99 II DRA pseudogene, DRB3*01012 genes, DRB9 pseudogene butyrophilin precursor and ESTs. GB_HTG1: HSA555E18 1177 AL121780 Homo sapiens chromosome 20 clone RP11-555E18, Homo sapiens 41,450 23-Nov-99 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG1: HSA555E18 1177 AL121780 Homo sapiens chromosome 20 clone RP11-555E18, Homo sapiens 41,450 23-Nov-99 *** SEQUENCING IN PROGRESS ***, in unordered pieces. rxa00781 411 GB_PR3: HS48A11 129294 AL031132 Human DNA sequence from clone 48A11 on chromosome 20p12 Contains EST, Homo sapiens 37,284 23-Nov-99 STS, GSS, complete sequence. GB_IN1: CELC03B1 42297 U40952 Caenorhabditis elegans cosmid C03B1. Caenorhabditis elegans 38,177 25-Nov-95 GB_PR3: HS48A11 129294 AL031132 Human DNA sequence from clone 48A11 on chromosome 20p12 Contains EST, Homo sapiens 35,162 23-Nov-99 STS, GSS, complete sequence. rxa00785 680 GB_EST11: AA223451 349 AA223451 zr06d01.r1 Stratagene NT2 neuronal precursor 937230 Homo sapiens Homo sapiens 38,682 19-Feb-97 cDNA clone IMAGE: 650689 5′, mRNA sequence. GB_EST9: AA081255 446 AA081255 zn33d08.r1 Stratagene endothelial cell 937223 Homo sapiens cDNA clone IMAGE: Homo sapiens 40,271 21-OCT-1996 549231 5′, mRNA sequence. GB_EST9: C16722 314 C16722 C16722 Clontech human aorta polyA+ mRNA (#6572) Homo sapiens cDNA clone Homo sapiens 44,013 30-Sep-96 GEN-522C02 5′, mRNA sequence. rxa00788 348 GB_PL2: UMU62738 13812 U62738 Ustilago maydis ferrichrome siderophore peptide synthetase (sid2) gene, complete cds. Ustilago maydis 31,792 30-DEC-1997 GB_PR1: AB012723 40850 AB012723 Homo sapiens gene for kinesin-like protein, complete cds. Homo sapiens 35,398 8-Jan-99 GB_HTG3: AC008625 16830 AC008625 Homo sapiens chromosome 5 clone CIT978SKB_157D17, Homo sapiens 42,560 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 19 unordered pieces. rxa00795 651 GB_IN2: AC003120 59991 AC003120 Drosophila melanogaster DNA sequence (P1 DS01523 (D34)), complete sequence. Drosophila melanogaster 39,252 17-Jul-98 GB_EST19: AA802212 574 AA802212 GM04027.5prime GM Drosophila melanogaster ovary BlueScript Drosophila melanogaster 37,828 25-Nov-98 Drosophila melanogaster cDNA clone GM04027 5prime, mRNA sequence. GB_IN2: AF168467 4652 AF168467 Drosophila melanogaster dual specificity kinase DYRK2 mRNA, complete cds. Drosophila melanogaster 36,933 5-Aug-99 rxa00804 567 GB_GSS12: AQ356039 499 AQ356039 CITBI-E1-2535P11.TR CITBI-E1 Homo sapiens genomic clone 2535P11, Homo sapiens 40,569 24-Jan-99 genomic survey sequence. GB_PR4: AC005037 190508 AC005037 Homo sapiens clone NH0469M07, complete sequence. Homo sapiens 41,209 14-MAY-1999 GB_HTG5: AC007272 175463 AC007272 Homo sapiens clone NH0013J08, *** SEQUENCING IN PROGRESS ***, Homo sapiens 41,209 2-Nov-99 5 unordered pieces. rxa00805 1005 GB_GSS1: CNS00U61 320 AL090583 Arabidopsis thaliana genome survey sequence SP6 end of BAC T6D17 Arabidopsis thaliana 36,364 28-Jun-99 of TAMU library from strain Columbia of Arabidopsis thaliana, genomic survey sequence. GB_PL1: AB026639 63921 AB026639 Arabidopsis thaliana genomic DNA, chromosome 5, TAC clone: K21L13, Arabidopsis thaliana 38,485 07-MAY-1999 complete sequence. GB_PL1: AB026639 63921 AB026639 Arabidopsis thaliana genomic DNA, chromosome 5, TAC clone: K21L13, Arabidopsis thaliana 35,451 07-MAY-1999 complete sequence. rxa00808 1581 GB_BA1: MLCB2548 38916 AL023093 Mycobacterium leprae cosmid B2548. Mycobacterium leprae 50,854 27-Aug-99 GB_BA1: MLCL373 37304 AL035500 Mycobacterium leprae cosmid L373. Mycobacterium leprae 40,295 27-Aug-99 GB_PL2: SCE9781 68302 U18916 Saccharomyces cerevisiae chromosome V cosmids 9781, 8198, 9115, 9981, Saccharomyces cerevisiae 37,677 1-Aug-97 and lambda clones 3955 and 6052. rxa00812 1182 GB_HTG2: AC006003 114949 AC006003 Homo sapiens clone DJ0782K24, *** SEQUENCING IN PROGRESS ***, Homo sapiens 35,284 22-Nov-98 16 unordered pieces. GB_HTG2: AC006003 114949 AC006003 Homo sapiens clone DJ0782K24, *** SEQUENCING IN PROGRESS ***, Homo sapiens 35,284 22-Nov-98 16 unordered pieces. GB_GSS9: AQ090529 323 AQ090529 HS_3007_B1_E09_MR CIT Approved Human Genomic Homo sapiens 41,176 26-Aug-98 Sperm Library D Homo sapiens genomic clone Plate = 3007 Col = 17 Row = J, genomic survey sequence. rxa00814 897 GB_VI: EHVU20824 184427 U20824 Equine herpesvirus 2, complete genome. Equine herpesvirus 2 35,274 2-Feb-96 GB_VI: EHVU20824 184427 U20824 Equine herpesvirus 2, Equine herpesvirus 2 38,808 2-Feb-96 complete genome. GB_PR3: HS466N1 79528 Z97630 Human DNA sequence from clone 466N1 on chromosome 22q12-13 Contains Homo sapiens 38,496 23-Nov-99 H1F0(H1 histone family, member 0) gene, 2-amino-3-ketobutyrate-CoA ligase(nuclear gene encoding mitochondrial protein), GALR3 (galanin receptor) gene, ESTs, GSSs and CpG islands, complete sequence. rxa00815 696 GB_PR3: CNS01DRL 174928 AL117355 Human chromosome 14 DNA sequence *** IN PROGRESS *** BAC R-354E14 of Homo sapiens 36,578 26-Nov-99 RPCI-11 library from chromosome 14 of Homo sapiens (Human), complete sequence. GB_PR4: AC007283 127361 AC007283 Homo sapiens clone NH0536I18, complete sequence. Homo sapiens 37,609 28-Sep-99 GB_EST14: AA406984 477 AA406984 MBAFCZ7H08T3 Brugia malayi adult female cDNA (SAW96MLW-BmAF) Brugia malayi 41,919 01-MAY-1997 Brugia malayi cDNA clone AFCZ7H08 5′, mRNA sequence. rxa00816 420 GB_EST27: AI414036 467 AI414036 ma03e08.x1 Soares mouse p3NMF19.5 Mus musculus cDNA clone IMAGE: 303494 3′ Mus musculus 40,176 9-Feb-99 similar to TR: Q85299 Q85299 HOMOLOGUE OF RETROVIRAL PSEUDOPROTEASE.;, mRNA sequence. GB_GSS15: AQ642295 501 AQ642295 RPCI93-Dpnll-28G21.TV RPCI93-Dpnll Trypanosoma brucei genomic clone Trypanosoma brucei 37,540 8-Jul-99 RPCI93-Dpnll-28G21, genomic survey sequence. GB_PL2: ZMU82481 2750 U82481 Zea mays KI domain interacting kinase 1 (KIK1) mRNA, complete cds. Zea mays 41,783 1-Jan-98 rxa00826 654 GB_PR4: AC008179 181745 AC008179 Homo sapiens clone NH0576F01, complete sequence. Homo sapiens 35,736 28-Sep-99 GB_HTG1: AC002413 63369 AC002413 Homo sapiens chromosome X clone bWXD111, Homo sapiens 37,600 12-Aug-97 *** SEQUENCING IN PROGRESS ***, 2 unordered pieces. GB_HTG1: AC002413 63369 AC002413 Homo sapiens chromosome X clone bWXD111, Homo sapiens 37,600 12-Aug-97 *** SEQUENCING IN PROGRESS ***, 2 unordered pieces. rxa00830 846 GB_GSS6: AQ823465 535 AQ823465 HS_3217_A1_D08_T7C CIT Approved Homo sapiens 40,417 26-Aug-99 Human Genomic Sperm Library D Homo sapiens genomic clone Plate = 3217 Col = 15 Row = G, genomic survey sequence. GB_GSS6: AQ825402 381 AQ825402 HS_5498_A1_G01_SP6E RPCI-11 Human Male BAC Homo sapiens 43,068 26-Aug-99 Library Homo sapiens genomic clone Plate = 1074 Col = 1 Row = M, genomic survey sequence. GB_HTG1: HSU242F8 92944 AL022167 Homo sapiens chromosome X clone LL0XNC01-242F8, Homo sapiens 38,321 23-Nov-99 *** SEQUENCING IN PROGRESS ***, in unordered pieces. rxa00831 rxa00835 1077 GB_EST35: AI864917 468 AI864917 wj66f11.x1 NCI_CGAP_Lu19 Homo sapiens cDNA clone IMAGE: 2407821 3′ Homo sapiens 37,607 30-Aug-99 similar to WP: F01F1.9 CE01235 VACUOLAR AMINOPEPTIDASE;, mRNA sequence. GB_EST35: AI864917 468 AI864917 wj66f11.x1 NCI_CGAP_Lu19 Homo sapiens cDNA clone IMAGE: Homo sapiens 38,444 30-Aug-99 2407821 3′ similar to WP: F01F1.9 CE01235 VACUOLAR AMINOPEPTIDASE;, mRNA sequence. rxa00836 1816 GB_EST11: AA212728 424 AA212728 mw81g02.r1 Soares mouse NML Mus musculus cDNA clone IMAGE: 677138 5′, Mus musculus 40,284 18-Feb-97 mRNA sequence. GB_EST26: AI390258 557 AI390258 mw81g02.y1 Soares mouse NML Mus musculus cDNA clone IMAGE: 677138 5′, Mus musculus 41,261 2-Feb-99 mRNA sequence. GB_PR3: AC003669 159446 AC003669 Homo sapiens Xp22 BAC GS-594A7 (Genome Systems Human BAC library) contains Homo sapiens 34,914 24-MAR-1998 Bmx gene, complete sequence. rxa00840 rxa00841 rxa00846 993 GB_BA1: U00017 42157 U00017 Mycobacterium leprae cosmid B2126. Mycobacterium leprae 35,635 01-MAR-1994 GB_BA1: MLCB2533 40245 AL035310 Mycobacterium leprae cosmid B2533. Mycobacterium leprae 38,280 27-Aug-99 GB_RO: AB022047S7 18721 AB022053 Mus musculus gene for prolyl oligopeptidase, exon 11, 12, 13, 14, 15 and Mus musculus 36,633 20-Aug-99 complete cds. rxa00853 726 GB_PR3: HS531H16 155116 AL031664 Human DNA sequence *** SEQUENCING IN PROGRESS *** from clone 531H16, Homo sapiens 41,110 23-Nov-99 complete sequence. GB_PR3: HS531H16 155116 AL031664 Human DNA sequence *** SEQUENCING IN PROGRESS *** from clone 531H16, Homo sapiens 37,343 23-Nov-99 complete sequence. GB_HTG3: AC010264 81671 AC010264 Homo sapiens chromosome 5 clone CIT-HSPC_468K18, Homo sapiens 38,776 15-Sep-99 *** SEQUENCING IN PROGRESS ***, 66 unordered pieces. rxa00854 336 GB_IN1: CELM04G7 41778 AF036700 Caenorhabditis elegans cosmid M04G7. Caenorhabditis elegans 37,349 05-DEC-1997 GB_EST20: AA850405 451 AA850405 EST193172 Normalized rat ovary, Bento Soares Rattus sp. cDNA clone ROVAF27 Rattus sp. 40,789 30-Apr-98 3′ end, mRNA sequence. GB_HTG2: AF165144 110891 AF165144 Homo sapiens chromosome 8 clone BAC 393A07 map 8q, *** SEQUENCING IN Homo sapiens 34,234 16-Jul-99 PROGRESS ***, in ordered pieces. rxa00855 408 GB_HTG2: AC007173 140775 AC007173 Drosophila melanogaster chromosome 2 clone BACR01A03 (D538) Drosophila melanogaster 36,341 2-Aug-99 RPCI-98 01.A.3 map 36E-36E strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 36 unordered pieces. GB_HTG2: AC007173 140775 AC007173 Drosophila melanogaster chromosome 2 clone BACR01A03 (D538) RPCI-98 Drosophila melanogaster 36,341 2-Aug-99 01.A.3 map 36E-36E strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 36 unordered pieces. GB_PL2: YSCH8179 44113 U00062 Saccharomyces cerevisiae chromosome VIII cosmid 8179. Saccharomyces cerevisiae 38,560 4-Sep-97 rxa00861 426 GB_BA1: CGORF4GEN 2398 X95649 C. glutamicum ORF4 gene. Corynebacterium 100,000 10-MAR-1998 glutamicum GB_BA1: SC9A10 9000 AL031260 Streptomyces coelicolor cosmid 9A10. Streptomyces coelicolor 63,830 11-Aug-98 GB_BA2: AF039028 2475 AF039028 Streptomyces toyocaensis D-ala-D-ala dipeptidase (vanXst) gene, complete cds; Streptomyces toyocaensis 61,939 5-Jan-99 and unknown gene. rxa00862 682 GB_PAT: E14520 2001 E14520 DNA encoding Brevibacterium dihydrodipicolinic acid synthase. Corynebacterium 36,154 28-Jul-99 glutamicum GB_PAT: E12773 2001 E12773 DNA encoding Brevibacterium dihydrodipicolinic acid reductase. Corynebacterium 36,154 24-Jun-98 glutamicum GB_PAT: E16749 2001 E16749 gDNA encoding dihydrodipicolinate synthase (DDPS). Corynebacterium 36,154 28-Jul-99 glutamicum rxa00869 1044 GB_EST24: AI166579 645 AI166579 xylem.est.398 Poplar xylem Lambda ZAPII library Populus balsamifera Populus balsamifera 39,854 03-DEC-1998 subsp. trichocarpa cDNA 5′, mRNA sequence. subsp. trichocarpa GB_BA1: MTCY06H11 38000 Z85982 Mycobacterium tuberculosis H37Rv complete genome; segment 73/162. Mycobacterium 42,801 17-Jun-98 tuberculosis GB_EST34: AV153098 283 AV153098 AV153098 Mus musculus hippocampus C57BL/6J adult Mus musculus cDNA Mus musculus 39,576 7-Jul-99 clone 2900052L10, mRNA sequence. rxa00874 1212 GB_HTG2: AC007885 108561 AC007885 Drosophila melanogaster chromosome 2 clone BACR02G15 (D643) Drosophila melanogaster 38,276 2-Aug-99 RPCI-98 02.G.15 map 60F-60F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 65 unordered pieces. GB_HTG2: AC007582 127205 AC007582 Drosophila melanogaster chromosome 2 clone BACR17E16 (D642) RPCI-98 Drosophila melanogaster 36,246 2-Aug-99 17.E.16 map 60F-60F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 81 unordered pieces. GB_HTG2: AC007885 108561 AC007885 Drosophila melanogaster chromosome 2 clone BACR02G15 (D643) RPCI-98 Drosophila melanogaster 38,276 2-Aug-99 02.G.15 map 60F-60F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 65 unordered pieces. rxa00876 1878 GB_EST10: AA144736 479 AA144736 mr72d08.r1 Stratagene mouse testis (#937308) Mus musculus Mus musculus 41,474 11-Feb-97 cDNA clone IMAGE: 602991 5′, mRNA sequence. GB_EST32: AU069076 316 AU069076 AU069076 Rice callus Oryza sativa cDNA clone C51993_1A, mRNA sequence. Oryza sativa 46,330 7-Jun-99 GB_EST10: AA144736 479 AA144736 mr72d08.r1 Stratagene mouse testis (#937308) Mus musculus cDNA clone Mus musculus 43,243 11-Feb-97 IMAGE: 602991 5′, mRNA sequence. rxa00881 501 GB_HTG4: AC010103 192320 AC010103 Homo sapiens chromosome unknown clone Homo sapiens 36,620 29-OCT-1999 NH0508H21, WORKING DRAFT SEQUENCE, in unordered pieces. GB_HTG4: AC010103 192320 AC010103 Homo sapiens chromosome unknown clone NH0508H21, Homo sapiens 36,620 29-OCT-1999 WORKING DRAFT SEQUENCE, in unordered pieces. GB_HTG4: AC010103 192320 AC010103 Homo sapiens chromosome unknown clone NH0508H21, Homo sapiens 34,280 29-OCT-1999 WORKING DRAFT SEQUENCE, in unordered pieces. rxa00882 801 GB_BA1: MTCY48 35377 Z74020 Mycobacterium tuberculosis H37Rv complete genome; segment 69/162. Mycobacterium 37,927 17-Jun-98 tuberculosis GB_PAT: AR005211 3453 AR005211 Sequence 1 from patent U.S. Pat. No. 5747651. Unknown. 39,620 04-DEC-1998 GB_PAT: I40600 3453 I40600 Sequence 1 from patent U.S. Pat. No. 5621090. Unknown. 39,620 13-MAY-1997 rxa00883 642 GB_PR2: HS217O16 87552 AL031771 Human DNA sequence from clone 217O16 on chromosome 6q24 Contains GSS, Homo sapiens 33,866 23-Nov-99 complete sequence. GB_PR2: HS217O16 87552 AL031771 Human DNA sequence from clone 217O16 on chromosome 6q24 Contains GSS, Homo sapiens 35,479 23-Nov-99 complete sequence. rxa00887 rxa00889 711 GB_BA1: MTCY27 27548 Z95208 Mycobacterium tuberculosis H37Rv complete genome; segment 104/162. Mycobacterium 36,978 17-Jun-98 tuberculosis GB_BA1: U00016 42931 U00016 Mycobacterium leprae cosmid B1937. Mycobacterium leprae 55,651 01-MAR-1994 GB_PR4: AC007326 102898 AC007326 Homo sapiens, complete sequence. Homo sapiens 40,205 2-Nov-99 rxa00893 720 GB_PL1: HVCPMII 6225 Y09602 H. vulgare gene encoding serine carboxypeptidase II, CP-MII. Hordeum vulgare 35,704 10-MAR-1997 GB_EST35: AI814621 441 AI814621 wj75d04.x1 NCI_CGAP_Lu19 Homo sapiens cDNA clone IMAGE: Homo sapiens 37,788 24-Aug-99 2408647 3′ similar to TR: O00578 O00578 KIAA0167. [1];, mRNA sequence. GB_EST3: R51723 376 R51723 yg77h06.r1 Soares infant brain 1NIB Homo sapiens cDNA clone IMAGE: Homo sapiens 41,489 18-MAY-1995 39671 5′ similar to gb: M77016 TROPOMODULIN (HUMAN);, mRNA sequence. rxa00895 714 GB_HTG3: AC009414 188673 AC009414 Homo sapiens clone NH0490M08, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,775 17-Sep-99 5 unordered pieces. GB_HTG3: AC009414 188673 AC009414 Homo sapiens clone NH0490M08, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,775 17-Sep-99 5 unordered pieces. GB_PR3: HSJ824F16 139330 AL050325 Human DNA sequence from clone 824F16 on chromosome 20, complete sequence. Homo sapiens 37,286 23-Nov-99 rxa00904 815 GB_HTG5: AC006447 141662 AC006447 Mus musculus, *** SEQUENCING IN PROGRESS ***, 2 unordered pieces. Mus musculus 35,945 17-Nov-99 GB_HTG5: AC011064 233428 AC011064 Drosophila melanogaster chromosome X clone BACN05G06 (D1107) Drosophila melanogaster 37,783 16-Nov-99 RPCI-98 05.G.6 map 12F-13A strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 220 unordered pieces. GB_HTG6: AC008334 154566 AC008334 Drosophila melanogaster chromosome X clone BACR08K05 (D885) RPCI-98 Drosophila melanogaster 37,783 02-DEC-1999 08.K.5 map 12F-12F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 84 unordered pieces. rxa00908 681 GB_GSS12: AQ409791 561 AQ409791 HS_5090_B2_B12_T7A RPCI-11 Homo sapiens 39,711 17-MAR-1999 Human Male BAC Library Homo sapiens genomic clone Plate = 666 Col = 24 Row = D, genomic survey sequence. GB_GSS3: B83773 535 B83773 CpG0110A CpIOWAgDNA1 Cryptosporidium parvum genomic, genomic Cryptosporidium parvum 44,615 06-MAY-1999 survey sequence. GB_GSS12: AQ409791 561 AQ409791 HS_5090_B2_B12_T7A RPCI-11 Human Male BAC Homo sapiens 41,333 17-MAR-1999 Library Homo sapiens genomic clone Plate = 666 Col = 24 Row = D, genomic survey sequence. rxa00915 753 GB_HTG2: HS1118M15 190466 AL109964 Homo sapiens chromosome 20 clone RP5-1118M15, Homo sapiens 40,027 30-Nov-99 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG2: HS1057B20 204291 AL109823 Homo sapiens chromosome 20 clone RP5-1057B20 map q11.21-12, Homo sapiens 38,535 30-Nov-99 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG2: HS1118M15 190466 AL109964 Homo sapiens chromosome 20 clone RP5-1118M15, Homo sapiens 40,027 30-Nov-99 *** SEQUENCING IN PROGRESS ***, in unordered pieces. rxa00916 3714 GB_EST28: AI543268 568 AI543268 SD09973.5prime SD Drosophila melanogaster Schneider L2 cell Drosophila melanogaster 40,426 22-MAR-1999 culture pOT2 Drosophila melanogaster cDNA clone SD09973 5prime, mRNA sequence. GB_IN2: AC004301 68620 AC004301 Drosophila melanogaster DNA sequence (P1 DS07134 (D192)), complete sequence. Drosophila melanogaster 37,696 29-MAY-1998 GB_EST37: AI994315 524 AI994315 701502677 A. thaliana, Ohio State clone set Arabidopsis thaliana cDNA Arabidopsis thaliana 40,076 8-Sep-99 clone 701502677, mRNA sequence. rxa00917 2802 GB_BA1: SYCSLRB 146271 D64000 Synechocystis sp. PCC6803 complete genome, 19/27, 2392729-2538999. Synechocystis sp. 38,447 13-Feb-99 GB_HTG1: CEY39E4_2 110000 Z94158 Caenorhabditis elegans chromosome III clone Y39E4, Caenorhabditis elegans 38,218 Z94158 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG1: CEY39E4_2 110000 Z94158 Caenorhabditis elegans chromosome III clone Y39E4, Caenorhabditis elegans 38,218 Z94158 *** SEQUENCING IN PROGRESS ***, in unordered pieces. rxa00921 rxa00926 486 GB_OM: SSU75316 5996 U75316 Sus scrofa beta-myosin heavy chain mRNA, complete cds. Sus scrofa 38,958 03-DEC-1996 GB_EST21: AA970971 371 AA970971 op10b11.s1 NCI_CGAP_Kid6 Homo sapiens cDNA clone IMAGE: Homo sapiens 40,841 13-Apr-99 1575261 3′, mRNA sequence. GB_OM: SSU75316 5996 U75316 Sus scrofa beta-myosin heavy chain mRNA, complete cds. Sus scrofa 38,578 03-DEC-1996 rxa00930 876 GB_BA1: MTCI270A 1670 Z98045 Mycobacterium tuberculosis H37Rv complete genome; segment 116/162. Mycobacterium 37,927 17-Jun-98 tuberculosis GB_BA1: U00011 40429 U00011 Mycobacterium leprae cosmid B1177. Mycobacterium leprae 38,623 01-MAR-1994 GB_RO: S58745 817 S58745 thyrotroph embryonic factor = leucine zipper transcription factor [rats, pituitary, Rattus sp. 41,483 07-MAY-1993 mRNA, 817 nt]. rxa00932 597 GB_PR4: AC009509 192690 AC009509 Homo sapiens 12p11-37.2-54.4 BAC RP11-1060J15 (Roswell Homo sapiens 38,776 01-DEC-1999 Park Cancer Institute Human BAC Library) complete sequence. GB_PR3: AC004072 170658 AC004072 Human Chromosome X clone bWXD342, complete sequence. Homo sapiens 35,000 08-MAR-1998 GB_PR4: AC004617 176552 AC004617 Homo sapiens chromosome Y, clone 264, M, 20, complete sequence. Homo sapiens 35,702 13-OCT-1999 rxa00933 585 GB PL1: MGNGAGPOLI 5638 L35053 Transposon MAGGY gag and pol gene homologues, partial cds's. Magnaporthe grisea 40,283 4-Aug-94 GB PL1: MGNGAGPOLI 5638 L35053 Transposon MAGGY gag and pol gene homologues, partial cds's. Magnaporthe grisea 37,739 4-Aug-94 rxa00940 519 GB_PR2: HS179N16 172048 Z95152 Homo sapiens DNA sequence from PAC 179N16 on chromosome Homo sapiens 38,252 23-Nov-99 6p21.1-21.33. Contains the SAPK4 (MAPK p38delta) gene, and the alternatively spliced SAPK2 gene coding for CSaids binding protein CSBP2 and a MAPK p38beta LIKE protein. Contains ESTs, STSs and two predicted CpG islands, complete sequence. GB_EST26: AU001018 304 AU001018 AU001018 Bombyx mori p50(Daizo) Bombyx mori cDNA clone fbf0932f, Bombyx mori 45,745 15-Jan-99 mRNA sequence. GB_EST26: AU001019 304 AU001019 AU001019 Bombyx mori p50(Daizo) Bombyx mori cDNA clone fbf0934f, Bombyx mori 45,745 15-Jan-99 mRNA sequence. rxa00943 1035 GB_BA2: AF079317 184457 AF079317 Sphingomonas aromaticivorans plasmid pNL1, complete plasmid sequence. Sphingomonas 38,151 12-Jan-99 aromaticivorans GB_HTG3: AC008329 114408 AC008329 Drosophila melanogaster chromosome 2 clone BACR31D05 (D861) RPCI-98 Drosophila melanogaster 34,317 17-Aug-99 31.D.5 map 28C-28D strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 105 unordered pieces. GB_HTG3: AC008329 114408 AC008329 Drosophila melanogaster chromosome 2 clone BACR31D05 (D861) RPCI-98 Drosophila melanogaster 34,317 17-Aug-99 31.D.5 map 28C-28D strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 105 unordered pieces. rxa00946 897 GB_BA1: MTV008 63033 AL021246 Mycobacterium tuberculosis H37Rv complete genome; segment 108/162. Mycobacterium 36,045 17-Jun-98 tuberculosis GB_GSS14: AQ571765 526 AQ571765 HS_2094_A2_B09_MR CIT Approved Human Genomic Sperm Library D Homo sapiens 38,021 1-Jun-99 Homo sapiens genomic clone Plate = 2094 Col = 18 Row = C, genomic survey sequence. GB_RO: RRFE65G 2464 X60468 R. rattus FE65 gene for adaptor protein interacting with the beta-amyloid Rattus rattus 38,417 1-Feb-96 precursor protein intracellular domain. rxa00949 771 GB_VI: PPCCGAAA 5366 M26281 Hamster papovavirus complete genome. Hamster papovavirus 36,579 22-MAY-1995 GB_VI: HAPVXX 5366 X02449 Hamster Papovavirus (HapV) genome. Hamster papovavirus 36,579 22-OCT-1999 GB_BA2: AE000878 15432 AE000878 Methanobacterium thermoautotrophicum from bases 976801 to 992232 Methanobacterium 36,856 15-Nov-97 (section 84 of 148) of the complete genome. thermoautotrophicum rxa00959 579 GB_BA1: CGMTRAR 951 X75083 C. glutamicum mtrA gene locus with 5-methyltryptophan resistance. Corynebacterium 99,133 18-Aug-94 glutamicum GB_BA1: CGMTRA 587 X75084 C. glutamicum sequence corresponding to mtrA locus. Corynebacterium 99,216 18-Aug-94 glutamicum GB_BA1: BLTRP 7725 X04960 Brevibacterium lactofermentum tryptophan operon. Corynebacterium 96,800 10-Feb-99 glutamicum rxa00963 960 GB_EST15: AA484511 504 AA484511 nf08f07.s1 NCI_CGAP_Li1 Homo sapiens cDNA Homo sapiens 43,750 18-Aug-97 clone IMAGE: 913189 similar to gb: Y00764 UBIQUINOL-CYTOCHROME C REDUCTASE 11 KD PROTEIN (HUMAN);, mRNA sequence. GB_EST20: AA894481 544 AA894481 nw76b10.s1 NCI_CGAP_Pr12 Homo sapiens cDNA clone IMAGE: Homo sapiens 37,500 6-Apr-98 1252507 similar to gb: Y00764 UBIQUINOL-CYTOCHROME C REDUCTASE 11 KD PROTEIN (HUMAN);, mRNA sequence. GB_EST15: AA526497 582 AA526497 ni96d07.s1 NCI_CGAP_Pr21 Homo sapiens cDNA clone IMAGE: Homo sapiens 38,554 5-Aug-97 984685 3′ similar to gb: Y00764 UBIQUINOL-CYTOCHROME C REDUCTASE 11 KD PROTEIN (HUMAN);, mRNA sequence. rxa00969 1458 GB_BA1: CGHOMTHR 3685 Y00546 Corynebacterium glutamicum hom-thrB genes for homoserine Corynebacterium 99,588 12-Sep-93 dehydrogenase and homoserine kinase. glutamicum GB_PAT: I09077 3685 I09077 Sequence 1 from Patent WO 8809819. Unknown. 99,246 02-DEC-1994 GB_BA1: BLTHRA 1483 Y00476 B. lactofermentum thr A gene. Corynebacterium 99,378 05-MAY-1993 glutamicum rxa00971 341 GB_BA1: CGHOMTHR 3685 Y00546 Corynebacterium glutamicum hom-thrB genes for homoserine dehydrogenase Corynebacterium 35,435 12-Sep-93 and homoserine kinase. glutamicum GB_PAT: I09077 3685 I09077 Sequence 1 from Patent WO 8809819. Unknown. 35,435 02-DEC-1994 GB_BA1: BLTHRB 1139 Y00140 Brevibacterium lactofermentum thrB gene for homoserine kinase. Corynebacterium 40,964 12-Sep-93 glutamicum rxa00973 726 GB_BA1: CGHOMTHR 3685 Y00546 Corynebacterium glutamicum hom-thrB genes for homoserine Corynebacterium 41,797 12-Sep-93 dehydrogenase and homoserine kinase. glutamicum GB_PAT: I09077 3685 I09077 Sequence 1 from Patent WO 8809819. Unknown. 41,797 02-DEC-1994 GB_IN2: AC006574 127035 AC006574 Drosophila melanogaster, chromosome 2R, region 39A3-39B1, P1 clones DS02919 Drosophila melanogaster 37,355 16-Feb-99 and DS05130, complete sequence. rxa00978 738 GB_PR2: HSAC000372 41730 AC000372 Human cosmid g1980a186, complete sequence. Homo sapiens 34,674 12-MAR-1997 GB_PR3: AC005503 40998 AC005503 Homo sapiens clone UWGC: g5129s003 from 7q31, complete sequence. Homo sapiens 34,674 20-Aug-98 GB_PR2: HSAC000372 41730 AC000372 Human cosmid g1980a186, complete sequence. Homo sapiens 38,881 12-MAR-1997 rxa00986 465 GB_GSS10: AQ258013 761 AQ258013 nbxb0019H05f CUGI Rice BAC Library Oryza sativa genomic clone Oryza sativa 31,533 23-OCT-1998 nbxb0019H05f, genomic survey sequence. GB_PR3: HS83L6 61187 Z99130 Human DNA sequence from PAC 83L6 on chromosome Xp11.1-11.22. Homo sapiens 38,395 23-Nov-99 Contains ZXDA (ZFPA) zinc finger gene, ESTs and STSs, complete sequence. GB_PR3: HS598A24 96558 AL031115 Human DNA sequence from clone 598A24 on chromosome Xp11.1-11.23 Homo sapiens 37,333 23-Nov-99 Contains zinc finger X-linked proteins ZXDA, ZXDB, ESTs and STS, complete sequence. rxa00987 588 GB_HTG1: HS24A17 2000 AL035452 Homo sapiens chromosome X clone RP6-24A17, Homo sapiens 38,821 23-Nov-99 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG1: HS24A17 2000 AL035452 Homo sapiens chromosome X clone RP6-24A17, Homo sapiens 38,821 23-Nov-99 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_PR2: HS1156N12 146360 AL009047 Human DNA sequence from clone 1156N12 on chromosome X. Homo sapiens 38,821 23-Nov-99 Contains an STS and GSSs, complete sequence. rxa00988 546 GB_IN1: CELZC328 30350 AF000194 Caenorhabditis elegans cosmid ZC328. Caenorhabditis elegans 36,122 23-Apr-97 GB_IN1: CELZC328 30350 AF000194 Caenorhabditis elegans cosmid ZC328. Caenorhabditis elegans 37,959 23-Apr-97 rxa01005 969 GB_BA1: FVBPOAD2A 45519 D26094 Flavobacterium sp. plasmid pOAD2 DNA, whole sequence. Flavobacterium sp. 37,998 6-Feb-99 GB_GSS1: CNS00UGV 472 AL090973 Arabidopsis thaliana genome survey sequence SP6 end of BAC T6P9 of TAMU Arabidopsis thaliana 39,024 28-Jun-99 library from strain Columbia of Arabidopsis thaliana, genomic survey sequence. GB_GSS1: CNS00S69 512 AL087999 Arabidopsis thaliana genome survey sequence SP6 end of BAC T1C4 of TAMU Arabidopsis thaliana 35,938 28-Jun-99 library from strain Columbia of Arabidopsis thaliana, genomic survey sequence. rxa01007 rxa01008 rxa01011 1356 GB_EST38: AW039107 598 AW039107 EST281080 tomato mixed elicitor, BTI Lycopersicon esculentum cDNA Lycopersicon esculentum 39,724 18-OCT-1999 clone cLET12F19, mRNA sequence. GB_BA1: MTY13E12 43401 Z95390 Mycobacterium tuberculosis H37Rv complete genome; segment 147/162. Mycobacterium 38,618 17-Jun-98 tuberculosis GB_BA1: MBU15140 2136 U15140 Mycobacterium bovis ribosomal proteins IF-1 (infA), L36 (rpmJ), S13 (rpsM) and Mycobacterium bovis 37,070 28-OCT-1996 S11 (rpsK) genes, complete cds, and S4 (rpsD) gene, partial cds. rxa01016 771 GB_BA1: CGBPHI16 962 Y12472 C. glutamicum DNA, attachment site bacteriophage Phi-16. Corynebacterium 45,098 05-MAR-1999 glutamicum GB_BA1: CGBPHI16 962 Y12472 C. glutamicum DNA, attachment site bacteriophage Phi-16. Corynebacterium 37,251 05-MAR-1999 glutamicum rxa01017 732 GB_BA1: CGBPHI16 962 Y12472 C. glutamicum DNA, attachment site bacteriophage Phi-16. Corynebacterium 39,245 05-MAR-1999 glutamicum GB_BA2: AF099014 2500 AF099014 Streptomyces coelicolor strain A3(2) transposase (tnpA) and Fe-containing Streptomyces coelicolor 38,036 1-Jun-99 superoxide dismutase I (sodF1) genes, complete cds. GB_HTG3: AC009249 119461 AC009249 Drosophila melanogaster chromosome 3 clone BACR02M06 (D1003) Drosophila 37,853 27-Aug-99 RPCI-98 02.M.6 map 98B-98B strain y; cn bw sp, *** melanogaster SEQUENCING IN PROGRESS ***, 97 unordered pieces. rxa01021 622 GB_BA2: U39718 8603 U39718 Mycoplasma genitalium section 40 of 51 of the complete genome. Mycoplasma genitalium 39,348 5-Nov-98 GB_GSS3: B46221 457 B46221 HS-1063-A2-D06-MR.abi CIT Human Genomic Sperm Library C Homo sapiens 39,933 21-OCT-1997 Homo sapiens genomic clone Plate = CT 796 Col = 12 Row = G, genomic survey sequence. GB_OV: AF035529 848 AF035529 Xenopus laevis Smad6 mRNA, partial cds. Xenopus laevis 37,203 1-Jan-98 rxa01023 1101 GB_HTG2: HSJ435K13 151301 AL109941 Homo sapiens chromosome 6 clone RP3-435K13 map q14.1-16.1, Homo sapiens 34,405 03-DEC-1999 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG2: HSJ435K13 151301 AL109941 Homo sapiens chromosome 6 clone RP3-435K13 map q14.1-16.1, Homo sapiens 34,405 03-DEC-1999 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_BA1: RCU57682 86896 U57682 Rhodobacter capsulatus cosmids 143-147, complete sequence. Rhodobacter capsulatus 39,022 7-Feb-97 rxa01028 2172 GB_IN1: CBU55260 2518 U55260 Caenorhabditis briggsae beta tubulin (mec-7) gene, complete cds. Caenorhabditis briggsae 39,467 5-Jun-96 GB_HTG1: CEY1A5 196643 AL008872 Caenorhabditis elegans chromosome III clone Y1A5, Caenorhabditis elegans 38,168 9-Nov-97 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG1: CEY1A5 196643 AL008872 Caenorhabditis elegans chromosome III clone Y1A5, Caenorhabditis elegans 38,168 9-Nov-97 *** SEQUENCING IN PROGRESS ***, in unordered pieces. rxa01029 612 GB_PR3: HS466P17 149963 AL023806 Human DNA sequence from clone 466P17 on chromosome 6q24. Contains a Homo sapiens 38,330 23-Nov-99 putative novel gene, the 5′ part of the EPM2A (Laforin) gene, ESTs, STSs, GSSs, genomic marker D6S1703 and D6S1443, a putative CpG island and a ca repeat polymorphism, complete sequence. GB_PR3: HS466P17 149963 AL023806 Human DNA sequence from clone 466P17 on chromosome 6q24. Contains Homo sapiens 39,262 23-Nov-99 a putative novel gene, the 5′ part of the EPM2A (Laforin) gene, ESTs. STSs, GSSs, genomic marker D6S1703 and D6S1443, a putative CpG island and a ca repeat polymorphism, complete sequence. GB_RO: D78344 59641 D78344 Mouse DNA for Ig gamma-chains, partial cds. Mus musculus 35,472 5-Feb-99 rxa01031 789 GB_PR4: AC006948 168558 AC006948 Homo sapiens chromosome 17, clone hRPK.334_M_10, complete sequence. Homo sapiens 44,005 27-Apr-99 GB_PL2: AC011665 101845 AC011665 Arabidopsis thaliana chromosome I BAC T6L1 genomic sequence, Arabidopsis thaliana 38,170 11-Nov-99 complete sequence. GB_RO: MMU19724 5523 U19724 Mus musculus MMTV integration locus, aromatase gene, 3′UTR. Mus musculus 35,256 17-Feb-96 rxa01032 498 GB_EST9: AA118349 576 AA118349 ml56b06.r1 Stratagene mouse testis (#937308) Mus musculus cDNA clone IMAGE: Mus musculus 43,056 19-Nov-96 515987 5′ similar to gb: L04852 Mouse (MOUSE);, mRNA sequence. GB_EST9: AA118349 576 AA118349 ml56b06.r1 Stratagene mouse testis (#937308)Mus musculus cDNA clone IMAGE: Mus musculus 42,273 19-Nov-96 515987 5′ similar to gb: L04852 Mouse (MOUSE);, mRNA sequence. rxa01033 459 GB_GSS13: AQ434868 520 AQ434868 HS_5117_B1_D07_SP6E RPCI-11 Human Male BAC Library Homo sapiens 38,608 31-MAR-1999 Homo sapiens genomic clone Plate = 693 Col = 13 Row = H, genomic survey sequence. GB_HTG2: HSDJ794I6 137124 AL109976 Homo sapiens chromosome 20 clone RP4-794I6, Homo sapiens 28,929 27-Nov-99 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG2: HSDJ794I6 137124 AL109976 Homo sapiens chromosome 20 clone RP4-794I6, Homo sapiens 28,929 27-Nov-99 *** SEQUENCING IN PROGRESS ***, in unordered pieces. rxa01034 477 GB_PL2: ATT29H11 87011 AL049659 Arabidopsis thaliana DNA chromosome 3, BAC clone T29H11. Arabidopsis thaliana 32,495 9-Jun-99 GB_PL2: ATT29H11 87011 AL049659 Arabidopsis thaliana DNA chromosome 3, BAC clone T29H11. Arabidopsis thaliana 40,042 9-Jun-99 GB_EST25: AU045739 436 AU045739 AU045739 Mouse sixteen-cell-embryo cDNA Mus musculus cDNA clone Mus musculus 35,435 09-DEC-1998 J0940F02 3′, mRNA sequence. rxa01035 729 GB_GSS1: CNS00QD8 526 AL085658 Arabidopsis thaliana genome survey sequence SP6 end of BAC F11C22 Arabidopsis thaliana 36,466 28-Jun-99 of IGF library from strain Columbia of Arabidopsis thaliana, genomic survey sequence. GB_GSS13: AQ447948 515 AQ447948 mgxb0015A01r CUGI Rice Blast BAC Library Magnaporthe Magnaporthe grisea 45,833 8-Apr-99 grisea genomic clone mgxb0015A01r, genomic survey sequence. GB_GSS1: CNS00QD8 526 AL085658 Arabidopsis thaliana genome survey sequence SP6 end of BAC F11C22 of Arabidopsis thaliana 37,500 28-Jun-99 IGF library from strain Columbia of Arabidopsis thaliana, genomic survey sequence. rxa01036 576 GB_HTG2: AC004846 143577 AC004846 Homo sapiens clone DJ0647C14, *** SEQUENCING IN PROGRESS ***, Homo sapiens 38,137 12-Jun-98 21 unordered pieces. GB_EST19: AA804532 427 AA804532 ns28c05.s1 NCI_CGAP_GCB1 Homo sapiens cDNA clone IMAGE: 1184936 Homo sapiens 33,582 18-Feb-98 3′ similar to contains element MER40 repetitive element;, mRNA sequence. GB_HTG2: AC006342 201618 AC006342 Homo sapiens clone DJ0054D12, *** SEQUENCING IN PROGRESS ***, Homo sapiens 38,137 11-Jan-99 3 unordered pieces. rxa01037 651 GB_PR4: AC004812 138532 AC004812 Homo sapiens PAC clone 267D11 from 12, complete sequence. Homo sapiens 39,750 05-DEC-1998 GB_HTG2: AC006342 201618 AC006342 Homo sapiens clone DJ0054D12, *** SEQUENCING IN PROGRESS ***, Homo sapiens 41,214 11-Jan-99 3 unordered pieces. GB_HTG2: AC004846 143577 AC004846 Homo sapiens clone DJ0647C14, *** SEQUENCING IN PROGRESS ***, Homo sapiens 41,214 12-Jun-98 21 unordered pieces. rxa01038 rxa01039 699 GB_PR4: HUAC004682 189134 AC004682 Homo sapiens Chromosome 16 BAC clone CIT987SK-A-259H10, complete sequence. Homo sapiens 36,192 23-Nov-99 GB_HTG2: HS500L14 164856 AL023583 Homo sapiens chromosome 6 clone RP3-500L14 map p23-24.3, Homo sapiens 34,632 30-Nov-99 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG2: HS500L14 164856 AL023583 Homo sapiens chromosome 6 clone RP3-500L14 map p23-24.3, Homo sapiens 34,632 30-Nov-99 *** SEQUENCING IN PROGRESS ***, in unordered pieces. rxa01040 1026 GB_EST24: AI193549 479 AI193549 qe70e06.x1 Soares_fetal_lung_NbHL19W Homo sapiens cDNA Homo sapiens 40,126 29-OCT-1998 clone IMAGE: 1744354 3′, mRNA sequence. GB_PR2: HSU38545 3609 U38545 Human ARF-activated phosphatidytcholine-specific phospholipase D1a Homo sapiens 38,652 10-MAR-1997 (hPLD1) mRNA, complete cds. GB_PR2: AC002481 28244 AC002481 Human cosmid clone LUCA12 from 3p21.3, complete sequence. Homo sapiens 39,643 21-Aug-97 rxa01041 276 GB_HTG6: AC007957 212658 AC007957 Homo sapiens, *** SEQUENCING IN PROGRESS ***, 2 ordered pieces. Homo sapiens 40,809 26-Nov-99 GB_PR2: AP000552 157086 AP000552 Homo sapiens genomic DNA, chromosome 22q11.2, BCRL2 region, Homo sapiens 40,809 01-OCT-1999 clone: KB1183D5. GB_PR3: HS57A13 169693 Z83848 Human DNA sequence from PAC 57A13 between markers DXS6791 and Homo sapiens 37,647 23-Nov-99 DXS8038 on chromosome X contains glutamate receptor subunit GluRC, ESTs, STS and polymorphic CA repeat. rxa01042 1401 GB_BA1: MTCY10G2 38970 Z92539 Mycobacterium tuberculosis H37Rv complete genome; segment 47/162. Mycobacterium 36,023 17-Jun-98 tuberculosis GB_BA1: MTCY10G2 38970 Z92539 Mycobacterium tuberculosis H37Rv complete genome; segment 47/162. Mycobacterium 37,010 17-Jun-98 tuberculosis GB_EST29: AI551042 538 AI551042 vx33d11.x1 Stratagene mouse lung 937302Mus musculus cDNA clone IMAGE: Mus musculus 38,806 23-MAR-1999 1277013 3′, mRNA sequence. rxa01043 696 GB_BA1: AF006658 2500 AF006658 Bacteroides fragilis beta-glucosidase gene, complete cds. Bacteroides fragilis 39,156 12-Jul-97 GB_BA1: MLB1790G 37617 Z14314 M. leprae genes rplL, rpoB, rpoC, end, rpsL, rpsG, efg, tuf, rpsJ, rplC for ribosomal Mycobacterium leprae 39,970 11-Feb-93 protein L7, RNA polymerase beta subunit, RNA polymerase beta' subunit, endonuclease, ribosomal protein S7, ribosomal protein S12, elongation factor G, elongation factor Tu, ribosomal protein S10, ribosomal protein L3 and mkl gene. GB_BA1: AF006658 2500 AF006658 Bacteroides fragilis beta-glucosidase gene, complete cds. Bacteroides fragilis 36,472 12-Jul-97 rxa01044 1380 GB_HTG6: AC010998 144338 AC010998 Homo sapiens clone RP11-95I16, *** SEQUENCING IN PROGRESS ***, Homo sapiens 37,630 08-DEC-1999 17 unordered pieces. GB_HTG6: AC010998 144338 AC010998 Homo sapiens clone RP11-95I16, *** SEQUENCING IN PROGRESS ***, 17 Homo sapiens 37,864 08-DEC-1999 unordered pieces. GB_BA2: AE000939 10599 AE000939 Methanobacterium thermoautotrophicum from bases 1698671 to 1709269 (section Methanobacterium 34,480 15-Nov-97 145 of 148) of the complete genome. thermoautotrophicum rxa01045 1947 GB_VI: FCVF6A 8440 M18247 Feline leukemia virus, subgroup A (FeLV-FAIDS), complete nucleotide sequence. Feline leukemia virus 37,617 29-MAR-1996 GB_OM: CATFLVPOL 3639 L06140 Felis catus endogenous FeLV proviral polyprotein (protease (PRO), reverse Felis catus 41,966 21-Aug-95 transcriptase (RT), integrase/endonuclease (INT)) and pol pseudogene, 3′ end. GB_VI: CEAVCG 9189 M33677 Caprine arthritis encephalitis virus, complete proviral genome. Caprine arthritis- 36,297 04-MAR-1996 encephalitis virus rxa01046 1902 GB_HTG3: AC008423 177734 AC008423 Homo sapiens chromosome 5 clone CIT-HSPC_298N6, *** SEQUENCING IN Homo sapiens 38,720 3-Aug-99 PROGRESS ***, 56 unordered pieces. GB_HTG3: AC008423 177734 AC008423 Homo sapiens chromosome 5 clone CIT-HSPC_298N6, *** SEQUENCING IN Homo sapiens 38,720 3-Aug-99 PROGRESS ***, 56 unordered pieces. GB_HTG3: AC008423 177734 AC008423 Homo sapiens chromosome 5 clone CIT-HSPC_298N6, *** SEQUENCING Homo sapiens 35,882 3-Aug-99 IN PROGRESS ***, 56 unordered pieces. rxa01047 597 GB_EST20: AA842685 510 AA842685 MBAFCZ9C11T3 Brugia malayi adult female cDNA (SAW96MLW-BmAF) Brugia malayi 37,965 02-MAR-1998 Brugia malayi cDNA clone AFCZ9C11 5′, mRNA sequence. GB_EST20: AA842685 510 AA842685 MBAFCZ9C11T3 Brugia malayi adult female cDNA (SAW96MLW-BmAF) Brugia malayi 41,697 02-MAR-1998 Brugia malayi cDNA clone AFCZ9C11 5′, mRNA sequence. rxa01058 444 GB_GSS9: AQ160800 745 AQ160800 nbxb0006C07r CUGI Rice BAC Library Oryza sativa genomic clone nbxb0006C07r, Oryza sativa 38,242 12-Sep-98 genomic survey sequence. GB_GSS3: B10162 1102 B10162 F11B10-Sp6 IGF Arabidopsis thaliana genomic clone F11B10, genomic Arabidopsis thaliana 42,263 14-MAY-1997 survey sequence. GB_BA1: AB032799 9077 AB032799 Chromobacterium violaceum violacein biosynthetic gene cluster (vioA, vio B, vio C, Chromobacterium 34,475 02-OCT-1999 vio D), complete cds. violaceum rxa01063 453 GB_GSS4: AQ707752 510 AQ707752 HS_5560_A2_G07_T7A RPCI-11 Human Male BAC LibraryHomo sapiens Homo sapiens 36,932 7-Jul-99 genomic clone Plate = 1136 Col = 14 Row = M, genomic survey sequence. GB_GSS4: AQ707752 510 AQ707752 HS_5560_A2_G07_T7A RPCI-11 Human Male BAC LibraryHomo sapiens Homo sapiens 35,885 7-Jul-99 genomic clone Plate = 1136 Col = 14 Row = M, genomic survey sequence. rxa01066 849 GB_BA2: U32709 10010 U32709 Haemophilus influenzae Rd section 24 of 163 of the complete genome. Haemophilus influenzae Rd 36,158 29-MAY-1998 GB_RO: AB009615 1515 AB009615 Mus musculus mRNA for type II phosphatidylinositolphosphate kinase-alpha, Mus musculus 37,861 13-Feb-99 complete cds. GB_RO: AB032899 1914 AB032899 Rattus norvegicus PIPK2 alpha mRNA for phosphatidylinositol 5-phosphate Rattus norvegicus 38,480 07-OCT-1999 4-kinase alpha, complete cds. rxa01068 1194 GB_HTG4: AC006091 176878 AC006091 Drosophila melanogaster chromosome 3 clone BACR48G05 (D475) RPCI-98 Drosophila melanogaster 35,539 27-OCT-1999 48.G.5 map 91F1-91F13 strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 4 unordered pieces. GB_HTG4: AC006091 176878 AC006091 Drosophila melanogaster chromosome 3 clone BACR48G05 (D475) RPCI-98 Drosophila melanogaster 35,539 27-OCT-1999 48.G.5 map 91F1-91F13 strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 4 unordered pieces. GB_HTG2: AC008141 100729 AC008141 Drosophila melanogaster chromosome 3 clone BACR17F04 (D988) RPCI-98 Drosophila melanogaster 34,415 2-Aug-99 17.F.4 map 91F-91F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 69 unordered pieces. rxa01069 837 GB_EST15: AA531901 524 AA531901 TgESTzz32g09.r1 TgME49 invivo Bradyzoite cDNA size selected Toxoplasma Toxoplasma gondii 43,005 22-Jul-97 gondii cDNA clone tgzz32g09.r1 5′, mRNA sequence. GB_EST15: AA520183 527 AA520183 TgESTzz39d01.s1 TgME49 invivo Bradyzoite cDNA size selected Toxoplasma Toxoplasma gondii 40,664 16-Jul-97 gondii cDNA clone tgzz39d01.s1 3′, mRNA sequence. GB_HTG6: AC010846 187611 AC010846 Drosophila melanogaster chromosome X clone BACR13G13 (D894) RPCI-98 Drosophila melanogaster 36,679 03-DEC-1999 13.G.13 map 14B-14C strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 97 unordered pieces. rxa01071 2187 GB_EST20: AA880319 450 AA880319 vx39h01.r1 Stratagene mouse lung 937302Mus musculus cDNA clone IMAGE: Mus musculus 40,724 26-MAR-1998 1277617 5′, mRNA sequence. GB_GSS14: AQ558382 435 AQ558382 HS_2068_B1_F06_T7C CIT Approved Human Genomic Sperm Library D Homo sapiens 36,882 29-MAY-1999 Homo sapiens genomic clone Plate = 2068 Col = 11 Row = L, genomic survey sequence. GB_GSS15: AQ600385 483 AQ600385 HS_5357_B2_C05_SP6E RPCI-11 Human Male BAC Library Homo sapiens 40,476 10-Jun-99 Homo sapiens genomic clone Plate = 933 Col = 10 Row = F, genomic survey sequence. rxa01074 828 GB_BA1: PSEHEDDH 3060 M74256 Pseudomonas aeruginosa 6-phosphogluconate dehydratase Pseudomonas aeruginosa 39,657 30-Nov-93 (edd) gene, and glyceraldehyde-3- phosphate dehydrogenase (gap) gene, complete cds. GB_BA1: CGL007732 4460 AJ007732 Corynebacterium glutamicum 3′ ppc gene, secG gene, amt gene, ocd gene and Corynebacterium 39,168 7-Jan-99 5′ soxA gene. glutamicum GB_EST9: AA066016 406 AA066016 ml52f12.r1 Stratagene mouse testis (#937308) Mus musculus cDNA clone IMAGE: Mus musculus 43,382 3-Feb-97 515663 5′, mRNA sequence. rxa01075 534 GB_EST21: AA986543 445 AA986543 ue14f08.x1 Sugano mouse embryo mewa Mus musculus cDNA clone IMAGE: Mus musculus 31,236 28-MAY-1998 1480359 3′, mRNA sequence. GB_EST22: AI035794 509 AI035794 ue17d01.y1 Sugano mouse embryo mewa Mus musculus cDNA clone IMAGE: Mus musculus 42,264 26-Jun-98 1480609 5′, mRNA sequence. GB_EST22: AI006506 384 AI006506 ue14f08.y1 Sugano mouse embryo mewa Mus musculus cDNA clone IMAGE: Mus musculus 46,637 12-Jun-98 1480359 5′, mRNA sequence. rxa01076 1143 GB_HTG2: AC007741 162450 AC007741 Homo sapiens clone NH0340F16, *** SEQUENCING IN PROGRESS ***, Homo sapiens 38,209 5-Jun-99 3 unordered pieces. GB_HTG2: AC007741 162450 AC007741 Homo sapiens clone NH0340F16, *** SEQUENCING IN PROGRESS ***, Homo sapiens 38,209 5-Jun-99 3 unordered pieces. GB_EST33: AV072325 317 AV072325 AV072325 Mus musculus stomach C57BL/6J adult Mus musculus cDNA clone Mus musculus 48,485 24-Jun-99 2200003E03, mRNA sequence. rxa01078 957 GB_BA2: RCPHSYNG 45959 Z11165 R. capsulatus complete photosynthesis gene cluster. Rhodobacter capsulatus 36,603 2-Sep-99 GB_BA2: RCPHSYNG 45959 Z11165 R. capsulatus complete photosynthesis gene cluster. Rhodobacter capsulatus 37,989 2-Sep-99 GB_PR4: AF073931 7898 AF073931 Homo sapiens low-voltage activated calcium channel alpha 1H mRNA, Homo sapiens 37,953 04-MAR-1999 complete cds. rxa01083 399 GB_BA2: AF112535 4363 AF112535 Corynebacterium glutamicum putative glutaredoxin NrdH (nrdH), Nrdl (nrdl), Corynebacterium 99,499 5-Aug-99 and ribonucleotide reductase alpha-chain (nrdE) genes, complete cds. glutamicum GB_PR3: HSH3D2 1789 AF053138 Homo sapiens histone deacetylase 3 gene, exons 11, 12, 13 and partial cds. Homo sapiens 33,512 28-MAR-1998 GB_PR4: AF059650 16015 AF059650 Homo sapiens histone deacetylase 3 (HDAC3) gene, complete cds. Homo sapiens 38,814 03-MAR-1999 rxa01085 902 GB_EST4: H55032 951 H55032 HHU58a Sorghum bicolor cv. TX430 Sorghum bicolor cDNA clone HHU58 Sorghum bicolor 41,111 27-Sep-99 5′ similar to transketolase, chloroplast (TKLC1), mRNA sequence. GB_HTG2: HSBA27F12 123489 AL109914 Homo sapiens chromosome 6 clone RP11-27F12 map p22.3-24, *** SEQUENCING Homo sapiens 35,156 30-Nov-99 IN PROGRESS ***, in unordered pieces. GB_HTG2: HSBA27F12 123489 AL109914 Homo sapiens chromosome 6 clone RP11-27F12 map p22.3-24, *** SEQUENCING Homo sapiens 35,156 30-Nov-99 IN PROGRESS ***, in unordered pieces. rxa01088 1305 GB_HTG5: AC010202 170004 AC010202 Homo sapiens chromosome 12q seeders clone RP11-210L7, Homo sapiens 37,313 6-Nov-99 *** SEQUENCING IN PROGRESS ***, 40 unordered pieces. GB_HTG5: AC010202 170004 AC010202 Homo sapiens chromosome 12q seeders clone RP11-210L7, Homo sapiens 37,422 6-Nov-99 *** SEQUENCING IN PROGRESS ***, 40 unordered pieces. GB_PR1: HSIGFACI 7260 X57025 Human IGF-I mRNA for insulin-like growth factor I. Homo sapiens 38,043 17-Feb-92 rxa01091 664 GB_BA1: ECORELA 4034 J04039 E. coli relA gene encoding ATP: GTP 3′-pyrophosphotransferase, complete cds. Escherichia coli 54,711 16-Nov-93 GB_BA2: ECU29580 13234 U29580 Escherichia coli K-12 genome; approximately 62 minute region. Escherichia coli 37,327 5-Apr-99 GB_BA2: AE000362 12595 AE000362 Escherichia coli K-12 MG1655 section 252 of 400 of the complete genome. Escherichia coli 37,327 12-Nov-98 rxa01096 547 GB_PL1: PCX24CRY 357 Z34459 P. cryptogea X24 gene for cryptogein. Phytophthora cryptogea 43,310 19-Sep-96 GB_EST24: AI244520 414 AI244520 qk14c08.x1 NCI_CGAP_Kid3 Homo sapiens cDNA clone IMAGE: 1868942 3′, Homo sapiens 33,528 28-Jan-99 mRNA sequence. GB_RO: MM26SPROT 1479 Y13071 Mus musculus mRNA for 26S proteasome non-ATPase subunit. Mus musculus 37,941 10-Sep-98 rxa01102 1368 GB_HTG3: AC009219 127519 AC009219 Drosophila melanogaster chromosome 3 clone BACR32N16 (D973) RPCI-98 32.N.16 Drosophila melanogaster 35,080 20-Aug-99 map 86C-86C strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 74 unordered pieces. GB_HTG3: AC009219 127519 AC009219 Drosophila melanogaster chromosome 3 clone BACR32N16 (D973) RPCI-98 Drosophila melanogaster 35,080 20-Aug-99 32.N.16 map 86C-86C strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 74 unordered pieces. GB_PR4: AC006065 191134 AC006065 Homo sapiens 12q24.2 BAC RPCI11-407A16 (Roswell Park Cancer Institute Human Homo sapiens 37,453 27-Feb-99 BAC Library) complete sequence. rxa01103 348 GB_EST13: AA340958 338 AA340958 EST46332 Fetal kidney II Homo sapiens cDNA 5′ end, mRNA sequence. Homo sapiens 36,596 21-Apr-97 GB_RO: MUSBCL22 5806 L31532 Mus musculus bcl-2 alpha gene, exon 2. Mus musculus 33,913 5-Apr-94 GB_BA2: AE001165 13021 AE001165 Borrelia burgdorferi (section 51 of 70) of the complete genome. Borrelia burgdorferi 31,412 15-DEC-1997 rxa01107 1323 GB_HTG1: HS1030M6 173804 AL035089 Homo sapiens chromosome 20 clone RP5-1030M6, *** SEQUENCING Homo sapiens 34,935 23-Nov-99 IN PROGRESS ***, in unordered pieces. GB_HTG1: HS1030M6 173804 AL035089 Homo sapiens chromosome 20 clone RP5-1030M6, *** SEQUENCING IN Homo sapiens 34,935 23-Nov-99 PROGRESS ***, in unordered pieces. GB_HTG2: AC005057 99370 AC005057 Homo sapiens clone RG052H06, *** SEQUENCING IN PROGRESS ***, 11 Homo sapiens 35,897 12-Jun-98 unordered pieces. rxa01108 774 GB_PR2: HSJ193N13 122961 AL078600 Human DNA sequence from clone RP1-193N13 on chromosome Homo sapiens 37,115 22-Nov-99 6q21-22.31, complete sequence. GB_EST34: AV139054 287 AV139054 AV139054 Mus musculus C57BL/6J 10-11 day embryo Mus musculus 35,540 1-Jul-99 Mus musculus cDNA clone 2810048D09, mRNA sequence. GB_PL1: GTU21246 926 U21246 Gracilariopsis tenuifrons internal transcribed spacer region of the ribosomal repeat, Gracilariopsis tenuifrons 37,200 12-MAR-1995 ITS1, 5.8S rRNA gene and ITS2, complete sequence. rxa01109 765 GB_BA1: AB003332 1424 AB003332 Anabaena variabilis rbpF gene for RNA binding protein, complete cds. Anabaena variabilis 35,958 21-MAY-1999 GB_BA1: BPETOXOP 9342 L10720 Bordetella pertussis toxin liberation operon. Bordetella pertussis 40,107 9-Jul-93 GB_PAT: I50844 951 I50844 Sequence 12 from patent U.S. Pat. No. 5643747. Unknown. 39,973 07-OCT-1997 rxa01119 1053 GB_GSS3: B36708 438 B36708 HS-1041-B1-C05-MF.abi CIT Human Genomic Sperm Library CHomo Homo sapiens 37,300 17-OCT-1997 sapiens genomic clone Plate = CT 823 Col = 9 Row = F, genomic survey sequence. GB_PL2: F11A17 102077 AC007932 Arabidopsis thaliana chromosome 1 BAC F11A17 sequence, complete sequence. Arabidopsis thaliana 37,488 16-Aug-99 GB_EST22: AI043264 283 AI043264 TENU0904 T. cruzi epimastigote normalized cDNA Library Trypanosoma cruzi Trypanosoma cruzi 40,989 1-Jul-98 cDNA clone 2i14 3′, mRNA sequence. rxa01121 1209 GB_PAT: I78756 737 I78756 Sequence 12 from patent U.S. Pat. No. 5693781. Unknown. 40,975 3-Apr-98 GB_PAT: I92045 737 I92045 Sequence 12 from patent U.S. Pat. No. 5726299. Unknown. 40,975 01-DEC-1998 GB_PL1: MTPACG 100314 X55026 P. anserina complete mitochondrial genome. Mitochondrion Podospora 34,477 08-DEC-1997 anserina rxa01122 645 GB_HTG4: AC010148 228794 AC010148 Homo sapiens chromosome unknown clone NH0367B19, WORKING Homo sapiens 42,130 29-OCT-1999 DRAFT SEQUENCE, in unordered pieces. GB_HTG4: AC010148 228794 AC010148 Homo sapiens chromosome unknown clone NH0367B19, WORKING Homo sapiens 42,130 29-OCT-1999 DRAFT SEQUENCE, in unordered pieces. GB_HTG4: AC010148 228794 AC010148 Homo sapiens chromosome unknown clone NH0367B19, WORKING Homo sapiens 37,559 29-OCT-1999 DRAFT SEQUENCE, in unordered pieces. rxa01123 570 GB_EST33: AV090612 274 AV090612 AV090612 Mus musculus tongue C57BL/6J adult Mus Mus musculus 33,212 28-Jun-99 musculus cDNA clone 2310051C21, mRNA sequence. GB_EST33: AV090612 274 AV090612 AV090612 Mus musculus tongue C57BL/6J adultMus musculus cDNA Mus musculus 34,529 28-Jun-99 clone 2310051C21, mRNA sequence. rxa01127 1143 GB_BA1: CGLEUB 2042 Y09578 C. glutamicum leuB gene. Corynebacterium 99,913 02-MAR-1999 glutamicum GB_BA1: MTV012 70287 AL021287 Mycobacterium tuberculosis H37Rv complete genome; segment 132/162. Mycobacterium 39,295 23-Jun-99 tuberculosis GB_BA1: SC1C2 42210 AL031124 Streptomyces coelicolor cosmid 1C2. Streptomyces coelicolor 62,456 15-Jan-99 rxa01128 1137 GB_BA1: CGLEUB 2042 Y09578 C. glutamicum leuB gene. Corynebacterium 38,515 02-MAR-1999 glutamicum GB_GSS8: AQ066341 241 AQ066341 HS_2243_B1_A02_MF CIT Approved Human Genomic Sperm Library D Homo sapiens 39,004 4-Aug-98 Homo sapiens genomic clone Plate = 2243 Col = 3 Row = B, genomic survey sequence. GB_EST24: AI168493 459 AI168493 ou64g08.s1 NCI_CGAP_Br2Homo sapiens cDNA clone IMAGE: 1632638 3′ similar Homo sapiens 42,117 23-OCT-1998 to gb: D90209 DNA-BINDING PROTEIN TAXREB67 (HUMAN);, mRNA sequence. rxa01129 1989 GB_BA1: MTCI28 36300 Z97050 Mycobacterium tuberculosis H37Rv complete genome; segment 10/162. Mycobacterium 38,159 23-Jun-98 tuberculosis GB_HTG1: LMFL6852 37286 AL034359 Leishmania major chromosome 4 clone L6852 strain Freidlin, *** SEQUENCING Leishmania major 38,485 29-Apr-99 IN PROGRESS ***, in unordered pieces. GB_HTG1: LMFL6852 37286 AL034359 Leishmania major chromosome 4 clone L6852 strain Freidlin, *** SEQUENCING Leishmania major 38,485 29-Apr-99 IN PROGRESS ***, in unordered pieces. rxa01131 990 GB_BA1: CGLEUB 2042 Y09578 C. glutamicum leuB gene. Corynebacterium 99,313 02-MAR-1999 glutamicum GB_PR4: AC007253 225699 AC007253 Homo sapiens BAC clone NH0454P05 from 2, complete sequence. Homo sapiens 35,421 22-OCT-1999 GB_HTG3: AC011305 171067 AC011305 Homo sapiens clone NH0390E09, *** SEQUENCING IN PROGRESS ***, Homo sapiens 35,955 05-OCT-1999 1 unordered pieces. rxa01134 871 GB_HTG4: AC009375 137069 AC009375 Drosophila melanogaster chromosome 3L/75A1 clone RPCI98-44L18, Drosophila melanogaster 37,380 16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 59 unordered pieces. GB_HTG4: AC009375 137069 AC009375 Drosophila melanogaster chromosome 3L/75A1 clone RPCI98-44L18, Drosophila melanogaster 37,380 16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 59 unordered pieces. GB_HTG4: AC009375 137069 AC009375 Drosophila melanogaster chromosome 3L/75A1 clone RPCI98-44L18, Drosophila melanogaster 38,489 16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 59 unordered pieces. rxa01137 483 GB_IN2: AC005421 69992 AC005421 Drosophila melanogaster, chromosome 2L, region 22A1-22A1, P1 clone DS03601, Drosophila melanogaster 37,367 31-OCT-1998 complete sequence. GB_GSS1: CNS00KX9 1101 AL078350 Drosophila melanogaster genome survey sequence TET3 end of BAC: BACR23A23 Drosophila melanogaster 30,670 3-Jun-99 of RPCI-98 library from Drosophila melanogaster (fruit fly), genomic survey sequence. GB_IN2: AC005421 69992 AC005421 Drosophila melanogaster, chromosome 2L, region 22A1-22A1, P1 clone DS03601, Drosophila melanogaster 33,333 31-OCT-1998 complete sequence. rxa01140 1056 GB_PR4: AC007948 99904 AC007948 Genomic sequence of Homo sapiens clone R417F14A from chromosome Homo sapiens 36,249 6-Nov-99 18, complete sequence. GB_HTG3: AC006278 140290 AC006278 Plasmodium falciparum chromosome 12 clone 3D7, *** SEQUENCING IN Plasmodium falciparum 36,592 23-Sep-99 PROGRESS ***, 18 unordered pieces. GB_HTG3: AC006278 140290 AC006278 Plasmodium falciparum chromosome 12 clone 3D7, *** SEQUENCING IN Plasmodium falciparum 36,592 23-Sep-99 PROGRESS ***, 18 unordered pieces. rxa01148 723 GB_BA1: MTCY261 27322 Z97559 Mycobacterium tuberculosis H37Rv complete genome; segment 95/162. Mycobacterium 50,139 17-Jun-98 tuberculosis GB_EST15: AA501229 548 AA501229 vh62g12.r1 Knowles Solter mouse 11 5day limb bud Mus musculus cDNA clone Mus musculus 36,250 1-Jul-97 IMAGE: 891622 5′ similar to TR: G762951 G762951 PRPL-2 PROTEIN;, mRNA sequence. GB_PR4: AF106062 1306 AF106062 Homo sapiens Wiskott-Aldrich syndrome protein interacting protein (WASPIP) Homo sapiens 43,205 31-Jul-99 mRNA, partial cds. rxa01153 543 GB_BA1: MTCY261 27322 Z97559 Mycobacterium tuberculosis H37Rv complete genome; segment 95/162. Mycobacterium 40,000 17-Jun-98 tuberculosis GB_BA1: MLCB2533 40245 AL035310 Mycobacterium leprae cosmid B2533. Mycobacterium leprae 61,765 27-Aug-99 GB_BA1: U00017 42157 U00017 Mycobacterium leprae cosmid B2126. Mycobacterium leprae 39,615 01-MAR-1994 rxa01154 677 GB_BA1: MTCY49 39430 Z73966 Mycobacterium tuberculosis H37Rv complete genome; segment 93/162. Mycobacterium 37,615 24-Jun-99 tuberculosis GB_BA1: U00017 42157 U00017 Mycobacterium leprae cosmid B2126. Mycobacterium leprae 36,957 01-MAR-1994 GB_BA2: AF086832 10612 AF086832 Streptomyces coelicolor putative ferredoxin, ARC (arc), 20S proteasome Streptomyces coelicolor 53,354 30-Jun-99 beta-subunit precursor (prcB), 20S proteasome alpha-subunit (prcA), putative Lacl family repressor, and putative transporter genes, complete cds; and unknown genes. rxa01155 1570 GB_BA1: MTCY49 39430 Z73966 Mycobacterium tuberculosis H37Rv complete genome; segment 93/162. Mycobacterium 37,025 24-Jun-99 tuberculosis GB_BA1: REZ82005 3301 Z82005 R. erythropolis DNA, 20S proteasome structural genes region (3301 bp). Rhodococcus erythropolis 54,128 8-Nov-97 GB_BA2: RSU26422 3554 U26422 Rhodococcus erythropolis ORF6(2), ORF7(2), proteasome beta-type subunit Rhodococcus erythropolis 45,951 08-OCT-1997 2 (prcB(2)), and proteasome alpha-type subunit 2 (prcA(2))genes, complete cds. rxa01156 257 GB_BA2: RSU26422 3554 U26422 Rhodococcus erythropolis ORF6(2), ORF7(2), proteasome beta-type subunit 2 Rhodococcus erythropolis 54,724 08-OCT-1997 (prcB(2)), and proteasome alpha-type subunit 2 (prcA(2)) genes, complete cds. GB_HTG6: AC009218 126649 AC009218 Drosophila melanogaster chromosome 2 clone BACR33D17 (D945) RPCI-98 33.D.17 Drosophila melanogaster 42,570 02-DEC-1999 map 57B-57B strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 76 unordered pieces. GB_OV: QULNFLW 7933 D13223 Japanese quail genomic DNA for neurofilament-L (NF-L). Coturnix coturnix 44,758 3-Feb-99 rxa01158 1065 GB_HTG3: AC011401 321277 AC011401 Homo sapiens chromosome 5 clone CIT978SKB_35K5, Homo sapiens 35,048 06-OCT-1999 *** SEQUENCING IN PROGRESS ***, 65 unordered pieces. GB_HTG3: AC011401 321277 AC011401 Homo sapiens chromosome 5 clone CIT978SKB_35K5, *** SEQUENCING IN Homo sapiens 35,048 06-OCT-1999 PROGRESS ***, 65 unordered pieces. GB_PR3: AC004386 172657 AC004386 Homo sapiens Chromosome X clone bWXD691, complete sequence. Homo sapiens 37,223 10-Apr-98 rxa01159 438 GB_PAT: I92035 413 I92035 Sequence 2 from patent U.S. Pat. No. 5726299. Unknown. 78,169 01-DEC-1998 GB_PAT: I78746 413 I78746 Sequence 2 from patent U.S. Pat. No. 5693781. Unknown. 78,169 3-Apr-98 GB_HTG3: AC009209 108370 AC009209 Drosophila melanogaster chromosome 2 clone BACR24G16 (D1051) RPCI-98 Drosophila melanogaster 43,590 20-Aug-99 24.G.16 map 47D- 47D strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 93 unordered pieces. rxa01160 998 GB_PAT: I78746 413 I78746 Sequence 2 from patent U.S. Pat. No. 5693781. Unknown. 96,032 3-Apr-98 GB_PAT: I92035 413 I92035 Sequence 2 from patent U.S. Pat. No. 5726299. Unknown. 96,032 01-DEC-1998 GB_BA2: AF014804 6449 AF014804 Neisseria meningitidis PgIB (pgIB), PgIC (pgIC), PgID (pgID), and AvtA (avtA) Neisseria meningitidis 37,977 3-Sep-99 genes, complete cds. rxa01165 696 GB_HTG2: AC007851 128979 AC007851 Drosophila melanogaster chromosome 2 clone BACR06M19 (D615) Drosophila melanogaster 37,900 2-Aug-99 RPCI-98 06.M.19 map 50C-50D strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 86 unordered pieces. GB_HTG2: AC007851 128979 AC007851 Drosophila melanogaster chromosome 2 clone BACR06M19 (D615) RPCI-98 Drosophila melanogaster 37,900 2-Aug-99 06.M.19 map 50C-50D strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 86 unordered pieces. GB_HTG2: AC007851 128979 AC007851 Drosophila melanogaster chromosome 2 clone BACR06M19 (D615) RPCI-98 Drosophila melanogaster 34,114 2-Aug-99 06.M.19 map 50C-50D strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 86 unordered pieces. rxa01166 1428 GB_BA1: LEUG6PD 1957 M64446 L. mesenteroides glucose-6-phosphate dehydrogenase gene, complete cds. Leuconostoc 41,259 26-Apr-93 mesenteroides GB_HTG3: AF188026 101456 AF188026 Homo sapiens chromosome 8 clone BAC 2379L20 map 8q24, *** SEQUENCING Homo sapiens 35,535 08-OCT-1999 IN PROGRESS ***, in ordered pieces. GB_HTG3: AF188026 101456 AF188026 Homo sapiens chromosome 8 clone BAC 2379L20 map 8q24, *** SEQUENCING Homo sapiens 35,535 08-OCT-1999 IN PROGRESS ***, in ordered pieces. rxa01167 519 GB_PR2: HS1026E2 100418 AL022143 Human DNA sequence from clone 1026E2 on chromosome Homo sapiens 38,281 23-Nov-99 1q24.1-25.3 EST, CA repeat, STS, GSS, complete sequence. GB_EST36: AI900015 496 AI900015 sb97f05.y1 Gm-c1012 Glycine max cDNA clone GENOME SYSTEMS CLONE ID: Glycine max 42,045 06-DEC-1999 Gm-c1012-634 5′ similar to WP: T11G6.8 CE06432 RNA RECOGNITION MOTIF.;, mRNA sequence. GB_PR2: HS1026E2 100418 AL022143 Human DNA sequence from clone 1026E2 on chromosome 1q24.1-25.3 EST, Homo sapiens 40,990 23-Nov-99 CA repeat, STS, GSS, complete sequence. rxa01169 1119 GB_HTG2: AC005978 92586 AC005978 Drosophila melanogaster chromosome 2 clone DS00678 (D449) map 59D3-59D4 Drosophila melanogaster 34,266 30-Jul-99 strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 6 unordered pieces. GB_HTG2: AC005978 92586 AC005978 Drosophila melanogaster chromosome 2 clone DS00678 (D449) map Drosophila melanogaster 34,266 30-Jul-99 59D3-59D4 strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 6 unordered pieces. GB_HTG3: AC008304 91552 AC008304 Drosophila melanogaster chromosome 2 clone BACR04G19 (D646) Drosophila melanogaster 31,278 20-Sep-99 RPCI-98 04.G.19 map 59D2-59D3 strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 90 unordered pieces. rxa01170 606 GB_PR1: AB014524 6542 AB014524 Homo sapiens mRNA for KIAA0624 protein, partial cds. Homo sapiens 43,478 6-Feb-99 GB_EST38: AW016078 496 AW016078 UI-H-BI0p-abf-h-01-0-UI.s1 NCI_CGAP_Sub2Homo sapiens cDNA clone IMAGE: Homo sapiens 36,667 10-Sep-99 2711665 3′, mRNA sequence. GB_EST24: AI193238 323 AI193238 qe56c06.x1 Soares_fetal_lung_NbHL19WHomo sapiens cDNA clone Homo sapiens 37,427 29-OCT-1998 IMAGE: 1742986 3′, mRNA sequence. rxa01171 816 GB_HTG2: AC007548 110249 AC007548 Drosophila melanogaster chromosome 2 clone BACR48M17 (D614) Drosophila melanogaster 35,634 2-Aug-99 RPCI-98 48.M.17 map 41C-41D strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 66 unordered pieces. GB_PR3: HS273F20 111253 AL034371 Human DNA sequence from clone 273F20 on chromosome 6q16.1-16.3 Homo sapiens 34,582 23-Nov-99 Contains ESTs, STSs and GSSs, complete sequence. GB_HTG2: AC007548 110249 AC007548 Drosophila melanogaster chromosome 2 clone BACR48M17 (D614) Drosophila melanogaster 35,634 2-Aug-99 RPCI-98 48.M.17 map 41C-41D strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 66 unordered pieces. rxa01173 738 GB_GSS8: B93272 338 B93272 CIT-HSP-2171E14.TF CIT-HSPHomo sapiens genomic clone 2171E14, Homo sapiens 42,012 25-Jun-98 genomic survey sequence. GB_EST35: AV156265 282 AV156265 AV156265 Mus musculus head C57BL/6J 12-day embryoMus musculus cDNA clone Mus musculus 41,350 7-Jul-99 3000001I03, mRNA sequence. GB_RO: AF035777 2154 AF035777 Mus musculus somatostatin receptor subtype 5 (sst5) gene, complete cds. Mus musculus 38,928 05-DEC-1997 rxa01174 873 GB_HTG1: CEY51A2_3 110000 Z99275 Caenorhabditis elegans chromosome V clone Y51A2, *** SEQUENCING IN Caenorhabditis elegans 38,045 3-Dec-98 PROGRESS ***, in unordered pieces. GB_IN1: CEY51A2D 139259 AL021497 Caenorhabditis elegans cosmid Y51A2D, complete sequence. Caenorhabditis elegans 38,045 2-Sep-99 GB_HTG1: CEY51A2_3 110000 Z99275 Caenorhabditis elegans chromosome V clone Y51A2, *** SEQUENCING IN Caenorhabditis elegans 38,045 3-Dec-98 PROGRESS ***, in unordered pieces. rxa01176 627 GB_BA1: MTV021 23400 AL021957 Mycobacterium tuberculosis H37Rv complete genome; segment 97/162. Mycobacterium 39,159 18-Jun-98 tuberculosis GB_BA1: MSGB1551CS 36548 L78813 Mycobacterium leprae cosmid B1551 DNA sequence. Mycobacterium leprae 53,215 15-Jun-96 GB_BA1: MSGB1554CS 36548 L78814 Mycobacterium leprae cosmid B1554 DNA sequence. Mycobacterium leprae 53,215 15-Jun-96 rxa01177 rxa01178 573 GB_PR4: AC006126 46100 AC006126 Homo sapiens chromosome 19, cosmid F18718, complete sequence. Homo sapiens 36,832 17-DEC-1998 GB_PR4: AC006126 46100 AC006126 Homo sapiens chromosome 19, cosmid F18718, complete sequence. Homo sapiens 40,463 17-DEC-1998 GB_EST23: AI128078 443 AI128078 qc47d10.x1 Soares_pregnant_uterus_NbHPUHomo sapiens cDNA clone IMAGE: Homo sapiens 38,318 27-OCT-1998 1712755 3′ similar to SW: IF16_HUMAN Q16666 GAMMA-INTERFERON-INDUCIBLE PROTEIN IFI-16;, mRNA sequence. rxa01184 1596 GB_HTG2: HSG248A21 96783 AL118512 Homo sapiens chromosome 1 clone GS1-248A21, *** SEQUENCING IN Homo sapiens 36,994 30-Nov-99 PROGRESS ***, in unordered pieces. GB_HTG2: HSG248A21 96783 AL118512 Homo sapiens chromosome 1 clone GS1-248A21, *** SEQUENCING IN Homo sapiens 36,994 30-Nov-99 PROGRESS ***, in unordered pieces. GB_PR3: AC004237 38715 AC004237 Homo sapiens chromosome 5, P1 clone 565a12 (LBNL H23), complete sequence. Homo sapiens 36,514 27-Feb-98 rxa01186 1221 GB_BA1: MTCY274 39991 Z74024 Mycobacterium tuberculosis N37Rv complete genome; segment 126/162. Mycobacterium 34,758 19-Jun-98 tuberculosis GB_BA1: SC6A9 39461 AL031035 Streptomyces coelicolor cosmid 6A9. Streptomyces coelicolor 38,500 24-Jul-98 GB_BA2: AE000689 14698 AE000689 Aquifex aeolicus section 21 of 109 of the complete genome. Aquifex aeolicus 45,379 25-MAR-1998 rxa01187 573 GB_EST5: H60943 361 H60943 yr14g08.r1 Soares fetal liver spleen 1NFLS Homo sapiens cDNA clone IMAGE: Homo sapiens 39,205 06-OCT-1995 205310 5′, mRNA sequence. GB_GSS1: AG018858 570 AG018858 Homo sapiens genomic DNA, 21q region, clone: B125C11 SpN045(−21), genomic Homo sapiens 41,423 10-OCT-1999 survey sequence. GB_GSS13: AQ454839 505 AQ454839 HS_5218_A1_E03_T7A RPCI-11 Human Male BAC Library Homo sapiens 34,599 21-Apr-99 Homo sapiens genomic clone Plate = 794 Col = 5 Row = I, genomic survey sequence. rxa01195 570 GB_PR3: AF022813 1358 AF022813 Homo sapiens tetraspan (NAG-2) mRNA, complete cds. Homo sapiens 40,614 18-Nov-97 GB_EST34: AI798721 765 AI798721 we91g10.x1 Soares_NFL_T_GBC_S1 Homo sapiens cDNA clone IMAGE: Homo sapiens 35,256 6-Jul-99 2348514 3′ similar to SW: NAG2_HUMAN O14817 NOVEL ANTIGEN 2;, mRNA sequence. GB_EST34: AI808898 696 AI808898 wf66d02.x1 Soares_NFL_T_GBC_S1 Homo sapiens cDNA clone IMAGE: Homo sapiens 35,354 7-Jul-99 2360547 3′ similar to SW: NAG2_HUMAN O14817 NOVEL ANTIGEN 2;, mRNA sequence. rxa01196 813 GB_BA1: MSGY151 37036 AD000018 Mycobacterium tuberculosis sequence from clone y151. Mycobacterium 36,634 10-DEC-1996 tuberculosis GB_BA1: MTCY130 32514 Z73902 Mycobacterium tuberculosis H37Rv complete genome; segment 59/162. Mycobacterium 59,596 17-Jun-98 tuberculosis GB_BA1: MSGY151 37036 AD000018 Mycobacterium tuberculosis sequence from clone y151. Mycobacterium 39,567 10-DEC-1996 tuberculosis rxa01197 576 GB_EST18: AA676822 524 AA676822 zj65c11.s1 Soares_fetal_liver_spleen_1NFLS_S1 Homo sapiens cDNA Homo sapiens 40,741 19-DEC-1997 clone IMAGE: 455156 3′, mRNA sequence. GB_EST18: AA676822 524 AA676822 zj65c11.s1 Soares_fetal_liver_spleen_1NFLS_S1 Homo sapiens cDNA Homo sapiens 40,331 19-DEC-1997 clone IMAGE: 455156 3′, mRNA sequence. rxa01198 426 GB_HTG4: AC010195 164935 AC010195 Homo sapiens chromosome 10 clone RPCI11-587C2, *** SEQUENCING Homo sapiens 36,058 21-OCT-1999 IN PROGRESS ***, 61 unordered pieces. GB_HTG4: AC010195 164935 AC010195 Homo sapiens chromosome 10 clone RPCI11-587C2, *** SEQUENCING Homo sapiens 36,058 21-OCT-1999 IN PROGRESS ***, 61 unordered pieces. GB_HTG1: CEY44A6 326074 Z98863 Caenorhabditis elegans chromosome V clone Y44A6, *** SEQUENCING Caenorhabditis elegans 39,151 03-DEC-1998 IN PROGRESS ***, in unordered pieces. rxa01206 400 GB_HTG1: CER08A5 51920 Z82281 Caenorhabditis elegans chromosome V clone R08A5, *** SEQUENCING Caenorhabditis elegans 43,557 14-OCT-1998 IN PROGRESS ***, in unordered pieces. GB_HTG1: CER08A5 51920 Z82281 Caenorhabditis elegans chromosome V clone R08A5, *** SEQUENCING Caenorhabditis elegans 43,557 14-OCT-1998 IN PROGRESS ***, in unordered pieces. GB_HTG1: CER08A5 51920 Z82281 Caenorhabditis elegans chromosome V clone R08A5, *** SEQUENCING Caenorhabditis elegans 34,987 14-OCT-1998 IN PROGRESS ***, in unordered pieces. rxa01207 771 GB_PL2: SPBC8D2 43757 AL022072 S. pombe chromosome II cosmid c8D2. Schizosaccharomyces 36,566 24-Nov-99 pombe GB_PL1: AB004538 38911 AB004538 Schizosaccharomyces pombe 39 kb genomic DNA, clone c568. Schizosaccharomyces 36,148 15-Jul-97 pombe GB_HTG6: AC009220 110000 AC009220 Homo sapiens chromosome 7, *** SEQUENCING IN PROGRESS ***, Homo sapiens 33,940 15-Sep-99 191 unordered pieces. rxa01210 954 GB_GSS4: AQ694235 530 AQ694235 HS_5496_A1_D03_T7A RPCI-11 Human Male BAC Library Homo sapiens 37,259 6-Jul-99 Homo sapiens genomic clone Plate = 1072 Col = 5 Row = G, genomic survey sequence. GB_GSS11: AQ322059 519 AQ322059 RPCI11-100G10.TV RPCI-11 Homo sapiens genomic clone RPCI-11-100G10, Homo sapiens 37,229 06-MAY-1999 genomic survey sequence. GB_BA1: SCH24 41625 AL049826 Streptomyces coelicolor cosmid H24. Streptomyces coelicolor 38,126 11-MAY-1999 rxa01213 1350 GB_PR3: HS356B7 20733 AL031714 Human DNA sequence from clone 356B7 on chromosome 16. Contains the UBE21 Homo sapiens 36,684 23-Nov-99 gene for ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9), and an RPS20 (40S Ribosomal protein S20) pseudogene. Contains ESTs, STSs. GSSs and a putative CpG island, complete sequence. GB_PR3: HS356B7 20733 AL031714 Human DNA sequence from clone 356B7 on chromosome 16. Contains the UBE21 Homo sapiens 39,621 23-Nov-99 gene for ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9), and an RPS20 (40S Ribosomal protein S20) pseudogene. Contains ESTs, STSs. GSSs and a putative CpG island, complete sequence. GB_PR1: HSEF1AL1 1815 X16870 Human DNA for elongation factor 1-alpha (clone lambda-1). Homo sapiens 37,462 12-Jun-90 rxa01218 552 GB_PR3: HS257I9 90695 AL031773 Human DNA sequence from clone 257I9 on chromosome 6q25.1-26 Contains gene Homo sapiens 35,897 23-Nov-99 similar to Cytochrome B, CA repeat, GSS, complete sequence. GB_PR3: HS287L14 112831 Z95325 Human DNA sequence from clone 287L14 on chromosome Xq21.1-21.33 Contains Homo sapiens 37,778 23-Nov-99 STSs and GSSs, complete sequence. GB_EST8: AA035251 493 AA035251 zk23d09.s1 Soares_pregnant_uterus_NbHPU Homo sapiens cDNA clone Homo sapiens 40,191 10-MAY-1997 IMAGE: 471377 3′, mRNA sequence. rxa01229 1401 GB_PR4: HUAC002394 107910 AC002394 Human Chromosome 16 BAC clone CIT987SK-A-211C6, complete sequence. Homo sapiens 33,633 23-Nov-99 GB_OV: AF138905 1678 AF138905 Gallus gallus NK class homeodomain transcription factor NKX3.2 mRNA, Gallus gallus 30,556 4-Sep-99 complete cds. GB_PAT: AR031772 30001 AR031772 Sequence 1 from patent U.S. Pat. No. 5866410. Unknown. 34,304 29-Sep-99 rxa01231 366 GB_EST25: AI295169 507 AI295169 LP08720.3prime LP Drosophila melanogaster larval-early pupal pOT2 Drosophila melanogaster 38,279 01-DEC-1998 Drosophila melanogaster cDNA clone LP08720 3prime, mRNA sequence. GB_EST25: AI297653 512 AI297653 LP12002.3prime LP Drosophila melanogaster larval-early pupal pOT2 Drosophila melanogaster 36,893 01-DEC-1998 Drosophila melanogaster cDNA clone LP12002 3prime, mRNA sequence. GB_EST21: AA951454 677 AA951454 LD31920.5prime LD Drosophila melanogaster embryo pOT2 Drosophila Drosophila melanogaster 44,167 24-Nov-98 melanogaster cDNA clone LD31920 5prime, mRNA sequence. rxa01234 507 GB_GSS12: AQ365352 431 AQ365352 nbxb0063L13f CUGI Rice BAC Library Oryza sativa genomic clone nbxb0063L13f, Oryza sativa 34,577 3-Feb-99 genomic survey sequence. GB_PR4: AC007544 119034 AC007544 Homo sapiens Human 12p11-37.2-54.4 BAC RPCI11-12D15 (Roswell Park Cancer Homo sapiens 34,350 29-OCT-1999 Institute Human BAC Library) complete sequence. GB_PR4: AC007544 119034 AC007544 Homo sapiens Human 12p11-37.2-54.4 BAC RPCI11-12D15 (Roswell Park Cancer Homo sapiens 37,988 29-OCT-1999 Institute Human BAC Library) complete sequence. rxa01237 564 GB_GSS1: AG009269 706 AG009269 Homo sapiens genomic DNA, 21q region, clone: 31C6X11, genomic survey sequence. Homo sapiens 36,328 14-Apr-99 GB_GSS1: AG009269 706 AG009269 Homo sapiens genomic DNA, 21q region, clone: 31C6X11, genomic survey sequence. Homo sapiens 37,391 14-Apr-99 rxa01246 630 GB_HTG2: AC007646 180133 AC007646 Drosophila melanogaster chromosome 3 clone BACR03J04 (D687) RPCI-98 03.J.4 Drosophila melanogaster 38,188 2-Aug-99 map 87F-87F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 10 unordered pieces. GB_HTG2: AC007646 180133 AC007646 Drosophila melanogaster chromosome 3 clone BACR03J04 (D687) RPCI-98 03.J.4 Drosophila melanogaster 38,188 2-Aug-99 map 87F-87F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 10 unordered pieces. GB_HTG4: AC009492 212394 AC009492 Homo sapiens clone NH0423F09, *** SEQUENCING IN PROGRESS ***, Homo sapiens 38,762 29-OCT-1999 2 unordered pieces. rxa01249 471 GB_EST7: W84105 361 W84105 T2969 MVAT4 bloodstream form of serodeme WRATat1.1 Trypanosoma brucei Trypanosoma brucei 38,261 12-Aug-96 rhodesiense cDNA 5′, mRNA sequence. rhodesiense GB_EST7: W84105 361 W84105 T2969 MVAT4 bloodstream form of serodeme WRATat1.1 Trypanosoma brucei Trypanosoma brucei 33,894 12-Aug-96 rhodesiense cDNA 5′, mRNA sequence. rhodesiense rxa01251 432 GB_RO: AC005240 41830 AC005240 Mus musculus clone UWGC: magap from 14D1-D2 (T-cell Receptor Alpha Locus), Mus musculus 41,463 8-Jul-98 complete sequence. GB_RO: AC004101 39491 AC004101 Mouse Cosmid ma53a016 from 14D1-D2, Mus musculus 41,463 2-Feb-98 complete sequence. GB_HTG3: AC009837 162287 AC009837 Homo sapiens chromosome 17 clone 550_K_23 map 17, *** SEQUENCING IN Homo sapiens 36,131 2-Sep-99 PROGRESS ***, 13 unordered pieces. rxa01263 1035 GB_PR4: AC005919 156300 AC005919 Homo sapiens chromosome 17, clone hRPK.142_H_19, complete sequence. Homo sapiens 39,822 18-Nov-98 GB_PR4: AC005919 156300 AC005919 Homo sapiens chromosome 17, clone hRPK.142_H_19, complete sequence. Homo sapiens 38,319 18-Nov-98 GB_HTG1: CEY71A12_3 110000 AL021390 Caenorhabditis elegans chromosome I clone Y71A12, *** SEQUENCING IN Caenorhabditis elegans 36,884 15-Sep-99 PROGRESS ***, in unordered pieces. rxa01266 1158 GB_HTG4: AC010775 165565 AC010775 Homo sapiens clone 2_G_17, *** SEQUENCING IN Homo sapiens 38,670 20-OCT-1999 PROGRESS ***, 14 unordered pieces. GB_HTG4: AC010775 165565 AC010775 Homo sapiens clone 2_G_17, *** SEQUENCING IN Homo sapiens 38,670 20-OCT-1999 PROGRESS ***, 14 unordered pieces. GB_HTG4: AC010775 165565 AC010775 Homo sapiens clone 2_G_17, *** SEQUENCING IN Homo sapiens 36,131 20-OCT-1999 PROGRESS ***, 14 unordered pieces. rxa01267 1437 GB_PR3: AF070717 100793 AF070717 Homo sapiens BAC clone 393I22 from 8q21, Homo sapiens 38,826 2-Jul-98 complete sequence. GB_BA2: MPU34931 2571 U34931 Mycoplasma pulmonis FtsZ (ftsZ) gene, complete cds, methionyl-tRNA synthetase Mycoplasma pulmonis 37,092 30-MAY-1996 (metG) gene, partial cds. GB_EST25: AI322057 638 AI322057 SWOv3MCAM09A04SK Onchocerca volvulus molting L3 larva cDNA Onchocerca volvulus 40,566 22-DEC-1998 (SL96MLW-OvmL3) Onchocerca volvulus cDNA clone SWOv3MCAM09A04 5′, mRNA sequence. rxa01268 963 GB_HTG3: AC010878 288945 AC010878 Homo sapiens clone NH0230E20, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,496 25-Sep-99 65 unordered pieces. GB_HTG3: AC010878 288945 AC010878 Homo sapiens clone NH0230E20, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,496 25-Sep-99 65 unordered pieces. GB_HTG3: AC010878 288945 AC010878 Homo sapiens clone NH0230E20, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,354 25-Sep-99 65 unordered pieces. rxa01271 1935 GB_BA2: U67549 14561 U67549 Methanococcus jannaschii section 91 of 150 of the complete genome. Methanococcus jannaschii 37,841 28-Jan-98 GB_PR2: HSJ836N17 111694 AL049539 Human DNA sequence from clone RP5-836N17 on chromosome 20q11.1-11.21, Homo sapiens 34,872 22-Nov-99 complete sequence. GB_OV: AF089743 30676 AF089743 Morone saxatilis homeodomain protein Hox-A10 (Hoxa10), homeodomain protein Morone saxatilis 36,738 2-Aug-99 Hox-A9 (Hoxa9), homeodomain protein Hox-A7 (Hoxa7), homeodomain protein Hox-A5 (Hoxa5), and homeodomain protein Hox-A4 (Hoxa4) genes, complete cds. rxa01273 1557 GB_PR3: AC004070 110192 AC004070 Human Chromosome X, complete sequence. Homo sapiens 37,679 29-Jan-98 GB_PR2: AC002410 96217 AC002410 Human BAC clone RG264L19 from 7p15-p21, complete sequence. Homo sapiens 38,587 11-Aug-97 GB_PR2: AC002410 96217 AC002410 Human BAC clone RG264L19 from 7p15-p21, complete sequence. Homo sapiens 37,035 11-Aug-97 rxa01275 1041 GB_EST8: C03322 357 C03322 C03322 Human heart cDNA (YNakamura) Homo sapiens cDNA clone 3NHC1263, Homo sapiens 35,393 30-Jul-96 mRNA sequence. GB_EST4: R92079 410 R92079 yp96g02.r1 Soares fetal liver spleen 1NFLS Homo sapiens cDNA clone IMAGE: Homo sapiens 37,010 25-Aug-95 195314 5′, mRNA sequence. GB_EST4: H57724 461 H57724 yr21a12.r1 Soares fetal liver spleen 1NFLS Homo sapiens cDNA clone IMAGE: Homo sapiens 37,281 05-OCT-1995 205918 5′, mRNA sequence. rxa01276 567 GB_OM: OCMYLC1 962 X54041 Rabbit mRNA for myosin light chain 1. Oryctolagus cuniculus 40,503 26-Nov-90 GB_PR3: AC005383 123110 AC005383 Homo sapiens chromosome 10 clone CIT987SK-1144G6 map 10q25.1, Homo sapiens 38,930 31-OCT-1998 complete sequence. GB_RO: RATPTPECA 2155 D78610 Rat mRNA for protein tyrosine phosphatase epsilon C, partial cds. Rattus norvegicus 37,770 5-Feb-99 rxa01281 885 GB_HTG4: AC009366 199607 AC009366 Drosophila melanogaster chromosome 3L/79D4 clone RPCI98-48E10, Drosophila melanogaster 34,025 16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 31 unordered pieces. GB_HTG4: AC009366 199607 AC009366 Drosophila melanogaster chromosome 3L/79D4 clone RPCI98-48E10, Drosophila melanogaster 34,025 16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 31 unordered pieces. GB_HTG4: AC009366 199607 AC009366 Drosophila melanogaster chromosome 3L/79D4 clone RPCI98-48E10, Drosophila melanogaster 34,386 16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 31 unordered pieces. rxa01282 903 GB_GSS11: AQ263970 363 AQ263970 CITBI-E1-2503H24.TF CITBI-E1 Homo sapiens genomic clone 2503H24, Homo sapiens 40,361 27-OCT-1998 genomic survey sequence. GB_GSS1: FR0025959 603 AL018794 F. rubripes GSS sequence, clone 165E10aE1, genomic Fugu rubripes 34,824 10-DEC-1997 survey sequence. GB_GSS9: AQ102435 334 AQ102435 HS_3038_B2_D09_MF CIT Approved Human Genomic Sperm Library D Homo sapiens 37,624 27-Aug-98 Homo sapiens genomic clone Plate = 3038 Col = 18 Row = H, genomic survey sequence. rxa01294 789 GB_PL2: AC007258 144422 AC007258 Arabidopsis thaliana chromosome I BAC F23H11 genomic sequence, complete Arabidopsis thaliana 39,453 16-Jun-99 sequence. GB_EST17: T04634 491 T04634 681 Lambda-PRL1 Arabidopsis thaliana cDNA clone SBD1T7P, mRNA sequence. Arabidopsis thaliana 38,693 6-Nov-97 GB_PL2: AC007258 144422 AC007258 Arabidopsis thaliana chromosome I BAC F23H11 genomic sequence, complete Arabidopsis thaliana 36,170 16-Jun-99 sequence. rxa01295 1098 GB_HTG3: AC009803 235360 AC009803 Homo sapiens clone RPCI11-1028N23, *** SEQUENCING IN PROGRESS ***, Homo sapiens 38,662 24-Sep-99 47 unordered pieces. GB_HTG3: AC009803 235360 AC009803 Homo sapiens clone RPCI11-1028N23, *** SEQUENCING IN PROGRESS ***, Homo sapiens 38,662 24-Sep-99 47 unordered pieces. GB_IN2: AC004333 63178 AC004333 Drosophila melanogaster DNA sequence (P1 DS05969 (D229)), complete sequence. Drosophila melanogaster 39,252 20-Jun-98 rxa01296 1206 GB_PR4: AC004961 68130 AC004961 Homo sapiens clone DJ1098J04, complete sequence. Homo sapiens 39,409 5-Jun-99 GB_GSS14: AQ525299 447 AQ525299 HS_5227_B2_H03_SP6E RPCI-11 Human Male BAC Library Homo sapiens 37,330 11-MAY-1999 Homo sapiens genomic clone Plate = 803 Col = 6 Row = P, genomic survey sequence. GB_BA2: BFU78108 1900 U78108 Bacteroides fragilis NAD(H) glutamate dehydrogenase (gdhB) gene, complete cds. Bacteroides fragilis 40,509 15-Jul-98 rxa01301 648 GB_PR4: AC007051 167810 AC007051 Homo sapiens chromosome 3, clone hRPK.44_A_1, complete sequence. Homo sapiens 38,498 11-Jun-99 GB_PR4: AC007919 184989 AC007919 Homo sapiens 3q26.2-27 BAC RPCI11-408H1 (Roswell Park Cancer Institute Human Homo sapiens 35,139 09-OCT-1999 BAC Library) complete sequence. GB_EST11: AA252547 454 AA252547 zp87g09.r1 Stratagene HeLa cell s3 937216 Homo sapiens cDNA clone IMAGE: Homo sapiens 38,538 12-MAR-1997 627232 5′ similar to gb: D13748 EUKARYOTIC INITIATION FACTOR 4A-I (HUMAN);, mRNA sequence. rxa01304 609 GB_HTG2: AC006779 119562 AC006779 Caenorhabditis elegans clone Y47D7, *** SEQUENCING IN PROGRESS ***, Caenorhabditis elegans 32,888 25-Feb-99 32 unordered pieces. GB_HTG2: AC006779 119562 AC006779 Caenorhabditis elegans clone Y47D7, *** SEQUENCING IN PROGRESS ***, Caenorhabditis elegans 32,888 25-Feb-99 32 unordered pieces. GB_VI: BHT1UL 37000 Z78205 Bovine herpesvirus type 1 UL22-35 genes. Bovine herpesvirus 1 38,047 14-Aug-96 rxa01306 1131 GB_GSS8: AQ047475 420 AQ047475 cLM-1c5-t cLM Giardia intestinalis genomic, genomic survey sequence. Giardia intestinalis 38,902 14-Jul-98 GB_PL1: CR1433P 1464 X79445 C. reinhardtii mRNA for 14-3-3 protein. Chlamydomonas reinhardtii 39,640 06-OCT-1995 GB_PR3: HSJ878I13 122400 AL049591 Human DNA sequence from clone 878I13 on chromosome Xq23-25 Contains a Homo sapiens 35,624 23-Nov-99 pseudogene similar to alpha tubulin, ESTs, STSs, GSSs, complete sequence. rxa01310 450 GB_HTG3: AC010530 274508 AC010530 Homo sapiens chromosome 16 clone RPCI-11_167P11, *** SEQUENCING IN Homo sapiens 38,462 15-Sep-99 PROGRESS ***, 19 unordered pieces. GB_HTG3: AC010530 274508 AC010530 Homo sapiens chromosome 16 clone RPCI-11_167P11, *** SEQUENCING IN Homo sapiens 38,462 15-Sep-99 PROGRESS ***, 19 unordered pieces. GB_HTG3: AC010530 274508 AC010530 Homo sapiens chromosome 16 clone RPCI-11_167P11, *** SEQUENCING IN Homo sapiens 32,063 15-Sep-99 PROGRESS ***, 19 unordered pieces. rxa01313 rxa01315 774 GB_BA2: AF031037 1472 AF031037 Neisseria meningitidis chloramphenicol acetyltransferase gene, complete cds. Neisseria meningitidis 35,638 21-Apr-98 GB_GSS11: AQ326599 662 AQ326599 nbxb0037P01r CUGI Rice BAC Library Oryza sativa genomic clone nbxb0037P01r, Oryza sativa 34,817 8-Jan-99 genomic survey sequence. GB_HTG1: PFMAL13PA 80518 AL109815 Plasmodium falciparum chromosome 13 strain 3D7, *** SEQUENCING IN Plasmodium falciparum 34,935 19-Aug-99 PROGRESS ***, in unordered pieces. rxa01316 426 GB_HTG3: AC010133 154773 AC010133 Homo sapiens clone NH0118E09, *** SEQUENCING IN PROGRESS ***, Homo sapiens 33,414 13-Sep-99 5 unordered pieces. GB_HTG3: AC010133 154773 AC010133 Homo sapiens clone NH0118E09, *** SEQUENCING IN PROGRESS ***, Homo sapiens 33,414 13-Sep-99 5 unordered pieces. GB_HTG3: AC010133 154773 AC010133 Homo sapiens clone NH0118E09, *** SEQUENCING IN PROGRESS ***, Homo sapiens 38,186 13-Sep-99 5 unordered pieces. rxa01317 543 GB_BA2: U67560 12215 U67560 Methanococcus jannaschii section 102 of 150 of the complete genome. Methanococcus jannaschii 38,476 28-Jan-98 GB_BA2: U67560 12215 U67560 Methanococcus jannaschii section 102 of 150 of the complete genome. Methanococcus jannaschii 35,867 28-Jan-98 rxa01318 1425 GB_BA1: MTV038 16094 AL021933 Mycobacterium tuberculosis H37Rv complete genome; segment 24/162. Mycobacterium 51,266 17-Jun-98 tuberculosis GB_IN1: CELC41A3 37149 U41541 Caenorhabditis elegans cosmid C41A3. Caenorhabditis elegans 36,887 08-DEC-1995 GB_HTG3: AC011298 205637 AC011298 Homo sapiens clone NH0118M12, *** SEQUENCING IN PROGRESS ***, Homo sapiens 35,760 05-OCT-1999 19 unordered pieces. rxa01326 489 GB_BA1: PAL249201 3390 AJ249201 Prevotella albensis ftsQ (partial), ftsA and ftsZ genes and ORF-fts (partial). Prevotella albensis 37,708 27-Aug-99 GB_BA1: PAL249201 3390 AJ249201 Prevotella albensis ftsQ (partial), ftsA and ftsZ genes and Prevotella albensis 37,474 27-Aug-99 ORF-fts (partial). rxa01330 rxa01331 2520 GB_HTG1: HSAJ02553 142807 AJ002553 Homo sapiens chromosome 11 clone 1118i22 map q13, *** SEQUENCING IN Homo sapiens 26,237 14-Nov-97 PROGRESS ***, in unordered pieces. GB_HTG1: HSAJ02553 142807 AJ002553 Homo sapiens chromosome 11 clone 1118i22 map q13, *** SEQUENCING IN Homo sapiens 26,237 14-Nov-97 PROGRESS ***, in unordered pieces. GB_PR3: AC005304 164017 AC005304 Homo sapiens chromosome 17, clone hRPK.131_K_5, Homo sapiens 35,318 25-Jul-98 complete sequence. rxa01333 1128 GB_BA1: CGU43536 3464 U43536 Corynebacterium glutamicum heat shock, ATP-binding protein (clpB) gene, complete Corynebacterium 38,075 13-MAR-1997 cds. glutamicum GB_OM: BTPRLP 924 X15975 Bovine mRNA for prolactin (PRL) related protein. Bos taurus 40,901 22-DEC-1994 GB_OM: BTPRLP 924 X15975 Bovine mRNA for prolactin (PRL) related protein. Bos taurus 39,580 22-DEC-1994 rxa01336 726 GB_BA1: AP000064 247695 AP000064 Aeropyrum pernix genomic DNA, section 7/7. Aeropyrum pernix 37,881 22-Jun-99 GB_BA1: AP000064 247695 AP000064 Aeropyrum pernix genomic DNA, section 7/7. Aeropyrum pernix 36,161 22-Jun-99 GB_EST1: T05458 363 T05458 EST03347 Fetal brain, Stratagene (cat#936206) Homo sapiens cDNA clone Homo sapiens 43,798 30-Jun-93 HFBCY86, mRNA sequence. rxa01337 1536 GB_PR2: AP000215 100000 AP000215 Homo sapiens genomic DNA, chromosome 21q22.3-ter, Ter region, clone Homo sapiens 36,438 20-Nov-99 f27E1-T1136, segment 1/4, complete sequence. GB_PR2: AP000215 100000 AP000215 Homo sapiens genomic DNA, chromosome 21q22.3-ter, Ter region, clone Homo sapiens 35,827 20-Nov-99 f27E1-T1136, segment 1/4, complete sequence. GB_PR2: AP000337 53553 AP000337 Homo sapiens genomic DNA, chromosome 21q22.3-ter, Ter region, clone: T1957, Homo sapiens 36,043 20-Nov-99 complete sequence. rxa01342 626 GB_EST35: AI814229 544 AI814229 wj70e01.x1 NCI_CGAP_Lu19 Homo sapiens cDNA clone IMAGE: 2408184 3′, Homo sapiens 36,803 24-Aug-99 mRNA sequence. GB_EST35: AI814229 544 AI814229 wj70e01.x1 NCI_CGAP_Lu19 Homo sapiens cDNA clone IMAGE: 2408184 3′, Homo sapiens 36,688 24-Aug-99 mRNA sequence. rxa01348 615 GB_HTG3: AC011246 210407 AC011246 Homo sapiens clone NH0498O20, *** SEQUENCING IN PROGRESS ***, Homo sapiens 39,101 04-OCT-1999 29 unordered pieces. GB_HTG3: AC011246 210407 AC011246 Homo sapiens clone NH0498O20, *** SEQUENCING IN PROGRESS ***, Homo sapiens 39,101 04-OCT-1999 29 unordered pieces. GB_PL1: ZMB32120 3093 X54212 Z. mays mRNA for b-32 protein, putative regulatory factor of zein expression Zea mays 35,902 18-Jan-93 (clone b-32.120). rxa01349 900 GB_IN1: CELK10G6 33588 AF016669 Caenorhabditis elegans cosmid K10G6. Caenorhabditis elegans 40,251 8-Aug-97 GB_IN1: CELK10G6 33588 AF016669 Caenorhabditis elegans cosmid K10G6. Caenorhabditis elegans 36,842 8-Aug-97 rxa01357 426 GB_BA1: MTCY274 39991 Z74024 Mycobacterium tuberculosis H37Rv complete genome; segment 126/162. Mycobacterium 36,058 19-Jun-98 tuberculosis GB_BA1: MLCB250 40603 Z97369 Mycobacterium leprae cosmid B250. Mycobacterium leprae 59,294 27-Aug-99 GB_BA2: SKZ86111 7860 Z86111 Streptomyces lividans rpsP, trmD, rplS, sipW, sipX, sipY, sipZ, mutT genes and Streptomyces lividans 57,882 27-OCT-1999 4 open reading frames. rxa01359 1305 GB_BA1: D87820 7217 D87820 Vibrio cholerae non-O1 gene for N-acetylglucosamine 6-phosphate deacetylase, NagC, Vibrio cholerae non-O1 38,152 17-OCT-1997 NagE, complete cds. GB_PR3: AC004540 131757 AC004540 Homo sapiens PAC clone DJ1066K24 from 7p15, complete sequence. Homo sapiens 35,714 9-Apr-98 GB_PR2: HSU44119 450 U44119 Human der(9) chromosome breakpoint region: alpha 1(V) collagen chain (COL5A1) Homo sapiens 38,085 14-Jan-97 gene, partial intron 24, and imperfect LINE-1 element of Xp21.2. rxa01362 3677 GB_EST30: AI665031 602 AI665031 605005H05.x1 605 —Endosperm cDNA library from Schmidt lab Zea mays cDNA, Zea mays 42,308 11-MAY-1999 mRNA sequence. GB_EST34: AI795319 661 AI795319 605005H05.y2 605 —Endosperm cDNA library from Schmidt lab Zea mays cDNA, Zea mays 38,729 2-Jul-99 mRNA sequence. GB_HTG3: AC008387 151804 AC008387 Homo sapiens chromosome 5 clone CIT-HSPC_229P9, *** SEQUENCING IN Homo sapiens 38,023 3-Aug-99 PROGRESS ***, 74 unordered pieces. rxa01366 513 GB_IN1: AF007166 1392 AF007166 Anopheles gambiae serine protease 14D mRNA, complete cds. Anopheles gambiae 41,379 14-Jul-97 GB_GSS13: AQ475498 476 AQ475498 CITBI-E1-2589F13.TR CITBI-E1 Homo sapiens genomic clone 2589F13, genomic Homo sapiens 40,511 23-Apr-99 survey sequence. GB_IN1: AF007166 1392 AF007166 Anopheles gambiae serine protease 14D mRNA, complete cds. Anopheles gambiae 40,000 14-Jul-97 rxa01367 525 GB_EST28: AI489958 591 AI489958 EST248297 tomato ovary, TAMU Lycopersicon esculentum cDNA clone cLED14O8, Lycopersicon esculentum 38,186 29-Jun-99 mRNA sequence. GB_GSS13: AQ475498 476 AQ475498 CITBI-E1-2589F13.TR CITBI-E1 Homo sapiens genomic clone 2589F13, genomic Homo sapiens 37,405 23-Apr-99 survey sequence. GB_EST28: AI489958 591 AI489958 EST248297 tomato ovary, TAMU Lycopersicon esculentum cDNA clone cLED14O8, Lycopersicon esculentum 35,882 29-Jun-99 mRNA sequence. rxa01370 rxa01372 614 GB_HTG5: AC011644 164746 AC011644 Homo sapiens clone 14_K_21, *** SEQUENCING IN PROGRESS ***, 8 unordered Homo sapiens 33,715 5-Nov-99 pieces. GB_HTG5: AC011644 164746 AC011644 Homo sapiens clone 14_K_21, *** SEQUENCING IN PROGRESS ***, 8 unordered Homo sapiens 35,821 5-Nov-99 pieces. rxa01378 1878 GB_IN1: DMBR42I17 155168 AL121806 Drosophila melanogaster clone BACR42I17. Drosophila melanogaster 36,373 10-OCT-1999 GB_IN2: AC005714 177740 AC005714 Drosophila melanogaster, chromosome 2R, region 58D4-58E2, BAC clone Drosophila melanogaster 36,234 01-MAY-1999 BACR48M13, complete sequence. GB_IN2: AC005639 188288 AC005639 Drosophila melanogaster, chromosome 2R, region 59E3-59F4, BAC clone Drosophila melanogaster 36,275 6-Jan-99 BACR48M01, complete sequence. rxa01379 1042 GB_HTG4: AC010031 132106 AC010031 Drosophila melanogaster chromosome 3L/70C1 clone RPCI98-2M20, Drosophila melanogaster 35,368 16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 69 unordered pieces. GB_HTG4: AC010031 132106 AC010031 Drosophila melanogaster chromosome 3L/70C1 clone RPCI98-2M20, Drosophila melanogaster 35,368 16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 69 unordered pieces. GB_HTG3: AC009932 68745 AC009932 Homo sapiens clone 114_O_12, LOW-PASS SEQUENCE SAMPLING. Homo sapiens 36,337 05-OCT-1999 rxa01380 2322 GB_BA1: SC5F2A 40105 AL049587 Streptomyces coelicolor cosmid 5F2A. Streptomyces coelicolor 39,699 24-MAY-1999 GB_BA1: BPTEX 2701 X95386 B. pertussis tex gene. Bordetella pertussis 59,687 31-Jul-96 GB_BA1: SC5F2A 40105 AL049587 Streptomyces coelicolor cosmid 5F2A. Streptomyces coelicolor 41,024 24-MAY-1999 rxa01384 1839 GB_GSS15: AQ613816 598 AQ613816 HS_5118_B1_F06_T7A RPCI-11 Human Male BAC Library Homo sapiens 39,300 15-Jun-99 Homo sapiens genomic clone Plate = 694 Col = 11 Row = L, genomic survey sequence. GB_GSS15: AQ613816 598 AQ613816 HS_5118_B1_F06_T7A RPCI-11 Human Male BAC Library Homo sapiens 36,455 15-Jun-99 Homo sapiens genomic clone Plate = 694 Col = 11 Row = L, genomic survey sequence. rxa01390 780 GB_BA2: CGL012293 2952 AJ012293 Corynebacterium glutamicum ilvD gene. Corynebacterium 40,413 01-OCT-1999 glutamicum GB_PR4: AC006213 160754 AC006213 Homo sapiens, clone hRPK.15_A_1, complete sequence. Homo sapiens 35,724 16-Jan-99 GB_PL2: ATF24G24 99856 AL049488 Arabidopsis thaliana DNA chromosome 4, BAC clone F24G24 (ESSA project). Arabidopsis thaliana 35,925 27-Aug-99 rxa01391 813 GB_HTG2: AC006171 44733 AC006171 Homo sapiens chromosome 10 clone LA10NC01_15_E_11 map 10q26.3, Homo sapiens 35,031 09-DEC-1998 *** SEQUENCING IN PROGRESS ***, 3 unordered pieces. GB_HTG2: AC006171 44733 AC006171 Homo sapiens chromosome 10 clone LA10NC01_15_E_11 map 10q26.3, Homo sapiens 35,031 09-DEC-1998 *** SEQUENCING IN PROGRESS ***, 3 unordered pieces. GB_HTG2: AC006171 44733 AC006171 Homo sapiens chromosome 10 clone LA10NC01_15_E_11 map 10q26.3, Homo sapiens 38,035 09-DEC-1998 *** SEQUENCING IN PROGRESS ***, 3 unordered pieces. rxa01396 381 GB_BA2: AE000775 14358 AE000775 Aquifex aeolicus section 107 of 109 of the complete genome. Aquifex aeolicus 43,085 25-MAR-1998 GB_EST26: AI329024 471 AI329024 a9c02ne.f1 Neurospora crassa evening cDNA library Neurospora crassa cDNA clone Neurospora crassa 39,286 28-DEC-1998 a9c02ne 5′, mRNA sequence. GB_EST26: AI329043 401 AI329043 a9d06ne.f1 Neurospora crassa evening cDNA library Neurospora crassa cDNA clone Neurospora crassa 44,484 28-DEC-1998 a9d06ne 5′, mRNA sequence. rxa01397 543 GB_BA2: AE000775 14358 AE000775 Aquifex aeolicus section 107 of 109 of the complete genome. Aquifex aeolicus 41,121 25-MAR-1998 GB_BA1: BSTMSPRS 3211 X16518 B. subtilis prs, tms, and ctc (partial) genes for PRPP synthetase and two undefined Bacillus subtilis 41,255 30-Sep-93 gene products. GB_EST4: H21691 382 H21691 yl29b01.r1 Soares breast 3NbHBst Homo sapiens cDNA clone IMAGE: Homo sapiens 35,407 6-Jul-95 159625 5′ similar to SP: XPEC_CERAE P33194 POSSIBLE DNA-REPAIR PROTEIN XP-E;, mRNA sequence. rxa01400 1623 GB_GSS11: AQ264714 353 AQ264714 CITBI-E1-2502C17.TR CITBI-E1 Homo sapiens genomic clone 2502C17, genomic Homo sapiens 40,227 27-OCT-1998 survey sequence. GB_BA1: TFENTRA 2803 M58480 Thiobacillus ferrooxidans nitrogen metabolism regulator (ntrA) gene, complete cds. Thiobacillus ferrooxidans 39,960 26-Apr-93 GB_BA1: NPSDHCDBA 5596 Y07709 N. pharaonis sdhC, sdhD, sdhB and sdhA genes. Natronomonas pharaonis 38,003 2-Sep-96 rxa01401 384 GB_HTG4: AC006583 110000 AC006583 Homo sapiens chromosome 3p21.3 clone RPCI11-491D6, *** SEQUENCING Homo sapiens 32,718 21-OCT-1999 IN PROGRESS ***, 90 unordered pieces. GB_HTG4: AC006583 110000 AC006583 Homo sapiens chromosome 3p21.3 clone RPCI11-491D6, *** SEQUENCING Homo sapiens 32,718 21-OCT-1999 IN PROGRESS ***, 90 unordered pieces. GB_HTG4: AC011291 173585 AC011291 Homo sapiens chromosome unknown clone NH0067G07, WORKING DRAFT Homo sapiens 33,596 29-OCT-1999 SEQUENCE, in unordered pieces. rxa01402 597 GB_BA1: CAJ10319 5368 AJ010319 Corynebacterium glutamicum amtP, glnB, glnD genes and partial ftsY and srp genes. Corynebacterium 39,389 14-MAY-1999 glutamicum GB_HTG4: AC010066 187240 AC010066 Drosophila melanogaster chromosome 3L/72A4 clone RPCI98-25O1, Drosophila melanogaster 33,681 16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 70 unordered pieces. GB_HTG4: AC010066 187240 AC010066 Drosophila melanogaster chromosome 3L/72A4 clone RPCI98-25O1, Drosophila melanogaster 33,681 16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 70 unordered pieces. rxa01403 771 GB_BA1: SC6E10 23990 AL109661 Streptomyces coelicolor cosmid 6E10. Streptomyces coelicolor 39,136 5-Aug-99 A3(2) GB_GSS12: AQ396728 608 AQ396728 mgxb0002E02f CUGI Rice Blast BAC Library Magnaporthe grisea genomic Magnaporthe grisea 36,626 06-MAR-1999 clone mgxb0002E02f, genomic survey sequence. GB_BA1: SC6E10 23990 AL109661 Streptomyces coelicolor cosmid 6E10. Streptomyces coelicolor 41,403 5-Aug-99 A3(2) rxa01405 579 GB_PL2: AF111709 52684 AF111709 Oryza sativa subsp. indica Retrosat 1 retrotransposon and Ty3-Gypsy type Retrosat 2 Oryza sativa subsp. indica 34,888 26-Apr-99 retrotransposon, complete sequences; and unknown genes. GB_GSS3: B88760 696 B88760 RPCI11-24L19.TPC RPCI-11 Homo sapiens genomic clone RPCI-11-24L19, genomic Homo sapiens 37,204 9-Apr-99 survey sequence. GB_STS: G52436 696 G52436 SHGC-85004 Human Homo sapiens STS genomic, sequence tagged site. Homo sapiens 37,204 25-Jun-99 rxa01409 845 GB_HTG5: AC008019 190459 AC008019 Mus musculus, *** SEQUENCING IN PROGRESS ***, 16 unordered pieces. Mus musculus 39,924 16-Nov-99 GB_PR4: AC006236 127593 AC006236 Homo sapiens chromosome 17, clone hCIT.162_E_12, complete sequence. Homo sapiens 33,907 29-DEC-1998 GB_HTG5: AC008019 190459 AC008019 Mus musculus, *** SEQUENCING IN PROGRESS ***, 16 unordered pieces. Mus musculus 40,819 16-Nov-99 rxa01413 723 GB_OV: AF038947 1617 AF038947 Ambystoma tigrinum red cone visual pigment mRNA, complete cds. Ambystoma tigrinum 35,846 16-DEC-1998 GB BA1: MSGB577COS 37770 L01263 M. leprae genomic dna sequence, cosmid b577. Mycobacterium leprae 38,042 14-Jun-96 GB_PR3: AC002558 102064 AC002558 Homo sapiens chromosome 17, clone hRPC867C24, complete sequence. Homo sapiens 36,820 31-OCT-1997 rxa01414 630 GB_PL1: SC5610 37730 Z38060 S. cerevisiae chromosome IX sequence derived from lambda clones 5610-5004. Saccharomyces cerevisiae 38,782 20-Aug-97 GB_PL1: YSCDIN1 2969 M58012 S. cerevisiae ribonucleotide reductase DNA damage-inducible regulatory Saccharomyces cerevisiae 35,877 27-Apr-93 subunit (DIN1) gene, 5′ end. GB_EST18: AA689161 624 AA689161 ET2100 Trypanosoma brucei rhodesiense ZAP II library Trypanosoma brucei Trypanosoma brucei 37,150 15-DEC-1997 rhodesiense cDNA 5′, mRNA sequence. rhodesiense rxa01417 720 GB_PL1: SC8419 30507 Z49701 S. cerevisiae chromosome IV cosmid 8419. Saccharomyces cerevisiae 36,248 11-Aug-97 GB_PL1: SCPRP28G 2452 X56934 S. cerevisiae PRP28 gene. Saccharomyces cerevisiae 45,036 9-Feb-95 GB_BA1: BACPEPFA 4654 M29035 B. subtilis bacillopeptidase F (bpr) gene, complete cds. Bacillus subtilis 37,324 06-MAR-1995 rxa01421 rxa01422 1095 GB_EST24: AU033392 344 AU033392 AU033392 Dictyostelium discoideum SL (H. Urushihara) Dictyostelium discoideum Dictyostelium discoideum 38,953 28-Apr-99 cDNA clone SLA715, mRNA sequence. GB_EST14: AA399243 301 AA399243 zt57d02.s1 Soares_testis_NHT Homo sapiens cDNA clone IMAGE: Homo sapiens 45,183 12-Aug-97 726435 3′ similar to SW: NIDO_HUMAN P14543 NIDOGEN PRECURSOR;, mRNA sequence. GB_PR2: AC002037 53897 AC002037 Human Chromosome 11 Overlapping Cosmids cSRL72g7 and cSRL140b8, complete Homo sapiens 37,500 6-Aug-97 sequence. rxa01425 1008 GB_PR4: AC005908 196501 AC005908 Homo sapiens 12p13.3 BAC RPCI11-476M19 (Roswell Park Cancer Institute Human Homo sapiens 34,410 20-Jan-99 BAC Library) complete sequence. GB_PR4: AF111169 183916 AF111169 Homo sapiens chromosome 14 BAC containing gene for KIAA0759 and other possible Homo sapiens 40,635 19-Jul-99 new transcripts, complete sequence. GB_HTG2: AC008284 146797 AC008284 Drosophila melanogaster chromosome 3 clone BACR03M22 (D1000) Drosophila melanogaster 35,822 2-Aug-99 RPCI-98 03.M.22 map 96C-96D strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 137 unordered pieces. rxa01429 741 GB_EST25: AI300084 635 AI300084 qn59f02.x1 NCI_CGAP_Kid5 Homo sapiens cDNA clone IMAGE: 1902555 3′, Homo sapiens 37,753 1-Feb-99 mRNA sequence. GB_EST18: AA706612 949 AA706612 ah26c02.s1 Soares_parathyroid_tumor_NbHPA Homo sapiens cDNA Homo sapiens 37,361 12-Jan-99 clone 1239938 3′, mRNA sequence. GB_EST35: AI817084 598 AI817084 wj76g07.x1 NCI_CGAP_Lu19 Homo sapiens cDNA clone IMAGE: 2408796 3′, Homo sapiens 38,627 24-Aug-99 mRNA sequence. rxa01434 3075 GB_PL1: CAC49C10 37825 AL033497 C. albicans cosmid Ca49C10. Candida albicans 34,724 10-Nov-98 GB_GSS3: B10423 1217 B10423 F19F22-T7 IGF Arabidopsis thaliana genomic clone F19F22, genomic survey Arabidopsis thaliana 36,003 14-MAY-1997 sequence. GB_PL1: CAC49C10 37825 AL033497 C. albicans cosmid Ca49C10. Candida albicans 33,794 10-Nov-98 rxa01439 669 GB_BA2: AF049897 9196 AF049897 Corynebacterium glutamicum N-acetylglutamylphosphate reductase (argC), ornithine Corynebacterium 41,564 1-Jul-98 acetyltransferase (argJ), N-acetylglutamate kinase (argB), acetylornithine transaminase glutamicum (argD), ornithine carbamoyltransferase (argF), arginine repressor (argR), argininosuccinate synthase (argG), and argininosuccinate lyase (argH) genes, complete cds. GB_BA1: CGARGCJBD 4355 X86157 C. glutamicum argC, argJ, argB, argD, and argF genes. Corynebacterium 41,564 25-Jul-96 glutamicum GB_BA2: AF049897 9196 AF049897 Corynebacterium glutamicum N-acetylglutamylphosphate reductase (argC), ornithine Corynebacterium 39,486 1-Jul-98 acetyltransferase (argJ), N-acetylglutamate kinase (argB), acetylornithine transaminase glutamicum (argD), ornithine carbamoyltransferase (argF), arginine repressor (argR), argininosuccinate synthase (argG), and argininosuccinate lyase (argH) genes, complete cds. rxa01440 1131 GB_PAT: E16763 2517 E16763 gDNA encoding aspartate transferase (AAT). Corynebacterium 42,188 28-Jul-99 glutamicum GB_EST20: AA870569 423 AA870569 vq23c09.r1 Barstead stromal cell line MPLRB8 Mus musculus cDNA clone Mus musculus 42,066 16-MAR-1998 IMAGE: 1095088 5′ similar to TR: Q14468 Q14468 KIAA0047;, mRNA sequence. GB_EST18: AA726390 436 AA726390 vu40b04.r1 Barstead mouse myotubes MPLRB5 Mus musculus cDNA clone IMAGE: Mus musculus 41,228 2-Jan-98 1193839 5′, mRNA sequence. rxa01441 1152 GB_EST32: AV053763 252 AV053763 AV053763 Mus musculus pancreas C57BL/6J adult Mus musculus cDNA Mus musculus 45,238 23-Jun-99 clone 1810028E06, mRNA sequence. GB_EST20: AA870569 423 AA870569 vq23c09.r1 Barstead stromal cell line MPLRB8 Mus musculus cDNA clone IMAGE: Mus musculus 39,643 16-MAR-1998 1095088 5′ similar to TR: Q14468 Q14468 KIAA0047;, mRNA sequence. GB_EST18: AA726390 436 AA726390 vu40b04.r1 Barstead mouse myotubes MPLRB5 Mus musculus cDNA clone Mus musculus 39,953 2-Jan-98 IMAGE: 1193839 5′, mRNA sequence. rxa01445 1116 GB_PR4: AC007786 229061 AC007786 Homo sapiens chromosome 19, BAC 41855 (CIT-B-32o4), complete sequence. Homo sapiens 39,545 11-Jun-99 GB_PR3: AC003957 126581 AC003957 Homo sapiens chromosome 17, clone hCIT.457_L_16, complete sequence. Homo sapiens 36,579 09-MAY-1998 GB_OV: AF108420 46626 AF108420 Fugu rubripes prohormone convertase PACE4 (PACE4) gene, partial cds; and Fugu rubripes 39,187 17-MAR-1999 1-aminocyclopropane-carboxilate synthase (ACC), recombination-activating protein 1 (RAG1), and recombination-activating protein 2 (RAG2) genes, complete cds. rxa01447 972 GB_PL2: AF049112 1436 AF049112 Zea mays retrotransposon Cinful prpol mRNA, partial cds. Zea mays 38,268 1-Feb-99 GB_EST36: AV190070 360 AV190070 AV190070 Yuji Kohara unpublished cDNA: Strain N2 hermaphrodite embryo Caenorhabditis elegans 40,390 22-Jul-99 Caenorhabditis elegans cDNA clone yk566e10 5′, mRNA sequence. GB_EST9: AA103228 477 AA103228 mo22h07.r1 Life Tech mouse embryo 13 5dpc 10666014 Mus musculus cDNA clone Mus musculus 40,411 29-OCT-1996 IMAGE: 554365 5′ similar to gb: J00068 ACTIN, ALPHA SKELETAL MUSCLE (HUMAN); gb: M12866 Mouse skeletal muscle actin mRNA, complete cds (MOUSE);, mRNA sequence. rxa01448 1290 GB_BA1: CGFDA 3371 X17313 Corynebacterium glutamicum fda gene for fructose-bisphosphate aldolase Corynebacterium 100,000 12-Sep-93 (EC 4.1.2.13). glutamicum GB_PL2: ENU75428 4443 U75428 Emericella nidulans acid trehalase precursor (treA) gene, complete cds. Emericella nidulans 36,271 15-MAY-1997 GB_BA1: CGFDA 3371 X17313 Corynebacterium glutamicum fda gene for fructose-bisphosphate aldolase Corynebacterium 37,872 12-Sep-93 (EC 4.1.2.13). glutamicum rxa01452 402 GB_BA1: MTV017 67200 AL021897 Mycobacterium tuberculosis H37Rv complete genome; segment 48/162. Mycobacterium 57,246 24-Jun-99 tuberculosis GB_BA1: MLCB1222 34714 AL049491 Mycobacterium leprae cosmid B1222. Mycobacterium leprae 34,872 27-Aug-99 GB_BA2: S71532 914 S71532 che = cholesterol esterase [Streptomyces lavendulae, H646-SY2, Genomic, 914 nt]. Streptomyces lavendulae 38,701 8-Nov-94 rxa01456 645 GB_GSS3: B16150 663 B16150 347A15.TP CIT978SKA1 Homo sapiens genomic clone A-347A15, genomic Homo sapiens 34,394 4-Jun-98 survey sequence. GB_HTG3: AC004157 132090 AC004157 Plasmodium falciparum chromosome 12 clone 3D7, *** SEQUENCING IN Plasmodium falciparum 34,165 23-Sep-99 PROGRESS ***, 9 unordered pieces. GB_HTG3: AC004157 132090 AC004157 Plasmodium falciparum chromosome 12 clone 3D7, *** SEQUENCING IN Plasmodium falciparum 34,165 23-Sep-99 PROGRESS ***, 9 unordered pieces. rxa01457 798 GB_HTG3: AC011009 158335 AC011009 Homo sapiens clone 2_I_22, LOW-PASS SEQUENCE SAMPLING. Homo sapiens 39,490 29-Sep-99 GB_HTG3: AC011009 158335 AC011009 Homo sapiens clone 2_I_22, LOW-PASS SEQUENCE SAMPLING. Homo sapiens 39,490 29-Sep-99 GB_HTG3: AC011009 158335 AC011009 Homo sapiens clone 2_I_22, LOW-PASS SEQUENCE SAMPLING. Homo sapiens 39,125 29-Sep-99 rxa01459 933 GB_HTG3: AC008670 113564 AC008670 Homo sapiens chromosome 5 clone CIT978SKB_36O1, *** SEQUENCING IN Homo sapiens 39,022 3-Aug-99 PROGRESS ***, 43 unordered pieces. GB_HTG3: AC008670 113564 AC008670 Homo sapiens chromosome 5 clone CIT978SKB_36O1, *** SEQUENCING IN Homo sapiens 39,022 3-Aug-99 PROGRESS ***, 43 unordered pieces. GB_IN2: CELT05A8 33896 AF040652 Caenorhabditis elegans cosmid T05A8. Caenorhabditis elegans 35,699 16-Jun-99 rxa01460 417 GB_HTG3: AC009186 48600 AC009186 Homo sapiens chromosome 5 clone CIT978SKB_148I14, *** SEQUENCING IN Homo sapiens 41,278 07-OCT-1999 PROGRESS ***, 3 ordered pieces. GB_HTG3: AC009186 48600 AC009186 Homo sapiens chromosome 5 clone CIT978SKB_148I14, *** SEQUENCING IN Homo sapiens 41,278 07-OCT-1999 PROGRESS ***, 3 ordered pieces. GB_HTG3: AC009186 48600 AC009186 Homo sapiens chromosome 5 clone CIT978SKB_148I14, *** SEQUENCING IN Homo sapiens 35,162 07-OCT-1999 PROGRESS ***, 3 ordered pieces. rxa01463 1287 GB_PR3: HS326L13 127247 Z82170 Human DNA sequence from PAC 326L13 containing brain-4 mRNA ESTs and Homo sapiens 37,956 23-Nov-99 polymorphic CA repeat. GB_HTG1: HS439A6 49379 AL031723 Homo sapiens chromosome 16 clone LA16-439A6, *** SEQUENCING IN Homo sapiens 38,035 23-Nov-99 PROGRESS ***, in unordered pieces. GB_HTG1: HS439A6 49379 AL031723 Homo sapiens chromosome 16 clone LA16-439A6, *** SEQUENCING IN Homo sapiens 38,035 23-Nov-99 PROGRESS ***, in unordered pieces. rxa01469 1155 GB_EST31: AI701691 349 AI701691 we81c04.x1 Soares_NFL_T_GBC_S1 Homo sapiens cDNA clone Homo sapiens 39,806 3-Jun-99 IMAGE: 2347494 3′ similar to gb: L19686_rna1 MACROPHAGE MIGRATION INHIBITORY FACTOR (HUMAN);, mRNA sequence. GB_EST15: AA480256 389 AA480256 ne31f04.s1 NCI_CGAP_Co3 Homo sapiens cDNA clone Homo sapiens 42,705 14-Aug-97 IMAGE: 898975 3′ similar to gb: L19686_rna1 MACROPHAGE MIGRATION INHIBITORY FACTOR (HUMAN);, mRNA sequence. GB_IN2: AF153269 1308 AF153269 Tetrahymena thermophila dynein heavy chain (DYH10) gene, partial cds. Tetrahymena thermophila 32,489 10-Jun-99 rxa01470 549 GB_PL2: ATF3L17 94319 AL080283 Arabidopsis thaliana DNA chromosome 4, BAC clone F3L17 (ESSA project). Arabidopsis thaliana 37,615 24-Jun-99 GB_PL2: ATF3L17 94319 AL080283 Arabidopsis thaliana DNA chromosome 4, BAC clone F3L17 (ESSA project). Arabidopsis thaliana 35,946 24-Jun-99 rxa01471 930 GB_EST11: AA233898 460 AA233898 zr49b12.s1 Soares_NhHMPu_S1 Homo sapiens cDNA clone IMAGE: Homo sapiens 40,570 6-Aug-97 666719 3′, mRNA sequence. GB_EST11: AA234033 428 AA234033 zr49b12.r1 Soares_NhHMPu_S1 Homo sapiens cDNA clone IMAGE: 666719 Homo sapiens 36,277 6-Aug-97 5′ similar to contains Alu repetitive element;, mRNA sequence. GB_PL2: AF084971 1874 AF084971 Catharanthus roseus G-box binding protein 1 (GBF1) mRNA, complete cds. Catharanthus roseus 36,821 7-Jul-99 rxa01472 rxa01473 888 GB_PL2: AC002329 76170 AC002329 DNA sequence of Arabidopsis thaliana BAC F5J6 from chromosome Arabidopsis thaliana 35,780 18-Nov-97 IV, complete sequence. GB_HTG3: AC009485 190706 AC009485 Homo sapiens clone NH0324G03, *** SEQUENCING IN Homo sapiens 39,649 04-OCT-1999 PROGRESS ***, 6 unordered pieces. GB_HTG3: AC009485 190706 AC009485 Homo sapiens clone NH0324G03, *** SEQUENCING IN Homo sapiens 39,649 04-OCT-1999 PROGRESS ***, 6 unordered pieces. rxa01474 669 GB_PR2: HSP373C6 85654 AL022393 Homo sapiens DNA sequence from P1 p373c6 on chromosome Homo sapiens 33,934 22-Nov-99 6p21.31-21.33. Contains zinc finger proteins, pseudogenes, ESTs and STS. GB_EST4: H30893 485 H30893 yp43e11.r1 Soares retina N2b5HR Homo sapiens cDNA clone IMAGE: 190220 Homo sapiens 37,866 16-Aug-95 5′ similar to contains Alu repetitive element;, mRNA sequence. GB_PL2: ATAC005398 80238 AC005398 Arabidopsis thaliana chromosome II BAC T6B13 genomic sequence, Arabidopsis thaliana 38,640 30-OCT-1998 complete sequence. rxa01475 549 GB_PL1: AB024028 70952 AB024028 Arabidopsis thaliana genomic DNA, chromosome 3, TAC clone: K1G2, Arabidopsis thaliana 40,520 20-Nov-99 complete sequence. GB_HTG2: AC007940 159279 AC007940 Homo sapiens clone 44_C_14, *** SEQUENCING IN Homo sapiens 36,044 1-Jul-99 PROGRESS ***, 12 unordered pieces. GB_HTG2: AC007940 159279 AC007940 Homo sapiens clone 44_C_14, *** SEQUENCING IN Homo sapiens 36,044 1-Jul-99 PROGRESS ***, 12 unordered pieces. rxa01476 465 GB_PL1: AB009087 1074 AB009087 Chlamydomonas sp. mRNA for alternative oxidase, partial cds. Chlamydomonas sp. 38,596 05-DEC-1997 GB_PL1: AB009087 1074 AB009087 Chlamydomonas sp. mRNA for alternative oxidase, partial cds. Chlamydomonas sp. 39,519 05-DEC-1997 rxa01479 363 GB_HTG1: HSJ136J15 148579 AL118496 Homo sapiens chromosome X clone RP1-136J15, *** SEQUENCING Homo sapiens 39,886 23-Nov-99 IN PROGRESS ***, in unordered pieces. GB_HTG1: HSJ136J15 148579 AL118496 Homo sapiens chromosome X clone RP1-136J15, *** SEQUENCING Homo sapiens 39,886 23-Nov-99 IN PROGRESS ***, in unordered pieces. GB_HTG2: AC007579 134344 AC007579 Drosophila melanogaster chromosome 2 clone BACR07M03 (D607) Drosophila melanogaster 39,266 2-Aug-99 RPCI-98 07.M.3 map 53A-53B strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 108 unordered pieces. rxa01484 669 GB_PR3: AF064858 193387 AF064858 Homo sapiens chromosome 21q22.3 BAC 28F9, complete sequence. Homo sapiens 38,281 2-Jun-98 GB_GSS10: AQ207755 496 AQ207755 HS_3026_B1_G04_T7 CIT Approved Human Genomic Sperm Library D Homo sapiens 37,150 18-Sep-98 Homo sapiens genomic clone Plate = 3026 Col = 7 Row = N, genomic survey sequence. GB_PR3: AF064858 193387 AF064858 Homo sapiens chromosome 21q22.3 BAC 28F9, complete sequence. Homo sapiens 38,379 2-Jun-98 rxa01485 2175 GB_IN1: CEY50E8A 61864 AL117200 Caenorhabditis elegans cosmid Y50E8A, complete sequence. Caenorhabditis elegans 39,617 19-Nov-99 GB_IN1: CEY50E8A 61864 AL117200 Caenorhabditis elegans cosmid Y50E8A, complete sequence. Caenorhabditis elegans 34,349 19-Nov-99 GB_PL1: AB028606 61510 AB028606 Arabidopsis thaliana genomic DNA, chromosome 5, BAC clone: F16F17, Arabidopsis thaliana 34,858 20-Nov-99 complete sequence. rxa01488 1071 GB_BA1: CGPROMF10 60 X90358 C. glutamicum DNA for promoter fragment F10. Corynebacterium 65,000 4-Nov-96 glutamicum GB_EST10: AA183656 465 AA183656 mt20f08.r1 Soares mouse 3NbMS Mus musculus cDNA clone IMAGE: 621639 Mus musculus 35,333 17-Feb-97 5′ similar to WP: T02C12.2 CE01062;, mRNA sequence. GB_EST9: AA110912 309 AA110912 mm02c01.r1 Stratagene mouse kidney (#937315) Mus musculus cDNA clone Mus musculus 37,662 4-Feb-97 IMAGE: 520320 5′ similar to WP: T02C12.2 CE01062;, mRNA sequence. rxa01492 927 GB_EST16: AA589576 567 AA589576 vl49b06.s1 Stratagene mouse skin (#937313) Mus musculus cDNA clone Mus musculus 34,104 16-Sep-97 IMAGE: 975539 3′ similar to gb: M63488 REPLICATION PROTEIN A 70 KD DNA-BINDING SUBUNIT (HUMAN);, mRNA sequence. GB_EST28: AU051490 865 AU051490 AU051490 Sugano mouse brain mncb Mus musculus cDNA clone MNCb-2105 Mus musculus 29,837 18-MAR-1999 5′, mRNA sequence. GB_EST32: AI738234 609 AI738234 606044C01.x2 606 —Ear tissue cDNA library from Schmidt lab Zea mays 38,291 16-Jun-99 Zea mays cDNA, mRNA sequence. rxa01494 1119 GB_PR4: AC007106 172188 AC007106 Homo sapiens chromosome 4 clone C0383J20 map 4p16, complete sequence. Homo sapiens 35,108 2-Jun-99 GB_BA2: AE001093 14097 AE001093 Archaeoglobus fulgidus section 14 of 172 of the complete genome. Archaeoglobus fulgidus 38,113 15-DEC-1997 GB_PR4: AC007106 172188 AC007106 Homo sapiens chromosome 4 clone C0383J20 map 4p16, complete sequence. Homo sapiens 34,657 2-Jun-99 rxa01497 1041 GB_BA2: SCJ1 36925 AL109962 Streptomyces coelicolor cosmid J1. Streptomyces coelicolor 50,722 24-Sep-99 A3(2) GB_BA1: MTY20B11 36330 Z95121 Mycobacterium tuberculosis H37Rv complete genome; segment 139/162. Mycobacterium 40,238 17-Jun-98 tuberculosis GB_BA1: PAU12891 4062 U12891 Pseudomonas aeruginosa PAO substrain OT684 pyoverdine gene Pseudomonas aeruginosa 39,856 03-OCT-1996 transcriptional regulator PvdS (pvdS) gene, complete cds. rxa01501 411 GB_PAT: I78757 2203 I78757 Sequence 13 from patent U.S. Pat. No. 5693781. Unknown. 61,364 3-Apr-98 GB_PAT: I92046 2203 I92046 Sequence 13 from patent U.S. Pat. No. 5726299. Unknown. 61,364 01-DEC-1998 GB_PR4: AC002427 101098 AC002427 Homo sapiens BAC clone GS011E15 from 5q31, complete sequence. Homo sapiens 42,250 02-DEC-1998 rxa01504 732 GB_HTG3: AC008954 23046 AC008954 Homo sapiens chromosome 5 clone CITB-H1_2340N2, *** SEQUENCING Homo sapiens 37,830 3-Aug-99 IN PROGRESS ***, 51 unordered pieces. GB_HTG3: AC008954 23046 AC008954 Homo sapiens chromosome 5 clone CITB-H1_2340N2, *** SEQUENCING IN Homo sapiens 37,830 3-Aug-99 PROGRESS ***, 51 unordered pieces. GB_BA1: QPHQSOP 4068 L28041 Plasmid QpH1 (from Coxiella burnetii) qsopA and qsopB genes, Plasmid QpH1 37,517 14-Jul-95 promoter region. rxa01505 621 GB_SY: SYNM13GAL 66 M10216 Bacteriophage M13gt102 N-terminal beta-galactosidase gene (lac+ phenotype). unidentified cloning vector 62,121 27-Apr-93 GB_SY: SYNM13GAL 66 M10216 Bacteriophage M13gt102 N-terminal beta-galactosidase gene (lac+ phenotype). unidentified cloning vector 62,121 27-Apr-93 GB_BA2: BJU56817 2892 U56817 Bradyrhizobium japonicum aconitase (acnA) gene, complete cds. Bradyrhizobium japonicum 40,214 13-Nov-96 rxa01506 534 GB_BA1: MTCY98 31225 Z83860 Mycobacterium tuberculosis H37Rv complete genome; segment 103/162. Mycobacterium 38,274 17-Jun-98 tuberculosis GB_BA1: MTCY98 31225 Z83860 Mycobacterium tuberculosis H37Rv complete genome; segment 103/162. Mycobacterium 33,710 17-Jun-98 tuberculosis rxa01507 546 GB_RO: D89731 1815 D89731 Rattus norvegicus mRNA for AIM-1, complete cds. Rattus norvegicus 38,125 7-Feb-99 GB_RO: D89731 1815 D89731 Rattus norvegicus mRNA for AIM-1, complete cds. Rattus norvegicus 34,600 7-Feb-99 rxa01518 rxa01519 870 GB_HTG2: AC007929 123885 AC007929 Drosophila melanogaster chromosome 3 clone BACR05C11 (D759) Drosophila melanogaster 34,075 2-Aug-99 RPCI-98 05.C.11 map 95A-95C strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 85 unordered pieces. GB_HTG2: AC007929 123885 AC007929 Drosophila melanogaster chromosome 3 clone BACR05C11 (D759) Drosophila melanogaster 34,075 2-Aug-99 RPCI-98 05.C.11 map 95A-95C strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 85 unordered pieces. GB_PL2: AC011437 95310 AC011437 Arabidopsis thaliana chromosome III BAC F7O18 genomic sequence, Arabidopsis thaliana 37,280 2-Nov-99 complete sequence. rxa01520 rxa01523 1074 GB_GSS11: AQ270206 389 AQ270206 HS_2037_A1_G10_T7 CIT Approved Human Genomic Sperm Homo sapiens 38,046 3-Nov-98 Library D Homo sapiens genomic clone Plate = 2037 Col = 19 Row = M, genomic survey sequence. GB_GSS14: AQ588624 480 AQ588624 CITBI-E1-2643C9.TF CITBI-E1 Homo sapiens genomic clone 2643C9, Homo sapiens 36,875 7-Jun-99 genomic survey sequence. GB_HTG1: CEY80D3 245017 AL020988 Caenorhabditis elegans chromosome V clone Y80D3, *** SEQUENCING IN Caenorhabditis elegans 35,646 6-Sep-99 PROGRESS ***, in unordered pieces. rxa01525 1845 GB_PR3: HS560B9 99074 Z98751 Human DNA sequence from PAC 560B9 on chromosome 1q24-1q25. Homo sapiens 37,981 23-Nov-99 Contains profilin-like pseudogene, 60S ribosomal protein L4 pseudogene RNA binding protein, ESTs, GSS. GB_PR3: HS560B9 99074 Z98751 Human DNA sequence from PAC 560B9 on chromosome 1q24-1q25. Homo sapiens 37,982 23-Nov-99 Contains profilin-like pseudogene, 60S ribosomal protein L4 pseudogene RNA binding protein, ESTs, GSS. rxa01527 rxa01536 1365 GB_HTG3: AC010745 193862 AC010745 Homo sapiens clone NH0549D18, *** SEQUENCING Homo sapiens 35,277 21-Sep-99 IN PROGRESS ***, 30 unordered pieces. GB_HTG3: AC010745 193862 AC010745 Homo sapiens clone NH0549D18, *** SEQUENCING Homo sapiens 35,277 21-Sep-99 IN PROGRESS ***, 30 unordered pieces. GB_HTG3: AC010745 193862 AC010745 Homo sapiens clone NH0549D18, *** SEQUENCING Homo sapiens 35,958 21-Sep-99 IN PROGRESS ***, 30 unordered pieces. rxa01539 2289 GB_BA1: CGPROMF10 60 X90358 C. glutamicum DNA for promoter fragment F10. Corynebacterium 61,667 4-Nov-96 glutamicum GB_HTG3: AC011577 151996 AC011577 Homo sapiens clone 12_P_19, LOW-PASS SEQUENCE SAMPLING. Homo sapiens 35,554 07-OCT-1999 GB_HTG3: AC011577 151996 AC011577 Homo sapiens clone 12_P_19, LOW-PASS SEQUENCE SAMPLING. Homo sapiens 35,554 07-OCT-1999 rxa01540 825 GB_EST10: AA152819 491 AA152819 mq67e04.r1 Soares 2NbMT Mus musculus cDNA clone Mus musculus 39,040 18-Feb-97 IMAGE: 583806 5′, mRNA sequence. GB_EST29: AI616027 481 AI616027 mq67e04.y1 Soares 2NbMT Mus musculus cDNA clone Mus musculus 36,688 21-Apr-99 IMAGE: 583806 5′, mRNA sequence. GB_GSS6: AQ843942 468 AQ843942 LMAJFV1_lm03d08.x2 Leishmania major FV1 random genomic library Leishmania major 40,899 04-OCT-1999 Leishmania major genomic clone LMAJFV1_lm03d08 3′, genomic survey sequence. rxa01543 2889 GB_BA2: ECOUW67_0 110000 U18997 Escherichia coli K-12 chromosomal region from 67.4 to 76.0 minutes. Escherichia coli 36,618 15-Sep-99 GB_BA2: ECOUW67_0 110000 U18997 Escherichia coli K-12 chromosomal region from 67.4 to 76.0 minutes. Escherichia coli 38,415 15-Sep-99 GB_BA2: AE000397 14820 AE000397 Escherichia coli K-12 MG1655 section 287 of 400 of the Escherichia coli 37,594 12-Nov-98 complete genome. rxa01544 723 GB_EST37: AI977486 479 AI977486 EST272080 Schistosoma mansoni male, Phil LoVerde/Joe Merrick Schistosoma mansoni 44,156 27-Aug-99 Schistosoma mansoni cDNA clone SMMAM80 5′ end, mRNA sequence. GB_VI: AF056119 564 AF056119 HIV-1 isolate z560 from Zimbabwe, envelope glycoprotein V3-V5 Human immunodeficiency 35,874 26-Sep-98 region (env) gene, partial cds. virus type 1 GB_VI: AF056119 564 AF056119 HIV-1 isolate z560 from Zimbabwe, envelope glycoprotein V3-V5 Human immunodeficiency 37,229 26-Sep-98 region (env) gene, partial cds. virus type 1 rxa01545 1374 GB_HTG1: CEY53C10_1 110000 Z93340 Caenorhabditis elegans chromosome I clone Y53C10, *** SEQUENCING Caenorhabditis elegans 36,885 4-Nov-98 IN PROGRESS ***, in unordered pieces. GB_HTG1: CEY53C10_1 110000 Z93340 Caenorhabditis elegans chromosome I clone Y53C10, *** SEQUENCING Caenorhabditis elegans 36,885 4-Nov-98 IN PROGRESS ***, in unordered pieces. GB_HTG1: CEY47H9_1 110000 Z92853 Caenorhabditis elegans chromosome I clone Y47H9, *** SEQUENCING Caenorhabditis elegans 30,285 4-Sep-98 IN PROGRESS ***, in unordered pieces. rxa01546 819 GB_GSS3: B58207 420 B58207 CIT-HSP-2012C11.TR CIT-HSP Homo sapiens genomic clone 2012C11, genomic Homo sapiens 45,228 20-Jun-98 survey sequence. GB_IN1: HAU02678 623 U02678 Helicoverpa armigera mitochondrion D-loop, partial 12S rRNA gene, and partial Mitochondrion Helicoverpa 37,500 27-OCT-1993 tRNA-Met gene. armigera GB_EST19: AA769027 473 AA769027 oa78g01.s1 NCI_CGAP_GCB1 Homo sapiens cDNA clone IMAGE: 1318416 Homo sapiens 39,583 28-Jan-98 3′ similar to TR: Q92617 Q92617 MYELOBLAST KIAA0220;, mRNA sequence. rxa01547 786 GB_EST26: AU002373 837 AU002373 AU002373 Bombyx mori p50(Daizo) Bombyx mori cDNA clone Bombyx mori 37,698 15-Jan-99 mg0832, mRNA sequence. GB_EST30: AV025617 494 AV025617 AV025617 Mus musculus adult C57BL/6J lung Mus musculus cDNA Mus musculus 38,316 31-Aug-99 clone 1200014J18, mRNA sequence. GB_EST26: AU002373 837 AU002373 AU002373 Bombyx mori p50(Daizo) Bombyx mori cDNA clone Bombyx mori 36,767 15-Jan-99 mg0832, mRNA sequence. rxa01548 1131 GB_IN1: PFARBPCA 8841 M88097 Plasmodium vivax retyculocyte binding protein 1 gene, complete cds. Plasmodium vivax 37,077 26-Apr-93 GB_PAT: I55034 1985 I55034 Sequence 2 from patent U.S. Pat. No. 5646247. Unknown. 38,250 07-OCT-1997 GB_OV: GGNEUROMP 1112 Y09597 G. gallus mRNA for NeuroM protein. Gallus gallus 37,104 15-OCT-1997 rxa01549 1727 GB_PR4: HSLONPG01 2443 AF059296 Homo sapiens LON protease (LON) gene, nuclear gene encoding mitochondrial Homo sapiens 39,401 11-Apr-99 protein, exon 1. GB_EST33: AI770254 555 AI770254 SAL2.F12 Black Tiger Shrimp Whole Cephalothorax UniZap library Penaeus Penaeus monodon 40,325 28-Jun-99 monodon cDNA clone SAL2.F12 5′ similar to muscle myosin heavy chain, mRNA sequence. GB_PR1: HSU02389 3179 U02389 Human hLON ATP-dependent protease mRNA, nuclear gene encoding mitochondrial Homo sapiens 38,868 27-Jan-95 protein, complete cds. rxa01552 1101 GB_HTG4: AC011192 144277 AC011192 Homo sapiens clone hRPK.53_A_1, *** SEQUENCING Homo sapiens 36,296 19-OCT-1999 IN PROGRESS ***, 9 unordered pieces. GB_HTG4: AC011192 144277 AC011192 Homo sapiens clone hRPK.53_A_1, *** SEQUENCING Homo sapiens 36,296 19-OCT-1999 IN PROGRESS ***, 9 unordered pieces. GB_HTG3: AC011203 70518 AC011203 Homo sapiens chromosome 3 clone 78_O_24 map 3, LOW-PASS Homo sapiens 36,440 03-OCT-1999 SEQUENCE SAMPLING. rxa01554 2265 GB_EST27: AA957437 340 AA957437 UI-R-E1-fy-g-02-0-UI.s1 UI-R-E1 Rattus norvegicus cDNA clone Rattus norvegicus 39,039 4-Jul-99 UI-R-E1-fy-g-02-0-UI 3′, mRNA sequence. GB_PL2: SPBC19G7 37727 AL021839 S. pombe chromosome II cosmid c19G7. Schizosaccharomyces 36,991 17-Nov-99 pombe GB_PL1: HVPROTZ 703 X05902 Barley mRNA fragment for protein Z. Hordeum vulgare 36,390 13-Jul-95 rxa01557 939 GB_EST24: AI167051 429 AI167051 xylem.est.822 Poplar xylem Lambda ZAPII library Populus balsamifera subsp. Populus balsamifera 40,326 03-DEC-1998 trichocarpa cDNA 5′, mRNA sequence. subsp. trichocarpa GB_PL2: AC007259 97146 AC007259 Arabidopsis thaliana chromosome I BAC T28P6 genomic sequence, complete Arabidopsis thaliana 34,442 17-Aug-99 sequence. GB_PL2: AC007259 97146 AC007259 Arabidopsis thaliana chromosome I BAC T28P6 genomic sequence, complete Arabidopsis thaliana 34,967 17-Aug-99 sequence. rxa01560 rxa01574 1158 GB_PR3: AC005242 160262 AC005242 Homo sapiens chromosome 17, clone hRPK.118_F_13, complete sequence. Homo sapiens 35,727 22-Jul-98 GB_PR3: AC005242 160262 AC005242 Homo sapiens chromosome 17, clone hRPK.118_F_13, complete sequence. Homo sapiens 33,969 22-Jul-98 GB_HTG2: AC007604 167373 AC007604 Homo sapiens chromosome 16 clone 344L6, *** SEQUENCING Homo sapiens 36,028 20-MAY-1999 IN PROGRESS***, 85 unordered pieces. rxa01575 1143 GB_PR4: AC004738 147404 AC004738 Homo sapiens Chromosome 15q11-q13 PAC clone pDJ351h23 from the Homo sapiens 37,312 25-Nov-98 Prader-Willi/Angelman Syndrome region, complete sequence. GB_PR3: AC005250 94336 AC005250 Homo sapiens BAC clone RG318M05 from 7q22-q31.1, complete sequence. Homo sapiens 38,201 3-Jul-98 GB_GSS11: AQ300376 487 AQ300376 HS_2206_A2_D05_MR CIT Approved Human Genomic Sperm Library D Homo sapiens 35,345 16-DEC-1998 Homo sapiens genomic clone Plate = 2206 Col = 10 Row = G, genomic survey sequence. rxa01577 498 GB_BA1: MTY15C10 33050 Z95436 Mycobacterium tuberculosis H37Rv complete genome; segment 154/162. Mycobacterium 58,385 17-Jun-98 tuberculosis GB_BA2: AF030975 2511 AF030975 Aeromonas salmonicida chaperonin GroES and chaperonin GroEL genes, Aeromonas salmonicida 41,322 2-Apr-98 complete cds. GB_EST7: W33355 488 W33355 mb97g01.r1 Soares mouse p3NMF19.5 Mus musculus cDNA clone IMAGE: Mus musculus 40,230 11-Sep-96 337392 5′ similar to gb: X58196_cds1 M. musculus H19 mRNA (MOUSE);, mRNA sequence. rxa01579 507 GB_GSS1: GGA300114 662 AJ231964 Gallus gallus anonymous sequence from Cosmid mapping to chicken chromosome 3 Gallus gallus 38,023 25-Aug-98 (Cosmid 30 - Contig 14), genomic survey sequence. GB_GSS1: GGA300114 662 AJ231964 Gallus gallus anonymous sequence from Cosmid mapping to chicken chromosome 3 Gallus gallus 38,608 25-Aug-98 (Cosmid 30 - Contig 14), genomic survey sequence. rxa01585 750 GB_PR4: AC004815 120538 AC004815 Homo sapiens clone 82F9, complete sequence. Homo sapiens 35,383 8-Sep-99 GB_PR2: AP000151 100000 AP000151 Homo sapiens genomic DNA, chromosome 21q22.2, DSCR region, clone Homo sapiens 39,722 20-Nov-99 D47-S479, segment 3/16, complete sequence. GB_PR2: AP000151 100000 AP000151 Homo sapiens genomic DNA, chromosome 21q22.2, DSCR region, clone Homo sapiens 34,683 20-Nov-99 D47-S479, segment 3/16, complete sequence. rxa01586 392 GB_GSS5: AQ791385 522 AQ791385 HS_5268_A2_C05_T7A RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 43,235 3-Aug-99 genomic clone Plate = 844 Col = 10 Row = E, genomic survey sequence. GB_EST15: AA463774 255 AA463774 aa09f10.r1 Soares_NhHMPu_S1 Homo sapiens cDNA clone IMAGE: Homo sapiens 42,045 10-Jun-97 812779 5′ similar to gb: X07868_rna1 PUTATIVE INSULIN-LIKE GROWTH FACTOR II ASSOCIATED (HUMAN); contains element PTR7 repetitive element;, mRNA sequence. GB_PR1: AP000010 100000 AP000010 Homo sapiens genomic DNA of 21q22.2 Down Syndrome Homo sapiens 38,684 24-Apr-99 region, segment 3/13. rxa01590 rxa01592 1425 GB_HTG2: AC008163 135300 AC008163 Homo sapiens clone NH0005B09, *** SEQUENCING IN Homo sapiens 34,141 31-Jul-99 PROGRESS ***, 1 unordered pieces. GB_HTG2: AC008163 135300 AC008163 Homo sapiens clone NH0005B09, *** SEQUENCING Homo sapiens 34,141 31-Jul-99 IN PROGRESS ***, 1 unordered pieces. GB_HTG3: AC009231 181006 AC009231 Homo sapiens clone NH0350124, *** SEQUENCING Homo sapiens 36,767 6-Aug-99 IN PROGRESS ***, 2 unordered pieces. rxa01595 1083 GB_BA1: MTCI125 37432 Z98268 Mycobacterium tuberculosis H37Rv complete genome; Mycobacterium 57,955 17-Jun-98 segment 76/162. tuberculosis GB_BA1: MTHYPROT 2544 X98295 M. tuberculosis TlyA gene. Mycobacterium 57,955 2-Jun-98 tuberculosis GB_BA1: U00021 39193 U00021 Mycobacterium leprae cosmid L247. Mycobacterium leprae 35,261 29-Sep-94 rxa01597 1305 GB_HTG3: AC009462 103046 AC009462 Drosophila melanogaster chromosome 3 clone BACR27G04 (D985) Drosophila melanogaster 38,898 30-Aug-99 RPCI-98 27.G.4 map 90E—90E strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 88 unordered pieces. GB_HTG3: AC009462 103046 AC009462 Drosophila melanogaster chromosome 3 clone BACR27G04 (D985) Drosophila melanogaster 38,898 30-Aug-99 RPCI-98 27.G.4 map 90E—90E strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 88 unordered pieces. GB_HTG2: AC006889 267118 AC006889 Caenorhabditis elegans clone Y65B4, *** SEQUENCING Caenorhabditis elegans 36,236 26-Feb-99 IN PROGRESS ***, 6 unordered pieces. rxa01598 1086 GB_EST2: R02663 397 R02663 ye80a04.r1 Soares fetal liver spleen 1NFLS Homo sapiens cDNA clone Homo sapiens 36,272 31-MAR-1995 IMAGE: 124014 5′, mRNA sequence. GB_EST6: W03663 346 W03663 za65b08.r1 Soares fetal liver spleen 1NFLS Homo sapiens cDNA clone Homo sapiens 42,775 19-Apr-96 IMAGE: 297399 5′, mRNA sequence. GB_IN2: AC007765 163403 AC007765 Drosophila melanogaster, chromosome 2L, region 23C1-23C5, P1 clones DS02190 Drosophila melanogaster 38,351 9-Jun-99 and DS00906, complete sequence. rxa01600 792 GB_STS: G39530 822 G39530 Z22942 Zebrafish AB Danio rerio STS genomic, sequence tagged site. Danio rerio 41,242 31-Jul-98 GB_STS: G39530 822 G39530 Z22942 Zebrafish AB Danio rerio STS genomic, sequence tagged site. Danio rerio 41,242 31-Jul-98 GB_PR3: HSDJ991C6 128995 AL078599 Human DNA sequence from clone 991C6 on chromosome 6q14.1-15, Homo sapiens 35,188 23-Nov-99 complete sequence. rxa01602 1653 GB_EST38: AW033000 685 AW033000 EST276559 tomato callus, TAMU Lycopersicon esculentum cDNA clone Lycopersicon esculentum 44,706 15-Sep-99 cLEC19N6, mRNA sequence. GB_PL2: SPAC3C7 35052 Z99568 S. pombe chromosome I cosmid c3C7. Schizosaccharomyces 38,158 29-Nov-99 pombe GB_PL2: SPAC3C7 35052 Z99568 S. pombe chromosome I cosmid c3C7. Schizosaccharomyces 37,888 29-Nov-99 pombe rxa01605 1638 GB_HTG3: AC008689 145122 AC008689 Homo sapiens chromosome 5 clone CIT978SKB_61G23, *** SEQUENCING Homo sapiens 35,448 3-Aug-99 IN PROGRESS ***, 44 unordered pieces. GB_HTG3: AC008689 145122 AC008689 Homo sapiens chromosome 5 clone CIT978SKB_61G23, *** SEQUENCING Homo sapiens 35,448 3-Aug-99 IN PROGRESS ***, 44 unordered pieces. GB_HTG3: AC009175 233932 AC009175 Homo sapiens chromosome 5 clone RPCI-PAC_241C15, *** SEQUENCING Homo sapiens 37,423 3-Aug-99 IN PROGRESS ***, 94 unordered pieces. rxa01610 852 GB_BA1: ECU82664 139818 U82664 Escherichia coli minutes 9 to 11 genomic sequence. Escherichia coli 34,198 11-Jan-97 GB_BA1: ECU82664 139818 U82664 Escherichia coli minutes 9 to 11 genomic sequence. Escherichia coli 36,949 11-Jan-97 GB_BA1: D90845 19366 D90845 E. coli genomic DNA, Kohara clone #356(46.1-46.5 min.). Escherichia coli 39,808 21-MAR-1997 rxa01611 480 GB_PR3: AC005581 39601 AC005581 Homo sapiens chromosome 19, cosmid R31237, complete sequence. Homo sapiens 38,901 1-Sep-98 GB_EST35: AI809560 443 AI809560 wf30h09.x1 Soares_NFL_T_GBC_S1 Homo sapiens cDNA clone Homo sapiens 35,989 7-Jul-99 IMAGE: 2357153 3′, mRNA sequence. GB_EST25: AI279953 416 AI279953 qh90b02.x1 Soares_NFL_T_GBC_S1 Homo sapiens cDNA clone Homo sapiens 35,276 27-Jan-99 IMAGE: 1854219 3′, mRNA sequence. rxa01612 rxa01618 507 GB_GSS14: AQ506815 616 AQ506815 RPCI-11-316B19.TV RPCI-11 Homo sapiens genomic clone RPCI-11-316B19, Homo sapiens 41,901 29-Apr-99 genomic survey sequence. GB_HTG2: AC007512 168140 AC007512 Homo sapiens clone hRPK.96_A_1, *** SEQUENCING IN Homo sapiens 39,549 07-MAY-1999 PROGRESS ***, 14 unordered pieces. GB_HTG2: AC007512 168140 AC007512 Homo sapiens clone hRPK.96_A_1, *** SEQUENCING Homo sapiens 39,549 07-MAY-1999 IN PROGRESS ***, 14 unordered pieces. rxa01619 1098 GB_BA1: ECOUW93 338534 U14003 Escherichia coli K-12 chromosomal region from 92.8 to 00.1 minutes. Escherichia coli 39,459 17-Apr-96 GB_BA2: AE000497 10334 AE000497 Escherichia coli K-12 MG1655 section 387 of 400 of the complete genome. Escherichia coli 39,459 12-Nov-98 GB_BA1: ECOLEUX 2147 M96355 Escherichia coli leucine tRNA gene and ORF1 gene, complete cds. Escherichia coli 41,434 26-Jul-95 rxa01622 726 GB_PR4: AC007664 162470 AC007664 Homo sapiens, complete sequence. Homo sapiens 37,006 18-Sep-99 GB_PR4: AC002472 147100 AC002472 Homo sapiens Chromosome 22q11.2 PAC Clone p_n5 In BCRL2-GGT Homo sapiens 33,058 13-Sep-99 Region, complete sequence. GB_BA1: SYCSLRG 135638 D64005 Synechocystis sp. PCC6803 complete genome, 24/27, 3002966-3138603. Synechocystis sp. 38,755 13-Feb-99 rxa01623 834 GB_HTG4: AC007422 156484 AC007422 Homo sapiens clone hRPK.68_A_1, *** SEQUENCING IN Homo sapiens 36,759 23-OCT-1999 PROGRESS ***, 3 unordered pieces. GB_HTG4: AC007422 156484 AC007422 Homo sapiens clone hRPK.68_A_1, *** SEQUENCING Homo sapiens 36,759 23-OCT-1999 IN PROGRESS ***, 3 unordered pieces. GB_HTG4: AC007422 156484 AC007422 Homo sapiens clone hRPK.68_A_1, *** SEQUENCING Homo sapiens 33,495 23-OCT-1999 IN PROGRESS ***, 3 unordered pieces. rxa01624 468 GB_BA2: AE001816 10007 AE001816 Thermotoga maritima section 128 of 136 of the complete genome. Thermotoga maritima 38,852 2-Jun-99 GB_RO: CCPH20 2152 X56332 Cavia cobaya mRNA for PH-20 protein. Cavia porcellus 38,293 20-Feb-91 GB_PAT: I89388 2152 I89388 Sequence 1 from patent U.S. Pat. No. 5721348. Unknown. 38,293 10-Aug-98 rxa01628 1137 GB_BA1: CGPROPGEN 2936 Y12537 C. glutamicum proP gene. Corynebacterium 37,882 17-Nov-98 glutamicum GB_IN1: CET06E6 33238 Z81117 Caenorhabditis elegans cosmid T06E6, complete sequence. Caenorhabditis elegans 38,330 2-Sep-99 GB_HTG2: AC006916 157093 AC006916 Caenorhabditis elegans clone Y9C9, *** SEQUENCING IN Caenorhabditis elegans 36,519 24-Feb-99 PROGRESS ***, 3 unordered pieces. rxa01630 1200 GB_PR3: AC004945 167372 AC004945 Homo sapiens PAC clone DJ0997N05 from 7q11.23-q21.1, complete sequence. Homo sapiens 34,996 26-Sep-98 GB_PR4: AC006385 173508 AC006385 Homo sapiens clone NH0559J05, complete sequence. Homo sapiens 32,525 05-MAY-1999 GB_PR3: AC004945 167372 AC004945 Homo sapiens PAC clone DJ0997N05 from 7q11.23-q21.1, complete sequence. Homo sapiens 37,972 26-Sep-98 rxa01634 675 GB_PR4: AC005901 156763 AC005901 Homo sapiens chromosome 17, clone hRPK.15_K_2, complete sequence. Homo sapiens 35,736 20-Jan-99 GB_PR4: AC005901 156763 AC005901 Homo sapiens chromosome 17, clone hRPK.15_K_2, complete sequence. Homo sapiens 35,549 20-Jan-99 rxa01635 864 GB_HTG3: AC008590 268470 AC008590 Homo sapiens chromosome 5 clone CIT-HSPC_575D19, *** SEQUENCING Homo sapiens 35,370 3-Aug-99 IN PROGRESS ***, 235 unordered pieces. GB_HTG3: AC008590 268470 AC008590 Homo sapiens chromosome 5 clone CIT-HSPC_575D19, *** SEQUENCING IN Homo sapiens 35,370 3-Aug-99 PROGRESS ***, 235 unordered pieces. GB_HTG3: AC008590 268470 AC008590 Homo sapiens chromosome 5 clone CIT-HSPC_575D19, *** SEQUENCING Homo sapiens 38,571 3-Aug-99 IN PROGRESS ***, 235 unordered pieces. rxa01638 1023 GB_HTG3: AC008261 93735 AC008261 Arabidopsis thaliana chromosome III clone TAMU-T4P13, *** SEQUENCING Arabidopsis thaliana 37,200 10-Aug-99 IN PROGRESS ***, 1 ordered pieces. GB_HTG3: AC008261 93735 AC008261 Arabidopsis thaliana chromosome III clone TAMU-T4P13, *** SEQUENCING IN Arabidopsis thaliana 37,200 10-Aug-99 PROGRESS ***, 1 ordered pieces. GB_HTG3: AC008261 93735 AC008261 Arabidopsis thaliana chromosome III clone TAMU-T4P13, *** SEQUENCING IN Arabidopsis thaliana 32,637 10-Aug-99 PROGRESS ***, 1 ordered pieces. rxa01641 1494 GB_PR3: HS681N20 130263 AL031670 Human DNA sequence from clone 681N20 on chromosome 20p12.1-13 Homo sapiens 34,676 23-Nov-99 Contains FTLL1(ferritin, light polypeptide-like 1), a gene similar to Zinc finger, C3HC4 type (RING finger), weakly similar to SW: GOLI_DROME Q06003 GOLIATH PROTEIN, ESTs, STS, GSS, CA repeat (D20S889), CpG Islands, complete sequence. GB_HTG4: AC011177 168660 AC011177 Homo sapiens clone 11_L_8, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,234 29-OCT-1999 7 unordered pieces. GB_HTG4: AC011177 168660 AC011177 Homo sapiens clone 11_L_8, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,234 29-OCT-1999 7 unordered pieces. rxa01642 1365 GB_BA1: MTY15F10 38204 Z94121 Mycobacterium tuberculosis H37Rv complete genome; segment 161/162. Mycobacterium 37,723 17-Jun-98 tuberculosis GB_BA1: SC3C3 31382 AL031231 Streptomyces coelicolor cosmid 3C3. Streptomyces coelicolor 39,602 10-Aug-98 GB_BA1: SCU33176 1238 U33176 Streptomyces coelicolor serine protease gene, complete cds. Streptomyces coelicolor 41,467 9-Jan-96 rxa01643 549 GB_IN1: CEZC101 26147 Z93395 Caenorhabditis elegans cosmid ZC101, complete sequence. Caenorhabditis elegans 36,280 23-Jul-99 GB_EST16: C47058 360 C47058 C47058 Yuji Kohara unpublished cDNA: Strain N2 hermaphrodite Caenorhabditis elegans 39,944 18-OCT-1999 embryo Caenorhabditis elegans cDNA clone yk432e11 5′, mRNA sequence. GB_HTG1: CEY54E2_1 110000 Z92861 Caenorhabditis elegans chromosome II clone Y54E2, *** SEQUENCING IN Caenorhabditis elegans 36,280 29-Jul-98 PROGRESS ***, in unordered pieces. rxa01645 729 GB_BA1: MTV025 121125 AL022121 Mycobacterium tuberculosis H37Rv complete genome; segment 155/162. Mycobacterium 60,310 24-Jun-99 tuberculosis GB_BA1: MLCB2407 35615 AL023596 Mycobacterium leprae cosmid B2407. Mycobacterium leprae 37,378 27-Aug-99 GB BA1: MSGB577COS 37770 L01263 M. leprae genomic dna sequence, cosmid b577. Mycobacterium leprae 57,829 14-Jun-96 rxa01646 942 GB BA1: MSGB577COS 37770 L01263 M. leprae genomic dna sequence, cosmid b577. Mycobacterium leprae 53,781 14-Jun-96 GB_BA1: MLCB2407 35615 AL023596 Mycobacterium leprae cosmid B2407. Mycobacterium leprae 39,348 27-Aug-99 GB_BA1: MTV025 121125 AL022121 Mycobacterium tuberculosis H37Rv complete genome; segment 155/162. Mycobacterium 53,503 24-Jun-99 tuberculosis rxa01647 1293 GB_GSS1: CNS010VB 837 AL099473 Drosophila melanogaster genome survey sequence T7 end of BAC BACN05B20 Drosophila melanogaster 39,412 26-Jul-99 of DrosBAC library from Drosophila melanogaster (fruit fly), genomic survey sequence. GB_EST1: T55021 429 T55021 yb42e09.r1 Stratagene fetal spleen (#937205) Homo sapiens cDNA clone IMAGE: Homo sapiens 39,730 6-Feb-95 73864 5′, mRNA sequence. GB_EST38: AL120803 505 AL120803 DKFZp762E202_r1 762 (synonym: hmel2) Homo sapiens cDNA clone Homo sapiens 40,476 27-Sep-99 DKFZp762E202 5′, mRNA sequence. rxa01656 1020 GB_BA1: MTCY1A10 25949 Z95387 Mycobacterium tuberculosis H37Rv complete genome; segment 117/162. Mycobacterium 37,771 17-Jun-98 tuberculosis GB_BA1: MLCL581 36225 Z96801 Mycobacterium leprae cosmid L581. Mycobacterium leprae 40,041 24-Jun-97 GB_PL2: ATAC003028 106448 AC003028 Arabidopsis thaliana chromosome II BAC F16M14 genomic sequence, Arabidopsis thaliana 57,692 22-Jul-98 complete sequence. rxa01658 1856 GB_BA1: MTV014 58280 AL021646 Mycobacterium tuberculosis H37Rv complete genome; segment 137/162. Mycobacterium 38,877 18-Jun-98 tuberculosis GB_BA1: MTV030 29256 AL021428 Mycobacterium tuberculosis H37Rv complete genome; segment 4/162. Mycobacterium 57,048 17-Jun-98 tuberculosis GB_BA1: MTV014 58280 AL021646 Mycobacterium tuberculosis H37Rv complete genome; segment 137/162. Mycobacterium 40,511 18-Jun-98 tuberculosis rxa01659 669 GB_HTG3: AC008604 136016 AC008604 Homo sapiens chromosome 5 clone CIT978SKB_109F8, *** SEQUENCING IN Homo sapiens 35,106 3-Aug-99 PROGRESS ***, 79 unordered pieces. GB_HTG3: AC008604 136016 AC008604 Homo sapiens chromosome 5 clone CIT978SKB_109F8, *** SEQUENCING IN Homo sapiens 35,106 3-Aug-99 PROGRESS ***, 79 unordered pieces. GB_HTG3: AC011403 124903 AC011403 Homo sapiens chromosome 5 clone CIT978SKB_3P13, *** SEQUENCING IN Homo sapiens 33,997 06-OCT-1999 PROGRESS ***, 7 ordered pieces. rxa01663 981 GB_HTG2: AC006799 278007 AC006799 Caenorhabditis elegans clone Y51H7, *** SEQUENCING IN Caenorhabditis elegans 34,787 23-Feb-99 PROGRESS ***, 7 unordered pieces. GB_HTG2: AC006799 278007 AC006799 Caenorhabditis elegans clone Y51H7, *** SEQUENCING IN Caenorhabditis elegans 34,787 23-Feb-99 PROGRESS ***, 7 unordered pieces. GB_HTG2: AC006799 278007 AC006799 Caenorhabditis elegans clone Y51H7, *** SEQUENCING IN Caenorhabditis elegans 39,148 23-Feb-99 PROGRESS ***, 7 unordered pieces. rxa01665 843 GB_BA1: CGU43535 2531 U43535 Corynebacterium glutamicum multidrug resistance protein (cmr) gene, complete cds. Corynebacterium 37,353 9-Apr-97 glutamicum GB_IN2: AF062971 359 AF062971 Anoplodactylus portus 28S ribosomal RNA gene, partial sequence. Anoplodactylus portus 42,462 20-Apr-99 GB_EST31: AU062109 544 AU062109 AU062109 Dictyostelium discoideum SL (H. Urushihara) Dictyostelium Dictyostelium discoideum 34,810 20-MAY-1999 discoideum cDNA clone SLH629, mRNA sequence. rxa01669 1038 GB_BA2: CGU89648 1105 U89648 Corynebacterium glutamicum unidentified sequence involved in histidine Corynebacterium 65,152 30-MAR-1999 biosynthesis, partial sequence. glutamicum GB_IN1: DMC86E4 29352 AL021086 Drosophila melanogaster cosmid clone 86E4. Drosophila melanogaster 39,289 27-Apr-99 GB_PL1: ENY13759 3141 Y13759 Emericella nidulans abfB gene. Emericella nidulans 38,552 05-MAR-1999 rxa01671 1272 GB_PH: MPU46938 15664 U46938 Mycobacterium phage DS6A, Spe1/Nhel G fragment sequence. Mycobacterium phage 60,751 29-Jun-96 DS6A GB_PAT: I31047 15664 I31047 Sequence 3 from patent U.S. Pat. No. 5582969. Unknown. 60,751 6-Feb-97 GB_PAT: I36863 15664 I36863 Sequence 3 from patent U.S. Pat. No. 5612182. Unknown. 60,751 13-MAY-1997 rxa01672 465 GB_GSS14: AQ512046 462 AQ512046 HS_5113_B1_B10_SP6E RPCI-11 Human Male BAC Library Homo sapiens 40,882 05-MAY-1999 Homo sapiens genomic clone Plate = 689 Col = 19 Row = D, genomic survey sequence. GB_GSS13: AQ475012 253 AQ475012 CITBI-E1-2592A3.TR CITBI-E1 Homo sapiens genomic clone 2592A3, Homo sapiens 35,417 23-Apr-99 genomic survey sequence. GB_GSS14: AQ512046 462 AQ512046 HS_5113_B1_B10_SP6E RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 35,106 05-MAY-1999 genomic clone Plate = 689 Col = 19 Row = D, genomic survey sequence. rxa01673 1158 GB_HTG5: AC010988 176452 AC010988 Homo sapiens clone NH0570F04, WORKING DRAFT Homo sapiens 37,489 11-Nov-99 SEQUENCE, 1 unordered pieces. GB_HTG5: AC010988 176452 AC010988 Homo sapiens clone NH0570F04, WORKING DRAFT SEQUENCE, Homo sapiens 35,492 11-Nov-99 1 unordered pieces. rxa01675 534 GB_EST19: AA797620 497 AA797620 vw26b03.r1 Soares mouse mammary gland NbMMG Mus musculus cDNA clone Mus musculus 44,318 10-Feb-98 IMAGE: 1244909 5′, mRNA sequence. GB_IN2: AF076597 846 AF076597 Dictyostelium discoideum ubiquitin-conjugating enzyme protein UbcC (ubcC) Dictyostelium discoideum 37,149 30-Jul-98 mRNA, complete cds. GB_EST22: C94466 698 C94466 C94466 Dictyostelium discoideum SS (H. Urushihara) Dictyostelium Dictyostelium discoideum 33,647 15-Jun-98 discoideum cDNA clone SSL136, mRNA sequence. rxa01676 879 GB_IN1: CELR03H10 35080 U29382 Caenorhabditis elegans cosmid R03H10. Caenorhabditis elegans 40,951 22-Jun-95 GB_EST37: AI998397 584 AI998397 701545552 A. thaliana, Columbia Col-0, rosette-2 Arabidopsis thaliana cDNA Arabidopsis thaliana 37,333 8-Sep-99 clone 701545552, mRNA sequence. GB_GSS14: AQ551731 577 AQ551731 RPCI-11-383J4.TJ RPCI-11 Homo sapiens genomic clone RPCI-11-383J4, Homo sapiens 39,321 28-MAY-1999 genomic survey sequence. rxa01677 867 GB_PL2: ATF6I18 122322 AL022198 Arabidopsis thaliana DNA chromosome 4, BAC clone F6I18 (ESSA project). Arabidopsis thaliana 34,335 27-Aug-99 GB_PL2: ATF6I18 122322 AL022198 Arabidopsis thaliana DNA chromosome 4, BAC clone F6I18 (ESSA project). Arabidopsis thaliana 34,895 27-Aug-99 GB_OV: XLSDK2 2306 Y10350 X. laevis mRNA for nuclear protein SDK2. Xenopus laevis 36,538 2-Apr-98 rxa01681 756 GB_HTG3: AC010798 172575 AC010798 Homo sapiens chromosome 18 clone 470_B_24 map 18, *** SEQUENCING Homo sapiens 37,116 23-Sep-99 IN PROGRESS ***, 7 unordered pieces. GB_HTG3: AC010798 172575 AC010798 Homo sapiens chromosome 18 clone 470_B_24 map 18, *** SEQUENCING Homo sapiens 37,116 23-Sep-99 IN PROGRESS ***, 7 unordered pieces. GB_PL2: AF085231 3158 AF085231 Arabidopsis thaliana phytochelatin synthase 1 (AtPCS1) gene, complete cds. Arabidopsis thaliana 42,149 3-Jun-99 rxa01685 702 GB_HTG1: CEY48A6 296699 Z92854 Caenorhabditis elegans chromosome III clone Y48A6, *** SEQUENCING Caenorhabditis elegans 37,393 31-Jul-98 IN PROGRESS ***, in unordered pieces. GB_HTG1: CEY48A6 296699 Z92854 Caenorhabditis elegans chromosome III clone Y48A6, *** SEQUENCING Caenorhabditis elegans 37,393 31-Jul-98 IN PROGRESS ***, in unordered pieces. GB_HTG1: CEY48A6 296699 Z92854 Caenorhabditis elegans chromosome III clone Y48A6, *** SEQUENCING Caenorhabditis elegans 32,946 31-Jul-98 IN PROGRESS ***, in unordered pieces. rxa01686 564 GB_EST35: AV156415 240 AV156415 AV156415 Mus musculus head C57BL/6J 12-day embryo Mus musculus Mus musculus 40,417 7-Jul-99 cDNA clone 3000002G04, mRNA sequence. GB_GSS15: AQ611518 597 AQ611518 HS_5084_B2_H01_T7A RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 41,848 15-Jun-99 genomic clone Plate = 660 Col = 2 Row = P, genomic survey sequence. GB_BA1: PDIORAB 5467 Z48918 P. diminuta iorA and iorB genes for isoquinoline 1-oxidoreductase. Brevundimonas diminuta 36,709 15-Aug-95 rxa01693 1545 GB_IN1: CEF46B6 36616 Z70780 Caenorhabditis elegans cosmid F46B6, complete sequence. Caenorhabditis elegans 36,856 04-DEC-1998 GB_EST5: L44364 362 L44364 HUMEST1G5 Human thymus NSTH II Homo sapiens cDNA, mRNA sequence. Homo sapiens 38,136 17-Jan-96 GB_PR2: AF009282 414 AF009282 Homo sapiens clone FBF3 Cri-du-chat region mRNA. Homo sapiens 46,809 17-Aug-97 rxa01694 1023 GB_BA1: CGA224946 2408 AJ224946 Corynebacterium glutamicum DNA for L-Malate: quinone oxidoreductase. Corynebacterium 100,000 11-Aug-98 glutamicum GB_EST7: W22650 715 W22650 71B2 Human retina cDNA Tsp509I-cleaved sublibrary Homo sapiens cDNA Homo sapiens 37,538 06-MAY-1996 not directional, mRNA sequence. GB_PR4: AC005343 137213 AC005343 Homo sapiens Chromosome 12p13.3 BAC RPCI11-21K20 (Roswell Park Homo sapiens 38,048 2-Apr-99 Cancer Institute Human BAC Library) complete sequence. rxa01696 1302 GB_BA1: MSGB1529CS 36985 L78824 Mycobacterium leprae cosmid B1529 DNA sequence. Mycobacterium leprae 67,442 15-Jun-96 GB_BA1: SC6A5 43632 AL049485 Streptomyces coelicolor cosmid 6A5. Streptomyces coelicolor 66,821 24-MAR-1999 GB_BA1: MTV003 13246 AL008883 Mycobacterium tuberculosis H37Rv complete genome; segment 125/162. Mycobacterium 38,802 17-Jun-98 tuberculosis rxa01697 1080 GB_PL2: HNNHAHR 2559 L76588 Helianthus annuus homeodomain protein 1 mRNA, complete cds. Helianthus annuus 38,257 02-OCT-1997 GB_PL2: HNNHAHR 2559 L76588 Helianthus annuus homeodomain protein 1 mRNA, complete cds. Helianthus annuus 37,196 02-OCT-1997 rxa01701 472 GB_BA2: AF069748 2103 AF069748 Pseudomonas chlororaphis polyurethanase esterase A (pueA) gene, complete cds. Pseudomonas chlororaphis 39,130 4-Apr-99 GB_BA2: AF069748 2103 AF069748 Pseudomonas chlororaphis polyurethanase esterase A (pueA) gene, complete cds. Pseudomonas chlororaphis 40,271 4-Apr-99 rxa01703 1236 GB_BA1: CGFDA 3371 X17313 Corynebacterium glutamicum fda gene for Corynebacterium 100,000 12-Sep-93 fructose-bisphosphate aldolase (EC 4.1.2.13). glutamicum GB_EST18: AA728419 340 AA728419 33598 CD4-6 Arabidopsis thaliana cDNA clone K2C9RP, mRNA sequence. Arabidopsis thaliana 36,176 5-Jan-98 GB_PL2: ATU90439 93639 U90439 Arabidopsis thaliana chromosome II BAC T06D20 genomic Arabidopsis thaliana 35,381 21-Jul-97 sequence, complete sequence. rxa01709 555 GB_OV: AF033670 2353 AF033670 Gallus gallus T-Box protein 4 (TBX4) mRNA, complete cds. Gallus gallus 37,917 9-Jun-98 GB_EST5: H85635 533 H85635 ys88c04.r1 Soares retina N2b5HR Homo sapiens cDNA Homo sapiens 36,735 14-Nov-95 clone IMAGE: 221862 5′, mRNA sequence. GB_EST35: AI829867 427 AI829867 wj58c05.x1 NCI_CGAP_Lu19 Homo sapiens cDNA clone Homo sapiens 40,299 26-Aug-99 IMAGE: 2407016 3′, mRNA sequence. rxa01711 1281 GB_GSS10: AQ217798 441 AQ217798 HS_2007_A1_A04_MR CIT Approved Human Genomic Sperm Library D Homo sapiens 38,292 19-Sep-98 Homo sapiens genomic clone Plate = 2007 Col = 7 Row = A, genomic survey sequence. GB_PAT: E05055 2053 E05055 DNA encoding D-threonine aldolase(DTA). Xanthomonas oryzae 36,475 29-Sep-97 GB_PR3: HSJ570L12 143508 AL049589 Human DNA sequence from clone 570L12 on chromosome Homo sapiens 36,262 23-Nov-99 Xq13.1-21.1. Contains the PGK1 gene for phosphoglycerate kinase 1, the gene for a novel protein similar to TAF2G (TATA box binding protein (TBP)-associated factor, RNA polymerase II, G, 32 kD) (TAFII31)), ESTs, STS, GSSs and a putative CpG island, complete sequence. rxa01714 rxa01715 819 GB_BA1: MTCY441 35187 Z80225 Mycobacterium tuberculosis H37Rv complete genome; segment 118/162. Mycobacterium 36,216 18-Jun-98 tuberculosis GB_BA1: SC1B5 14866 AL023517 Streptomyces coelicolor cosmid 1B5. Streptomyces coelicolor 56,807 11-MAY-1998 GB_BA1: MSGB1912CS 38503 L01536 M. leprae genomic dna sequence, cosmid b1912. Mycobacterium leprae 55,651 14-Jun-96 rxa01729 642 GB_BA2: CORCSLYS 2821 M89931 Corynebacterium glutamicum beta C-S lyase (aecD) and branched-chain amino Corynebacterium 41,993 4-Jun-98 acid uptake carrier (brnQ) genes, complete cds, and hypothetical protein glutamicum Yhbw (yhbw) gene, partial cds. GB_HTG4: AC010037 166249 AC010037 Drosophila melanogaster chromosome 3L/66B6 clone RPCI98-6E4, Drosophila melanogaster 34,951 16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 52 unordered pieces. GB_HTG4: AC010037 166249 AC010037 Drosophila melanogaster chromosome 3L/66B6 clone RPCI98-6E4, Drosophila melanogaster 34,951 16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 52 unordered pieces. rxa01731 822 GB_GSS3: B83621 616 B83621 RPCI11-16H17.TPB RPCI-11 Homo sapiens genomic clone Homo sapiens 40,899 9-Apr-99 RPCI-11-16H17, genomic survey sequence. GB_GSS3: B82563 586 B82563 RPCI11-16N17.TP RPCI-11 Homo sapiens genomic clone Homo sapiens 40,235 9-Apr-99 RPCI-11-16N17, genomic survey sequence. GB_HTG3: AC009074 45999 AC009074 Homo sapiens chromosome 16 clone RPCI-11_323C21, *** SEQUENCING Homo sapiens 36,783 3-Aug-99 IN PROGRESS ***, 27 unordered pieces. rxa01734 657 GB_GSS14: AQ545618 327 AQ545618 CITBI-E1-2636O13.TR CITBI-E1 Homo sapiens genomic clone Homo sapiens 38,154 28-MAY-1999 2636O13, genomic survey sequence. GB_HTG2: AC006629 27659 AC006629 Caenorhabditis elegans clone F12E12, *** SEQUENCING Caenorhabditis elegans 35,658 23-Feb-99 IN PROGRESS***, 1 unordered pieces. GB_HTG2: AC006629 27659 AC006629 Caenorhabditis elegans clone F12E12, *** SEQUENCING Caenorhabditis elegans 35,714 23-Feb-99 IN PROGRESS ***, 1 unordered pieces. rxa01738 837 GB_HTG1: CNS01DSB 222193 AL121768 Homo sapiens chromosome 14 clone R-976B16, *** SEQUENCING Homo sapiens 36,978 05-OCT-1999 IN PROGRESS ***, in ordered pieces. GB_HTG1: CNS01DSB 222193 AL121768 Homo sapiens chromosome 14 clone R-976B16, *** SEQUENCING Homo sapiens 36,978 05-OCT-1999 IN PROGRESS ***, in ordered pieces. GB_HTG5: AC011170 171788 AC011170 Homo sapiens clone 10_L_13, *** SEQUENCING Homo sapiens 35,259 5-Nov-99 IN PROGRESS ***, 14 unordered pieces. rxa01741 921 GB_IN1: CEK04G11 34190 Z78544 Caenorhabditis elegans cosmid K04G11, complete sequence. Caenorhabditis elegans 35,055 6-Sep-99 GB_HTG2: AC005995 170023 AC005995 Homo sapiens clone DJ0042M02, *** SEQUENCING Homo sapiens 33,624 23-Apr-99 IN PROGRESS ***, 13 unordered pieces. GB_HTG2: AC005995 170023 AC005995 Homo sapiens clone DJ0042M02, *** SEQUENCING Homo sapiens 33,624 23-Apr-99 IN PROGRESS ***, 13 unordered pieces. rxa01742 627 GB_EST30: AI658116 497 AI658116 fc22e07.y1 Zebrafish WashU MPIMG EST Danio rerio cDNA 5′ Danio rerio 35,604 06-MAY-1999 similar to TR: Q15883 Q15883 X104.;, mRNA sequence. GB_HTG1: CEY60A9 275370 AL022281 Caenorhabditis elegans chromosome X clone Y60A9, *** SEQUENCING Caenorhabditis elegans 35,610 2-Sep-99 IN PROGRESS ***, in unordered pieces. GB_HTG1: CEY60A9 275370 AL022281 Caenorhabditis elegans chromosome X clone Y60A9, *** SEQUENCING Caenorhabditis elegans 35,610 2-Sep-99 IN PROGRESS ***, in unordered pieces. rxa01748 903 GB_GSS13: AQ447364 439 AQ447364 mgxb0006N01r CUGI Rice Blast BAC Library Magnaporthe grisea Magnaporthe grisea 34,889 8-Apr-99 genomic clone mgxb0006N01r, genomic survey sequence. GB_PR2: HSJ247G22 120487 AL096866 Human DNA sequence from clone RP1-247G22 on Homo sapiens 39,310 22-Nov-99 chromosome 6p12.2-21.2, complete sequence. GB_GSS5: AQ811603 375 AQ811603 HS_5460_B1_C09_SP6E RPCI-11 Human Male BAC Library Homo sapiens 38,133 25-Aug-99 Homo sapiens genomic clone Plate = 1036 Col = 17 Row = F, genomic survey sequence. rxa01749 1740 GB_HTG5: AC009544 211057 AC009544 Homo sapiens chromosome 11 clone RP11-85D24 map 11, Homo sapiens 37,433 19-Nov-99 WORKING DRAFT SEQUENCE, 14 unordered pieces. GB_HTG5: AC009544 211057 AC009544 Homo sapiens chromosome 11 clone RP11-85D24 map 11, Homo sapiens 37,069 19-Nov-99 WORKING DRAFT SEQUENCE, 14 unordered pieces. rxa01750 rxa01752 1584 GB_PR1: HUMPROFILX 17630 M96943 Human profilaggrin gene exons 1-3, 5′ end. Homo sapiens 36,352 27-Apr-93 GB_PL2: AF049174 535 AF049174 Tolypocladium inflatum NRRL 28024 28S ribosomal RNA gene, partial sequence. Tolypocladium inflatum 40,187 03-MAR-1999 GB_BA1: MLCL458 43839 AL049478 Mycobacterium leprae cosmid L458. Mycobacterium leprae 40,322 27-Aug-99 rxa01753 1662 GB_PR1: HUMPROFILX 17630 M96943 Human profilaggrin gene exons 1-3, 5′ end. Homo sapiens 36,794 27-Apr-93 GB_PL1: YSCFBPA 2202 J03207 S. cerevisiae fructose-1,6-bisphosphatase (FBP) gene, complete cds. Saccharomyces cerevisiae 37,762 27-Apr-93 GB_PL2: YSCL8039 31806 U19103 Saccharomyces cerevisiae chromosome XII cosmid 8039. Saccharomyces cerevisiae 37,685 22-Aug-97 rxa01754 rxa01760 405 GB_IN1: CELF43C9 34037 U40427 Caenorhabditis elegans cosmid F43C9. Caenorhabditis elegans 40,945 16-Nov-95 GB_IN1: CELF43C9 34037 U40427 Caenorhabditis elegans cosmid F43C9. Caenorhabditis elegans 35,484 16-Nov-95 GB_RO: MUSOP5F 3405 D14816 Mouse osteopontin gene, 5′ flanking region. Mus musculus 35,264 4-Feb-99 rxa01761 4587 GB_PR4: AC004600 133863 AC004600 Homo sapiens Chromosome 15q11-q13 PAC clone pDJ373b1 Homo sapiens 37,037 11-MAR-1999 containing Angelman Syndrome gene (UBE3A), complete sequence. GB_PR3: AC004259 118684 AC004259 Human Chromosome 15q11-q13 PAC clone pDJ14i12 Homo sapiens 37,037 3-Jun-98 containing Angelman Syndrome gene (UBE3A), complete sequence. GB_PR4: AC004600 133863 AC004600 Homo sapiens Chromosome 15q11-q13 PAC clone pDJ373b1 containing Homo sapiens 35,995 11-MAR-1999 Angelman Syndrome gene (UBE3A), complete sequence. rxa01765 1065 GB_EST31: AI694883 370 AI694883 we52h02.x1 NCI_CGAP_Co3 Homo sapiens cDNA Homo sapiens 39,566 3-Jun-99 clone IMAGE: 2344755 3′, mRNA sequence. GB_EST6: W08057 341 W08057 mb37e05.r1 Soares mouse p3NMF19.5 Mus musculus cDNA clone IMAGE: Mus musculus 37,353 5-Sep-96 331616 5′ similar to gb: Z23090 HEAT SHOCK 27 KD PROTEIN (HUMAN); gb: L11609 Mus musculus heat shock protein 25 (MOUSE);, mRNA sequence. GB_IN1: CELC39D10 40897 U39678 Caenorhabditis elegans cosmid C39D10. Caenorhabditis elegans 39,590 2-Nov-95 rxa01767 588 GB_IN1: CEF16H9 21721 Z50005 Caenorhabditis elegans cosmid F16H9, complete sequence. Caenorhabditis elegans 36,667 2-Sep-99 GB_IN1: CECC4 32063 Z81490 Caenorhabditis elegans cosmid CC4, complete sequence. Caenorhabditis elegans 35,094 2-Sep-99 GB_HTG1: CEY26D4 156152 AL022595 Caenorhabditis elegans chromosome I clone Y26D4, *** SEQUENCING Caenorhabditis elegans 33,276 7-Sep-99 IN PROGRESS ***, in unordered pieces. rxa01768 rxa01769 564 GB_HTG4: AC010034 130818 AC010034 Drosophila melanogaster clone RPCI98-4O3, *** SEQUENCING Drosophila melanogaster 35,740 16-OCT-1999 IN PROGRESS ***, 63 unordered pieces. GB_HTG4: AC010034 130818 AC010034 Drosophila melanogaster clone RPCI98-4O3, *** SEQUENCING Drosophila melanogaster 35,740 16-OCT-1999 IN PROGRESS ***, 63 unordered pieces. GB_EST1: D36647 360 D36647 CELK035EZF Yuji Kohara unpublished cDNA Caenorhabditis elegans cDNA Caenorhabditis elegans 37,870 8-Aug-94 clone yk35e12 5′, mRNA sequence. rxa01770 3888 GB_IN1: SUSENDO16C 4692 L34680 Strongylocentrotus purpuratus calcium-binding protein Strongylocentrotus 39,337 21-Jul-94 (endo16) mRNA, complete cds. purpuratus GB_EST31: AF121176 535 AF121176 AF121176 Homo sapiens liver (Chang L-Y) Homo sapiens Homo sapiens 39,626 24-MAY-1999 cDNA clone PFTTA2-2, mRNA sequence. GB_PR1: AB011149 5134 AB011149 Homo sapiens mRNA for KIAA0577 protein, complete cds. Homo sapiens 38,279 10-Apr-98 rxa01771 825 GB_BA1: CGPROPGEN 2936 Y12537 C. glutamicum proP gene. Corynebacterium 100,000 17-Nov-98 glutamicum GB_EST33: AI778471 545 AI778471 EST259350 tomato susceptible, Cornell Lycopersicon esculentum Lycopersicon esculentum 41,187 29-Jun-99 cDNA clone cLES5M16, mRNA sequence. GB_IN1: CET11F9 37714 Z74042 Caenorhabditis elegans cosmid T11F9, complete sequence. Caenorhabditis elegans 38,077 23-Nov-98 rxa01773 600 GB_HTG2: U82212 46387 U82212 Homo sapiens chromosome 10 clone LA10NC01_23_C_3 Homo sapiens 42,142 09-DEC-1998 map 10q26.1-10q26.2, *** SEQUENCING IN PROGRESS ***, 1 ordered pieces. GB_HTG2: U82212 46387 U82212 Homo sapiens chromosome 10 clone LA10NC01_23_C_3 Homo sapiens 42,142 09-DEC-1998 map 10q26.1-10q26.2, *** SEQUENCING IN PROGRESS ***, 1 ordered pieces. GB_HTG2: U82212 46387 U82212 Homo sapiens chromosome 10 clone LA10NC01_23_C_3 Homo sapiens 37,748 09-DEC-1998 map 10q26.1-10q26.2, *** SEQUENCING IN PROGRESS ***, 1 ordered pieces. rxa01774 849 GB_HTG1: HSA557H15 228174 AL078590 Homo sapiens chromosome 6 clone RP11-557H15, *** SEQUENCING Homo sapiens 38,054 23-Nov-99 IN PROGRESS ***, in unordered pieces. GB_HTG1: HSA557H15 228174 AL078590 Homo sapiens chromosome 6 clone RP11-557H15, *** SEQUENCING Homo sapiens 38,054 23-Nov-99 IN PROGRESS ***, in unordered pieces. GB_PL2: YSCH9998 35600 U00030 Saccharomyces cerevisiae chromosome VIII cosmid 9998. Saccharomyces cerevisiae 39,110 2-Sep-97 rxa01775 687 GB_PR3: HS37J18 131427 Z98747 Human DNA sequence from clone 37J18 on chromosome 1p36.2-36.3. Homo sapiens 35,036 23-Nov-99 Contains a putative novel gene, ESTs and GSSs, complete sequence. GB_HTG2: AC007475 185087 AC007475 Drosophila melanogaster chromosome 2 clone BACR04E21 Drosophila melanogaster 37,333 2-Aug-99 (D592) RPCI-98 04.E.21 map 49A-49B strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 36 unordered pieces. GB_HTG2: AC007475 185087 AC007475 Drosophila melanogaster chromosome 2 clone BACR04E21 (D592) Drosophila melanogaster 37,333 2-Aug-99 RPCI-98 04.E.21 map 49A-49B strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 36 unordered pieces. rxa01776 1575 GB_GSS10: AQ174954 416 AQ174954 HS_3211_B2_C03_MR CIT Approved Human Genomic Sperm Library D Homo sapiens 43,171 17-OCT-1998 Homo sapiens genomic clone Plate = 3211 Col = 6 Row = F, genomic survey sequence. GB_PR1: HSFGF6 1032 X57075 H. sapiens FGF6 gene. Homo sapiens 41,196 15-Feb-95 GB_PR2: HSAC000055 93578 AC000055 Human PAC clone DJ073F11 from Xq23, complete sequence. Homo sapiens 35,080 14-Nov-96 rxa01777 582 GB_BA2: AF076997 15398 AF076997 Comamonas testosteroni PtL5 cryptic plasmid pPT1, complete sequence. Comamonas testosteroni 37,805 30-Nov-99 GB_BA2: AF076997 15398 AF076997 Comamonas testosteroni PtL5 cryptic plasmid pPT1, complete sequence. Comamonas testosteroni 35,529 30-Nov-99 rxa01778 1260 GB_PR3: AC002981 153568 AC002981 Homo sapiens Xp22 BAC GS279A12 (Genome Systems) complete sequence. Homo sapiens 37,305 22-Jan-98 GB_EST29: AI587176 384 AI587176 tr54c10.x1 NCI_CGAP_Pan1 Homo sapiens cDNA clone IMAGE: Homo sapiens 37,240 14-MAY-1999 2222130 3′, mRNA sequence. GB_PR1: HSCP450 1346 X65962 H. sapiens mRNA for cytochrome P-450. Homo sapiens 38,908 29-MAY-1992 rxa01779 1542 GB_EST19: AA202518 661 AA202518 LD02757.5prime LD Drosophila melanogaster embryo BlueScript Drosophila Drosophila melanogaster 40,212 27-Nov-98 melanogaster cDNA clone LD02757 5prime, mRNA sequence. GB_EST34: AI805834 453 AI805834 te52b03.x1 Soares_NFL_T_GBC_S1 Homo sapiens Homo sapiens 38,000 7-Jul-99 cDNA clone IMAGE: 2090285 3′ similar to contains Alu repetitive element;, mRNA sequence. GB_EST30: AI648920 754 AI648920 uk32h03.x1 Sugano mouse kidney mkia Mus musculus cDNA clone IMAGE: Mus musculus 36,967 30-Apr-99 1970741 3′ similar to WP: Y76A2B.5 CE19277;, mRNA sequence. rxa01780 498 GB_GSS8: AQ038759 670 AQ038759 CIT-HSP-2325O13.TV CIT-HSP Homo sapiens genomic Homo sapiens 32,645 11-Jul-98 clone 2325O13, genomic survey sequence. GB_GSS8: AQ038759 670 AQ038759 CIT-HSP-2325O13.TV CIT-HSP Homo sapiens genomic clone Homo sapiens 39,474 11-Jul-98 2325O13, genomic survey sequence. rxa01781 384 GB_IN1: CELF52G3 42696 AF026212 Caenorhabditis elegans cosmid F52G3. Caenorhabditis elegans 39,314 25-Sep-97 GB_GSS14: AQ579313 877 AQ579313 nbxb0084O07r CUGI Rice BAC Library Oryza sativa genomic Oryza sativa 36,053 2-Jun-99 clone nbxb0084O07r, genomic survey sequence. GB_VI: HAV19AE3 3441 X95259 Human adenovirus type 19a early region 3 genes. Human adenovirus type 38,624 9-Jul-97 19a rxa01782 519 GB_IN1: DMSED5 930 X78219 D. melanogaster (Barton) SED5 mRNA. Drosophila melanogaster 38,372 21-Apr-95 GB_IN2: L49408 83527 L49408 Drosophila melanogaster DNA sequence (P1 DS02740 (D27)), complete sequence. Drosophila melanogaster 35,992 17-Jul-98 GB_STS: G46002 398 G46002 Z556_1 Zebrafish AB Danio rerio STS genomic clone Z556 5′, sequence tagged site. Danio rerio 33,920 23-MAR-1999 rxa01783 360 GB_VI: CITV18420 19259 Y18420 Citrus tristeza virus complete genome, isolate T385. Citrus tristeza virus 41,457 6-Apr-99 GB_IN1: DMSED5 930 X78219 D. melanogaster (Barton) SED5 mRNA. Drosophila melanogaster 45,802 21-Apr-95 GB_VI: CTY18368 2759 Y18368 Citrus tristeza virus defective RNA, strain T411. Citrus tristeza virus 41,457 6-Apr-99 rxa01785 699 GB_BA2: AF121000 19751 AF121000 Corynebacterium glutamicum strain 22243 R-plasmid pAG1, complete sequence. Corynebacterium 40,529 14-Apr-99 glutamicum GB_PR2: HS1014D13 71263 AL022311 Human DNA sequence from clone 1014D13 on chromosome 22q13.1-13.2 Homo sapiens 35,362 23-Nov-99 Contains ESTs, STSs, and a CpG island, complete sequence. GB_BA2: AF121000 19751 AF121000 Corynebacterium glutamicum strain 22243 R-plasmid pAG1, complete sequence. Corynebacterium 38,012 14-Apr-99 glutamicum rxa01787 816 GB_RO: RATSIALYLA 1128 L13445 Rat sialyltransferase gene family related mRNA, complete cds. Rattus norvegicus 35,012 26-Jul-93 GB_PR3: HSN75H12 46144 Z84496 Human DNA sequence from cosmid N75H12 on chromosome 22q12-qter. Homo sapiens 37,738 23-Nov-99 GB_GSS13: AQ496514 532 AQ496514 HS_5118_B2_F05_SP6E RPCI-11 Human Male BAC Library Homo sapiens 39,238 28-Apr-99 Homo sapiens genomic clone Plate = 694 Col = 10 Row = L, genomic survey sequence. rxa01788 rxa01789 765 GB_BA1: MTV029 3279 AL021427 Mycobacterium tuberculosis H37Rv complete genome; segment 1/162. Mycobacterium 39,229 17-Jun-98 tuberculosis GB_BA1: MTORIREP 8400 X92504 M. tuberculosis origin of replication and genes rnpA, rpmH, dnaA, dnaN, recF. Mycobacterium 36,328 26-Aug-97 tuberculosis GB_GSS4: AQ729452 763 AQ729452 HS_5474_A1_G07_T7AHS_5474_A1 RPCI-11 Human Male BAC Library Homo sapiens 39,451 15-Jul-99 Homo sapiens genomic clone Plate = 1050 Col = 13 Row = M, genomic survey sequence. rxa01790 183 GB_EST37: AI935426 436 AI935426 wo84d02.x1 NCI_CGAP_Kid11 Homo sapiens cDNA clone IMAGE: Homo sapiens 39,877 2-Sep-99 2462019 3′ similar to TR: O00193 O00193 SMALL ACIDIC PROTEIN.;, mRNA sequence. GB_GSS11: AQ265301 621 AQ265301 CITBI-E1-2509K16.TF CITBI-E1 Homo sapiens genomic clone 2509K16, Homo sapiens 45,856 27-OCT-1998 genomic survey sequence. GB_HTG2: AC007596 199300 AC007596 Homo sapiens chromosome 16 clone 116B6, *** SEQUENCING Homo sapiens 37,572 20-MAY-1999 IN PROGRESS ***, 42 unordered pieces. rxa01791 486 GB_PL2: ATAC004521 104797 AC004521 Arabidopsis thaliana chromosome II BAC F4I1 genomic Arabidopsis thaliana 43,167 12-MAY-1998 sequence, complete sequence. GB_GSS13: AQ436125 508 AQ436125 HS_5049_B2_G12_T7A RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 32,762 31-MAR-1999 genomic clone Plate = 625 Col = 24 Row = N, genomic survey sequence. GB_GSS12: AQ342410 674 AQ342410 RPCI11-121E5.TJ RPCI-11 Homo sapiens genomic clone RPCI-11-121E5, Homo sapiens 37,269 06-MAY-1999 genomic survey sequence. rxa01792 396 GB_STS: KLAJ9905 178 AJ229905 Kluyveromyces lactis DNA fragment for sequence tagged site, clone okam5e06r. Kluyveromyces lactis 42,697 20-Nov-98 GB_STS: KLAJ9905 178 AJ229905 Kluyveromyces lactis DNA fragment for sequence tagged site, clone okam5e06r. Kluyveromyces lactis 42,697 20-Nov-98 GB_GSS15: AQ612295 472 AQ612295 HS_5121_A2_D09_SP6E RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 40,885 15-Jun-99 genomic clone Plate = 697 Col = 18 Row = G, genomic survey sequence. rxa01793 357 GB_GSS3: B82515 613 B82515 RPCI11-16J10.TV RPCI-11 Homo sapiens genomic clone RPCI-11-16J10, Homo sapiens 40,164 9-Apr-99 genomic survey sequence. GB_PR2: CNS0000B 196287 AL049829 Human chromosome 14 DNA sequence *** IN PROGRESS *** BAC R-124D2 of Homo sapiens 33,621 27-OCT-1999 RPCI-11 library from chromosome 14 of Homo sapiens (Human), complete sequence. GB_OV: AF001393 4329 AF001393 Oryzias latipes Medaka OG-12 (MOG-12) mRNA, complete cds. Oryzias latipes 35,511 30-Sep-99 rxa01794 357 GB_GSS15: AQ644157 665 AQ644157 RPCI93-Dpnll-29O12.TV RPCI93-Dpnll Trypanosoma brucei genomic clone Trypanosoma brucei 39,894 8-Jul-99 RPCI93-Dpnll-29O12, genomic survey sequence. GB_GSS15: AQ657704 665 AQ657704 Sheared DNA-24C24.TR Sheared DNA Trypanosoma brucei genomic clone Trypanosoma brucei 37,110 23-Jun-99 Sheared DNA-24C24, genomic survey sequence. GB_OV: GGU25125 6418 U25125 Gallus gallus preprogastrin Gallus gallus 40,584 06-MAY-1995 gene, complete cds. rxa01796 897 GB_PR3: HS404G5 119737 AL035695 Human DNA sequence from clone 404G5 on chromosome 6q24.1-25.2. Homo sapiens 34,793 23-Nov-99 Contains part of a human estrogen receptor gene, STSs and GSSs, complete sequence. GB_PR1: HSPTP1CHG 8545 X82818 H. sapiens PTP1C/HCP gene. Homo sapiens 35,531 26-Jun-97 GB_PR3: HS404G5 119737 AL035695 Human DNA sequence from clone 404G5 on chromosome 6q24.1-25.2. Homo sapiens 37,058 23-Nov-99 Contains part of a human estrogen receptor gene, STSs and GSSs, complete sequence. rxa01799 1317 GB_HTG3: AC010869 38000 AC010869 Leishmania major chromosome 35 clone L7195 strain Friedlin, Leishmania major 40,522 02-OCT-1999 *** SEQUENCING IN PROGRESS ***, 4 unordered pieces. GB_HTG3: AC010869 38000 AC010869 Leishmania major chromosome 35 clone L7195 strain Friedlin, Leishmania major 40,522 02-OCT-1999 *** SEQUENCING IN PROGRESS ***, 4 unordered pieces. GB_OM: SSU12574 2190 U12574 Sus scrofa myogenic regulatory factor MyoD (myoD) gene, complete cds. Sus scrofa 37,068 10-Feb-96 rxa01800 843 GB_PH: C2PVCG 22172 L48605 Bacteriophage c2 complete genome. Lactococcus bacteriophage 36,747 14-MAR-1996 c2 GB_EST38: AW066009 641 AW066009 687004F08.y1 687 - Early embryo from Delaware Zea mays 40,000 12-OCT-1999 Zea mays cDNA, mRNA sequence. GB_PH: C2PVCG 22172 L48605 Bacteriophage c2 complete genome. Lactococcus bacteriophage 36,867 14-MAR-1996 c2 rxa01803 1083 GB_BA2: SCJ1 36925 AL109962 Streptomyces coelicolor cosmid J1. Streptomyces coelicolor 54,267 24-Sep-99 A3(2) GB_BA1: PAU12891 4062 U12891 Pseudomonas aeruginosa PAO substrain OT684 pyoverdine gene Pseudomonas aeruginosa 37,841 03-OCT-1996 transcriptional regulator PvdS (pvdS) gene, complete cds. GB_HTG6: AC010203 230460 AC010203 Homo sapiens clone RP11-175P13, *** SEQUENCING Homo sapiens 35,185 03-DEC-1999 IN PROGRESS ***, 48 unordered pieces. rxa01804 444 GB_EST24: AI189912 784 AI189912 qd33e07.x1 Soares_placenta_8to9weeks_2NbHP8to9 W Homo sapiens cDNA clone Homo sapiens 40,000 28-OCT-1998 IMAGE: 1725540 3′ similar to gb: Z23064_cds1 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN G (HUMAN);, mRNA sequence. GB_EST24: AI189912 784 AI189912 qd33e07.x1 Soares_placenta_8to9weeks_2NbHP8to9 W Homo sapiens cDNA clone Homo sapiens 35,294 28-OCT-1998 IMAGE: 1725540 3′ similar to gb: Z23064_cds1 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN G (HUMAN);, mRNA sequence. rxa01805 453 GB_PR2: HSU73628 32289 U73628 Human chromosome 11 101h11 cosmid, complete sequence. Homo sapiens 36,099 19-Jun-97 GB_PR2: HSU73628 32289 U73628 Human chromosome 11 101h11 cosmid, complete sequence. Homo sapiens 35,227 19-Jun-97 rxa01806 603 GB_IN1: CELK02E7 36535 AF025465 Caenorhabditis elegans cosmid K02E7. Caenorhabditis elegans 37,479 23-Sep-97 GB_HTG3: AC011217 157261 AC011217 Homo sapiens clone 7_J_14, LOW-PASS SEQUENCE SAMPLING. Homo sapiens 33,333 03-OCT-1999 GB_HTG3: AC011217 157261 AC011217 Homo sapiens clone 7_J_14, LOW-PASS SEQUENCE SAMPLING. Homo sapiens 33,333 03-OCT-1999 rxa01809 1299 GB_HTG3: AC010759 155875 AC010759 Homo sapiens clone 1_K_15, *** SEQUENCING IN PROGRESS ***, 15 Homo sapiens 37,920 22-Sep-99 unordered pieces. GB_HTG3: AC010759 155875 AC010759 Homo sapiens clone 1_K_15, *** SEQUENCING IN PROGRESS ***, 15 Homo sapiens 37,920 22-Sep-99 unordered pieces. GB_HTG2: AC006235 190842 AC006235 Homo sapiens clone hRPK.520_J_4, *** SEQUENCING IN PROGRESS ***, 5 Homo sapiens 36,019 17-Jul-99 unordered pieces. rxa01813 789 GB_PR4: AC004047 134649 AC004047 Homo sapiens chromosome 4 clone B150J4 map 4q25, complete sequence. Homo sapiens 36,205 01-DEC-1998 GB_HTG2: HS1012F16 74539 AL080274 Homo sapiens chromosome 20 clone RP5-1012F16, *** SEQUENCING IN Homo sapiens 35,032 03-DEC-1999 PROGRESS ***, in unordered pieces. GB_HTG2: HS1012F16 74539 AL080274 Homo sapiens chromosome 20 clone RP5-1012F16, *** SEQUENCING IN Homo sapiens 35,032 03-DEC-1999 PROGRESS ***, in unordered pieces. rxa01815 915 GB_PR3: AC005740 186780 AC005740 Homo sapiens chromosome 5p, BAC clone 50g21 (LBNL H154), complete sequence. Homo sapiens 37,315 01-OCT-1998 GB_HTG3: AC008328 114617 AC008328 Drosophila melanogaster chromosome 2 clone BACR09A04 (D860) RPCI-98 09.A.4 Drosophila melanogaster 30,516 6-Aug-99 map 28B-28C strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 74 unordered pieces. GB_HTG3: AC008328 114617 AC008328 Drosophila melanogaster chromosome 2 clone BACR09A04 (D860) RPCI-98 09.A.4 Drosophila melanogaster 30,516 6-Aug-99 map 28B-28C strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 74 unordered pieces. rxa01816 855 GB_PR3: AC003101 208396 AC003101 Homo sapiens chromosome 17, clone HRPC41C23, complete sequence. Homo sapiens 34,272 5-Jun-98 GB_EST23: AI144656 492 AI144656 UI-R-BT0-pl-f-04-0-UI.s1 UI-R-BT0 Rattus norvegicus cDNA clone Rattus norvegicus 37,526 5-Jul-99 UI-R-BT0-pl-f-04-0-UI 3′, mRNA sequence. GB_GSS11: AQ341706 506 AQ341706 RPCI11-120J20.TJ RPCI-11 Homo sapiens genomic clone RPCI-11-120J20, Homo sapiens 40,789 06-MAY-1999 genomic survey sequence. rxa01817 756 GB_BA2: AF030176 7000 AF030176 Rhodococcus opacus putative transposase gene, partial cds; and putative FAD Rhodococcus opacus 42,577 5-Aug-98 synthetase, putative short-chain dehydrogenase/reductase, mateylacetate reductase (macA), and putative transcription factor genes, complete cds. GB_EST19: AA263350 423 AA263350 LD06495.5prime LD Drosophila melanogaster embryo BlueScript Drosophila Drosophila melanogaster 38,955 27-Nov-98 melanogaster cDNA clone LD06495 5prime, mRNA sequence. GB_EST19: AA202194 368 AA202194 LD02304.5prime LD Drosophila melanogaster embryo BlueScript Drosophila Drosophila melanogaster 39,891 27-Nov-98 melanogaster cDNA clone LD02304 5prime, mRNA sequence. rxa01820 1497 GB_BA2: AF030176 7000 AF030176 Rhodococcus opacus putative transposase gene, partial cds; and putative Rhodococcus opacus 41,799 5-Aug-98 FAD synthetase, putative short-chain dehydrogenase/reductase, maleylacetate reductase (macA), and putative transcription factor genes, complete cds. GB_EST32: AI728582 666 AI728582 BNLGHi11124 Six-day Cotton fiber Gossypium hirsutum cDNA 5′ similar to Gossypium hirsutum 37,915 11-Jun-99 (U64918) ATGP1 [Arabidopsis thaliana], mRNA sequence. GB_BA2: AF030176 7000 AF030176 Rhodococcus opacus putative transposase gene, partial cds; and putative FAD Rhodococcus opacus 37,127 5-Aug-98 synthetase, putative short-chain dehydrogenase/reductase, maleylacetate reductase (macA), and putative transcription factor genes, complete cds. rxa01825 393 GB_HTG1: HSJCF13 293368 AJ239320 Homo sapiens chromosome X clone cosmid 244B12 map Xq13, *** SEQUENCING Homo sapiens 34,748 28-Sep-99 IN PROGRESS ***, in ordered pieces. GB_HTG1: HSJCF13 293368 AJ239320 Homo sapiens chromosome X clone cosmid 244B12 map Xq13, *** SEQUENCING Homo sapiens 34,748 28-Sep-99 IN PROGRESS ***, in ordered pieces. GB_HTG1: AP000568 136627 AP000568 Homo sapiens chromosome 21 clone B753B2 map 21q21.2, *** SEQUENCING Homo sapiens 34,884 07-OCT-1999 IN PROGRESS ***, in unordered pieces. rxa01831 585 GB_IN2: AF047757 408 AF047757 Trichogramma australicum internal transcribed spacer 2, complete sequence. Trichogramma australicum 38,390 10-Jul-98 GB_EST18: AA687516 513 AA687516 ns58h11.r1 NCI_CGAP_Pr22 Homo sapiens cDNA clone IMAGE: 1187877 Homo sapiens 35,057 11-DEC-1997 5′ similar to gb: X15341 CYTOCHROME C OXIDASE POLYPEPTIDE VIA-LIVER (HUMAN);, mRNA sequence. GB_EST18: AA687516 513 AA687516 ns58h11.r1 NCI_CGAP_Pr22 Homo sapiens cDNA clone IMAGE: 1187877 Homo sapiens 37,624 11-DEC-1997 5′ similar to gb: X15341 CYTOCHROME C OXIDASE POLYPEPTIDE VIA-LIVER (HUMAN);, mRNA sequence. rxa01834 825 GB_PL2: T8F5 87192 AC004512 Arabidopsis thaliana chromosome 1 BAC T8F5 sequence, complete sequence. Arabidopsis thaliana 38,101 22-Jul-98 GB_PR4: AC007677 166949 AC007677 Homo sapiens clone NH0086N01, complete sequence. Homo sapiens 35,888 28-Sep-99 GB_PR4: AC007677 166949 AC007677 Homo sapiens clone NH0086N01, complete sequence. Homo sapiens 36,906 28-Sep-99 rxa01842 1041 GB_HTG3: AC009183 145694 AC009183 Drosophila melanogaster chromosome 3 clone BACR39F04 Drosophila melanogaster 40,430 16-Sep-99 (D839) RPCI-98 39.F.4 map 85F-85F strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 139 unordered pieces. GB_HTG3: AC009183 145694 AC009183 Drosophila melanogaster chromosome 3 clone BACR39F04 (D839) Drosophila melanogaster 40,430 16-Sep-99 RPCI-98 39.F.4 map 85F-85F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 139 unordered pieces. GB_HTG5: AC008338 136685 AC008338 Drosophila melanogaster chromosome X clone BACR30J04 (D908) Drosophila melanogaster 40,527 15-Nov-99 RPCI-98 30.J.4 map 19C-19E strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 93 unordered pieces. rxa01844 303 GB_HTG2: AC007597 163880 AC007597 Homo sapiens chromosome 16 clone RPCI-11_137H10, *** SEQUENCING Homo sapiens 34,564 20-Jul-99 IN PROGRESS ***, 3 ordered pieces. GB_HTG2: AC007597 163880 AC007597 Homo sapiens chromosome 16 clone RPCI-11_137H10, *** SEQUENCING Homo sapiens 34,564 20-Jul-99 IN PROGRESS ***, 3 ordered pieces. GB_HTG3: AC009998 163590 AC009998 Homo sapiens chromosome 15 clone BAC 573G7 map 15q24, Homo sapiens 40,816 10-Sep-99 LOW-PASS SEQUENCE SAMPLING. rxa01845 531 GB_OV: AF012348 4921 AF012348 Gallus gallus smooth muscle gamma actin (gamma actin) gene, complete cds. Gallus gallus 37,333 17-MAR-1998 GB_BA1: D85417 7984 D85417 Propionibacterium freudenreichii hemY, hemH, hemB, hemX, hemR and hemL Propionibacterium 45,243 6-Feb-99 genes, complete cds. freudenreichii GB_BA1: D85417 7984 D85417 Propionibacterium freudenreichii hemY, hemH, hemB, hemX, hemR and Propionibacterium 40,232 6-Feb-99 hemL genes, complete cds. freudenreichii rxa01846 382 GB_HTG1: HSJ323A24 278948 AL121750 Homo sapiens chromosome 4 clone RP3-323A24, *** SEQUENCING Homo sapiens 34,840 23-Nov-99 IN PROGRESS ***, in unordered pieces. GB_HTG1: HSJ323A24 278948 AL121750 Homo sapiens chromosome 4 clone RP3-323A24, *** SEQUENCING IN Homo sapiens 34,840 23-Nov-99 PROGRESS ***, in unordered pieces. GB_PR2: HS181C9 92472 Z98743 Human DNA sequence from clone 181C9 on chromosome Homo sapiens 42,480 23-Nov-99 22q13.2-13.33.Contains a PHAPI2 Leucine Rich Acidic Nuclear Protein pseudogene, part of a putative novel gene, ESTs, STSs and GSSs, complete sequence. rxa01847 858 GB_PR3: AC004893 103738 AC004893 Homo sapiens PAC clone DJ0808A01 from 7q21.1-q31.1, complete sequence. Homo sapiens 38,321 03-OCT-1998 GB_HTG4: AC010182_3 110000 AC010182 Homo sapiens chromosome 12q seeders clone RPCI11-185N2, *** SEQUENCING Homo sapiens 36,998 15-Sep-99 IN PROGRESS ***, 172 unordered pieces. GB_HTG4: AC010182_3 110000 AC010182 Homo sapiens chromosome 12q seeders clone RPCI11-185N2, Homo sapiens 36,998 15-Sep-99 *** SEQUENCING IN PROGRESS ***, 172 unordered pieces. rxa01856 669 GB_GSS15: AQ612487 433 AQ612487 HS_5122_A1_B07_SP6E RPCI-11 Human Male BAC Library Homo sapiens 39,723 15-Jun-99 Homo sapiens genomic clone Plate = 698 Col = 13 Row = C, genomic survey sequence. GB_PR4: AC005876 89817 AC005876 citb_188_i_5, complete sequence. Homo sapiens 39,567 5-Nov-99 GB_PR4: AC005876 89817 AC005876 citb_188_i_5, complete sequence. Homo sapiens 36,677 5-Nov-99 rxa01857 774 GB_PR3: HS742C19 122748 AL031846 Human DNA sequence from clone RP4-742C19 on Homo sapiens 33,506 29-Nov-99 chromosome 22, complete sequence. GB_PR2: HSJ1100I6 161525 AL110503 Human DNA sequence from clone RP5-1100I6 on chromosome 20 Contains a Homo sapiens 37,450 22-Nov-99 novel mRNA, GSSs and a CpG Island, complete sequence. GB_HTG6: AC009893 186769 AC009893 Homo sapiens chromosome 8 clone RP11-4P3, *** SEQUENCING Homo sapiens 37,368 23-Nov-99 IN PROGRESS ***, 5 unordered pieces. rxa01858 rxa01870 798 GB_RO: AC004155 128026 AC004155 Mus musculus DNA from BAC 10818 containing the Ercc-4 gene, complete sequence. Mus musculus 37,387 19-Feb-98 GB_RO: AC004155 128026 AC004155 Mus musculus DNA from BAC 10818 containing the Ercc-4 gene, complete sequence. Mus musculus 37,707 19-Feb-98 GB_BA2: AF144563 5971 AF144563 Thermobifida fusca beta-1,4-exocellulase E6 precursor (celF) gene, Thermobifida fusca 38,619 21-Jun-99 complete cds; and unknown genes. rxa01871 1086 GB_BA2: AF079304 3350 AF079304 Eikenella corrodens type IV pilin (pilA1), type IV pilin (pilA2), putative fimbrial Eikenella corrodens 40,465 15-Jul-99 protein (pilB), and putative hemagglutinin protein (hagA) genes, complete cds. GB_BA1: ECECPHAG 3589 Z12609 E. corrodens ecpA and ecpB genes encoding type 4 N-methylphenylalanine pilin Eikenella corrodens 40,517 5-Aug-92 and hag1 gene for hemagglutinin protein. GB_BA2: AE001707 19518 AE001707 Thermotoga maritima section 19 of 136 of the complete genome. Thermotoga maritima 38,124 2-Jun-99 rxa01874 448 GB_EST6: N51407 505 N51407 yz17a08.s1 Soares_multiple_sclerosis_2NbHMSP Homo sapiens cDNA Homo sapiens 35,735 14-Feb-96 clone IMAGE: 283286 3′, mRNA sequence. GB_EST29: AI619782 374 AI619782 ty53b03.x1 NCI_CGAP_Ut2 Homo sapiens cDNA clone IMAGE: Homo sapiens 38,966 21-Apr-99 2282765 3′, mRNA sequence. GB_EST36: AI885047 466 AI885047 wl89a01.x1 NCI_CGAP_Brn25 Homo sapiens cDNA clone IMAGE: 2432040 Homo sapiens 37,419 1-Sep-99 3′, mRNA sequence. rxa01875 969 GB_EST13: AA356276 291 AA356276 EST64843 Jurkat T-cells VI Homo sapiens cDNA 5′ end, mRNA sequence. Homo sapiens 41,667 21-Apr-97 GB_EST22: AI050653 443 AI050653 ub38f03.r1 Soares 2NbMT Mus musculus cDNA clone IMAGE: Mus musculus 38,851 9-Jul-98 1380029 5′, mRNA sequence. GB_GSS1: CNS0022Z 1101 AL061786 Drosophila melanogaster genome survey sequence T7 end of BAC # Drosophila melanogaster 39,039 3-Jun-99 BACR05B21 of RPCI-98 library from Drosophila melanogaster (fruit fly), genomic survey sequence. rxa01877 1194 GB_HTG4: AC009849 114993 AC009849 Drosophila melanogaster chromosome 2 clone BACR07H08 (D864) Drosophila melanogaster 37,274 25-OCT-1999 RPCI-98 07.H.8 map 31B-31C strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 55 unordered pieces. GB_HTG4: AC009849 114993 AC009849 Drosophila melanogaster chromosome 2 clone BACR07H08 (D864) RPCI-98 Drosophila melanogaster 37,274 25-OCT-1999 07.H.8 map 31B-31C strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 55 unordered pieces. GB_IN2: AC005454 84367 AC005454 Drosophila melanogaster, chromosome 2R, region 31C1-31D6, Drosophila melanogaster 38,679 15-DEC-1998 P1 clone DS08879, complete sequence. rxa01879 1056 GB_PR2: CNS0000Q 192932 AL049874 Human chromosome 14 DNA sequence *** IN PROGRESS *** BAC Homo sapiens 37,094 7-Jul-99 R-1042B17 of RPCI-11 library from chromosome 14 of Homo sapiens (Human), complete sequence. GB_HTG2: AC006732 159453 AC006732 Caenorhabditis elegans clone Y32G9, *** SEQUENCING IN Caenorhabditis elegans 34,862 23-Feb-99 PROGRESS ***, 9 unordered pieces. GB_HTG2: AC006732 159453 AC006732 Caenorhabditis elegans clone Y32G9, *** SEQUENCING IN Caenorhabditis elegans 34,862 23-Feb-99 PROGRESS ***, 9 unordered pieces. rxa01896 759 GB_BA1: SC2G5 38404 AL035478 Streptomyces coelicolor cosmid 2G5. Streptomyces coelicolor 38,420 11-Jun-99 GB_PL1: AP000570 157903 AP000570 Oryza sativa genomic DNA, chromosome 1, clone: P0711E10. Oryza sativa 40,272 03-DEC-1999 GB_BA1: SC2G5 38404 AL035478 Streptomyces coelicolor cosmid 2G5. Streptomyces coelicolor 40,270 11-Jun-99 rxa01899 909 GB_BA1: MTV002 56414 AL008967 Mycobacterium tuberculosis H37Rv complete genome; segment 122/162. Mycobacterium 38,702 17-Jun-98 tuberculosis GB_BA1: MTV002 56414 AL008967 Mycobacterium tuberculosis H37Rv complete genome; segment 122/162. Mycobacterium 38,229 17-Jun-98 tuberculosis rxa01902 1182 GB_HTG6: AC009893 186769 AC009893 Homo sapiens chromosome 8 clone RP11-4P3, *** SEQUENCING IN Homo sapiens 34,868 23-Nov-99 PROGRESS ***, 5 unordered pieces. GB_OV: D84063 2363 D84063 Oryzias latipes Bf/C2 mRNA, complete cds. Oryzias latipes 38,074 6-Feb-99 GB_HTG6: AC009893 186769 AC009893 Homo sapiens chromosome 8 clone RP11-4P3, *** SEQUENCING IN Homo sapiens 35,616 23-Nov-99 PROGRESS ***, 5 unordered pieces. rxa01903 302 GB_BA1: MSGILVB 4210 L49392 Mycobacterium avium acetolactate synthase (ilvBN) and acetohydroxy Mycobacterium avium 38,667 11-DEC-1996 acid isomeroreductase (ilvC) gene, complete cds. GB_PR3: AC004833 68890 AC004833 Homo sapiens PAC clone DJ0547C10 from 7p21-p22, complete sequence. Homo sapiens 34,615 5-Nov-98 GB_PR3: AC004833 68890 AC004833 Homo sapiens PAC clone DJ0547C10 from 7p21-p22, complete sequence. Homo sapiens 42,712 5-Nov-98 rxa01904 546 GB_HTG2: AC006740 200965 AC006740 Caenorhabditis elegans clone Y38B5, *** SEQUENCING IN Caenorhabditis elegans 34,074 25-Feb-99 PROGRESS ***, 12 unordered pieces. GB_HTG2: AC006695 33622 AC006695 Caenorhabditis elegans clone W06H8, *** SEQUENCING IN Caenorhabditis elegans 35,556 23-Feb-99 PROGRESS ***, 1 unordered pieces. GB_HTG2: AC006695 33622 AC006695 Caenorhabditis elegans clone W06H8, *** SEQUENCING IN Caenorhabditis elegans 35,556 23-Feb-99 PROGRESS ***, 1 unordered pieces. rxa01905 654 GB_IN1: CEW04G3 32158 Z68014 Caenorhabditis elegans cosmid W04G3, complete sequence. Caenorhabditis elegans 38,730 2-Sep-99 GB_PL2: AF067082 6947 AF067082 Apium graveolens mannitol dehydrogenase (Mtd) gene, complete cds. Apium graveolens 38,242 30-Sep-98 GB_IN1: CEW04G3 32158 Z68014 Caenorhabditis elegans cosmid W04G3, complete sequence. Caenorhabditis elegans 36,834 2-Sep-99 rxa01906 588 GB_PL1: AB012242 78973 AB012242 Arabidopsis thaliana genomic DNA, chromosome 5, TAC clone: Arabidopsis thaliana 39,071 20-Nov-99 K24G6, complete sequence. GB_EST6: N49608 454 N49608 yy58g01.s1 Soares_multiple_sclerosis_2NbHMSP Homo sapiens cDNA Homo sapiens 43,603 14-Feb-96 clone IMAGE: 277776 3′, mRNA sequence. GB_EST6: N49609 452 N49609 yy58g02.s1 Soares_multiple_sclerosis_2NbHMSP Homo sapiens cDNA Homo sapiens 43,307 14-Feb-96 clone IMAGE: 277778 3′, mRNA sequence. rxa01907 735 GB_HTG3: AC009437 159691 AC009437 Homo sapiens chromosome 11 clone 56_G_09 map 11, *** SEQUENCING Homo sapiens 36,226 22-Aug-99 IN PROGRESS ***, 10 unordered pieces. GB_HTG3: AC009437 159691 AC009437 Homo sapiens chromosome 11 clone 56_G_09 map 11, *** SEQUENCING Homo sapiens 36,226 22-Aug-99 IN PROGRESS ***, 10 unordered pieces. GB_HTG3: AC009437 159691 AC009437 Homo sapiens chromosome 11 clone 56_G_09 map 11, *** SEQUENCING IN Homo sapiens 38,483 22-Aug-99 PROGRESS ***, 10 unordered pieces. rxa01908 969 GB_PR3: HS90G24 154414 AL008723 Human DNA sequence from clone 90G24 on chromosome 22. Contains Homo sapiens 37,331 23-Nov-99 the RFPL2 gene for RET finger protein-like 2, an Immunoglobulin Lambda Light Chain C region (IGLC) pseudogene, the gene for SAAT1 (low affinity sodium glucose cotransporter (sodium: solute symporter family)) and a Cleavage and Polyadenylation Specific Factor CPSF 160 kD subunit pseudogene. Contains ESTs, GSSs and three putative CpG islands, complete sequence. GB_EST25: AI316482 972 AI316482 uj60g12.y1 Sugano mouse liver mlia Mus musculus cDNA clone IMAGE: Mus musculus 36,800 17-DEC-1998 1924390 5′ similar to gb: M12529 APOLIPOPROTEIN E PRECURSOR (HUMAN); gb: D00466 Mouse apolipoprotein E gene (MOUSE);, mRNA sequence. GB_EST27: AI398904 556 AI398904 NCW10G7T7 Westergaards Neurospora crassa cDNA clone W10G7 Neurospora crassa 38,095 8-Feb-99 3′, mRNA sequence. rxa01909 970 GB_HTG1: HSJ658I14 133423 AL109845 Homo sapiens chromosome 1 clone RP4-658I14, *** SEQUENCING Homo sapiens 40,520 23-Nov-99 IN PROGRESS ***, in unordered pieces. GB_HTG1: HSJ658I14 133423 AL109845 Homo sapiens chromosome 1 clone RP4-658I14, *** SEQUENCING Homo sapiens 40,520 23-Nov-99 IN PROGRESS ***, in unordered pieces. GB_HTG1: HSJ658I14 133423 AL109845 Homo sapiens chromosome 1 clone RP4-658I14, *** SEQUENCING Homo sapiens 36,364 23-Nov-99 IN PROGRESS ***, in unordered pieces. rxa01910 969 GB_PR2: CNS00008 218956 AL049831 Human chromosome 14 DNA sequence *** IN PROGRESS *** BAC R-330O19 Homo sapiens 35,393 29-Jun-99 of RPCI-11 library from chromosome 14 of Homo sapiens (Human), complete sequence. GB_PR2: CNS00008 218956 AL049831 Human chromosome 14 DNA sequence *** IN PROGRESS *** BAC Homo sapiens 38,405 29-Jun-99 R-330O19 of RPCI-11 library from chromosome 14 of Homo sapiens (Human), complete sequence. GB_HTG5: AC009217 118561 AC009217 Drosophila melanogaster chromosome X clone BACR41N19 (D907) Drosophila melanogaster 36,765 16-Nov-99 RPCI-98 41.N.19 map 19A-19C strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 78 unordered pieces. rxa01911 1062 GB_HTG2: AC002317 94882 AC002317 Homo sapiens chromosome 17 clone HCIT7H10 map 17, *** SEQUENCING Homo sapiens 36,654 20-Feb-98 IN PROGRESS ***, 8 unordered pieces. GB_HTG2: AC002317 94882 AC002317 Homo sapiens chromosome 17 clone HCIT7H10 map 17, *** SEQUENCING Homo sapiens 36,654 20-Feb-98 IN PROGRESS ***, 8 unordered pieces. GB_HTG2: AC002317 94882 AC002317 Homo sapiens chromosome 17 clone HCIT7H10 map 17, *** SEQUENCING Homo sapiens 37,012 20-Feb-98 IN PROGRESS ***, 8 unordered pieces. rxa01923 873 GB_HTG2: AC006844 299782 AC006844 Caenorhabditis elegans clone Y108G3Y, *** SEQUENCING IN Caenorhabditis elegans 37,176 24-Feb-99 PROGRESS***, 4 unordered pieces. GB_HTG2: AC006844 299782 AC006844 Caenorhabditis elegans clone Y108G3Y, *** SEQUENCING IN Caenorhabditis elegans 37,176 24-Feb-99 PROGRESS ***, 4 unordered pieces. GB_BA1: ECOUW76 225419 U00039 E. coli chromosomal region from 76.0 to 81.5 minutes. Escherichia coli 38,902 7-Nov-96 rxa01930 1074 GB_BA1: CGPAN 2164 X96580 C. glutamicum panB, panC & xylB genes. Corynebacterium 100,000 11-MAY-1999 glutamicum GB_HTG2: AC007598 248427 AC007598 Homo sapiens chromosome 16 clone 165M1, *** SEQUENCING IN Homo sapiens 38,469 20-MAY-1999 PROGRESS ***, 105 unordered pieces. GB_HTG2: AC007598 248427 AC007598 Homo sapiens chromosome 16 clone 165M1, *** SEQUENCING IN Homo sapiens 38,469 20-MAY-1999 PROGRESS ***, 105 unordered pieces. rxa01931 777 GB_IN1: CEH12I19 37427 Z98851 Caenorhabditis elegans cosmid H12I19, complete sequence. Caenorhabditis elegans 32,763 18-DEC-1998 GB_HTG1: CEY37A1 316170 Z93243 Caenorhabditis elegans chromosome IV clone Y37A1, *** SEQUENCING Caenorhabditis elegans 32,763 03-DEC-1998 IN PROGRESS ***, in unordered pieces. GB_HTG1: CEY37A1 316170 Z93243 Caenorhabditis elegans chromosome IV clone Y37A1, *** SEQUENCING Caenorhabditis elegans 32,763 03-DEC-1998 IN PROGRESS ***, in unordered pieces. rxa01941 558 GB_EST25: AI313927 520 AI313927 uj38h06.x1 Sugano mouse kidney mkia Mus musculus cDNA clone Mus musculus 41,148 17-DEC-1998 IMAGE: 1922267 3′ similar to TR: O09047 O09047 COMPLEMENT COMPONENT 3A RECEPTOR 1;, mRNA sequence. GB_RO: AF053757 8308 AF053757 Mus musculus complement C3a anaphylatoxin receptor (C3ar) gene, complete cds. Mus musculus 38,649 30-Jul-98 GB_RO: MMU77461 2657 U77461 Mus musculus anaphylatoxin C3a receptor gene, complete cds. Mus musculus 38,649 28-MAY-1997 rxa01942 723 GB_BA1: BRLPTSG 3163 L18875 Brevibacterium lactofermentum phosphoenolpyruvate sugar Brevibacterium 67,407 01-OCT-1993 phosphotransferase (ptsG) gene, complete cds. lactofermentum GB_BA1: CORPTSMA 2656 L18874 Corynebacterium glutamicum phosphoenolpyruvate sugar Corynebacterium 100,000 24-Nov-94 phosphotransferase (ptsM) mRNA, complete cds. glutamicum GB_BA1: CORPTSMA 2656 L18874 Corynebacterium glutamicum phosphoenolpyruvate sugar Corynebacterium 37,008 24-Nov-94 phosphotransferase (ptsM) mRNA, complete cds. glutamicum rxa01944 1095 GB_HTG2: AC004840 162485 AC004840 Homo sapiens clone DJ0607J02, *** SEQUENCING IN Homo sapiens 36,287 12-Jun-98 PROGRESS ***, 12 unordered pieces. GB_HTG2: AC004840 162485 AC004840 Homo sapiens clone DJ0607J02, *** SEQUENCING IN Homo sapiens 36,287 12-Jun-98 PROGRESS ***, 12 unordered pieces. GB_VI: MCU60315 190289 U60315 Molluscum contagiosum virus subtype 1, complete genome. Molluscum contagiosum 37,650 17-Aug-96 virus subtype 1 rxa01945 2115 GB_GSS15: AQ632158 445 AQ632158 RPCI-11-473F7.TJ RPCI-11 Homo sapiens genomic clone Homo sapiens 38,095 17-Jun-99 RPCI-11-473F7, genomic survey sequence. GB_GSS15: AQ632158 445 AQ632158 RPCI-11-473F7.TJ RPCI-11 Homo sapiens genomic clone Homo sapiens 40,275 17-Jun-99 RPCI-11-473F7, genomic survey sequence. rxa01957 585 GB_EST16: C35275 300 C35275 C35275 Yuji Kohara unpublished cDNA: Strain N2 hermaphrodite Caenorhabditis elegans 37,698 18-OCT-1999 embryo Caenorhabditis elegans cDNA clone yk427e6 3′, mRNA sequence. GB_IN2: CELC29H12 42635 U23169 Caenorhabditis elegans cosmid C29H12. Caenorhabditis elegans 34,477 13-Jul-95 GB_GSS1: CNS00GP0 1101 AL072364 Drosophila melanogaster genome survey sequence T7 end of BAC: Drosophila melanogaster 34,321 3-Jun-99 BACR33I08 of RPCI-98 library from Drosophila melanogaster (fruit fly), genomic survey sequence. rxa01958 630 GB_PR1: HSIL1RECA 12565 X64532 H. sapiens gene for interleukin-1 receptor antagonist. Homo sapiens 42,079 25-Jun-97 GB_PR3: HSU65590 33414 U65590 Homo sapiens IL-1 receptor antagonist IL-1Ra (IL-1RN) gene, alternatively Homo sapiens 42,079 21-DEC-1997 spliced forms, complete cds. GB_GSS11: AQ293677 476 AQ293677 HS_2254_A2_C03_MF CIT Approved Human Genomic Sperm Homo sapiens 36,772 15-DEC-1998 Library D Homo sapiens genomic clone Plate = 2254 Col = 6 Row = E, genomic survey sequence. rxa01959 rxa01960 rxa01961 603 GB_BA2: U67460 12589 U67460 Methanococcus jannaschii section 2 of 150 of the complete genome. Methanococcus jannaschii 36,013 28-Jan-98 GB_EST25: AI260761 626 AI260761 LP04729.3prime LP Drosophila melanogaster larval-early pupal pOT2 Drosophila melanogaster 39,130 17-Nov-98 Drosophila melanogaster cDNA clone LP04729 3prime, mRNA sequence. GB_EST25: AI294890 554 AI294890 LP08371.3prime LP Drosophila melanogaster larval-early pupal pOT2 Drosophila melanogaster 38,940 01-DEC-1998 Drosophila melanogaster cDNA clone LP08371 3prime, mRNA sequence. rxa01962 693 GB_BA2: U67460 12589 U67460 Methanococcus jannaschii section 2 of 150 of the complete genome. Methanococcus jannaschii 34,795 28-Jan-98 GB_BA2: U67460 12589 U67460 Methanococcus jannaschii section 2 of 150 of the complete genome. Methanococcus jannaschii 37,666 28-Jan-98 rxa01963 784 GB_PR4: AC006397 91460 AC006397 Homo sapiens BAC clone GS170I02 from 7p21-p15.1, complete sequence. Homo sapiens 35,401 17-Feb-99 GB_PR3: AC005565 39441 AC005565 Homo sapiens chromosome 16, cosmid clone 444B9 (LANL), complete sequence. Homo sapiens 37,891 30-Aug-98 GB_PR2: D86999 40778 D86999 Homo sapiens immunoglobulin lambda gene locus DNA, clone: 22A12. Homo sapiens 38,212 5-Nov-99 rxa01964 1426 GB_GSS13: AQ465174 437 AQ465174 HS_5109_A2_C07_SP6E RPCI-11 Human Male BAC Homo sapiens 40,084 23-Apr-99 Library Homo sapiens genomic clone Plate = 685 Col = 14 Row = E, genomic survey sequence. GB_GSS13: AQ457528 599 AQ457528 HS_5087_A1_H06_SP6E RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 36,728 23-Apr-99 genomic clone Plate = 663 Col = 11 Row = O, genomic survey sequence. GB_GSS13: AQ454028 527 AQ454028 HS_5171_B1_D12_T7A RPCI-11 Human Male BAC Homo sapiens 37,137 21-Apr-99 Library Homo sapiens genomic clone Plate = 747 Col = 23 Row = H, genomic survey sequence. rxa01965 684 GB_IN2: AC004283 80095 AC004283 Drosophila melanogaster DNA sequence (P1 DS05557 (D152)), complete sequence. Drosophila melanogaster 36,982 29-Aug-98 GB_EST28: AI541584 585 AI541584 SD02734.5prime SD Drosophila melanogaster Schneider L2 cell Drosophila melanogaster 38,375 22-MAR-1999 culture pOT2 Drosophila melanogaster cDNA clone SD02734 5prime, mRNA sequence. GB_EST22: AI013385 434 AI013385 EST208060 Normalized rat spleen, Bento Soares Rattus sp. cDNA clone Rattus sp. 42,126 31-Jan-99 RSPBK32 3′ end, mRNA sequence. rxa01966 780 GB_GSS1: CNS00AMI 810 AL055260 Drosophila melanogaster genome survey sequence TET3 end of BAC # Drosophila melanogaster 37,592 4-Jun-99 BACR21F10 of RPCI-98 library from Drosophila melanogaster (fruit fly), genomic survey sequence. GB_HTG3: AC009567 164147 AC009567 Homo sapiens chromosome 4 clone 21_G_20 map 4, *** SEQUENCING Homo sapiens 35,844 29-Sep-99 IN PROGRESS ***, 14 unordered pieces. GB_HTG3: AC009567 164147 AC009567 Homo sapiens chromosome 4 clone 21_G_20 map 4, *** SEQUENCING Homo sapiens 35,844 29-Sep-99 IN PROGRESS ***, 14 unordered pieces. rxa01968 1281 GB_PR4: AC005146 157653 AC005146 Homo sapiens 12q24.2 PAC RPCI1-157K6 (Roswell Park Cancer Institute Homo sapiens 40,620 11-Nov-98 Human PAC library) complete sequence. GB_PR4: AC006549 174844 AC006549 Homo sapiens, complete sequence. Homo sapiens 34,202 26-Nov-99 GB_PR2: HSAC002070 165197 AC002070 Human BAC clone 7E17 from 12q, complete sequence. Homo sapiens 36,482 12-MAY-1997 rxa01969 489 GB_SY: SCU53587 4546 U53587 Artificial Corynebacterium glutamicum IS1207-derived transposon synthetic construct 98,160 06-MAY-1996 transposase genes, complete cds, and 3′5″-aminoglycoside phosphotransferase (aphA-3) gene, complete cds. GB_PAT: I43826 1452 I43826 Sequence 1 from patent U.S. Pat. No. 5633154. Unknown. 98,963 07-OCT-1997 GB_BA1: CGIS1207 1453 X96962 C. glutamicum insertion sequence IS1207 and transposase gene. Corynebacterium 98,755 01-MAY-1997 glutamicum rxa01973 rxa01974 1908 GB_PL1: SC9320A 24000 Z68329 S. cerevisiae chromosome IV cosmid 9320A. Saccharomyces cerevisiae 36,528 11-Aug-97 GB_PL1: SC9320X 22253 Z70202 S. cerevisiae chromosome IV cosmid 9320X. Saccharomyces cerevisiae 36,528 11-Aug-97 GB_PR4: AC006210 186986 AC006210 Homo sapiens Xp22-150 BAC GSHB-309P15 (Genome Systems Human Homo sapiens 38,351 31-DEC-1998 BAC Library) complete sequence. rxa01976 1644 GB_BA2: CGU13922 4412 U13922 Corynebacterium glutamicum putative type II 5-cytosoine methyltransferase Corynebacterium 47,727 3-Feb-98 (cglIM) and putative type II restriction endonuclease (cglIR) and putative glutamicum type I or type III restriction endonuclease (clgIIR) genes, complete cds. GB_BA2: CGU13922 4412 U13922 Corynebacterium glutamicum putative type II 5-cytosoine methyltransferase Corynebacterium 37,515 3-Feb-98 (cglIM) and putative type II restriction endonuclease (cglIR) and putative type I or glutamicum type III restriction endonuclease (clgIIR) genes, complete cds. rxa01977 699 GB_PR3: HS426F10 91640 AL023586 Human DNA sequence from clone 426F10 on chromosome 1p36.21-36.33 Homo sapiens 38,295 23-Nov-99 Contains EST, CA repeat, STS, complete sequence. GB_GSS6: AQ823696 587 AQ823696 HS_3228_A1_D10_T7C CIT Approved Human Genomic Sperm Library Homo sapiens 37,637 26-Aug-99 D Homo sapiens genomic clone Plate = 3228 Col = 19 Row = G, genomic survey sequence. GB_VI: HS3DNA1 892 M29629 Varicella-zoster virus (VZV) DNA, 5′ end. Human herpesvirus 3 33,857 2-Aug-93 rxa01982 1281 GB_EST8: AA009257 472 AA009257 mh02g07.r1 Soares mouse embryo NbME13.5 14.5 Mus musculus cDNA clone Mus musculus 36,017 26-Jul-96 IMAGE: 441372 5′, mRNA sequence. GB_EST8: AA009257 472 AA009257 mh02g07.r1 Soares mouse embryo NbME13.5 14.5 Mus musculus cDNA clone Mus musculus 38,710 26-Jul-96 IMAGE: 441372 5′, mRNA sequence. rxa01987 336 GB_PR4: AC009330 174768 AC009330 Homo sapiens clone RP11-83M17 from 7q31, complete sequence. Homo sapiens 33,036 09-DEC-1999 GB_HTG6: AC007300 171472 AC007300 Drosophila melanogaster chromosome 2 clone BACR09I15 (D570) Drosophila melanogaster 38,782 07-DEC-1999 RPCI-98 09.I.15 map 32A-32A strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 43 unordered pieces. GB_HTG3: AC009542 160367 AC009542 Homo sapiens chromosome 7, *** SEQUENCING IN Homo sapiens 35,065 27-Aug-99 PROGRESS ***, 17 unordered pieces. rxa01988 549 GB_IN1: AC002446 50978 AC002446 Drosophila melanogaster (P1 DS06754 (D83)) DNA sequence, complete sequence. Drosophila melanogaster 38,920 19-Aug-97 GB_PR3: HSU19H10 43303 AL021182 Human DNA sequence from cosmid U19H10 on chromosome X. Homo sapiens 39,006 23-Nov-99 Contains ESTs and CA repeat. GB_PR3: HSU19H10 43303 AL021182 Human DNA sequence from cosmid U19H10 on chromosome X. Contains Homo sapiens 38,447 23-Nov-99 ESTs and CA repeat. rxa01990 1022 GB_GSS9: AQ100628 382 AQ100628 HS_3054_B2_A05_MF CIT Approved Human Genomic Sperm Library D Homo sapiens 38,320 27-Aug-98 Homo sapiens genomic clone Plate = 3054 Col = 10 Row = B, genomic survey sequence. GB_EST14: AA406679 338 AA406679 MBAFCZ2F12T3A Brugia malayi adult female cDNA (SAW96MLW-BmAF) Brugia malayi 38,039 01-MAY-1997 Brugia malayi cDNA clone AFCZ2F12 5′, mRNA sequence. GB_EST21: AA991134 600 AA991134 BSBmMFSZ06C1SK Brugia malayi microfilaria cDNA (SAW94LS-BmMf) Brugia malayi 40,090 5-Jun-98 Brugia malayi cDNA clone BSBmMFSZ06C1 5′, mRNA sequence. rxa01991 996 GB_HTG3: AC007559 156374 AC007559 Homo sapiens clone NH0364J06, *** SEQUENCING IN Homo sapiens 35,931 13-Aug-99 PROGRESS ***, 29 unordered pieces. GB_HTG3: AC007559 156374 AC007559 Homo sapiens clone NH0364J06, *** SEQUENCING IN Homo sapiens 35,931 13-Aug-99 PROGRESS ***, 29 unordered pieces. GB_HTG3: AC007559 156374 AC007559 Homo sapiens clone NH0364J06, *** SEQUENCING IN Homo sapiens 36,120 13-Aug-99 PROGRESS ***, 29 unordered pieces. rxa01992 rxa01996 660 GB_BA1: XCXPSGEN 5324 X59079 X. campestris xps E, F, G, H, I, and J genes for protein secretion Xanthomonas campestris 38,447 12-Sep-93 and pathogenicity functions. GB_GSS15: AQ659461 394 AQ659461 Sheared DNA-5C7.TR Sheared DNA Trypanosoma brucei genomic clone Trypanosoma brucei 49,180 23-Jun-99 Sheared DNA-5C7, genomic survey sequence. GB_GSS4: AQ741049 713 AQ741049 HS_2272_A2_B02_MR CIT Approved Human Genomic Sperm Library Homo sapiens 39,614 16-Jul-99 D Homo sapiens genomic clone Plate = 2272 Col = 4 Row = C, genomic survey sequence. rxa01999 594 GB_HTG2: AC007321 159558 AC007321 Homo sapiens clone NH0507C01, *** SEQUENCING IN Homo sapiens 34,524 16-Apr-99 PROGRESS ***, 4 unordered pieces. GB_HTG2: AC007321 159558 AC007321 Homo sapiens clone NH0507C01, *** SEQUENCING IN Homo sapiens 34,524 16-Apr-99 PROGRESS ***, 4 unordered pieces. GB_HTG2: AC007321 159558 AC007321 Homo sapiens clone NH0507C01, *** SEQUENCING IN Homo sapiens 35,094 16-Apr-99 PROGRESS ***, 4 unordered pieces. rxa02001 1281 GB_BA1: D90917 154619 D90917 Synechocystis sp. PCC6803 complete genome, 27/27, 3418852-3573470. Synechocystis sp. 50,474 7-Feb-99 GB_BA1: MTV016 53662 AL021841 Mycobacterium tuberculosis H37Rv complete genome; segment 143/162. Mycobacterium 39,223 23-Jun-99 tuberculosis GB_BA1: BSUB0006 210440 Z99109 Bacillus subtilis complete genome (section 6 of 21): from 999501 to 1209940. Bacillus subtilis 36,445 26-Nov-97 rxa02004 230 GB_HTG3: AC011491 162134 AC011491 Homo sapiens chromosome 19 clone CIT978SKB_180A7, *** SEQUENCING Homo sapiens 37,383 07-OCT-1999 IN PROGRESS ***, 161 unordered pieces. GB_HTG3: AC011491 162134 AC011491 Homo sapiens chromosome 19 clone CIT978SKB_180A7, Homo sapiens 37,383 07-OCT-1999 *** SEQUENCING IN PROGRESS ***, 161 unordered pieces. GB_HTG3: AC011357 160676 AC011357 Homo sapiens chromosome 5 clone CIT-HSPC_362D12, *** SEQUENCING Homo sapiens 54,585 06-OCT-1999 IN PROGRESS ***, 42 unordered pieces. rxa02006 595 GB_HTG2: AC006901 294136 AC006901 Caenorhabditis elegans clone Y74A11X, *** SEQUENCING IN Caenorhabditis elegans 37,500 26-Feb-99 PROGRESS ***, 81 unordered pieces. GB_HTG2: AC006901 294136 AC006901 Caenorhabditis elegans clone Y74A11X, *** SEQUENCING Caenorhabditis elegans 37,500 26-Feb-99 IN PROGRESS ***, 81 unordered pieces. GB_HTG1: CEY70C5 224525 Z98878 Caenorhabditis elegans chromosome V clone Y70C5, Caenorhabditis elegans 36,021 28-Aug-97 *** SEQUENCING IN PROGRESS ***, in unordered pieces. rxa02007 756 GB_BA2: CGL012293 2952 AJ012293 Corynebacterium glutamicum ilvD gene. Corynebacterium 100,000 01-OCT-1999 glutamicum GB_PR4: AC006285 150172 AC006285 Homo sapiens ,complete sequence. Homo sapiens 38,740 15-Nov-99 GB_PR4: AC006285 150172 AC006285 Homo sapiens ,complete sequence. Homo sapiens 38,701 15-Nov-99 rxa02009 223 GB_PR4: AC004926 153556 AC004926 Homo sapiens PAC clone DJ0910H09 from 7q21.1-q21.2, complete sequence. Homo sapiens 38,462 17-Feb-99 GB_PR2: AP000053 100000 AP000053 Homo sapiens genomic DNA, chromosome 21q22.1, Homo sapiens 37,674 20-Nov-99 segment 24/28, complete sequence. GB_PR2: AP000121 100000 AP000121 Homo sapiens genomic DNA of 21q22.1, GART and AML Homo sapiens 37,674 25-Sep-99 related, SLC5A3-f4A4 region, segment 4/8, complete sequence. rxa02013 649 GB_BA1: MTCI237 27030 Z94752 Mycobacterium tuberculosis H37Rv complete genome; segment 46/162. Mycobacterium 39,308 17-Jun-98 tuberculosis GB_HTG4: AC010885 201581 AC010885 Homo sapiens chromosome unknown clone NH0368K23, WORKING Homo sapiens 37,206 29-OCT-1999 DRAFT SEQUENCE, in unordered pieces. GB_HTG4: AC010885 201581 AC010885 Homo sapiens chromosome unknown clone NH0368K23, WORKING Homo sapiens 37,206 29-OCT-1999 DRAFT SEQUENCE, in unordered pieces. rxa02014 630 GB_HTG3: AC010769 119431 AC010769 Homo sapiens chromosome 15 clone 28_B_17 map 15, Homo sapiens 33,816 22-Sep-99 LOW-PASS SEQUENCE SAMPLING. GB_HTG3: AC010769 119431 AC010769 Homo sapiens chromosome 15 clone 28_B_17 map 15, Homo sapiens 33,816 22-Sep-99 LOW-PASS SEQUENCE SAMPLING. GB_EST34: AI783738 320 AI783738 tu45b07.x1 NCI_CGAP_Pr28 Homo sapiens cDNA Homo sapiens 37,855 1-Jul-99 clone IMAGE: 2253973 3′, mRNA sequence. rxa02019 524 GB_EST15: AA473289 318 AA473289 vd44g09.r1 Barstead MPLRB1 Mus musculus cDNA clone Mus musculus 38,153 18-Jun-97 IMAGE: 803488 5′, mRNA sequence. GB_HTG1: CEY102A5_3 110000 Z99711 Caenorhabditis elegans chromosome V clone Y102A5, Caenorhabditis elegans 38,867 9-Jun-98 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG1: CEY102A5_3 110000 Z99711 Caenorhabditis elegans chromosome V clone Y102A5, Caenorhabditis elegans 38,867 9-Jun-98 *** SEQUENCING IN PROGRESS ***, in unordered pieces. rxa02021 1071 GB_BA1: CGDNAAROP 2612 X85965 C. glutamicum ORF3 and aroP gene. Corynebacterium 99,905 30-Nov-97 glutamicum GB_BA1: CGDAPE 1966 X81379 C. glutamicum dapE gene and orf2. Corynebacterium 36,406 8-Aug-95 glutamicum GB_BA1: SCI7 34893 AL096743 Streptomyces coelicolor cosmid I7. Streptomyces coelicolor 36,782 1-Jul-99 rxa02023 891 GB_BA1: CGDAPE 1966 X81379 C. glutamicum dapE gene and orf2. Corynebacterium 99,864 8-Aug-95 glutamicum GB_PR3: AC004067 161326 AC004067 Homo sapiens chromosome 4 clone B366O24 map 4q25, complete sequence. Homo sapiens 39,651 8-Nov-98 GB_HTG3: AC009725 145005 AC009725 Mus musculus chromosome 6 clone 388_N_17 map 6, Mus musculus 38,215 01-OCT-1999 *** SEQUENCING IN PROGRESS ***, 2 ordered pieces. rxa02032 693 GB_PR4: AC006961 171419 AC006961 Homo sapiens chromosome 18, clone RP11-31P16, complete sequence. Homo sapiens 37,703 19-Nov-99 GB_PR4: AC006961 171419 AC006961 Homo sapiens chromosome 18, clone RP11-31P16, complete sequence. Homo sapiens 40,839 19-Nov-99 rxa02036 504 GB_PR2: HSDJ799G3 127639 AL078624 Human DNA sequence from clone RP4-799G3 on Homo sapiens 35,657 22-Nov-99 chromosome 1q42.11-42.3, complete sequence. GB_BA1: AOPCZA361 37941 AJ223998 Amycolatopsis orientalis cosmid PCZA361. Amycolatopsis orientalis 46,341 29-MAR-1999 GB_PL1: ATDNADAL1 8747 Y14851 Arabidopsis thaliana dal1 gene. Arabidopsis thaliana 35,223 23-Sep-97 rxa02039 863 GB_PR3: AC005609 157970 AC005609 Homo sapiens chromosome 5, BAC clone 203o13 (LBNL H155), complete sequence. Homo sapiens 37,176 4-Sep-98 GB_HTG3: AC008468 245016 AC008468 Homo sapiens chromosome 5 clone CIT-HSPC_365B8, Homo sapiens 36,842 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 14 unordered pieces. GB_HTG3: AC008468 245016 AC008468 Homo sapiens chromosome 5 clone CIT-HSPC_365B8, Homo sapiens 36,842 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 14 unordered pieces. rxa02040 551 GB_HTG3: AC009303 198549 AC009303 Homo sapiens clone NH0098C01, Homo sapiens 35,424 13-Aug-99 *** SEQUENCING IN PROGRESS ***, 2 unordered pieces. GB_HTG3: AC009303 198549 AC009303 Homo sapiens clone NH0098C01, Homo sapiens 35,424 13-Aug-99 *** SEQUENCING IN PROGRESS ***, 2 unordered pieces. GB_HTG3: AC009303 198549 AC009303 Homo sapiens clone NH0098C01, Homo sapiens 32,597 13-Aug-99 *** SEQUENCING IN PROGRESS ***, 2 unordered pieces. rxa02045 384 GB_EST3: R23812 459 R23812 yh34g05.r1 Soares placenta Nb2HP Homo sapiens cDNA clone Homo sapiens 47,273 20-Apr-95 IMAGE: 131672 5′, mRNA sequence. GB_EST19: AA778733 611 AA778733 af88d02.s1 Soares_testis_NHT Homo sapiens cDNA Homo sapiens 38,806 5-Feb-98 clone 1049091 3′, mRNA sequence. GB_PR2: HSU59185 2529 U59185 Human putative monocarboxylate transporter (MCT) mRNA, complete cds. Homo sapiens 43,164 03-OCT-1997 rxa02046 540 GB_HTG3: AC005507 196595 AC005507 Plasmodium falciparum chromosome 12 clone 3D7, Plasmodium falciparum 37,218 23-Sep-99 *** SEQUENCING IN PROGRESS ***, 3 unordered pieces. GB_HTG3: AC005507 196595 AC005507 Plasmodium falciparum chromosome 12 clone 3D7, Plasmodium falciparum 37,218 23-Sep-99 *** SEQUENCING IN PROGRESS ***, 3 unordered pieces. GB_EST1: T09984 330 T09984 0540m7 gmbPfHB3.1, G. Roman Reddy Plasmodium falciparum genomic Plasmodium falciparum 32,121 29-Nov-93 clone 0540m, mRNA sequence. rxa02049 732 GB_PL1: ATHCOLR 1098 M37778 A. thaliana middle repetative sequence. Arabidopsis thaliana 33,755 27-Apr-93 GB_PL2: ATAC006954 87035 AC006954 Arabidopsis thaliana chromosome II BAC F25P17 genomic Arabidopsis thaliana 33,755 7-Apr-99 sequence, complete sequence. GB_EST33: AI779067 495 AI779067 EST259946 tomato susceptible, Cornell Lycopersicon esculentum Lycopersicon esculentum 35,223 29-Jun-99 cDNA clone cLES7C7, mRNA sequence. rxa02050 918 GB_HTG2: AC008307 91654 AC008307 Drosophila melanogaster chromosome 3 clone BACR03D22 (D709) RPCI-98 Drosophila melanogaster 36,182 2-Aug-99 03.D.22 map 86F-87A strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 94 unordered pieces. GB_HTG2: AC008307 91654 AC008307 Drosophila melanogaster chromosome 3 clone BACR03D22 (D709) RPCI-98 03.D.22 Drosophila melanogaster 36,182 2-Aug-99 map 86F-87A strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 94 unordered pieces. GB_EST31: AU060923 663 AU060923 AU060923 Dictyostelium discoideum SL (H. Urushihara) Dictyostelium discoideum 39,388 20-MAY-1999 Dictyostelium discoideum cDNA clone SLC248, mRNA sequence. rxa02051 621 GB_EST16: C43896 369 C43896 C43896 Yuji Kohara unpublished cDNA: Strain N2 Caenorhabditis elegans 41,160 18-OCT-1999 hermaphrodite embryo Caenorhabditis elegans cDNA clone yk336c10 5′, mRNA sequence. GB_EST16: C40413 360 C40413 C40413 Yuji Kohara unpublished cDNA: Strain N2 hermaphrodite embryo Caenorhabditis elegans 42,090 18-OCT-1999 Caenorhabditis elegans cDNA clone yk230e7 5′, mRNA sequence. GB_EST36: AV191515 360 AV191515 AV191515 Yuji Kohara unpublished cDNA: Strain N2 hermaphrodite embryo Caenorhabditis elegans 40,833 22-Jul-99 Caenorhabditis elegans cDNA clone yk594g6 5′, mRNA sequence. rxa02053 702 GB_IN1: AF035264 6397 AF035264 Drosophila melanogaster POU domain protein (pdm-1) gene, Drosophila melanogaster 36,888 04-DEC-1997 promoter region and exon 1. GB_BA1: MTV036 24055 AL021931 Mycobacterium tuberculosis H37Rv complete genome; segment 19/162. Mycobacterium 37,647 17-Jun-98 tuberculosis GB_EST30: AI658116 497 AI658116 fc22e07.y1 Zebrafish WashU MPIMG EST Danio rerio cDNA 5′ similar Danio rerio 41,129 06-MAY-1999 to TR: Q15883 Q15883 X104.;, mRNA sequence. rxa02057 654 GB_PAT: E14601 4394 E14601 Brevibacterium lactofermentum gene for alpha-ketoglutaric acid dehydrogenase. Corynebacterium 96,667 28-Jul-99 glutamicum GB_BA1: D84102 4394 D84102 Corynebacterium glutamicum DNA for 2-oxoglutarate dehydrogenase, complete cds. Corynebacterium 96,667 6-Feb-99 glutamicum GB_PAT: E14601 4394 E14601 Brevibacterium lactofermentum gene for alpha-ketoglutaric acid dehydrogenase. Corynebacterium 38,199 28-Jul-99 glutamicum rxa02058 675 GB_GSS9: AQ129748 432 AQ129748 HS_2254_B1_H03_MF CIT Approved Human Genomic Sperm Library D Homo sapiens 40,000 23-Sep-98 Homo sapiens genomic clone Plate = 2254 Col = 5 Row = P, genomic survey sequence. GB_PL2: T15B16 90596 AF104919 Arabidopsis thaliana BAC T15B16. Arabidopsis thaliana 35,338 11-Nov-98 GB_PL2: AC007138 120185 AC007138 Arabidopsis thaliana BAC T7B11 from chromosome IV near 10 cM, Arabidopsis thaliana 39,426 1-Apr-99 complete sequence. rxa02059 618 GB_HTG3: AC008672 131573 AC008672 Homo sapiens chromosome 5 clone CIT978SKB_3B12, Homo sapiens 40,871 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 71 unordered pieces. GB_HTG3: AC008672 131573 AC008672 Homo sapiens chromosome 5 clone CIT978SKB_3B12, Homo sapiens 40,871 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 71 unordered pieces. GB_IN1: DDU06228 2695 U06228 Dictyostelium discoideum CRAC (dagA) gene, complete cds. Dictyostelium discoideum 36,513 1-Feb-95 rxa02066 615 GB_PR2: CNS01DRA 198444 AL110505 Human chromosome 14 DNA sequence *** IN PROGRESS *** BAC R-816J8 of Homo sapiens 36,903 11-Nov-99 RPCI-11 library from chromosome 14 of Homo sapiens (Human), complete sequence. GB_PR2: HS230G1 125515 Z84466 Homo sapiens DNA sequence from PAC 230G1 on chromosome Xp11.3. Homo sapiens 41,751 23-Nov-99 Contains EST, STS and GSS, complete sequence. GB_PR2: CNS01DRA 198444 AL110505 Human chromosome 14 DNA sequence *** IN PROGRESS *** BAC R-816J8 Homo sapiens 36,589 11-Nov-99 of RPCI-11 library from chromosome 14 of Homo sapiens (Human), complete sequence. rxa02067 579 GB_HTG3: AC009543 159209 AC009543 Homo sapiens chromosome 11 clone 63_H_13 map 11, Homo sapiens 35,366 07-OCT-1999 *** SEQUENCING IN PROGRESS ***, 12 unordered pieces. GB_HTG3: AC009543 159209 AC009543 Homo sapiens chromosome 11 clone 63_H_13 map 11, Homo sapiens 35,366 07-OCT-1999 *** SEQUENCING IN PROGRESS ***, 12 unordered pieces. GB_PR2: HS230G1 125515 Z84466 Homo sapiens DNA sequence from PAC 230G1 on chromosome Xp11.3. Homo sapiens 36,348 23-Nov-99 Contains EST, STS and GSS, complete sequence. rxa02069 702 GB_BA1: MTCI61 13540 Z98260 Mycobacterium tuberculosis H37Rv complete genome; segment 53/162. Mycobacterium 36,642 17-Jun-98 tuberculosis GB_BA1: MTCI61 13540 Z98260 Mycobacterium tuberculosis H37Rv complete genome; segment 53/162. Mycobacterium 39,474 17-Jun-98 tuberculosis rxa02070 1245 GB_BA2: AE001112 14704 AE001112 Archaeoglobus fulgidus section 167 of 172 of the complete genome. Archaeoglobus fulgidus 39,352 15-DEC-1997 GB_PR3: HSDJ47M23 129320 AL096816 Human DNA sequence *** SEQUENCING IN PROGRESS *** Homo sapiens 40,413 23-Nov-99 from clone dJ47M23, complete sequence. GB_HTG3: AC009139 152666 AC009139 Homo sapiens chromosome 16 clone RPCI-11_538I12, Homo sapiens 35,275 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 27 unordered pieces. rxa02076 657 GB_EST34: AI789138 594 AI789138 uk51e02.y1 Sugano mouse kidney mkia Mus musculus cDNA clone IMAGE: Mus musculus 43,041 2-Jul-99 1972538 5′ similar to WP: R10H10.7 CE06298 TYROSINE-PROTEIN KINASE LIKE;, mRNA sequence. GB_GSS1: FR0013995 552 AL005239 F. rubripes GSS sequence, clone 137O18aC6, genomic survey sequence. Fugu rubripes 37,079 18-Sep-97 GB_GSS3: B27548 642 B27548 F19J9TFB IGF Arabidopsis thaliana genomic clone F19J9, genomic survey sequence. Arabidopsis thaliana 37,056 13-OCT-1997 rxa02080 930 GB_GSS15: AQ652136 411 AQ652136 Sheared DNA-7M23.TR Sheared DNA Trypanosoma brucei genomic Trypanosoma brucei 39,259 22-Jun-99 clone Sheared DNA-7M23, genomic survey sequence. GB_GSS15: AQ652498 450 AQ652498 Sheared DNA-22K16.TR Sheared DNA Trypanosoma brucei genomic clone Trypanosoma brucei 39,597 22-Jun-99 Sheared DNA-22K16, genomic survey sequence. GB_HTG3: AC009683 171597 AC009683 Homo sapiens chromosome 8 clone 76_N_5 map 8, Homo sapiens 37,053 29-Sep-99 *** SEQUENCING IN PROGRESS ***, 10 unordered pieces. rxa02081 1752 GB_OV: BSU43200 2070 U43200 Boreogadus saida antifreeze glycopeptide AFGP polyprotein Boreogadus saida 37,016 12-MAY-1997 precursor gene, complete cds. GB_BA2: AE001615 12401 AE001615 Chlamydia pneumoniae section 31 of 103 of the complete genome. Chlamydophila pneumoniae 36,385 08-MAR-1999 GB_OV: BSU43200 2070 U43200 Boreogadus saida antifreeze glycopeptide AFGP polyprotein Boreogadus saida 37,672 12-MAY-1997 precursor gene, complete cds. rxa02084 468 GB_PR4: AC007382 80547 AC007382 Homo sapiens clone NH0288C18, complete sequence. Homo sapiens 41,138 8-Sep-99 GB_GSS4: AQ731530 508 AQ731530 HS_5543_A2_A05_T7A RPCI-11 Human Male BAC Library Homo sapiens 36,245 15-Jul-99 Homo sapiens genomic clone Plate = 1119 Col = 10 Row = A, genomic survey sequence. GB_PR4: AC007382 80547 AC007382 Homo sapiens clone NH0288C18, complete sequence. Homo sapiens 35,398 8-Sep-99 rxa02089 594 GB_PR2: AP000031 149298 AP000031 Homo sapiens genomic DNA, chromosome 21q22.1, segment 2/28, Homo sapiens 38,699 20-Nov-99 complete sequence. GB_PR2: AP000135 111894 AP000135 Homo sapiens genomic DNA of 21q22.1, GART and AML, f43D11-119B8 region, Homo sapiens 38,699 25-Sep-99 segment 10/10, complete sequence. GB_PR2: AP000213 100000 AP000213 Homo sapiens genomic DNA, chromosome 21q22.1, D21S226-AML region, Homo sapiens 38,699 20-Nov-99 clone f43D11-119B8, segment 11/12, complete sequence. rxa02090 924 GB_PL2: ATAC006841 123183 AC006841 Arabidopsis thaliana chromosome II BAC F3K23 genomic Arabidopsis thaliana 39,826 6-Apr-99 sequence, complete sequence. GB_PL1: SCXV55KB 54719 Z70678 S. cerevisiae chromosome XV DNA, 54.7 kb region. Saccharomyces cerevisiae 37,817 16-MAY-1997 GB_PR1: D87675 301692 D87675 Homo sapiens DNA for amyloid precursor protein, complete cds. Homo sapiens 39,140 22-Sep-97 rxa02091 774 GB_BA2: AF031929 2675 AF031929 Lactobacillus helveticus cochaperonin GroES and chaperonin GroEL genes, Lactobacillus helveticus 35,509 8-Aug-98 complete cds; and DNA mismatch repair enzyme (hexA) gene, partial cds. GB_BA1: CGU43536 3464 U43536 Corynebacterium glutamicum heat shock, ATP-binding protein Corynebacterium 39,124 13-MAR-1997 (clpB) gene, complete cds. glutamicum GB_BA1: RCFBC 3874 X03476 Rhodopseudomonas sphaeroides fbc operon (fbcF, fbcB, fbcC genes). Rhodobacter sphaeroides 36,478 10-Feb-99 rxa02094 840 GB_RO: MMHC188A7 120990 AF109719 Mus musculus casein kinase 2 beta subunit (gMCK2) gene, partial cds; BAT4, Mus musculus 38,118 25-OCT-1999 NG20 (NG20), BAT3, BAT2, AIF-1, B144, lymphotoxin beta, TNF, and TNF beta genes, complete cds; IKBL gene, partial cds; and unknown gene. GB_EST10: AA168948 549 AA168948 ms39c08.r1 Life Tech mouse embryo 13 5dpc 10666014 Mus musculus cDNA Mus musculus 40,789 19-DEC-1996 clone IMAGE: 613934 5′ similar to gb: U15980 Mus musculus (MOUSE);, mRNA sequence. GB_EST24: AI101223 348 AI101223 EST210512 Normalized rat brain, Bento Soares Rattus sp. cDNA clone Rattus sp. 40,634 31-Jan-99 RBRBK04 3′ end, mRNA sequence. rxa02097 3495 GB_BA2: RMU31512 1974 U31512 Rhizobium meliloti RmDEGP Sinorhizobium meliloti 39,159 05-MAR-1996 (degP) gene, complete cds. GB_EST15: AA502050 346 AA502050 ng57c04.s1 NCI_CGAP_Lip2 Homo sapiens cDNA clone IMAGE: 938886 Homo sapiens 40,751 18-Aug-97 similar to contains Alu repetitive element;, mRNA sequence. GB_EST16: AA589883 400 AA589883 vl80h08.r1 Stratagene mouse diaphragm (#937303) Mus musculus cDNA Mus musculus 35,427 16-Sep-97 clone IMAGE: 987039 5′ similar to gb: M75716 Mus musculus alpha-1 protease inhibitor 2 (MOUSE);, mRNA sequence. rxa02102 1281 GB_IN2: AF135118 10830 AF135118 Drosophila melanogaster laminin alpha1, 2 (wing blister) mRNA, complete cds. Drosophila melanogaster 36,926 23-MAY-1999 GB_IN1: AC002516 48158 AC002516 Drosophila melanogaster (P1 DS01068 (D37)) DNA sequence, complete sequence. Drosophila melanogaster 37,838 28-Aug-97 GB_GSS3: B09866 1194 B09866 T16G20-Sp6 TAMU Arabidopsis thaliana genomic clone T16G20, Arabidopsis thaliana 35,332 14-MAY-1997 genomic survey sequence. rxa02103 519 GB_GSS3: B09866 1194 B09866 T16G20-Sp6 TAMU Arabidopsis thaliana genomic clone T16G20, Arabidopsis thaliana 36,310 14-MAY-1997 genomic survey sequence. GB_EST34: AV165661 290 AV165661 AV165661 Mus musculus head C57BL/6J 13-day embryo Mus musculus cDNA Mus musculus 37,716 6-Jul-99 clone 3110038F04, mRNA sequence. GB_RO: AC002121 84056 AC002121 Genomic sequence from Mouse 11, complete sequence. Mus musculus 39,096 10-Jul-97 rxa02104 1245 GB_BA2: ECOUW67_0 110000 U18997 Escherichia coli K-12 chromosomal region from 67.4 to 76.0 minutes. Escherichia coli 39,024 22-Dec-94 GB_BA2: AE000394 12221 AE000394 Escherichia coli K-12 MG1655 section 284 of 400 of the complete genome. Escherichia coli 39,024 12-Nov-98 GB_BA1: ECORNPBW 4434 D90212 E. coli rnpB gene and ORFs. Escherichia coli 45,255 7-Feb-99 rxa02107 rxa02108 732 GB_BA1: D90912 128598 D90912 Synechocystis sp. PCC6803 complete genome, 14/27, 1719644-1848241. Synechocystis sp. 38,095 7-Feb-99 GB_GSS13: AQ498890 431 AQ498890 HS_5154_A1_E06_SP6E RPCI-11 Human Male BAC Library Homo sapiens 37,150 28-Apr-99 Homo sapiens genomic clone Plate = 730 Col = 11 Row = I, genomic survey sequence. GB_BA1: D90912 128598 D90912 Synechocystis sp. PCC6803 complete genome, 14/27, 1719644-1848241. Synechocystis sp. 38,781 7-Feb-99 rxa02109 1044 GB_IN2: AC001658 91019 AC001658 Drosophila melanogaster DNA sequence (P1 DS00913 (D24)), complete sequence. Drosophila melanogaster 35,687 17-Jul-98 GB_EST19: AA802304 581 AA802304 GM04170.5prime GM Drosophila melanogaster ovary BlueScript Drosophila melanogaster 40,451 25-Nov-98 Drosophila melanogaster cDNA clone GM04170 5prime, mRNA sequence. GB_EST35: AI822653 733 AI822653 L0-1173T3 Ice plant Lambda Uni-Zap XR expression library, 0 hours NaCl treatment Mesembryanthemum 36,957 12-Jul-99 Mesembryanthemum crystallinum cDNA clone L0-1173 5′ similar to Profilin 1 crystallinum (AF092547) [Ricinus communis, mRNA sequence. rxa02114 509 GB_BA1: SMU94899 2379 U94899 Sinorhizobium meliloti dissimilatory nitrous oxide reduction proteins NosY, Sinorhizobium meliloti 42,744 6-Sep-97 NosL and NosX genes, complete cds. GB_BA1: SMU94899 2379 U94899 Sinorhizobium meliloti dissimilatory nitrous oxide reduction proteins NosY, Sinorhizobium meliloti 39,486 6-Sep-97 NosL and NosX genes, complete cds. rxa02117 597 GB_BA2: AF094575 18754 AF094575 Streptococcus pneumoniae serotype 19A DexB (dexB) gene, partial sequence; capsular Streptococcus pneumoniae 40,480 9-Sep-99 polysaccharide biosynthesis operon, complete sequence; and oligopeptide permease AliA (aliA) gene, partial cds. GB_BA2: AF105113 5832 AF105113 Streptococcus pneumoniae type 19A putative oligosaccharide repeat Streptococcus pneumoniae 40,652 9-Sep-99 unit transporter (cps19AJ) gene, partial cds; UDP-N-acetyl glucosamine-2-epimerase (cps19AK), glucose-1-phosphate thymidylyl transferase (cps19AL), dTDP-4-keto-6-deoxyglucose-3,5-epimerase (cps19AM), dTDP- glucose-4,6 dehydratase (cps19AN), and dTDP-L-rhamnose synthase (cps19AO) genes, complete cds; and AliA (aliA) gene, partial cds. GB_EST9: AA073381 429 AA073381 mm93a12.r1 Stratagene mouse heart (#937316) Mus musculus cDNA clone Mus musculus 46,341 15-Feb-97 IMAGE: 535966 5′ similar to gb: X03765 Mouse mRNA for cytoplasmatic beta-actin (MOUSE);, mRNA sequence. rxa02121 828 GB_PR4: AC004874 95983 AC004874 Homo sapiens PAC clone DJ0744D13 from 7q11, complete sequence. Homo sapiens 40,791 21-Nov-98 GB_EST14: AA418305 440 AA418305 zv96g05.s1 Soares_NhHMPu_S1 Homo sapiens cDNA clone IMAGE: Homo sapiens 40,093 16-OCT-1997 767672 3′, mRNA sequence. GB_BA2: U32763 12021 U32763 Haemophilus influenzae Rd section 78 of 163 of the complete genome. Haemophilus influenzae Rd 37,715 29-MAY-1998 rxa02123 1494 GB_BA1: MTCY10D7 39800 Z79700 Mycobacterium tuberculosis H37Rv complete genome; segment 44/162. Mycobacterium 62,083 17-Jun-98 tuberculosis GB_BA1: MTCY10D7 39800 Z79700 Mycobacterium tuberculosis H37Rv complete genome; segment 44/162. Mycobacterium 38,462 17-Jun-98 tuberculosis GB_GSS15: AQ639831 649 AQ639831 927P1-20A2.TV 927P1 Trypanosoma brucei genomic clone Trypanosoma brucei 36,124 8-Jul-99 927P1-20A2, genomic survey sequence. rxa02124 2079 GB_PR2: HS242N11 167514 AL023655 Human DNA sequence from clone 242N11 on chromosome 6p22.3-23. Homo sapiens 33,866 23-Nov-99 Contains ESTs, STSs, GSSs, genomic marker D6S285, and ca and gaaa repeat polymorphisms, complete sequence. GB_PR2: HS242N11 167514 AL023655 Human DNA sequence from clone 242N11 on chromosome 6p22.3-23. Homo sapiens 36,342 23-Nov-99 Contains ESTs, STSs, GSSs, genomic marker D6S285, and ca and gaaa repeat polymorphisms, complete sequence. rxa02125 924 GB_HTG1: CEY116A8_4 110000 Z98858 Caenorhabditis elegans chromosome IV clone Y116A8, Caenorhabditis elegans 36,615 23-Jan-98 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_IN1: CEY116A8B 29344 AL021469 Caenorhabditis elegans cosmid Y116A8B, complete sequence. Caenorhabditis elegans 36,615 23-Nov-98 GB_HTG1: CEY116A8_4 110000 Z98858 Caenorhabditis elegans chromosome IV clone Y116A8, Caenorhabditis elegans 36,615 23-Jan-98 *** SEQUENCING IN PROGRESS ***, in unordered pieces. rxa02129 357 GB_HTG5: AC007809 141122 AC007809 Drosophila melanogaster chromosome 3 clone BACR45M03 (D718) RPCI-98 Drosophila melanogaster 37,255 16-Nov-99 45.M.3 map 88C-88C strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 98 unordered pieces. GB_IN2: CELT02C5 36267 U55374 Caenorhabditis elegans cosmid T02C5. Caenorhabditis elegans 41,834 08-OCT-1999 GB_IN1: CEZC101 26147 Z93395 Caenorhabditis elegans cosmid ZC101, complete sequence. Caenorhabditis elegans 38,873 23-Jul-99 rxa02132 rxa02137 921 GB_EST16: C48630 360 C48630 C48630 Yuji Kohara unpublished cDNA: Strain N2 hermaphrodite Caenorhabditis elegans 39,326 18-OCT-1999 embryo Caenorhabditis elegans cDNA clone yk459c11 5′, mRNA sequence. GB_GSS12: AQ381854 597 AQ381854 RPCI11-137P5.TJ RPCI-11 Homo sapiens genomic clone Homo sapiens 37,879 21-MAY-1999 RPCI-11-137P5, genomic survey sequence. GB_HTG3: AC010253 74835 AC010253 Homo sapiens chromosome 5 clone CIT-HSPC_432B14, Homo sapiens 35,082 15-Sep-99 *** SEQUENCING IN PROGRESS ***, 34 unordered pieces. rxa02138 465 GB_BA1: SC6G10 36734 AL049497 Streptomyces coelicolor cosmid 6G10. Streptomyces coelicolor 40,047 24-MAR-1999 GB_BA1: MSGB1554CS 36548 L78814 Mycobacterium leprae cosmid B1554 DNA sequence. Mycobacterium leprae 60,991 15-Jun-96 GB_BA1: MSGB1551CS 36548 L78813 Mycobacterium leprae cosmid B1551 DNA sequence. Mycobacterium leprae 60,991 15-Jun-96 rxa02141 531 GB_HTG2: AC003118 98940 AC003118 Homo sapiens chromosome 1, Homo sapiens 34,008 24-Nov-97 *** SEQUENCING IN PROGRESS ***, 3 unordered pieces. GB_HTG2: AC003118 98940 AC003118 Homo sapiens chromosome 1, Homo sapiens 34,008 24-Nov-97 *** SEQUENCING IN PROGRESS ***, 3 unordered pieces. GB_PR3: HS395P12 147724 AL022310 Human DNA sequence from clone 395P12 on chromosome 1q24-25. Contains Homo sapiens 34,008 23-Nov-99 the TXGP1 gene for tax-transcriptionally activated glycoprotein 1 (34 kD) (OX40 ligand, OX40L) and a GOT2 (Aspartate Aminotransferase, mitochondrial precursor, EC 2.6.1.1, Transaminase A, Glutamate Oxaloacetate Transaminase-2) pseudogene. Contains ESTs, STSs and GSSs, complete sequence. rxa02146 750 GB_BA1: SC6G10 36734 AL049497 Streptomyces coelicolor cosmid 6G10. Streptomyces coelicolor 36,167 24-MAR-1999 GB_HTG6: AC008224 199774 AC008224 Drosophila melanogaster chromosome 3 clone BACR29J02 (D817) RPCI-98 Drosophila melanogaster 36,437 24-Nov-99 29.J.2 map 83D-83D strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 37 unordered pieces. GB_GSS12: AQ407179 476 AQ407179 HS_5088_A2_G01_T7A RPCI-11 Human Male BAC Library Homo sapiens 37,143 17-MAR-1999 Homo sapiens genomic clone Plate = 664 Col = 2 Row = M, genomic survey sequence. rxa02151 1311 GB_PR3: AC000074 44450 AC000074 Homo sapiens Chromosome 22q11.2 Cosmid Clone 20b in DGCR Homo sapiens 37,798 31-OCT-1998 Region, complete sequence. GB_PR2: HSAC002122 79931 AC002122 Human unknown clone GS293J04 from 5p15.2, complete sequence. Homo sapiens 36,064 27-MAY-1997 GB_PR2: HSAC002122 79931 AC002122 Human unknown clone GS293J04 from 5p15.2, complete sequence. Homo sapiens 35,051 27-MAY-1997 rxa02152 525 GB_PAT: AR009990 2793 AR009990 Sequence 1 from patent U.S. Pat. No. 5756677. Unknown. 44,311 04-DEC-1998 GB_IN1: AF027735 3060 AF027735 Nephila clavipes minor ampullate silk protein MiSp1 mRNA, partial cds. Nephila clavipes 44,311 23-Apr-98 GB_PAT: I95876 2793 I95876 Sequence 1 from patent U.S. Pat. No. 5733771. Unknown. 44,311 01-DEC-1998 rxa02163 876 GB_PR3: HSJ1175I6 96276 AL049538 Human DNA sequence from clone 1175I6 on chromosome 20. Contains Homo sapiens 36,385 23-Nov-99 the gene for Ras inhibitor JC265 (Ras association (RalGDS/AF-6) domain containing protein), ESTs, STSs, GSSs and two putative CpG islands, complete sequence. GB_GSS4: AQ690740 975 AQ690740 nbxb0082N18f CUGI Rice BAC Library Oryza sativa genomic clone nbxb0082N18f, Oryza sativa 39,474 1-Jul-99 genomic survey sequence. GB_PH: SVVWBORF 6051 X72092 Streptomyces venezuelae bacteriophage VWB orfs. Bacteriophage VWB 41,416 24-Aug-95 rxa02164 1698 GB_BA2: AF000579 8931 AF000579 Bordetella bronchiseptica LysR transcriptional activator homolog (bbuR), Bordetella bronchiseptica 38,005 23-Feb-98 urease accessory protein D (ureD), urease structural subunit A (ureA), urease accessory protein J (ureJ), urease structural subunits B (ureB) and C (ureC), urease accessory proteins EF (ureEF) and G (ureG) genes, complete cds. GB_PR3: HS431P23 147971 AL009178 Human DNA sequence from clone 431P23 on chromosome 6q27. Contains the first Homo sapiens 35,604 23-Nov-99 coding exon of the MLLT4 gene for myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); translocated to, 4 (AF-6, Afadin, MLLT-4, ALL-1 fusion partner), and a Serine Palmitoyltransferase 2 (EC 2.3.1.50, Long Chain Base Biosynthesis protein 2, LCB-2, SPT-2) pseudogene. Contains ESTs, STss, GSSs, and a putative CpG island, complete sequence. GB_PR2: AB016897 331211 AB016897 Homo sapiens genomic DNA, chromosome 6q27, complete sequence. Homo sapiens 38,314 20-Nov-99 rxa02165 735 GB_IN2: AF079177 2159 AF079177 Theileria parva strain KNP2 p67 surface antigen (p67) gene, complete cds. Theileria parva 39,207 09-MAR-1999 GB_IN2: AF079176 2285 AF079176 Theileria parva strain Hluhluwe3 p67 surface antigen (p67) gene, complete cds. Theileria parva 39,049 09-MAR-1999 GB_EST27: AI397572 482 AI397572 NCSC5G2T3 Subtracted Conidial Neurospora crassa cDNA clone SC5G2 Neurospora crassa 38,936 8-Feb-99 5′, mRNA sequence. rxa02166 300 GB_BA1: MLCB1351 38936 Z95117 Mycobacterium leprae cosmid B1351. Mycobacterium leprae 37,627 24-Jun-97 GB_BA1: MLCB1351 38936 Z95117 Mycobacterium leprae cosmid B1351. Mycobacterium leprae 40,741 24-Jun-97 rxa02168 2937 GB_BA1: MAFASGEN 10520 X87822 B. ammoniagenes FAS gene. Corynebacterium 61,515 03-OCT-1996 ammoniagenes GB_BA1: MLCL458 43839 AL049478 Mycobacterium leprae cosmid L458. Mycobacterium leprae 50,292 27-Aug-99 GB_PR3: HSL19H1 40145 Z68164 Human DNA sequence from cosmid L19H1, Huntington's Disease Homo sapiens 37,621 23-Nov-99 Region, chromosome 4p16.3, containing multiple EST matches. rxa02169 969 GB_RO: MMA3CA212 4784 X94406 Mus musculus partial b3 gene for alpha3 subunit of L-type Ca2+ channel, exons 2-13. Mus musculus 37,620 24-Nov-99 GB_RO: RATCACH3B 2525 M88751 Rat calcium channel beta subunit-III mRNA, complete cds. Rattus norvegicus 36,345 27-MAY-1994 GB_RO: MMU20372 2469 U20372 Mus musculus voltage-dependent calcium channel beta-3 subunit Mus musculus 36,865 02-MAR-1996 (CCHB3) mRNA, complete cds. rxa02170 897 GB_HTG6: AC005497 212097 AC005497 Homo sapiens chromosome 17 clone RP11-952N18 map 17, Homo sapiens 36,101 20-Nov-99 *** SEQUENCING IN PROGRESS ***, 2 ordered pieces. GB_HTG6: AC005497 212097 AC005497 Homo sapiens chromosome 17 clone RP11-952N18 map 17, Homo sapiens 37,570 20-Nov-99 *** SEQUENCING IN PROGRESS ***, 2 ordered pieces. GB_PR2: AP000104 100000 AP000104 Homo sapiens genomic DNA of 21q22.1, GART and AML related, Homo sapiens 34,871 25-Sep-99 Q78C10-149C3 region, segment 7/20, complete sequence. rxa02172 462 GB_EST24: AI170522 367 AI170522 EST216450 Normalized rat lung, Bento Soares Rattus sp. Rattus sp. 38,904 20-Jan-99 cDNA clone RLUCO75 3′ end, mRNA sequence. GB_GSS13: AQ430048 538 AQ430048 HS_5061_B2_G09_T7A RPCI-11 Human Male BAC Library Homo sapiens 37,143 31-MAR-1999 Homo sapiens genomic clone Plate = 637 Col = 18 Row = N, genomic survey sequence. GB_GSS4: AQ701704 589 AQ701704 HS_2130_A1_E03_MR CIT Approved Human Genomic Sperm Library D Homo sapiens 35,280 7-Jul-99 Homo sapiens genomic clone Plate = 2130 Col = 5 Row = I, genomic survey sequence. rxa02177 1056 GB_HTG4: AC009403 198495 AC009403 Homo sapiens clone DJ1015O24, Homo sapiens 37,154 28-OCT-1999 *** SEQUENCING IN PROGRESS ***, 3 unordered pieces. GB_HTG4: AC009403 198495 AC009403 Homo sapiens clone DJ1015O24, Homo sapiens 37,154 28-OCT-1999 *** SEQUENCING IN PROGRESS ***, 3 unordered pieces. GB_PR2: AP000094 100000 AP000094 Homo sapiens genomic DNA of 21q22.1, GART and AML related, Homo sapiens 38,536 25-Sep-99 B335D16-P10G11 region, segment 4/7, complete sequence. rxa02178 rxa02180 1581 GB_BA1: SC6C5 18160 AL034492 Streptomyces coelicolor cosmid 6C5. Streptomyces coelicolor 53,635 14-DEC-1998 GB_HTG4: AC011121 172050 AC011121 Homo sapiens chromosome 11 clone 364_C_06 map 11, Homo sapiens 37,170 14-OCT-1999 *** SEQUENCING IN PROGRESS ***, 9 ordered pieces. GB_HTG4: AC011121 172050 AC011121 Homo sapiens chromosome 11 clone 364_C_06 map 11, Homo sapiens 37,170 14-OCT-1999 *** SEQUENCING IN PROGRESS ***, 9 ordered pieces. rxa02181 801 GB_PL1: STU76701 3049 U76701 Solanum tuberosum NADH nitrate reductase (StNR2) mRNA, complete cds. Solanum tuberosum 38,846 18-Nov-96 GB_EST36: AI896605 633 AI896605 EST266048 tomato callus, TAMU Lycopersicon esculentum Lycopersicon esculentum 39,671 27-Jul-99 cDNA clone cLEC16C12, mRNA sequence. GB_EST38: AW035744 620 AW035744 EST281898 tomato callus, TAMU Lycopersicon esculentum Lycopersicon esculentum 40,555 15-Sep-99 cDNA clone cLEC36M13, mRNA sequence. rxa02183 rxa02185 702 GB_BA1: MTV043 68848 AL022004 Mycobacterium tuberculosis H37Rv complete genome; segment 40/162. Mycobacterium 38,793 24-Jun-99 tuberculosis GB_BA1: MSGB1935CS 40085 L04666 M. leprae genomic sequence, cosmid b1935. Mycobacterium leprae 38,067 14-Jun-96 GB_BA1: MLCB57 38029 Z99494 Mycobacterium leprae cosmid B57. Mycobacterium leprae 38,067 10-Feb-99 rxa02186 321 GB_BA2: CNSPAX03 307120 AJ248285 Pyrococcus abyssi complete genome; segment 3/6. Pyrococcus abyssi 35,873 9-Sep-99 GB_HTG3: AC010677 116108 AC010677 Homo sapiens clone MS2304L04, Homo sapiens 39,145 04-OCT-1999 *** SEQUENCING IN PROGRESS ***, 4 unordered pieces. GB_HTG3: AC010677 116108 AC010677 Homo sapiens clone MS2304L04, Homo sapiens 39,145 04-OCT-1999 *** SEQUENCING IN PROGRESS ***, 4 unordered pieces. rxa02187 2322 GB_EST33: AI779784 362 AI779784 EST260663 tomato susceptible, Cornell Lycopersicon esculentum Lycopersicon esculentum 41,011 29-Jun-99 cDNA clone cLES9K1, mRNA sequence. GB_EST33: AI779784 362 AI779784 EST260663 tomato susceptible, Cornell Lycopersicon esculentum Lycopersicon esculentum 41,011 29-Jun-99 cDNA clone cLES9K1, mRNA sequence. rxa02199 693 GB_PR3: AC005274 205150 AC005274 Homo sapiens chromosome 17, clone hRPK.1090_M_7, complete sequence. Homo sapiens 36,337 29-Jul-98 GB_HTG2: AC007732 110348 AC007732 Homo sapiens chromosome 17 clone hRPC.1030_A_12 map 17, Homo sapiens 35,924 5-Jun-99 *** SEQUENCING IN PROGRESS ***, 7 unordered pieces. GB_IN1: DMU11052 4871 U11052 Drosophila melanogaster peroxidasin precursor mRNA, complete cds. Drosophila melanogaster 39,873 26-Jan-95 rxa02203 501 GB_EST17: AA642571 323 AA642571 nq73c08.s1 NCI_CGAP_Pr22 Homo sapiens cDNA clone IMAGE: 1157966 Homo sapiens 49,485 27-OCT-1997 3′ similar to TR: G9372 G9372 UBIQUITIN;, mRNA sequence. GB_EST27: AI425489 312 AI425489 my32e11.y1 Barstead mouse pooled organs MPLRB4 Mus musculus cDNA Mus musculus 40,514 09-MAR-1999 clone IMAGE: 697580 5′, mRNA sequence. GB_EST23: AI154481 308 AI154481 ua03h07.r1 Soares 2NbMT Mus musculus cDNA clone IMAGE: Mus musculus 42,748 30-Sep-98 1345693 5′, mRNA sequence. rxa02206 1059 GB_PR2: AP000269 70932 AP000269 Homo sapiens genomic DNA, chromosome 21q22.1, D21S226-AML region, Homo sapiens 39,306 20-Nov-99 clone: T293, complete sequence. GB_PL1: D32140 1360 D32140 Cyanidioschyzon merolae DNA for actin, complete cds. Cyanidioschyzon merolae 37,331 7-Feb-99 GB_PR2: AP000269 70932 AP000269 Homo sapiens genomic DNA, chromosome 21q22.1, Homo sapiens 35,481 20-Nov-99 D21S226-AML region, clone: T293, complete sequence. rxa02207 898 GB_EST21: AA982901 442 AA982901 vx59f07.r1 Stratagene mouse macrophage (#937306) Mus musculus Mus musculus 42,141 27-MAY-1998 cDNA clone IMAGE: 1279525 5′ similar to gb: X59543_rna1RIBONUCLEOSIDE- DIPHOSPHATE REDUCTASE M1 CHAIN (HUMAN); gb: K02927 Mouse ribonucleotide reductase subunit M1 mRNA, complete (MOUSE);, mRNA sequence. GB_EST8: W85369 558 W85369 mf48h04.r1 Soares mouse embryo NbME13.5 14.5 Mus musculus Mus musculus 39,964 12-Sep-96 cDNA clone IMAGE: 408343 5′ similar to gb: K02927 Mouse ribonucleotide reductase subunit M1 mRNA, complete (MOUSE);, mRNA sequence. GB_PAT: E14824 2379 E14824 cDNA encoding M1 subunit of human ribonucleotide reductase. Homo sapiens 36,812 28-Jul-99 rxa02211 rxa02212 621 GB_HTG3: AC009518 241128 AC009518 Homo sapiens chromosome 7, Homo sapiens 36,542 1-Sep-99 *** SEQUENCING IN PROGRESS ***, 68 unordered pieces. GB_HTG3: AC009518 241128 AC009518 Homo sapiens chromosome 7, Homo sapiens 36,542 1-Sep-99 *** SEQUENCING IN PROGRESS ***, 68 unordered pieces. GB_HTG3: AC009518 241128 AC009518 Homo sapiens chromosome 7, Homo sapiens 41,362 1-Sep-99 *** SEQUENCING IN PROGRESS ***, 68 unordered pieces. rxa02216 329 GB_HTG2: AC007641 102402 AC007641 Mus musculus chromosome 10 clone 644_M_8 map 10, Mus musculus 31,307 22-MAY-1999 *** SEQUENCING IN PROGRESS ***, 7 unordered pieces. GB_HTG2: AC007641 102402 AC007641 Mus musculus chromosome 10 clone 644_M_8 map 10, Mus musculus 31,307 22-MAY-1999 *** SEQUENCING IN PROGRESS ***, 7 unordered pieces. GB_HTG2: AC007641 102402 AC007641 Mus musculus chromosome 10 clone 644_M_8 map 10, Mus musculus 32,198 22-MAY-1999 *** SEQUENCING IN PROGRESS ***, 7 unordered pieces. rxa02217 786 GB_RO: RNU91516 1540 U91516 Rattus norvegicus oxytocin receptor (OTR) gene, promoter region. Rattus norvegicus 36,256 25-Nov-97 GB_RO: RNU91516 1540 U91516 Rattus norvegicus oxytocin receptor (OTR) gene, promoter region. Rattus norvegicus 37,176 25-Nov-97 rxa02218 390 GB_HTG3: AC008656 43033 AC008656 Homo sapiens chromosome 5 clone CIT978SKB_194J6, Homo sapiens 39,894 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 64 unordered pieces. GB_HTG3: AC008656 43033 AC008656 Homo sapiens chromosome 5 clone CIT978SKB_194J6, Homo sapiens 39,894 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 64 unordered pieces. GB_HTG3: AC008656 43033 AC008656 Homo sapiens chromosome 5 clone CIT978SKB_194J6, Homo sapiens 37,598 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 64 unordered pieces. rxa02219 1509 GB_PR3: HS475N16 113109 AL035587 Human DNA sequence from clone 475N16 on chromosome Homo sapiens 36,266 23-Nov-99 6p12.3-21.2, complete sequence. GB_PR3: HS475N16 113109 AL035587 Human DNA sequence from clone 475N16 on chromosome Homo sapiens 35,255 23-Nov-99 6p12.3-21.2, complete sequence. GB_EST10: AA142336 411 AA142336 ms07f02.r1 Stratagene mouse skin (#937313) Mus musculus cDNA clone IMAGE: Mus musculus 38,398 12-Feb-97 606267 5′ similar to SW: RCA1_YEAST P40341 MITOCHONDRIAL RESPIRATORY CHAIN COMPLEXES ASSEMBLY PROTEIN RCA1;, mRNA sequence. rxa02221 1485 GB_PR3: AC002422 160091 AC002422 Human Chromosome X, complete sequence. Homo sapiens 38,435 30-Jan-98 GB_HTG2: AC006755 199917 AC006755 Caenorhabditis elegans clone Y40C5, Caenorhabditis elegans 39,229 23-Feb-99 *** SEQUENCING IN PROGRESS ***, 1 unordered pieces. GB_HTG2: AC006755 199917 AC006755 Caenorhabditis elegans clone Y40C5, Caenorhabditis elegans 39,229 23-Feb-99 *** SEQUENCING IN PROGRESS ***, 1 unordered pieces. rxa02223 601 GB_HTG6: AC008224 199774 AC008224 Drosophila melanogaster chromosome 3 clone BACR29J02 Drosophila melanogaster 35,333 24-Nov-99 (D817) RPCI-98 29.J.2 map 83D-83D strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 37 unordered pieces. GB_HTG3: AC011511 158296 AC011511 Homo sapiens chromosome 19 clone CITB-H1_2369P2, *** SEQUENCING Homo sapiens 35,593 07-OCT-1999 IN PROGRESS ***, 57 unordered pieces. GB_HTG3: AC011511 158296 AC011511 Homo sapiens chromosome 19 clone CITB-H1_2369P2, *** SEQUENCING Homo sapiens 35,593 07-OCT-1999 IN PROGRESS ***, 57 unordered pieces. rxa02226 1156 GB_HTG2: AC006890 298195 AC006890 Caenorhabditis elegans clone Y67D8x, *** SEQUENCING IN Caenorhabditis elegans 36,810 24-Feb-99 PROGRESS ***, 23 unordered pieces. GB_HTG2: AC006890 298195 AC006890 Caenorhabditis elegans clone Y67D8x, *** SEQUENCING Caenorhabditis elegans 35,433 24-Feb-99 IN PROGRESS ***, 23 unordered pieces. GB_HTG2: AC006890 298195 AC006890 Caenorhabditis elegans clone Y67D8x, *** SEQUENCING Caenorhabditis elegans 36,810 24-Feb-99 IN PROGRESS ***, 23 unordered pieces. rxa02227 741 GB_EST5: H98835 440 H98835 yx14f12.s1 Soares melanocyte 2NbHM Homo sapiens cDNA Homo sapiens 38,182 15-DEC-1995 clone IMAGE: 261743 3′, mRNA sequence. GB_EST5: N25530 586 N25530 yx76c03.s1 Soares melanocyte 2NbHM Homo sapiens cDNA Homo sapiens 37,543 29-DEC-1995 clone IMAGE: 267652 3′, mRNA sequence. GB_BA1: CGU43535 2531 U43535 Corynebacterium glutamicum multidrug resistance protein (cmr) gene, complete cds. Corynebacterium 38,812 9-Apr-97 glutamicum rxa02230 660 GB_EST16: AA570388 527 AA570388 nk62c08.s1 NCI_CGAP_Sch1 Homo sapiens cDNA clone Homo sapiens 41,096 9-Sep-97 IMAGE: 1018094 3′ similar to contains element MSR1 repetitive element;, mRNA sequence. GB_PR2: HSU43030 1539 U43030 Human cardiotrophin-1 (CTF1) mRNA, complete cds. Homo sapiens 36,335 9-Jan-96 GB_IN1: CELK08B5 35728 U41022 Caenorhabditis elegans cosmid K08B5. Caenorhabditis elegans 35,387 30-Nov-95 rxa02231 879 GB_PL2: ATAC006429 94818 AC006429 Arabidopsis thaliana chromosome II Arabidopsis thaliana 33,687 23-Apr-99 BAC F15K19 genomic sequence, complete sequence. GB_PR3: AC004554 195142 AC004554 Homo sapiens Xp22 BAC GSHB-590J6 (Genome Systems Homo sapiens 38,921 30-MAY-1998 Human BAC library) complete sequence. GB_HTG2: AC007853 116280 AC007853 Drosophila melanogaster chromosome 3 clone BACR03L02 Drosophila melanogaster 36,237 2-Aug-99 (D766) RPCI-98 03.L.2 map 96B-96C strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 80 unordered pieces. rxa02238 408 GB_BA1: MTCY21B4 39150 Z80108 Mycobacterium tuberculosis Mycobacterium 52,206 23-Jun-98 H37Rv complete genome; segment 62/162. tuberculosis GB_BA1: MTCY21B4 39150 Z80108 Mycobacterium tuberculosis H37Rv complete genome; segment 62/162. Mycobacterium 36,935 23-Jun-98 tuberculosis GB_VI: AF105451 801 AF105451 HIV-1 isolate A-DII-07 from Italy, envelope glycoprotein, C2-V5 Human immunodeficiency 40,864 25-Apr-99 region (env) gene, partial cds. virus type 1 rxa02244 1656 GB_PR1: AB016195 10558 AB016195 Homo sapiens ELK1 pseudogene (ELK2) and Homo sapiens 38,929 9-Apr-99 immunoglobulin heavy chain gamma pseudogene (IGHGP). GB_PR3: HSN21F1 39212 Z94162 Human DNA sequence from cosmid N21F1 on chromosome Homo sapiens 38,763 23-Nov-99 22 Contains exon trap and STS, complete sequence. GB_IN1: DMAC001648 51989 AC001648 Drosophila melanogaster (P1 DS03431 (D102)) Drosophila melanogaster 36,884 22-Apr-97 DNA sequence, complete sequence. rxa02254 800 GB_GSS12: AQ360240 541 AQ360240 HS_5035_A2_E07_T7 RPCI11 Human Male BAC Library Homo sapiens 36,386 06-MAR-1999 Homo sapiens genomic clone Plate = 611 Col = 14 Row = I, genomic survey sequence. GB_GSS11: AQ258453 620 AQ258453 nbxb0020L15f CUGI Rice BAC Library Oryza sativa genomic Oryza sativa 36,271 23-OCT-1998 clone nbxb0020L15f, genomic survey sequence. GB_GSS14: AQ577777 568 AQ577777 nbxb0091L17f CUGI Rice BAC Library Oryza sativa genomic Oryza sativa 39,456 2-Jun-99 clone nbxb0091L17f, genomic survey sequence. rxa02255 1059 GB_PR4: AC006332 153477 AC006332 Homo sapiens clone NH0376O14, complete sequence. Homo sapiens 35,019 11-Nov-99 GB_PAT: E02669 1197 E02669 DNA encoding Bacillus sp. L-lactic acid dehydrogenase. Bacillus sp. 39,719 29-Sep-97 GB_PL1: YSCBOI2 3201 D38310 Yeast BOI2 gene for Boi2p. Saccharomyces cerevisiae 35,769 8-Feb-99 rxa02266 636 GB_BA1: REGIONB 4961 Z13995 N. meningitidis lipA and lipB genes for LipA and LipB proteins. Neisseria meningitidis 35,691 29-DEC-1993 GB_HTG1: AP000568 136627 AP000568 Homo sapiens chromosome 21 clone B753B2 map 21q21.2, Homo sapiens 37,500 07-OCT-1999 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG1: AP000568 136627 AP000568 Homo sapiens chromosome 21 clone B753B2 map 21q21.2, Homo sapiens 37,500 07-OCT-1999 *** SEQUENCING IN PROGRESS ***, in unordered pieces. rxa02267 996 GB_PR4: AC007283 127361 AC007283 Homo sapiens clone NH0536I18, complete sequence. Homo sapiens 37,155 28-Sep-99 GB_IN1: CEC54C6 35500 Z77131 Caenorhabditis elegans cosmid C54C6, complete sequence. Caenorhabditis elegans 38,280 23-Nov-98 GB_HTG3: AC008905 129915 AC008905 Homo sapiens chromosome 5 clone CITB-H1_2259I14, Homo sapiens 35,895 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 40 unordered pieces. rxa02271 681 GB_HTG3: AC007441 219832 AC007441 Drosophila melanogaster chromosome 3 clone BACR10E03 Drosophila melanogaster 33,284 08-OCT-1999 (D690) RPCI-98 10.E.3 map 88A-88B strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 188 unordered pieces. GB_HTG3: AC007441 219832 AC007441 Drosophila melanogaster chromosome 3 clone BACR10E03 Drosophila melanogaster 33,284 08-OCT-1999 (D690) RPCI-98 10.E.3 map 88A-88B strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 188 unordered pieces. GB_HTG2: AC008029 123186 AC008029 Drosophila melanogaster chromosome 3 clone BACR01C11 (D819) Drosophila melanogaster 34,315 2-Aug-99 RPCI-98 01.C.11 map 84D-84D strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 92 unordered pieces. rxa02279 1581 GB_IN1: AC003121 69822 AC003121 Drosophila melanogaster (P1 DS00329 (D89)) DNA sequence, complete sequence. Drosophila melanogaster 38,046 26-Nov-97 GB_IN1: AC003121 69822 AC003121 Drosophila melanogaster (P1 DS00329 (D89)) DNA sequence, complete sequence. Drosophila melanogaster 39,220 26-Nov-97 GB_BA1: MTCY39 38500 Z74025 Mycobacterium tuberculosis H37Rv complete genome; segment 89/162. Mycobacterium 39,685 17-Jun-98 tuberculosis rxa02280 rxa02286 672 GB_BA1: MTV025 121125 AL022121 Mycobacterium tuberculosis H37Rv complete genome; segment 155/162. Mycobacterium 36,953 24-Jun-99 tuberculosis GB_PL2: AC002130 114738 AC002130 The sequence of BAC F1N21 from Arabidopsis thaliana Arabidopsis thaliana 39,216 8-Jan-98 chromosome 1, complete sequence. GB_PL2: AC007259 97146 AC007259 Arabidopsis thaliana chromosome I BAC T28P6 genomic Arabidopsis thaliana 36,090 17-Aug-99 sequence, complete sequence. rxa02287 675 GB_HTG3: AC009281 221178 AC009281 Homo sapiens chromosome 15 clone 8_C_22 map 15, Homo sapiens 35,565 12-Aug-99 *** SEQUENCING IN PROGRESS ***, 49 unordered pieces. GB_HTG3: AC009281 221178 AC009281 Homo sapiens chromosome 15 clone 8_C_22 map 15, Homo sapiens 35,565 12-Aug-99 *** SEQUENCING IN PROGRESS ***, 49 unordered pieces. GB_RO: MUSMURINC 4597 M65736 Mouse murinoglobulin mRNA, complete cds. Mus musculus 38,485 27-Apr-93 rxa02294 498 GB_EST19: AA813194 398 AA813194 ai80g12.s1 Soares_testis_NHT Homo sapiens cDNA Homo sapiens 36,797 31-DEC-1998 clone 1377190 3′, mRNA sequence. GB_EST19: AA813194 398 AA813194 ai80g12.s1 Soares_testis_NHT Homo sapiens cDNA Homo sapiens 33,417 31-DEC-1998 clone 1377190 3′, mRNA sequence. rxa02295 903 GB_PAT: I89451 18318 I89451 Sequence 6 from patent U.S. Pat. No. 5721354. Unknown. 38,839 10-Aug-98 GB_VI: HCU33331 18535 U33331 Human cytomegalovirus Toledo strain UL/b' region. human herpesvirus 5 38,839 27-Jan-96 GB_PR3: HS550H1 108803 AL035420 Human DNA sequence from clone 550H1 on chromosome Homo sapiens 38,796 23-Nov-99 20q11.1-11.22 Contains a pseudogene similar to HIGH MOBILITY GROUP PROTEIN 2A, a novel mRNA, ESTs, STSs, GSSs and CpG Islands, complete sequence. rxa02296 612 GB_BA2: AF065312 1694 AF065312 Yersinia pestis hypothetical protein (yceG) gene, partial cds; Yersinia pestis 41,351 16-Nov-99 thymidylate kinase (tmk) gene, complete cds; and putative DNA polymerase III delta' subunit (holB) gene, partial cds. GB_PR3: HS550H1 108803 AL035420 Human DNA sequence from clone 550H1 on chromosome Homo sapiens 37,919 23-Nov-99 20q11.1-11.22 Contains a pseudogene similar to HIGH MOBILITY GROUP PROTEIN 2A, a novel mRNA, ESTs, STSs, GSSs and CpG Islands, complete sequence. GB_PR3: HS550H1 108803 AL035420 Human DNA sequence from clone 550H1 on chromosome Homo sapiens 37,607 23-Nov-99 20q11.1-11.22 Contains a pseudogene similar to HIGH MOBILITY GROUP PROTEIN 2A, a novel mRNA, ESTs, STSs, GSSs and CpG Islands, complete sequence. rxa02297 1260 GB_BA2: AF065312 1694 AF065312 Yersinia pestis hypothetical protein (yceG) gene, Yersinia pestis 39,683 16-Nov-99 partial cds; thymidylate kinase (tmk) gene, complete cds; and putative DNA polymerase III delta' subunit (holB) gene, partial cds. GB_RO: AF007836 5655 AF007836 Rattus norvegicus rab3 effector (RIM) mRNA, alternatively spliced, complete cds. Rattus norvegicus 37,844 15-Aug-97 GB_IN2: EGU27015 2394 U27015 Echinococcus granulosus 18S ribosomal RNA gene, complete sequence. Echinococcus granulosus 38,710 16-Jul-96 rxa02298 1782 GB_BA2: AF116184 540 AF116184 Corynebacterium glutamicum L-aspartate-alpha-decarboxylase Corynebacterium 44,231 02-MAY-1999 precursor (panD) gene, complete cds. glutamicum GB_BA2: AF116184 540 AF116184 Corynebacterium glutamicum L-aspartate-alpha-decarboxylase precursor Corynebacterium 42,007 02-MAY-1999 (panD) gene, complete cds. glutamicum rxa02300 456 GB_BA2: AF116184 540 AF116184 Corynebacterium glutamicum L-aspartate-alpha-decarboxylase Corynebacterium 46,250 02-MAY-1999 precursor (panD) gene, complete cds. glutamicum GB_BA1: MTV004 69350 AL009198 Mycobacterium tuberculosis H37Rv complete genome; segment 144/162. Mycobacterium 39,602 18-Jun-98 tuberculosis GB_EST22: AI048692 172 AI048692 ub30g04.r1 Soares 2NbMT Mus musculus cDNA clone IMAGE: Mus musculus 43,284 8-Jul-98 1379286 5′, mRNA sequence. rxa02301 840 GB_HTG3: AC008573 205755 AC008573 Homo sapiens chromosome 5 clone CIT-HSPC_551I11, Homo sapiens 35,115 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 95 unordered pieces. GB_HTG3: AC008573 205755 AC008573 Homo sapiens chromosome 5 clone CIT-HSPC_551I11, Homo sapiens 35,115 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 95 unordered pieces. GB_HTG3: AC008573 205755 AC008573 Homo sapiens chromosome 5 clone CIT-HSPC_551I11, Homo sapiens 36,527 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 95 unordered pieces. rxa02302 1002 GB_HTG6: AC008076 200000 AC008076 Homo sapiens chromosome 4, *** SEQUENCING Homo sapiens 34,884 02-DEC-1999 IN PROGRESS ***, 18 unordered pieces. GB_HTG3: AC008930 258026 AC008930 Homo sapiens chromosome 5 clone CITB-H1_2292M9, *** SEQUENCING Homo sapiens 36,945 3-Aug-99 IN PROGRESS ***, 166 unordered pieces. GB_HTG3: AC008930 258026 AC008930 Homo sapiens chromosome 5 clone CITB-H1_2292M9, Homo sapiens 36,945 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 166 unordered pieces. rxa02303 rxa02304 1014 GB_PAT: A69720 53789 A69720 Sequence 3 from Patent WO9807868. unidentified 36,915 07-MAY-1999 GB_BA1: AMM223012 53784 AJ223012 Amycolatopsis mediterranei genes encoding rifamycin Amycolatopsis 36,915 9-Feb-98 polyketide synthases, ORFs 1 to 5. mediterranei GB_BA2: AF040570 76199 AF040570 Amycolatopsis mediterranei rifamycin biosynthetic gene cluster. Amycolatopsis 36,915 5-Feb-98 mediterranei rxa02307 rxa02308 552 GB_HTG3: AC009340 110415 AC009340 Drosophila melanogaster chromosome 2 clone BACR04E19 (D1026) Drosophila melanogaster 36,066 27-Aug-99 RPCI-98 04.E.19 map 34A-34E strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 103 unordered pieces. GB_HTG3: AC009340 110415 AC009340 Drosophila melanogaster chromosome 2 clone BACR04E19 (D1026) Drosophila melanogaster 36,066 27-Aug-99 RPCI-98 04.E.19 map 34A-34E strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 103 unordered pieces. GB_IN2: AC005656 48443 AC005656 Drosophila melanogaster, chromosome 2R, region 34B6-34C2, Drosophila melanogaster 46,154 6-Feb-99 P1 clone DS08787, complete sequence. rxa02314 564 GB_HTG5: AC011247 206436 AC011247 Homo sapiens clone NH0541E12, WORKING DRAFT Homo sapiens 36,201 13-Nov-99 SEQUENCE, 1 unordered pieces. GB_HTG5: AC011247 206436 AC011247 Homo sapiens clone NH0541E12, WORKING Homo sapiens 35,036 13-Nov-99 DRAFT SEQUENCE, 1 unordered pieces. GB_HTG3: AC011152 142616 AC011152 Homo sapiens clone 7_H_4, Homo sapiens 35,548 01-OCT-1999 LOW-PASS SEQUENCE SAMPLING. rxa02324 1209 GB_BA2: AF110185 20302 AF110185 Burkholderia pseudomallei strain 1026b DbhB (dbhB), general Burkholderia pseudomallei 39,670 2-Aug-99 secretory pathway protein D (gspD), general secretory pathway protein E (gspE), general secretory pathway protein F (gspF), GspC (gspC), general secretory pathway protein G (gspG), general secretory pathway protein H (gspH), general secretory pathway protein I (gspI), general secretory pathway protein J (gspJ), general secretory pathway protein K (gspK), general secretory pathway protein L (gspL), general secretory pathway protein M (gspM), and general secretory pathway protein N (gspN) genes, complete cds; and unknown genes. GB_BA1: PSEAMNH 5215 D90216 P. chlororaphis genes for amidase (EC 3.5.1.4) and for nitrile hydratase (EC 4.2.1.84). Pseudomonas chlororaphis 51,254 7-Feb-99 GB_PAT: E12519 4775 E12519 Nucleotide sequence of Rhodococcus rhodochrous genomic DNA Rhodococcus rhodochrous 51,646 24-Jun-98 region containing amidase and nitrilehydratase genes. rxa02325 990 GB_BA1: CGPYC 3728 Y09548 Corynebacterium glutamicum pyc gene. Corynebacterium 100,000 08-MAY-1998 glutamicum GB_PR4: AC006079 178109 AC006079 Homo sapiens chromosome 17, clone hRPK.855_D_21, complete sequence. Homo sapiens 37,807 12-DEC-1998 GB_GSS8: AQ036832 441 AQ036832 CIT-HSP-2334L1.TF CIT-HSP Homo sapiens genomic Homo sapiens 42,359 11-Jul-98 clone 2334L1, genomic survey sequence. rxa02331 489 GB_PL1: YSKGA11 4159 M68870 Kluyveromyces lactis transcriptional activator (GAL11) gene, complete cds. Kluyveromyces lactis 40,252 14-MAY-1993 GB_PR2: HSAY18950 584 Y18950 Homo sapiens partial gene for caspase-9, intronic sequence (584 bp). Homo sapiens 40,529 08-OCT-1999 GB_PL1: YSKGA11 4159 M68870 Kluyveromyces lactis transcriptional activator (GAL11) gene, complete cds. Kluyveromyces lactis 38,679 14-MAY-1993 rxa02336 303 GB_BA1: CGU35023 3195 U35023 Corynebacterium glutamicum thiosulfate sulfurtransferase Corynebacterium 35,548 16-Jan-97 (thtR) gene, partial cds, acyl CoA carboxylase glutamicum (accBC) gene, complete cds. GB_PL2: AF114171 183990 AF114171 Sorghum bicolor BAC clone 25.M18, complete sequence. Sorghum bicolor 41,414 25-Apr-99 GB_PR4: AC006324 157310 AC006324 Homo sapiens clone DJ1164F05, complete sequence. Homo sapiens 41,786 11-Nov-99 rxa02337 1446 GB_BA1: CGU35023 3195 U35023 Corynebacterium glutamicum thiosulfate sulfurtransferase (thtR) Corynebacterium 100,000 16-Jan-97 gene, partial cds, acyl CoA carboxylase (accBC) gene, complete cds. glutamicum GB_BA1: MTCY22G8 22550 Z95585 Mycobacterium tuberculosis H37Rv complete genome; segment 49/162. Mycobacterium 38,072 17-Jun-98 tuberculosis GB_PR2: HSAY18950 584 Y18950 Homo sapiens partial gene for caspase-9, intronic sequence (584 bp). Homo sapiens 42,949 08-OCT-1999 rxa02339 515 GB_PR2: HS149A16 173354 AL021937 Human DNA sequence from clone 149A16 on chromosome Homo sapiens 37,376 23-Nov-99 22q12-13. Contains an IGLC (Immunoglobulin Lambda Chain C) pseudogene, the RFPL3 and RFPL3S genes for Ret finger protein-like 3 and Ret finger protein-like 3 antisense respectively, a gene for a novel Immunoblobulin Lambda Chain V family protein, a novel gene for a protein similar to mouse RGDS (RALGDS, RALGEF, Guanine Nucleotide Dissociation Stimulator A) and rabbit oncogene RSC, a novel gene for the human ortholog of worm F16A11.2 and bacterial and archea-bacterial predicted proteins, a novel gene for a protein similar to BPI (Bacterial Permeability-Increasing Protein) and rabbit LBP (Liposaccharide-Binding Protein), and a the 5′ part of a novel gene. Contains ESTs, STSs, GSSs, genomic marker D22S1175, a ca repeat polymorphism and putative CpG islands, complete sequence. GB_HTG3: AC009726 177618 AC009726 Homo sapiens chromosome 18 clone 263_O_14 map 18, Homo sapiens 37,037 29-Aug-99 *** SEQUENCING IN PROGRESS ***, 12 unordered pieces. GB_HTG3: AC009726 177618 AC009726 Homo sapiens chromosome 18 clone 263_O_14 map 18, Homo sapiens 37,037 29-Aug-99 *** SEQUENCING IN PROGRESS ***, 12 unordered pieces. rxa02340 1188 GB_VI: AF063866 236120 AF063866 Melanoplus sanguinipes entomopoxvirus, complete genome. Melanoplus sanguinipes 34,480 22-DEC-1998 entomopoxvirus GB_HTG4: AC011089 171283 AC011089 Homo sapiens chromosome 2 clone 303_K_20 map 2, Homo sapiens 37,757 14-OCT-1999 *** SEQUENCING IN PROGRESS ***, 25 ordered pieces. GB_HTG4: AC011089 171283 AC011089 Homo sapiens chromosome 2 clone 303_K_20 map 2, Homo sapiens 37,757 14-OCT-1999 *** SEQUENCING IN PROGRESS ***, 25 ordered pieces. rxa02341 609 GB_GSS14: AQ580594 303 AQ580594 RPCI-11-452K5.TJ RPCI-11 Homo sapiens genomic Homo sapiens 38,305 7-Jun-99 clone RPCI-11-452K5, genomic survey sequence. GB_GSS12: AQ393454 561 AQ393454 CITBI-E1-2556E3.TR CITBI-E1 Homo sapiens genomic clone Homo sapiens 37,882 06-MAR-1999 2556E3, genomic survey sequence. GB_GSS14: AQ507468 627 AQ507468 RPCI-11-298O19.TJ RPCI-11 Homo sapiens genomic clone Homo sapiens 38,480 29-Apr-99 RPCI-11-298O19, genomic survey sequence. rxa02347 444 GB_PR3: AC005549 147416 AC005549 Homo sapiens chromosome 17, clone hRPK.215_E_13, complete sequence. Homo sapiens 39,909 22-Sep-98 GB_PR3: AC005549 147416 AC005549 Homo sapiens chromosome 17, clone hRPK.215_E_13, complete sequence. Homo sapiens 33,784 22-Sep-98 GB_GSS8: B92789 742 B92789 CIT-HSP-2164J8.TR CIT-HSP Homo sapiens genomic clone Homo sapiens 39,409 25-Jun-98 2164J8, genomic survey sequence. rxa02349 rxa02352 578 GB_EST19: AA738949 396 AA738949 vv68d12.r1 Stratagene mouse skin (#937313) Mus musculus Mus musculus 36,023 14-Jan-98 cDNA clone IMAGE: 1227575 5′, mRNA sequence. GB_GSS14: AQ526017 500 AQ526017 HS_5329_A2_F02_T7A RPCI-11 Human Male BAC Homo sapiens 38,537 11-MAY-1999 Library Homo sapiens genomic clone Plate = 905 Col = 4 Row = K, genomic survey sequence. GB_PR3: U82695 167460 U82695 Homo sapiens cosmid LM1937 from Xq28. Homo sapiens 38,421 3-Jan-98 rxa02356 1119 GB_BA1: MTCY16B7 43430 Z81331 Mycobacterium tuberculosis H37Rv complete genome; segment 123/162. Mycobacterium 39,087 17-Jun-98 tuberculosis GB_BA1: SRMSIK 2384 Y08921 S. reticuli gene encoding Msik protein and orf1. Streptomyces reticuli 58,356 21-MAR-1997 GB_BA1: MSGY414A 40121 AD000007 Mycobacterium tuberculosis sequence from clone y414a. Mycobacterium 58,423 03-DEC-1996 tuberculosis rxa02358 414 GB_BA1: BSUB0021 215534 Z99124 Bacillus subtilis complete genome (section 21 of 21): from 3999281 to 4214814. Bacillus subtilis 36,829 26-Nov-97 GB_PR3: HSDA22P16 103367 AL049641 Human DNA sequence *** SEQUENCING IN PROGRESS *** Homo sapiens 36,430 23-Nov-99 from clone DA22P16, complete sequence. GB_BA1: BSUB0021 215534 Z99124 Bacillus subtilis complete genome (section 21 of 21): from 3999281 to 4214814. Bacillus subtilis 37,440 26-Nov-97 rxa02360 2556 GB_EST21: AA970555 420 AA970555 oo94h05.s1 NCI_CGAP_Kid5 Homo sapiens cDNA clone IMAGE: Homo sapiens 36,905 20-MAY-1998 1573881 3′ similar to gb: X61970 PROTEASOME ZETA CHAIN (HUMAN);, mRNA sequence. GB_GSS4: AQ739589 909 AQ739589 HS_5381_B2_G06_T7A RPCI-11 Human Male BAC Library Homo sapiens 44,912 16-Jul-99 Homo sapiens genomic clone Plate = 957 Col = 12 Row = N, genomic survey sequence. GB_IN1: CEY53H1C 37004 AL117201 Caenorhabditis elegans cosmid Y53H1C, complete sequence. Caenorhabditis elegans 38,436 19-Nov-99 rxa02361 774 GB_IN2: CELK04F10 35413 AF039719 Caenorhabditis elegans cosmid K04F10. Caenorhabditis elegans 36,891 26-MAY-1999 GB_PL1: AB011477 78181 AB011477 Arabidopsis thaliana genomic DNA, chromosome 5, P1 Arabidopsis thaliana 37,095 20-Nov-99 clone: MHK7, complete sequence. GB_PL1: AB011477 78181 AB011477 Arabidopsis thaliana genomic DNA, chromosome 5, P1 clone: Arabidopsis thaliana 36,794 20-Nov-99 MHK7, complete sequence. rxa02362 3822 GB_EST10: AA178985 357 AA178985 zp12g08.s1 Stratagene fetal retina 937202 Homo sapiens cDNA clone Homo sapiens 39,875 31-DEC-1996 IMAGE: 609278 3′, mRNA sequence. GB_GSS4: AQ710468 555 AQ710468 HS_5336_A2_B09_T7A RPCI-11 Human Male BAC Library Homo sapiens 39,820 13-Jul-99 Homo sapiens genomic clone Plate = 912 Col = 18 Row = C, genomic survey sequence. GB_EST37: AI986900 380 AI986900 rs19a09.y1 Sommer Pristionchus Pristionchus pacificus cDNA clone Pristionchus pacificus 42,105 1-Sep-99 IMAGE: 5′ similar to WP: C06A1.1 CE02114 TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE HOMOLOG 1;, mRNA sequence. rxa02367 732 GB_BA2: SCF76 18292 AL121600 Streptomyces coelicolor cosmid F76. Streptomyces coelicolor 40,195 29-Sep-99 A3(2) GB_SY: SCU53587 4546 U53587 Artificial Corynebacterium glutamicum IS1207-derived transposon synthetic construct 36,755 06-MAY-1996 transposase genes, complete cds, and 3′5″-aminoglycoside phosphotransferase (aphA-3) gene, complete cds. GB_PAT: E16763 2517 E16763 gDNA encoding Corynebacterium 38,687 28-Jul-99 aspartate transferase (AAT). glutamicum rxa02368 rxa02374 744 GB_PL2: AC010924 80442 AC010924 Arabidopsis thaliana chromosome 1 BAC T24D18 sequence, complete sequence. Arabidopsis thaliana 39,261 6-Nov-99 GB_VI: HE1CG 152261 X14112 Herpes simplex virus (HSV) type 1 complete genome. human herpesvirus 1 39,856 17-Apr-97 GB_VI: HS1ULR 108360 D10879 Herpes simplex virus type 1 long unique region UL. human herpesvirus 1 39,856 3-Feb-99 rxa02381 1146 GB_BA1: CGPROAGEN 1783 X82929 C. glutamicum proA gene. Corynebacterium 98,974 23-Jan-97 glutamicum GB_BA1: CGPROAGEN 1783 X82929 C. glutamicum proA gene. Corynebacterium 37,156 23-Jan-97 glutamicum GB_GSS10: AQ215523 445 AQ215523 HS_2259_B2_F03_MR CIT Approved Human Genomic Sperm Library Homo sapiens 40,674 19-Sep-98 D Homo sapiens genomic clone Plate = 2259 Col = 6 Row = L, genomic survey sequence. rxa02383 736 GB_EST35: AI810729 450 AI810729 tt86h09.x1 NCI_CGAP_Pr28 Homo sapiens cDNA clone IMAGE: Homo sapiens 41,568 7-Jul-99 2248481 3′, mRNA sequence. GB_EST22: AI048725 347 AI048725 ub31d01.r1 Soares 2NbMT Mus musculus cDNA clone IMAGE: Mus musculus 39,412 8-Jul-98 1379329 5′, mRNA sequence. GB_EST15: AA466288 431 AA466288 vh34c01.r1 Barstead mouse pooled organs MPLRB4 Mus musculus cDNA Mus musculus 39,336 11-Jun-97 clone IMAGE: 888864 5′, mRNA sequence. rxa02387 885 GB_PR3: AC004687 175120 AC004687 Homo sapiens chromosome 17, clone hRPC.1171_I_10, complete sequence. Homo sapiens 34,518 26-Jun-98 GB_PR3: AC004687 175120 AC004687 Homo sapiens chromosome 17, clone hRPC.1171_I_10, complete sequence. Homo sapiens 38,551 26-Jun-98 GB_GSS15: AQ604975 536 AQ604975 HS_2135_B2_G04_T7C CIT Approved Human Genomic Sperm Library Homo sapiens 39,321 10-Jun-99 D Homo sapiens genomic clone Plate = 2135 Col = 8 Row = N, genomic survey sequence. rxa02390 792 GB_BA2: SC51A 42527 AL121596 Streptomyces coelicolor cosmid 51A. Streptomyces coelicolor 38,804 28-Sep-99 A3(2) GB_BA2: AF073776 5138 AF073776 Pseudomonas aeruginosa MexZ (mexZ), complete cds; and mexGH Pseudomonas aeruginosa 37,245 19-OCT-1998 operon, complete sequence. GB_BA1: AB015853 5461 AB015853 Pseudomonas aeruginosa gene for Pseudomonas aeruginosa 40,641 13-Nov-98 MexX and MexY, complete cds. rxa02393 405 GB_BA1: RCU57682 86896 U57682 Rhodobacter capsulatus cosmids 143-147, complete sequence. Rhodobacter capsulatus 44,246 7-Feb-97 GB_PL2: T2K10 88037 AC005966 Arabidopsis thaliana chromosome 1 BAC T2K10 sequence, complete sequence. Arabidopsis thaliana 42,455 10-Feb-99 GB_PL2: T24H24 88848 AF075598 Arabidopsis thaliana BAC T24H24. Arabidopsis thaliana 34,826 3-Aug-98 rxa02395 2013 GB_BA1: SC5F2A 40105 AL049587 Streptomyces coelicolor cosmid 5F2A. Streptomyces coelicolor 51,688 24-MAY-1999 GB_BA1: CGBETPGEN 2339 X93514 C. glutamicum betP gene. Corynebacterium 48,877 8-Sep-97 glutamicum GB_PL2: AF015436 682 AF015436 Liquidambar formosana internal transcribed spacer 1, 5.8S ribosomal Liquidambar formosana 36,217 1-Feb-99 RNA gene; and internal transcribed spacer 2, complete sequence. rxa02396 402 GB_BA2: AE000070 9973 AE000070 Rhizobium sp. NGR234 plasmid pNGR234a, section 7 of 46 of the Rhizobium sp. NGR234 35,572 12-DEC-1997 complete plasmid sequence. GB_BA2: AE000070 9973 AE000070 Rhizobium sp. NGR234 plasmid pNGR234a, section 7 of 46 of the Rhizobium sp. NGR234 37,436 12-DEC-1997 complete plasmid sequence. GB_BA1: CVAJ677 1087 AJ000677 Chromatium vinosum recA gene. Allochromatium vinosum 37,500 8-Aug-97 rxa02398 1725 GB_PR1: HUMJUNA 3622 J04111 Human c-jun proto oncogene (JUN), complete cds, clone hCJ-1. Homo sapiens 37,806 6-Jan-95 GB_EST35: AL041724 462 AL041724 DKFZp434O0317_r1 434 (synonym: htes3) Homo sapiens cDNA Homo sapiens 40,260 29-Sep-99 clone DKFZp434O0317 5′, mRNA sequence. GB_PAT: I96176 3622 I96176 Sequence Unknown. 37,806 01-DEC-1998 13 from patent U.S. Pat. No. 5734039. rxa02403 888 GB_BA1: CGACEB 3024 X78491 C. glutamicum (ATCC 13032) aceB gene. Corynebacterium 47,410 13-Jan-95 glutamicum GB_BA1: CORACEB 2725 L27123 Corynebacterium glutamicum malate synthase (aceB) gene, complete cds. Corynebacterium 43,981 8-Jun-95 glutamicum GB_IN1: CEK06A4 34006 Z70755 Caenorhabditis elegans cosmid K06A4, complete sequence. Caenorhabditis elegans 37,875 23-Nov-98 rxa02406 672 GB_EST22: AI062160 629 AI062160 GH01261.5prime GH Drosophila melanogaster head pOT2 Drosophila melanogaster 37,687 24-Nov-98 Drosophila melanogaster cDNA clone GH01261 5prime, mRNA sequence. GB_PR1: HSRPIILS 6732 X63564 H. sapiens mRNA for RNA polymerase II largest subunit. Homo sapiens 36,486 13-Feb-92 GB_PR1: HSRPIILS 6732 X63564 H. sapiens mRNA for RNA polymerase II largest subunit. Homo sapiens 38,813 13-Feb-92 rxa02407 495 GB_BA1: MTCY130 32514 Z73902 Mycobacterium tuberculosis H37Rv complete genome; segment 59/162. Mycobacterium 54,321 17-Jun-98 tuberculosis GB_BA1: MSGY151 37036 AD000018 Mycobacterium tuberculosis sequence from clone y151. Mycobacterium 40,000 10-DEC-1996 tuberculosis GB_EST19: AA391133 474 AA391133 LD10081.5prime LD Drosophila melanogaster embryo BlueScript Drosophila melanogaster 38,015 27-Nov-98 Drosophila melanogaster cDNA clone LD10081 5prime, mRNA sequence. rxa02408 1035 GB_PAT: I92047 551 I92047 Sequence 14 from patent U.S. Pat. No. 5726299. Unknown. 46,000 01-DEC-1998 GB_PAT: I78759 549 I78759 Sequence 15 from patent U.S. Pat. No. 5693781. Unknown. 45,438 3-Apr-98 GB_PAT: I92048 549 I92048 Sequence 15 from patent U.S. Pat. No. 5726299. Unknown. 45,438 01-DEC-1998 rxa02409 660 GB_EST19: AA438982 672 AA438982 LD13390.5prime LD Drosophila melanogaster embryo BlueScript Drosophila melanogaster 36,130 27-Nov-98 Drosophila melanogaster cDNA clone LD13390 5prime, mRNA sequence. GB_EST28: AI513795 635 AI513795 GH26887.5prime GH Drosophila melanogaster head pOT2 Drosophila melanogaster 38,840 16-MAR-1999 Drosophila melanogaster cDNA clone GH26887 5prime, mRNA sequence. GB_HTG3: AC009601 40300 AC009601 Leishmania major chromosome 35 clone L165 strain Friedlin, Leishmania major 35,759 30-Sep-99 *** SEQUENCING IN PROGRESS ***, 2 ordered pieces. rxa02412 603 GB_BA1: AB020624 1605 AB020624 Corynebacterium glutamicum murl gene for D-glutamate Corynebacterium 40,237 24-Jul-99 racemase, complete cds. glutamicum GB_EST19: AA756805 646 AA756805 vv72b10.r1 Stratagene mouse skin (#937313) Mus musculus cDNA clone IMAGE: Mus musculus 34,483 21-Jan-98 1227931 5′ similar to gb: D21261 SM22-ALPHA HOMOLOG (HUMAN);, mRNA sequence. GB_RO: AF149291 1388 AF149291 Mus musculus transgelin mRNA, complete cds. Mus musculus 37,540 8-Jun-99 rxa02417 2247 GB_GSS14: AQ554774 813 AQ554774 RPCI-11-436G15.TV RPCI-11 Homo sapiens genomic clone Homo sapiens 34,649 28-MAY-1999 RPCI-11-436G15, genomic survey sequence. GB_GSS4: AQ713076 500 AQ713076 HS_5384_A2_C05_SP6E RPCI-11 Human Male BAC Library Homo sapiens 35,200 13-Jul-99 Homo sapiens genomic clone Plate = 960 Col = 10 Row = E, genomic survey sequence. GB_STS: G47161 448 G47161 Z15758_1 Zebrafish AB Danio rerio STS genomic clone Danio rerio 39,910 23-MAR-1999 Z15758 5′, sequence tagged site. rxa02421 933 GB_HTG2: AC005708 76712 AC005708 Drosophila melanogaster chromosome 2 clone DS08537 (D425) map Drosophila melanogaster 36,207 15-Jan-99 50C1-50C2 strain y2; cn bw sp, *** SEQUENCING IN PROGRESS ***, 20 unordered pieces. GB_HTG3: AC005812 76721 AC005812 Drosophila melanogaster chromosome 2 clone DS07345 (D445) map 50C1-50C2 Drosophila melanogaster 36,205 20-Sep-99 strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 8 unordered pieces. GB_HTG2: AC005673 77023 AC005673 Drosophila melanogaster chromosome 2 clone DS00096 (D427) map Drosophila melanogaster 39,321 30-Jul-99 50C1-50C4 strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 12 unordered pieces. rxa02425 653 GB_BA1: PFPHCOAHL 2700 Y13067 Pseudomonas fluorescens genes encoding p-hydroxycinnamoyl Pseudomonas fluorescens 40,854 05-MAY-1998 CoA hydratase/lyase and vanillin: NAD+ oxidoreductase. GB_EST27: AI438343 610 AI438343 SWOvAFCAP31F09SK Onchocerca volvulus adult female cDNA Onchocerca volvulus 41,244 09-MAR-1999 (SAW98MLW-OvAF) Onchocerca volvulus cDNA clone SWOvAFCAP31F09 5′, mRNA sequence. GB_BA1: XANHRPA1A 1824 M99173 Xanthomonas campstris HrpA1 gene, complete cds. Xanthomonas campestris 37,520 14-Sep-93 rxa02427 510 GB_OV: CCA245635 2455 AJ245635 Cyprinus carpio IL-1 gene for interleukin-1-beta. Cyprinus carpio 35,614 5-Aug-99 GB_OV: AB010701 1213 AB010701 Cyprinus carpio mRNA for interleukin-1 beta, complete cds. Cyprinus carpio 36,821 29-Jan-98 GB_OV: CCA245635 2455 AJ245635 Cyprinus carpio IL-1 gene for interleukin-1-beta. Cyprinus carpio 35,060 5-Aug-99 rxa02428 1257 GB_IN1: CEY40B1B 29313 AL032636 Caenorhabditis elegans cosmid Y40B1B, complete sequence. Caenorhabditis elegans 37,068 12-Nov-99 GB_GSS12: AQ374513 640 AQ374513 RPCI11-145N15.TJ RPCI-11 Homo sapiens genomic clone Homo sapiens 35,636 20-MAY-1999 RPCI-11-145N15, genomic survey sequence. GB_IN1: CEY40B1B 29313 AL032636 Caenorhabditis elegans cosmid Y40B1B, complete sequence. Caenorhabditis elegans 32,800 12-Nov-99 rxa02430 309 GB_BA1: MTCY1A11 30850 Z78020 Mycobacterium tuberculosis H37Rv complete genome; segment 83/162. Mycobacterium 64,610 17-Jun-98 tuberculosis GB_PR4: AC004998 135572 AC004998 Homo sapiens clone DJ164D05, complete sequence. Homo sapiens 41,118 17-Jun-99 GB_PR2: AC002091 161799 AC002091 Genomic sequence from Human 17, complete sequence. Homo sapiens 36,393 9-Sep-97 rxa02433 723 GB_HTG5: AC009754 212978 AC009754 Homo sapiens chromosome 15 clone RP11-519C12, WORKING DRAFT Homo sapiens 33,008 17-Nov-99 SEQUENCE, 16 ordered pieces. GB_HTG5: AC009754 212978 AC009754 Homo sapiens chromosome 15 clone RP11-519C12, WORKING Homo sapiens 39,716 17-Nov-99 DRAFT SEQUENCE, 16 ordered pieces. GB_PR4: HUAC003108 164564 AC003108 Human Chromosome 16 BAC clone CIT987SK-327O24, complete sequence. Homo sapiens 35,180 23-Nov-99 rxa02437 933 GB_IN2: AC005650 60019 AC005650 Drosophila melanogaster, chromosome 2R, region 59B4-59B7, Drosophila melanogaster 40,397 30-Jan-99 P1 clone DS02885, complete sequence. GB_IN2: AC005650 60019 AC005650 Drosophila melanogaster, chromosome 2R, region 59B4-59B7, Drosophila melanogaster 37,719 30-Jan-99 P1 clone DS02885, complete sequence. GB_RO: AF081193 2250 AF081193 Mus musculus calcium and DAG-regulated guanine nucleotide exchange Mus musculus 37,835 28-Nov-98 factor I mRNA, complete cds. rxa02443 1077 GB_HTG4: AC009370 59409 AC009370 Drosophila melanogaster chromosome 3L/75C1 clone RPCI98-35F4, Drosophila melanogaster 35,460 16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 40 unordered pieces. GB_HTG4: AC009370 59409 AC009370 Drosophila melanogaster chromosome 3L/75C1 clone RPCI98-35F4, Drosophila melanogaster 35,460 16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 40 unordered pieces. GB_EST9: AA081445 311 AA081445 zn18a01.r1 Stratagene neuroepithelium NT2RAMI 937234 Homo sapiens cDNA clone Homo sapiens 36,334 21-OCT-1996 IMAGE: 547752 5′, mRNA sequence. rxa02444 1401 GB_BA2: SCF76 18292 AL121600 Streptomyces coelicolor cosmid F76. Streptomyces coelicolor 39,226 29-Sep-99 A3(2) GB_PR2: HS1022J11 137658 AL049765 Human DNA sequence from clone 1022J11 on chromosome 20q13.13-13.2, complete Homo sapiens 35,444 23-Nov-99 sequence. GB_HTG1: AC002345 132645 AC002345 Homo sapiens chromosome 17 clone 20D5, *** SEQUENCING IN PROGRESS ***, Homo sapiens 35,106 25-Aug-97 10 unordered pieces. rxa02452 303 GB_GSS14: AQ579499 825 AQ579499 nbxb0084D17f CUGI Rice BAC Library Oryza sativa genomic clone nbxb0084D17f, Oryza sativa 39,535 2-Jun-99 genomic survey sequence. GB_GSS14: AQ579499 825 AQ579499 nbxb0084D17f CUGI Rice BAC Library Oryza sativa genomic clone nbxb0084D17f, Oryza sativa 36,213 2-Jun-99 genomic survey sequence. rxa02454 1365 GB_HTG3: AC007810 140175 AC007810 Drosophila melanogaster chromosome 3 clone BACR14A01 (D720) RPCI-98 14.A.1 Drosophila melanogaster 33,931 17-Sep-99 map 90C—90C strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 89 unordered pieces. GB_HTG3: AC007810 140175 AC007810 Drosophila melanogaster chromosome 3 clone BACR14A01 (D720) RPCI-98 14.A.1 Drosophila melanogaster 33,931 17-Sep-99 map 90C—90C strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 89 unordered pieces. GB_PR3: AC005339 32360 AC005339 Homo sapiens chromosome 19, cosmid R33729, Homo sapiens 38,131 30-Jul-98 complete sequence. rxa02457 1233 GB_HTG3: AC009346 105005 AC009346 Drosophila melanogaster chromosome 3 clone BACR03P13 (D672) Drosophila melanogaster 36,829 27-Aug-99 RPCI-98 03.P.13 map 83A-83B strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 83 unordered pieces. GB_EST20: AA820427 436 AA820427 LD24042.5prime LD Drosophila melanogaster embryo pOT2 Drosophila Drosophila melanogaster 38,018 25-Feb-99 melanogaster cDNA clone LD24042 5prime, mRNA sequence. GB_HTG3: AC009346 105005 AC009346 Drosophila melanogaster chromosome 3 clone BACR03P13 (D672) RPCI-98 Drosophila melanogaster 36,829 27-Aug-99 03.P.13 map 83A-83B strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 83 unordered pieces. rxa02459 858 GB_BA2: AF114233 1852 AF114233 Corynebacterium glutamicum Corynebacterium 99,248 7-Feb-99 5-enolpyruvylshikimate 3-phosphate synthase (aroA) gene, complete cds. glutamicum GB_HTG1: CEY45F10_2 110000 Z93245 Caenorhabditis elegans chromosome IV clone Y45F10, Caenorhabditis elegans 35,621 17-Sep-97 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG1: CEY45F10_2 110000 Z93245 Caenorhabditis elegans chromosome IV clone Y45F10, Caenorhabditis elegans 35,621 17-Sep-97 *** SEQUENCING IN PROGRESS ***, in unordered pieces. rxa02460 rxa02461 531 GB_EST10: AA153371 590 AA153371 ms02a12.r1 Stratagene mouse embryonic carcinoma (#937317) Mus musculus Mus musculus 39,203 11-Feb-97 cDNA clone IMAGE: 605758 5′ similar to gb: M24194 GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT-LIKE PROTEIN (HUMAN); gb: X75313 M. musculus (MOUSE);, mRNA sequence. GB_EST10: AA153371 590 AA153371 ms02a12.r1 Stratagene mouse embryonic carcinoma (#937317) Mus musculus Mus musculus 41,920 11-Feb-97 cDNA clone IMAGE: 605758 5′ similar to gb: M24194 GUANINE NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT-LIKE PROTEIN (HUMAN); gb: X75313 M. musculus (MOUSE);, mRNA sequence. rxa02464 1323 GB_HTG4: AC008754 86446 AC008754 Homo sapiens chromosome 19 clone CITB-E1_3023J11, *** SEQUENCING IN Homo sapiens 36,064 31-OCT-1999 PROGRESS ***, 73 unordered pieces. GB_HTG4: AC008754 86446 AC008754 Homo sapiens chromosome 19 clone CITB-E1_3023J11, *** SEQUENCING IN Homo sapiens 36,064 31-OCT-1999 PROGRESS ***, 73 unordered pieces. GB_HTG4: AC008754 86446 AC008754 Homo sapiens chromosome 19 clone CITB-E1_3023J11, *** SEQUENCING IN Homo sapiens 37,589 31-OCT-1999 PROGRESS ***, 73 unordered pieces. rxa02465 522 GB_PR3: AC004960 143834 AC004960 Homo sapiens PAC clone DJ1098B01 from 7q11.23-q21, complete sequence. Homo sapiens 35,010 5-Nov-98 GB_GSS9: AQ122158 428 AQ122158 HS_3083_A1_E10_MR CIT Approved Human Genomic Sperm Library D Homo Homo sapiens 39,720 22-Sep-98 sapiens genomic clone Plate = 3083 Col = 19 Row = I, genomic survey sequence. GB_BA2: AF053227 840 AF053227 Photobacterium leiognathi probable flavin reductase (luxG) gene, complete cds. Photobacterium leiognathi 37,572 12-Jun-98 rxa02466 187 GB_EST21: AA942401 825 AA942401 LD26583.5prime LD Drosophila melanogaster embryo pOT2 Drosophila Drosophila melanogaster 37,705 25-Nov-98 melanogaster cDNA clone LD26583 5prime, mRNA sequence. GB_GSS12: AQ400564 485 AQ400564 HS_5064_A1_G09_T7A RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 38,043 13-MAR-1999 genomic clone Plate = 640 Col = 17 Row = M, genomic survey sequence. GB_GSS12: AQ400564 485 AQ400564 HS_5064_A1_G09_T7A RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 37,647 13-MAR-1999 genomic clone Plate = 640 Col = 17 Row = M, genomic survey sequence. rxa02467 348 GB_HTG2: AC005718 149592 AC005718 Drosophila melanogaster chromosome 2 clone DS02336 (D440) map 60C8-60D2 Drosophila melanogaster 40,525 30-Jul-99 strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 68 unordered pieces. GB_HTG2: AC005718 149592 AC005718 Drosophila melanogaster chromosome 2 clone DS02336 (D440) map 60C8-60D2 Drosophila melanogaster 40,525 30-Jul-99 strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 68 unordered pieces. GB_PR3: AC004217 103319 AC004217 Homo sapiens 12q24.1 PAC RPCI3-521E19 (Roswell Park Cancer Institute Human Homo sapiens 37,389 2-Jun-98 PAC library) complete sequence. rxa02472 414 GB_GSS12: AQ413964 550 AQ413964 RPCI-11-207C17.TV RPCI-11 Homo sapiens genomic clone RPCI-11-207C17, Homo sapiens 37,870 23-MAR-1999 genomic survey sequence. GB_IN2: CELR09H3 10687 U58740 Caenorhabditis elegans cosmid R09H3. Caenorhabditis elegans 37,408 26-MAY-1999 GB_GSS13: AQ488397 734 AQ488397 RPCI-11-243H14.TV RPCI-11 Homo sapiens genomic clone RPCI-11-243H14, Homo sapiens 37,569 24-Apr-99 genomic survey sequence. rxa02473 864 GB_HTG1: CEY7A5 235922 AL021576 Caenorhabditis elegans chromosome X clone Y7A5, *** SEQUENCING IN Caenorhabditis elegans 38,561 19-Aug-99 PROGRESS ***, in unordered pieces. GB_HTG1: CEY7A5 235922 AL021576 Caenorhabditis elegans chromosome X clone Y7A5, *** SEQUENCING IN Caenorhabditis elegans 38,561 19-Aug-99 PROGRESS ***, in unordered pieces. GB_IN1: CEY7A5A 68270 AL034489 Caenorhabditis elegans cosmid Y7A5A, complete sequence. Caenorhabditis elegans 38,081 18-DEC-1998 rxa02475 1278 GB_BA1: AB009078 2686 AB009078 Brevibacterium saccharolyticum gene for L-2.3-butanediol dehydrogenase, Brevibacterium 99,217 13-Feb-99 complete cds. saccharolyticum GB_PH: AF074945 15644 AF074945 Mycoplasma arthritidis bacteriophage MAV1, complete genome. Mycoplasma arthritidis 36,876 27-Jul-99 bacteriophage MAV1 GB_BA1: MTV008 63033 AL021246 Mycobacterium tuberculosis H37Rv complete genome; segment 108/162. Mycobacterium 37,520 17-Jun-98 tuberculosis rxa02478 1338 GB_HTG1: AC002419 128340 AC002419 Homo sapiens chromosome X clone bWXD40, *** SEQUENCING Homo sapiens 34,700 12-Aug-97 IN PROGRESS ***, 2 unordered pieces. GB_PR3: AC004073 79612 AC004073 Human Chromosome X, complete sequence. Homo sapiens 34,700 29-Jan-98 GB_HTG1: AC002419 128340 AC002419 Homo sapiens chromosome X clone bWXD40, *** SEQUENCING IN Homo sapiens 34,700 12-Aug-97 PROGRESS ***, 2 unordered pieces. rxa02482 933 GB_OV: AF077329 1645 AF077329 Coturnix coturnix pro-alpha2(I) collagen mRNA, partial cds, Coturnix coturnix 40,202 3-Feb-99 GB_PL2: SFU59150 2854 U59150 Sartorya fumigata nucleolar protein AfCbf5p (AfCBF5p) mRNA, complete cds. Aspergillus fumigatus 36,789 1-Jan-98 GB_BA2: AE000106 12554 AE000106 Rhizobium sp. NGR234 plasmid pNGR234a, section 43 of 46 of the complete plasmid Rhizobium sp. NGR234 36,630 12-DEC-1997 sequence. rxa02483 936 GB_HTG1: AC002345 132645 AC002345 Homo sapiens chromosome 17 clone 20D5, *** SEQUENCING IN PROGRESS***, Homo sapiens 37,942 25-Aug-97 10 unordered pieces. GB_HTG1: AC002345 132645 AC002345 Homo sapiens chromosome 17 clone 20D5, *** SEQUENCING IN PROGRESS ***, Homo sapiens 37,942 25-Aug-97 10 unordered pieces. GB_PR4: AF118569 24070 AF118569 Homo sapiens angiotensin I converting enzyme precursor (DCP1) gene, Homo sapiens 37,352 28-OCT-1999 alternative splice products, complete cds. rxa02484 624 GB_BA1: RLSPRLVCP 3696 Y09534 R. leguminosarum Symbiosis Plasmid DNA, rlvCP gene. Rhizobium leguminosarum 38,003 26-Feb-97 GB_BA2: RLU23040 3931 U23040 Rhizobium leguminosarum bv. viciae putative glycerol-3-phosphate transport protein Rhizobium leguminosarum 38,003 26-Aug-96 (ugpC) gene, partial cds, and chemoreceptor protein (mcpA), putative bv. viciae 2-hydroxychromene-2-carboxylate isomerase, and putative alcohol dehydrogenase genes, complete cds. GB_BA1: NGORBKGME 1580 L07845 Neisseria gonorrhoeae ribokinase (rbk) gene, 3′ end; ADP-L-glycero-D- Neisseria gonorrhoeae 46,939 11-OCT-1995 mannoheptose epimerase (gme) gene, complete cds. rxa02486 759 GB_IN1: CELM02D8 40876 U41034 Caenorhabditis elegans cosmid M02D8. Caenorhabditis elegans 38,358 30-Nov-95 GB_IN2: CELC36C5 41596 AF016444 Caenorhabditis elegans cosmid C36C5. Caenorhabditis elegans 38,482 08-OCT-1999 GB_HTG3: AC011467 188118 AC011467 Homo sapiens chromosome 19 clone CIT-HSPC_457E21, *** SEQUENCING IN Homo sapiens 37,954 07-OCT-1999 PROGRESS ***, 59 unordered pieces. rxa02488 392 GB_HTG2: AC006765 274498 AC006765 Caenorhabditis elegans clone Y43H11, *** SEQUENCING IN PROGRESS ***, 7 Caenorhabditis elegans 38,961 23-Feb-99 unordered pieces. GB_HTG2: AC006765 274498 AC006765 Caenorhabditis elegans clone Y43H11, *** SEQUENCING IN PROGRESS ***, Caenorhabditis elegans 38,961 23-Feb-99 7 unordered pieces. GB_HTG4: AC010035 173152 AC010035 Drosophila melanogaster chromosome 3L/74B2 clone RPCO98-6H1, Drosophila melanogaster 38,010 16-OCT-1999 *** SEQUENCING IN PROGRESS ***, 60 unordered pieces. rxa02489 724 GB_GSS8: AQ050210 796 AQ050210 nbxb0003cD08r CUGI Rice BAC Library Oryza sativa genomic clone Oryza sativa 40,201 24-MAR-1999 nbxb0003H15r, genomic survey sequence. GB_PL1: D87819 2036 D87819 Oryza sativa mRNA for sucrose transporter, complete cds. Oryza sativa 39,356 26-DEC-1997 GB_STS: G53565 627 G53565 SHGC-83995 Human Homo sapiens STS genomic, sequence tagged site. Homo sapiens 40,237 25-Jun-99 rxa02495 2691 GB_BA1: MTCY19H9 20679 Z83857 Mycobacterium tuberculosis H37Rv complete genome; segment 129/162. Mycobacterium 40,853 18-Jun-98 tuberculosis GB_BA1: MTCY19H9 20679 Z83857 Mycobacterium tuberculosis H37Rv complete genome; segment 129/162. Mycobacterium 40,358 18-Jun-98 tuberculosis GB_HTG1: HSDJ901O8 114599 AL078461 Homo sapiens chromosome 20 clone RP5-901O8 map q11.1-11.23, Homo sapiens 34,059 25-Nov-99 *** SEQUENCING IN PROGRESS ***, in unordered pieces. rxa02496 930 GB_EST36: AV201062 373 AV201062 AV201062 Yuji Kohara unpublished cDNA Caenorhabditis elegans cDNA clone Caenorhabditis elegans 41,287 26-Jul-99 yk250f11 5′, mRNA sequence. GB_IN1: CELC10F3 40172 AF022968 Caenorhabditis elegans cosmid C10F3. Caenorhabditis elegans 35,217 10-Sep-97 GB_EST29: AI612578 357 AI612578 TENG0372 T. Cruzi epimastigote normalised cDNA Library Trypanosoma cruzi Trypanosoma cruzi 39,474 7-Jul-99 cDNA clone n715.r 5′, mRNA sequence. rxa02498 927 GB_BA2: CGU31225 1817 U31225 Corynebacterium glutamicum L-proline: NADP+ 5-oxidoreductase (proC) gene, Corynebacterium 92,580 2-Aug-96 complete cds. glutamicum GB_PR2: AP000197 100000 AP000197 Homo sapiens genomic DNA, chromosome 21q22.1, D21S226-AML region, clone Homo sapiens 36,344 20-Nov-99 B355D16-T1073, segment 3/8, complete sequence. GB_PR2: AP000093 100000 AP000093 Homo sapiens genomic DNA of 21q22.1, GART and AML related, Homo sapiens 36,344 25-Sep-99 B335D16-P10G11 region, segment 3/7, complete sequence. rxa02500 222 GB_BA1: MTCY20G9 37218 Z77162 Mycobacterium tuberculosis H37Rv complete genome; segment 25/162. Mycobacterium 58,257 17-Jun-98 tuberculosis GB_BA1: U00018 42991 U00018 Mycobacterium leprae cosmid B2168. Mycobacterium leprae 44,776 01-MAR-1994 GB_BA1: SCE68 38084 AL079345 Streptomyces coelicolor cosmid E68. Streptomyces coelicolor 37,624 16-Jul-99 A3(2) rxa02505 294 GB_RO: MM2B4J 289 X00621 Mouse hybridoma 2B4 gene fragment (J-region) for T-cell receptor. Mus musculus 36,364 10-Nov-95 GB_RO: MUSTCBJB1 2276 K02802 Mouse T-cell receptor germline beta-chain J-beta-2 gene cluster, including J-beta- Mus musculus 32,862 27-Apr-93 [2.1, 2.2, 2.3, 2.4, 2.5, 2.psi, 2.6] genes. GB_RO: MMAE000665 199101 AE000665 Mus musculus TCR beta locus from bases 501860 to 700960 (section 3 of 3) Mus musculus 36,879 4-Sep-97 of the complete sequence. rxa02506 rxa02510 759 GB_OM: PIGMTNADP 1585 M86719 Pig mitochondrial NADP-isocitrate dehydrogenase mRNA, 3′ end. Sus scrofa 36,963 12-Jun-93 GB_EST17: AA629042 359 AA629042 zu77d08.s1 Soares_testis_NHT Homo sapiens cDNA clone IMAGE: 744015 3′, Homo sapiens 37,184 16-OCT-1997 mRNA sequence. GB_EST20: AA837524 528 AA837524 oe31d07.s1 NCI_CGAP_Pr25 Homo sapiens cDNA clone IMAGE: 1410157 similar Homo sapiens 40,039 26-Feb-98 to gb: X69391 60S RIBOSOMAL PROTEIN L6 (HUMAN);, mRNA sequence. rxa02514 857 GB_PR2: CNS01DS9 175148 AL121694 Human chromosome 14 DNA sequence *** IN PROGRESS *** BAC R-701B16 of Homo sapiens 35,185 8-Nov-99 RPCI-11 library from chromosome 14 of Homo sapiens (Human), complete sequence. GB_PR4: AC006222 165643 AC006222 Homo sapiens, clone hRPK.12_A_1, complete sequence. Homo sapiens 33,411 15-Jan-99 GB_PR4: AC006222 165643 AC006222 Homo sapiens, clone hRPK.12_A_1, complete sequence. Homo sapiens 35,629 15-Jan-99 rxa02518 534 GB_BA1: MTV007 32806 AL021184 Mycobacterium tuberculosis H37Rv complete genome; segment 64/162. Mycobacterium 57,965 17-Jun-98 tuberculosis GB_EST16: AA576027 231 AA576027 nm57e05.s1 NCI_CGAP_Br3 Homo sapiens cDNA clone IMAGE: 1072352 Homo sapiens 47,674 9-Sep-97 3′ similar to TR: G1001455 G1001455 HYPOTHETICAL 141.7 KD PROTEIN.;, mRNA sequence. GB_BA2: AE000226 10466 AE000226 Escherichia coli K-12 MG1655 section 116 of 400 of the complete genome. Escherichia coli 38,447 12-Nov-98 rxa02519 1752 GB_IN2: DMNRG2 8574 AF050085 Drosophila melanogaster neuroglian (nrg) gene, exons 3-6, 7a, 7b and alternatively Drosophila melanogaster 38,498 5-Aug-98 spliced products, complete cds. GB_IN2: AC004322 32480 AC004322 Drosophila melanogaster DNA sequence (P1 DS01962 (D216)), complete sequence. Drosophila melanogaster 36,126 29-Aug-98 GB_HTG2: AC008188 129128 AC008188 Drosophila melanogaster chromosome 2 clone BACR08I18 (D660) RPCI-98 08.I.18 Drosophila melanogaster 35,660 2-Aug-99 map 56A2-56B1 strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 72 unordered pieces. rxa02520 807 GB_GSS3: B68449 228 B68449 CIT-HSP-2025P8.TF CIT-HSP Homo sapiens genomic clone 2025P8, genomic Homo sapiens 42,544 21-Jun-98 survey sequence. GB_HTG3: AC010642 45982 AC010642 Homo sapiens chromosome 19 clone LLNL-R_245B6, *** SEQUENCING IN Homo sapiens 34,543 16-Sep-99 PROGRESS ***, 26 unordered pieces. GB_HTG3: AC010642 45982 AC010642 Homo sapiens chromosome 19 clone LLNL-R_245B6, *** SEQUENCING IN Homo sapiens 34,543 16-Sep-99 PROGRESS ***, 26 unordered pieces. rxa02521 1566 GB_BA1: SCC22 22115 AL096839 Streptomyces coelicolor cosmid C22. Streptomyces coelicolor 40,885 12-Jul-99 GB_BA1: BSUB0017 217420 Z99120 Bacillus subtilis complete genome (section 17 of 21): from 3197001 to 3414420. Bacillus subtilis 38,441 26-Nov-97 GB_BA1: MLCL536 36224 Z99125 Mycobacterium leprae cosmid L536. Mycobacterium leprae 37,233 04-DEC-1998 rxa02524 813 GB_IN1: CELF42H10 28687 L08403 C. elegans cosmid F42H10. Caenorhabditis elegans 32,878 22-OCT-1993 GB_IN1: CEU02289 4824 U02289 Caenorhabditis elegans Bristol N2 GTPase-activating protein (CEGAP) mRNA, Caenorhabditis elegans 34,457 11-Jun-94 partial cds. GB_IN1: CELF42H10 28687 L08403 C. elegans cosmid F42H10. Caenorhabditis elegans 34,243 22-OCT-1993 rxa02525 501 GB_EST36: AU076280 416 AU076280 AU076280 Rice green shoot Oryza sativa cDNA clone S10896_11A, Oryza sativa 42,671 27-Jul-99 mRNA sequence. GB_EST1: D34202 355 D34202 CELK042E5R Yuji Kohara unpublished cDNA Caenorhabditis elegans cDNA Caenorhabditis elegans 42,553 8-Aug-94 clone yk42e5 3′, mRNA sequence. GB_EST1: D34202 355 D34202 CELK042E5R Yuji Kohara unpublished cDNA Caenorhabditis elegans cDNA Caenorhabditis elegans 37,892 8-Aug-94 clone yk42e5 3′, mRNA sequence. rxa02534 927 GB_EST15: AA490533 426 AA490533 aa51h04.r1 NCI_CGAP_GCB1 Homo sapiens cDNA clone IMAGE: 824503 5′, Homo sapiens 41,176 15-Aug-97 mRNA sequence. GB_PL2: ATFCA3 200252 Z97338 Arabidopsis thaliana DNA chromosome 4, ESSA I FCA contig fragment No. 3. Arabidopsis thaliana 35,568 27-Aug-99 GB_PL2: ATFCA3 200252 Z97338 Arabidopsis thaliana DNA chromosome 4, ESSA I FCA contig fragment No. 3. Arabidopsis thaliana 37,376 27-Aug-99 rxa02537 585 GB_HTG4: AC009732 165576 AC009732 Drosophila melanogaster chromosome 2 clone BACR05E17 (D1059) Drosophila melanogaster 30,727 26-OCT-1999 RPCI-98 05.E.17 map 57F—57F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 83 unordered pieces. GB_HTG4: AC009732 165576 AC009732 Drosophila melanogaster chromosome 2 clone BACR05E17 (D1059) Drosophila melanogaster 30,727 26-OCT-1999 RPCI-98 05.E.17 map 57F—57F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 83 unordered pieces. GB_HTG4: AC009732 165576 AC009732 Drosophila melanogaster chromosome 2 clone BACR05E17 (D1059) Drosophila melanogaster 36,460 26-OCT-1999 RPCI-98 05.E.17 map 57F—57F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 83 unordered pieces. rxa02538 795 GB_GSS15: AQ606090 658 AQ606090 HS_5392_A1_E12_T7A RPCI-11 Human Male BAC Library Homo Homo sapiens 39,369 10-Jun-99 sapiens genomic clone Plate = 968 Col = 23 Row = I, genomic survey sequence. GB_BA1: AXACE 5323 X94981 A. xylinum aceB, aceC, aceD, and aceE genes. Acetobacter xylinus 37,009 12-Feb-97 GB_BA1: AXACE 5323 X94981 A. xylinum aceB, aceC, aceD, and aceE genes. Acetobacter xylinus 37,879 12-Feb-97 rxa02540 561 GB_BA1: MTY13E10 35019 Z95324 Mycobacterium tuberculosis H37Rv complete genome; segment 18/162. Mycobacterium 51,002 17-Jun-98 tuberculosis GB_BA1: MTDNAGRP 4644 X58406 M. tuberculosis dnaK, grpE, and dnaJ genes. Mycobacterium 51,002 21-OCT-1992 tuberculosis GB_BA1: AB007847 2400 AB007847 Rhodococcus rhodochrous gene for 3-ketosteroid-delta1-dehydrogenase, complete cds. Rhodococcus rhodochrous 53,723 13-Feb-99 rxa02544 1521 GB_PAT: E14041 2776 E14041 gDNA encoding laminaripentaose forming enzyme (LPHase). Streptomyces sp. 47,351 28-Jul-99 GB_HTG3: AC010592 45971 AC010592 Homo sapiens chromosome 5 clone CIT-HSPC_459H20, Homo sapiens 37,689 16-Sep-99 *** SEQUENCING IN PROGRESS ***, 38 unordered pieces. GB_HTG3: AC010592 45971 AC010592 Homo sapiens chromosome 5 clone CIT-HSPC_459H20, Homo sapiens 37,689 16-Sep-99 *** SEQUENCING IN PROGRESS ***, 38 unordered pieces. rxa02545 681 GB_HTG3: AC009016 128095 AC009016 Homo sapiens chromosome 5 clone P1_889E7, Homo sapiens 34,763 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 67 unordered pieces. GB_HTG3: AC009016 128095 AC009016 Homo sapiens chromosome 5 clone P1_889E7, *** SEQUENCING IN Homo sapiens 34,763 3-Aug-99 PROGRESS ***, 67 unordered pieces. GB_HTG3: AC009010 72817 AC009010 Homo sapiens chromosome 5 clone P1_1352A1, *** SEQUENCING IN Homo sapiens 34,763 3-Aug-99 PROGRESS ***, 19 unordered pieces. rxa02546 1227 GB_HTG3: AC006519 134365 AC006519 Homo sapiens clone RPCI5-951N9, *** SEQUENCING IN PROGRESS ***, Homo sapiens 32,868 16-Sep-99 41 unordered pieces. GB_BA1: D90738 17528 D90738 Escherichia coli genomic DNA. (23.0-23.4 min). Escherichia coli 38,674 7-Feb-99 GB_HTG3: AC006519 134365 AC006519 Homo sapiens clone RPCI5-951N9, *** SEQUENCING IN PROGRESS ***, Homo sapiens 32,868 16-Sep-99 41 unordered pieces. rxa02549 2826 GB_BA1: CGBPHI16 962 Y12472 C. glutamicum DNA, attachment site bacteriophage Phi-16. Corynebacterium 41,702 05-MAR-1999 glutamicum GB_BA2: AE001095 10592 AE001095 Archaeoglobus fulgidus section 12 of 172 of the complete genome. Archaeoglobus fulgidus 36,817 15-DEC-1997 GB_EST20: AA887411 587 AA887411 oj37d06.s1 NCI_CGAP_Lu5 Homo sapiens cDNA clone IMAGE: 1500491 Homo sapiens 41,738 9-Jun-98 3′ similar to gb: X69908_rna1 ATP SYNTHASE LIPID-BINDING PROTEIN P2 PRECURSOR (HUMAN);, mRNA sequence. rxa02552 918 GB_GSS9: AQ129371 377 AQ129371 HS_3045_A2_B07_MR CIT Approved Human Genomic Sperm Library D Homo Homo sapiens 42,857 23-Sep-98 sapiens genomic clone Plate = 3045 Col = 14 Row = C, genomic survey sequence. GB_GSS14: AQ566979 600 AQ566979 HS_2105_A2_D12_MR CIT Approved Human Genomic Sperm Library D Homo Homo sapiens 35,443 29-MAY-1999 sapiens genomic clone Plate = 2105 Col = 24 Row = G, genomic survey sequence. GB_IN1: MEPAP 4636 X54422 M. edulis gene for polyphenolic adhesive protein. Mytilus edulis 35,619 27-MAY-1992 rxa02554 747 GB_PR4: AC004882 171878 AC004882 Homo sapiens PAC clone DJ076B20 from 22, complete sequence. Homo sapiens 37,346 22-OCT-1999 GB_PR4: AC004882 171878 AC004882 Homo sapiens PAC clone DJ076B20 from 22, complete sequence. Homo sapiens 38,440 22-OCT-1999 GB_BA2: U32830 16388 U32830 Haemophilus influenzae Rd section 145 of 163 of the complete genome. Haemophilus influenzae Rd 33,514 29-MAY-1998 rxa02555 726 GB_GSS1: FR0020618 466 AL013501 F. rubripes GSS sequence, clone 042H13bD8, genomic survey sequence. Fugu rubripes 40,215 10-DEC-1997 GB_GSS1: FR0020576 555 AL013459 F. rubripes GSS sequence, clone 042H13aE5, genomic survey sequence. Fugu rubripes 35,379 10-DEC-1997 GB_GSS1: FR0020585 431 AL013468 F. rubripes GSS sequence, clone 042H13aH5, genomic survey sequence. Fugu rubripes 39,718 10-DEC-1997 rxa02564 1125 GB_PR3: AC004976 127425 AC004976 Homo sapiens PAC clone DJ1143H19 from 7p14-p15, complete sequence. Homo sapiens 37,364 5-Nov-98 GB_PR2: HUAC002038 161973 AC002038 Homo sapiens chromosome 2 clone 101B6 map 2p11, complete sequence. Homo sapiens 36,404 30-Jun-97 GB_HTG3: AC010791 111643 AC010791 Homo sapiens chromosome 17 clone 6_M_14 map 17, *** SEQUENCING IN Homo sapiens 34,293 22-Sep-99 PROGRESS ***, 8 unordered pieces. rxa02568 1753 GB_BA1: FT16SRNAA 1521 Z21931 F. tularensis 16S rRNA. Francisella tularensis 39,065 5-Jun-97 GB_BA1: FT16SRNAB 1520 Z21932 F. tularensis 16S rRNA. Francisella tularensis 37,807 16-DEC-1997 GB_BA1: FP16SRNAA 1518 Z21933 F. philomiragia 16S rRNA. Francisella philomiragia 36,380 5-Jun-97 rxa02569 873 GB_GSS13: AQ469518 553 AQ469518 CITBI-E1-2596J20.TR CITBI-E1 Homo sapiens genomic clone 2596J20, Homo sapiens 39,201 23-Apr-99 genomic survey sequence. GB_GSS12: AQ403903 495 AQ403903 HS_5058_B1_F07_T7A RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 36,049 13-MAR-1999 genomic clone Plate = 634 Col = 13 Row = L, genomic survey sequence. GB_PR2: AF004715 2889 AF004715 Homo sapiens jerky gene product homolog mRNA, complete cds. Homo sapiens 35,689 6-Aug-97 rxa02570 765 GB_BA1: CGU43535 2531 U43535 Corynebacterium glutamicum multidrug resistance protein (cmr) gene, complete cds. Corynebacterium 38,165 9-Apr-97 glutamicum GB_EST33: AI776398 499 AI776398 EST257498 tomato resistant, Cornell Lycopersicon esculentum cDNA clone Lycopersicon esculentum 42,084 29-Jun-99 cLER18I10, mRNA sequence. GB_EST23: AI119807 431 AI119807 uc21a06.r1 Soares mouse mammary gland NbMMG Mus musculus cDNA Mus musculus 40,281 2-Sep-98 clone IMAGE: 1398610 5′, mRNA sequence. rxa02573 rxa02575 1258 GB_BA1: SCGD3 33779 AL096822 Streptomyces coelicolor cosmid GD3. Streptomyces coelicolor 39,742 8-Jul-99 GB_RO: AC002108 41125 AC002108 Genomic sequence from Mouse 4, complete sequence. Mus musculus 36,100 29-MAY-1997 GB_PR1: HUMIDS 36845 L35485 Homo sapiens iduronate sulphate sulphatase (IDS) gene, complete cds. Homo sapiens 34,183 16-Aug-94 rxa02576 1545 GB_GSS15: AQ618143 582 AQ618143 HS_5168_B1_H08_T7A RPCI-11 Human Male BAC Library Homo Homo sapiens 34,874 15-Jun-99 sapiens genomic clone Plate = 744 Col = 15 Row = P, genomic survey sequence. GB_OV: XLFB1A1 2172 X64759 X. laevis mRNA for transcription factor (clone XLFB1a1). Xenopus laevis 38,589 26-Jan-93 GB_PR4: AC005039 151316 AC005039 Homo sapiens clone NH0512E16, complete sequence. Homo sapiens 33,575 14-Jan-99 rxa02577 1008 GB_PL2: AF034976 7130 AF034976 Pilayella littoralis ribosomal protein S14 (rps14) gene, partial cds; ATPase subunit Mitochondrion Pilayella 34,690 22-Jun-98 8 (atp8) gene, complete cds; tRNA-Ser gene, complete sequence; ribosomal littoralis protein S10 (rps10) and ribosomal protein L31 (rpl31) genes, complete cds; tRNA-Ser gene, complete sequence; T7-like RNA polymerase (rpox) gene, complete cds; and unknown genes, mitochondrial genes for mitochondrial products. GB_EST30: AI655188 456 AI655188 wb67g02.x1 NCI_CGAP_GC6 Homo sapiens cDNA clone IMAGE: 2310770 3′, Homo sapiens 39,198 04-MAY-1999 mRNA sequence. GB_PL2: AF034976 7130 AF034976 Pilayella littoralis ribosomal protein S14 (rps14) gene, partial cds; ATPase subunit Mitochondrion Pilayella 39,959 22-Jun-98 8 (atp8) gene, complete cds; tRNA-Ser gene, complete sequence; littoralis ribosomal protein S10 (rps10) and ribosomal protein L31 (rpl31) genes, complete cds; tRNA-Ser gene, complete sequence; T7-like RNA polymerase (rpox) gene, complete cds; and unknown genes, mitochondrial genes for mitochondrial products. rxa02584 474 GB_PR2: AP000191 100000 AP000191 Homo sapiens genomic DNA, chromosome 21q22.1, D21S226-AML region, clone Homo sapiens 37,199 20-Nov-99 Q78C10-f32E9, segment 18/21, complete sequence. GB_EST13: AA349881 293 AA349881 EST56832 infant brain Homo sapiens cDNA 5′ end similar to EST containing Alu Homo sapiens 42,466 21-Apr-97 repeat, mRNA sequence. GB_EST23: AI078215 404 AI078215 oz12h12.x1 Soares_fetal_liver_spleen_1NFLS_S1 Homo sapiens cDNA clone Homo sapiens 48,780 29-Sep-98 IMAGE: 1675175 3′ similar to contains Alu repetitive element; contains element THR repetitive element;, mRNA sequence. rxa02585 1104 GB_PR2: AP000115 100000 AP000115 Homo sapiens genomic DNA of 21q22.1, GART and AML related, Q78C10-149C3 Homo sapiens 35,502 25-Sep-99 region, segment 18/20, complete sequence. GB_PR2: AP000191 100000 AP000191 Homo sapiens genomic DNA, chromosome 21q22.1, D21S226-AML region, clone Homo sapiens 35,502 20-Nov-99 Q78C10-f32E9, segment 18/21, complete sequence. GB_PR2: AP000047 50188 AP000047 Homo sapiens genomic DNA, chromosome 21q22.1, segment 18/28, Homo sapiens 35,502 20-Nov-99 complete sequence. rxa02588 807 GB_BA1: MTCY8D5 39730 Z92669 Mycobacterium tuberculosis H37Rv complete genome; segment 12/162. Mycobacterium 38,354 18-Jun-98 tuberculosis GB_BA1: MTCY349 43523 Z83018 Mycobacterium tuberculosis H37Rv complete genome; segment 131/162. Mycobacterium 39,949 17-Jun-98 tuberculosis GB_HTG2: AC007879 158841 AC007879 Homo sapiens clone NH0309L06, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,835 31-Jul-99 2 unordered pieces. rxa02591 1953 GB_BA1: MTCY8D5 39730 Z92669 Mycobacterium tuberculosis H37Rv complete genome; segment 12/162. Mycobacterium 65,398 18-Jun-98 tuberculosis GB_BA1: MLCL622 42498 Z95398 Mycobacterium leprae cosmid L622. Mycobacterium leprae 63,875 24-Jun-97 GB_BA1: CHBATP2OP 5477 L08777 Chlorobium limicola atp2 operon. Chlorobium limicola 37,979 26-Apr-93 rxa02593 720 GB_GSS1: CNS0056G 994 AL057090 Drosophila melanogaster genome survey sequence T7 end of BAC # BACR11M23 Drosophila melanogaster 27,206 3-Jun-99 of RPCI-98 library from Drosophila melanogaster (fruit fly), genomic survey sequence. GB_GSS1: CNS0056G 994 AL057090 Drosophila melanogaster genome survey sequence T7 end of BAC # BACR11M23 of Drosophila melanogaster 30,270 3-Jun-99 RPCI-98 library from Drosophila melanogaster (fruit fly), genomic survey sequence. rxa02598 714 GB_IN1: PFMAL3P5 86829 AL034556 Plasmodium falciparum MAL3P5, complete sequence. Plasmodium falciparum 40,057 04-OCT-1999 GB_PL1: AB024026 23026 AB024026 Arabidopsis thaliana genomic DNA, chromosome 5, TAC clone: K15O15, Arabidopsis thaliana 38,865 20-Nov-99 complete sequence. GB_BA2: AE000930 15553 AE000930 Methanobacterium thermoautotrophicum from bases 1592014 to 1607566 Methanobacterium 36,804 15-Nov-97 (section 136 of 148) of the complete genome. thermoautotrophicum rxa02600 1521 GB_IN2: AC004301 68620 AC004301 Drosophila melanogaster DNA sequence (P1 DS07134 (D192)), complete sequence. Drosophila melanogaster 36,063 29-MAY-1998 GB_PL2: AC007504 125021 AC007504 Arabidopsis thaliana chromosome I BAC F13F21 genomic sequence, Arabidopsis thaliana 37,074 9-Jul-99 complete sequence. GB_PH: AF125520 61670 AF125520 Bacteriophage 933W, complete genome. Bacteriophage 933W 35,396 16-Apr-99 rxa02601 2112 GB_BA1: MTV026 23740 AL022076 Mycobacterium tuberculosis H37Rv complete genome; segment 157/162. Mycobacterium 38,676 24-Jun-99 tuberculosis GB_BA2: SSU73128 2331 U73128 Sphingomonas sp. A8AN3 catechol 2,3-dioxygenase gene, complete cds Sphingomonas sp. A8AN3 40,020 1-Feb-99 and 2-hydroxymuconic semialdehyde hydrolase and 2-hydroxymuconic semialdehyde dehydrogenase genes, partial cds. GB_BA2: SSU73128 2331 U73128 Sphingomonas sp. A8AN3 catechol 2,3-dioxygenase gene, complete cds Sphingomonas sp. A8AN3 40,101 1-Feb-99 and 2-hydroxymuconic semialdehyde hydrolase and 2-hydroxymuconic semialdehyde dehydrogenase genes, partial cds. rxa02602 627 GB_PR3: AF006751 3106 AF006751 Homo sapiens ES/130 mRNA, complete cds. Homo sapiens 37,582 10-Jul-98 GB_PR3: AF006751 3106 AF006751 Homo sapiens ES/130 mRNA, complete cds. Homo sapiens 38,462 10-Jul-98 GB_GSS9: AQ090116 404 AQ090116 HS_3000_B1_E09_MF CIT Approved Human Genomic Sperm Library D Homo sapiens 39,481 26-Aug-98 Homo sapiens genomic clone Plate = 3000 Col = 17 Row = J, genomic survey sequence. rxa02604 2199 GB_PL1: CREHIH3G 4358 L41841 Chlamydomonas reinhardtii histone H3, histone H4, histone H2B, and histone Chlamydomonas reinhardtii 37,500 16-MAY-1996 H2A genes, complete cds. GB_GSS13: AQ455681 621 AQ455681 HS_5068_B1_E01_T7A RPCI-11 Human Male BAC Library Homo Homo sapiens 36,246 21-Apr-99 sapiens genomic clone Plate = 644 Col = 1 Row = J, genomic survey sequence. GB_GSS6: AQ829471 392 AQ829471 HS_5442_A2_F11_SP6E RPCI-11 Human Male BAC Library Homo Homo sapiens 42,347 27-Aug-99 sapiens genomic clone Plate = 1018 Col = 22 Row = K, genomic survey sequence. rxa02606 1494 GB_PAT: A26027 2547 A26027 C. melassecola gene for extracellular antigen PS1. Corynebacterium 42,857 2-Apr-95 melassecola GB_BA1: CGCOP1G 2547 X66078 C. glutamicum cop1 gene for PS1. Corynebacterium 42,857 30-Jun-93 glutamicum GB_PR2: AP000134 100000 AP000134 Homo sapiens genomic DNA of 21q22.1, GART and AML, f43D11-119B8 region, Homo sapiens 36,145 25-Sep-99 segment 9/10, complete sequence. rxa02609 372 GB_HTG3: AC009212 125452 AC009212 Drosophila melanogaster chromosome 3 clone BACR01A18 (D669) Drosophila melanogaster 35,753 23-Aug-99 RPCI-98 01.A.18 map 82E-82F strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 119 unordered pieces. GB_HTG3: AC009212 125452 AC009212 Drosophila melanogaster chromosome 3 clone BACR01A18 (D669) RPCI-98 Drosophila melanogaster 35,753 23-Aug-99 01.A.18 map 82E-82F strain y; cn bw sp, *** SEQUENCING IN PROGRESS***, 119 unordered pieces. GB_HTG2: AC007589 134659 AC007589 Drosophila melanogaster chromosome 3 clone BACR20D10 (D667) Drosophila melanogaster 35,484 2-Aug-99 RPCI-98 20.D.10 map 82D-82E strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 73 unordered pieces. rxa02610 1050 GB_BA2: AF073776 5138 AF073776 Pseudomonas aeruginosa MexZ (mexZ), complete cds; and mexGH operon, Pseudomonas aeruginosa 38,323 19-OCT-1998 complete sequence. GB_BA1: AB015853 5461 AB015853 Pseudomonas aeruginosa gene for MexX and MexY, complete cds. Pseudomonas aeruginosa 38,447 13-Nov-98 GB_VI: HIM237805 2400 AJ237805 Human immunodeficiency virus type 1 partial envelope gene (gp160), isolate MP255. Human immunodeficiency 37,928 15-Jun-99 virus type 1 rxa02617 630 GB_PR2: HSL81781 4041 L81781 Homo sapiens (subclone 7_e4 from P1 H25) DNA sequence, complete sequence. Homo sapiens 38,835 9-Apr-97 GB_HTG3: AC011430 106902 AC011430 Homo sapiens chromosome 5 clone P1_660D11, Homo sapiens 38,662 06-OCT-1999 *** SEQUENCING IN PROGRESS ***, 28 unordered pieces. GB_HTG3: AC011430 106902 AC011430 Homo sapiens chromosome 5 clone P1_660D11, Homo sapiens 38,662 06-OCT-1999 *** SEQUENCING IN PROGRESS ***, 28 unordered pieces. rxa02619 1023 GB_BA1: CGL133719 1839 AJ133719 Corynebacterium glutamicum yjcc gene, amtR gene and citE gene, partial. Corynebacterium 100,000 12-Aug-99 glutamicum GB_BA1: CGL133719 1839 AJ133719 Corynebacterium glutamicum yjcc gene, amtR gene and citE gene, partial. Corynebacterium 100,000 12-Aug-99 glutamicum GB_EST18: AA734344 378 AA734344 vv24f02.r1 Stratagene mouse heart (#937316) Mus musculus cDNA Mus musculus 37,968 7-Jan-98 clone IMAGE: 1223355 5′, mRNA sequence. rxa02620 789 GB_BA1: CGL133719 1839 AJ133719 Corynebacterium glutamicum yjcc gene, amtR gene and citE gene, partial. Corynebacterium 100,000 12-Aug-99 glutamicum GB_BA1: CGL133719 1839 AJ133719 Corynebacterium glutamicum yjcc gene, amtR gene and citE gene, partial. Corynebacterium 100,000 12-Aug-99 glutamicum GB_EST16: C27457 252 C27457 C27457 Rice callus cDNA Oryza sativa cDNA clone C51917_1A, mRNA sequence. Oryza sativa 39,044 6-Aug-97 rxa02624 1419 GB_HTG2: AC005995 170023 AC005995 Homo sapiens clone DJ0042M02, *** SEQUENCING IN PROGRESS ***, Homo sapiens 38,533 23-Apr-99 13 unordered pieces. GB_HTG2: AC005995 170023 AC005995 Homo sapiens clone DJ0042M02, *** SEQUENCING IN PROGRESS ***, Homo sapiens 38,533 23-Apr-99 13 unordered pieces. GB_PR4: AC004895 152927 AC004895 Homo sapiens clone DJ0810E06, complete sequence. Homo sapiens 38,533 29-MAY-1999 rxa02639 957 GB_BA1: MSGY409 41321 AD000017 Mycobacterium tuberculosis sequence from clone y409. Mycobacterium 50,370 10-DEC-1996 tuberculosis GB_BA1: MTCY409 30352 Z97188 Mycobacterium tuberculosis H37Rv complete genome; segment 158/162. Mycobacterium 38,039 17-Jun-98 tuberculosis GB_HTG2: AC006765 274498 AC006765 Caenorhabditis elegans clone Y43H11, *** SEQUENCING IN PROGRESS***, Caenorhabditis elegans 35,225 23-Feb-99 7 unordered pieces. rxa02647 585 GB_PAT: A45577 1925 A45577 Sequence 1 from Patent WO9519442. Corynebacterium 37,545 07-MAR-1997 glutamicum GB_PAT: A45579 1925 A45579 Sequence 3 from Patent WO9519442. Corynebacterium 37,545 07-MAR-1997 glutamicum GB_PAT: A45581 1925 A45581 Sequence 5 from Patent WO9519442. Corynebacterium 37,545 07-MAR-1997 glutamicum rxa02649 1125 GB_BA1: D90904 150894 D90904 Synechocystis sp. PCC6803 complete genome, 6/27, 630555-781448. Synechocystis sp. 37,772 7-Feb-99 GB_PR3: HS941F9 127587 Z95331 Human DNA sequence from BAC 941F9 on Homo sapiens 38,748 23-Nov-99 chromosome 22q11.2-qter. Contains ESTs, STSs and 3′ part of FIBULIN-1 D PRECURSOR like gene, part of a Brain Protein E46 like gene and a CpG island, complete sequence. GB_BA1: D90904 150894 D90904 Synechocystis sp. PCC6803 complete genome, 6/27, 630555-781448. Synechocystis sp. 36,364 7-Feb-99 rxa02652 702 GB_BA2: AF048749 24454 AF048749 Bacteroides fragilis capsular polysaccharide biosynthesis operon, complete sequence. Bacteroides fragilis 37,464 25-Jun-99 GB_HTG4: AC009244 318775 AC009244 Homo sapiens chromosome 7, *** Homo sapiens 35,447 26-OCT-1999 SEQUENCING IN PROGRESS ***, 36 unordered pieces. GB_HTG4: AC009244 318775 AC009244 Homo sapiens chromosome 7, *** Homo sapiens 35,447 26-OCT-1999 SEQUENCING IN PROGRESS ***, 36 unordered pieces. rxa02655 1107 GB_EST10: AA185699 290 AA185699 mt62d11.r1 Soares 2NbMT Mus musculus cDNA clone IMAGE: 634485 5′ similar Mus musculus 39,510 19-Feb-97 to TR: G300372 G300372 CELL GROWTH REGULATING NUCLEOLAR PROTEIN.;, mRNA sequence. GB_GSS13: AQ429764 439 AQ429764 HS_5079_A2_C12_SP6E RPCI-11 Human Male BAC Homo sapiens 37,701 31-MAR-1999 Library Homo sapiens genomic clone Plate = 655 Col = 24 Row = E, genomic survey sequence. GB_GSS8: AQ012380 646 AQ012380 CIT-HSP-2300L9.TF CIT-HSP Homo sapiens genomic clone 2300L9, Homo sapiens 38,874 6-Jun-98 genomic survey sequence. rxa02662 387 GB_HTG2: AC007802 118569 AC007802 Drosophila melanogaster chromosome 2 clone BACR07I11 (D648) Drosophila melanogaster 37,696 2-Aug-99 RPCI-98 07.I.11 map 58A1-58A2 strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 70 unordered pieces. GB_HTG2: AC007802 118569 AC007802 Drosophila melanogaster chromosome 2 clone BACR07I11 (D648) RPCI-98 07.I.11 Drosophila melanogaster 37,696 2-Aug-99 map 58A1-58A2 strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 70 unordered pieces. GB_HTG2: AC007802 118569 AC007802 Drosophila melanogaster chromosome 2 clone BACR07I11 (D648) Drosophila melanogaster 35,616 2-Aug-99 RPCI-98 07.I.11 map 58A1-58A2 strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 70 unordered pieces. rxa02665 603 GB_HTG1: AC002419 128340 AC002419 Homo sapiens chromosome X clone bWXD40, *** SEQUENCING Homo sapiens 32,941 12-Aug-97 IN PROGRESS***, 2 unordered pieces. GB_HTG1: AC002419 128340 AC002419 Homo sapiens chromosome X clone bWXD40, *** SEQUENCING Homo sapiens 32,941 12-Aug-97 IN PROGRESS ***, 2 unordered pieces. GB_GSS15: AQ655091 630 AQ655091 Sheared DNA-21B5.TF Sheared DNA Trypanosoma brucei genomic Trypanosoma brucei 41,794 22-Jun-99 clone Sheared DNA-21B5, genomic survey sequence. rxa02670 705 GB_HTG2: AC006450 177555 AC006450 Homo sapiens chromosome 9 clone hRPK.85_O_21 map 9, Homo sapiens 41,374 15-Jul-99 *** SEQUENCING IN PROGRESS ***, 2 ordered pieces. GB_HTG2: AC006450 177555 AC006450 Homo sapiens chromosome 9 clone hRPK.85_O_21 map 9, Homo sapiens 41,374 15-Jul-99 *** SEQUENCING IN PROGRESS ***, 2 ordered pieces. GB_BA1: SPU86147 2268 U86147 Synechococcus PCC7942 UDP-N-acetylmuramate-alanine ligase (murC) Synechococcus PCC7942 40,177 15-Feb-97 gene, partial cds, UDP-N- acetylenolpyruvylglucosamine reductase (murB), and mercuric resistance operon regulatory protein (merR) genes, complete cds. rxa02672 1221 GB_BA1: MTV024 8189 AL022075 Mycobacterium tuberculosis H37Rv Mycobacterium 53,197 17-Jun-98 complete genome; segment 151/162. tuberculosis GB_BA1: MSGY23 40806 AD000016 Mycobacterium tuberculosis Mycobacterium 37,500 10-DEC-1996 sequence from clone y23. tuberculosis GB_EST38: AW029724 634 AW029724 EST272979 tomato callus, TAMU Lycopersicon esculentum cDNA Lycopersicon esculentum 40,000 15-Sep-99 clone cLEC28I17 similar to beta- ketoacyl-ACP synthase, putative, mRNA sequence. rxa02673 756 GB_GSS12: AQ356661 518 AQ356661 CITBI-E1-2531G11.TF CITBI-E1 Homo sapiens genomic Homo sapiens 33,022 24-Jan-99 clone 2531G11, genomic survey sequence. GB_IN1: CELC50A2 36582 AF036689 Caenorhabditis elegans cosmid C50A2. Caenorhabditis elegans 35,443 05-DEC-1997 GB_HTG2: AC006702 299864 AC006702 Caenorhabditis elegans clone Y104H12b, *** Caenorhabditis elegans 35,443 23-Feb-99 SEQUENCING IN PROGRESS ***, 3 unordered pieces. rxa02678 1041 GB_HTG1: AP000452 83103 AP000452 Homo sapiens chromosome 11 clone PAC2 map 11q11, Homo sapiens 35,098 13-Sep-99 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG1: AP000452 83103 AP000452 Homo sapiens chromosome 11 clone PAC2 map 11q11, Homo sapiens 35,098 13-Sep-99 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_PR3: HS498I24 58190 AL031057 Human DNA sequence from clone 498I24 on chromosome Homo sapiens 35,328 23-Nov-99 6p22.1-22.3 Contains STS, GSS and a CpG island, complete sequence. rxa02680 1407 GB_BA1: MLCB268 38859 AL022602 Mycobacterium leprae cosmid B268. Mycobacterium leprae 37,797 27-Aug-99 GB_BA1: MSGB1554CS 36548 L78814 Mycobacterium leprae cosmid B1554 DNA sequence. Mycobacterium leprae 36,900 15-Jun-96 GB_BA1: MSGB1551CS 36548 L78813 Mycobacterium leprae cosmid B1551 DNA sequence. Mycobacterium leprae 36,900 15-Jun-96 rxa02683 rxa02685 780 GB_HTG3: AC008640 198483 AC008640 Homo sapiens chromosome 5 clone CIT978SKB_17P2, Homo sapiens 37,299 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 70 unordered pieces. GB_HTG3: AC008640 198483 AC008640 Homo sapiens chromosome 5 clone CIT978SKB_17P2, Homo sapiens 37,299 3-Aug-99 *** SEQUENCING IN PROGRESS ***, 70 unordered pieces. GB_BA2: AE000945 11317 AE000945 Archaeoglobus fulgidus section 162 of 172 of the complete genome. Archaeoglobus fulgidus 38,760 15-DEC-1997 rxa02688 792 GB_BA1: CORPHEA 1088 M13774 C. glutamicum pheA gene encoding prephenate dehydratase, complete cds. Corynebacterium 100,000 26-Apr-93 glutamicum GB_HTG2: AC007554 167095 AC007554 Homo sapiens clone hRPK.74_A_1, *** Homo sapiens 35,226 14-MAY-1999 SEQUENCING IN PROGRESS ***, 10 unordered pieces. GB_HTG2: AC007554 167095 AC007554 Homo sapiens clone hRPK.74_A_1, Homo sapiens 35,226 14-MAY-1999 *** SEQUENCING IN PROGRESS ***, 10 unordered pieces. rxa02689 465 GB_GSS9: AQ110873 414 AQ110873 CIT-HSP-2378K10.TR CIT-HSP Homo sapiens genomic Homo sapiens 34,768 29-Aug-98 clone 2378K10, genomic survey sequence. GB_OV: DUKFASA 9138 M21635 Duck (A. platyrhynchos) S-acyl fatty acid synthase Anas platyrhynchos 39,177 28-Apr-93 thioesterase gene, complete cds. GB_OV: DUKFASA 9138 M21635 Duck (A. platyrhynchos) S-acyl fatty acid Anas platyrhynchos 35,022 28-Apr-93 synthase thioesterase gene, complete cds. rxa02690 1221 GB_HTG4: AC010096 223607 AC010096 Homo sapiens chromosome unknown clone NH0364A16, Homo sapiens 39,301 29-OCT-1999 WORKING DRAFT SEQUENCE, in unordered pieces. GB_HTG4: AC010096 223607 AC010096 Homo sapiens chromosome unknown clone Homo sapiens 39,301 29-OCT-1999 NH0364A16, WORKING DRAFT SEQUENCE, in unordered pieces. GB_BA2: AF132788 1411 AF132788 Fischerella muscicola small subunit ribosomal Fischerella muscicola 36,156 1-Sep-99 RNA gene, partial sequence. rxa02693 1899 GB_GSS5: AQ784372 542 AQ784372 HS_3181_A2_H12_T7C CIT Approved Human Genomic Sperm Homo sapiens 41,546 3-Aug-99 Library D Homo sapiens genomic clone Plate = 3181 Col = 24 Row = O, genomic survey sequence. GB_HTG4: AC010573 80511 AC010573 Drosophila melanogaster chromosome 3L/70C12 clone Drosophila melanogaster 36,839 16-OCT-1999 RPCI98-2M13, *** SEQUENCING IN PROGRESS ***, 45 unordered pieces. GB_EST18: AA696238 640 AA696238 GM05354.5prime GM Drosophila melanogaster ovary BlueScript Drosophila melanogaster 39,523 28-Nov-98 Drosophila melanogaster cDNA clone GM05354 5prime, mRNA sequence. rxa02696 579 GB_BA1: AB003132 4116 AB003132 Corynebacterium glutamicum gene for MurC, FtsQ, FtsZ, complete cds. Corynebacterium 100,000 4-Aug-97 glutamicum GB_PR4: AC006024 90583 AC006024 Homo sapiens PAC clone DJ1166G19 from 7p12-p11.2, complete sequence. Homo sapiens 36,049 20-Feb-99 GB_HTG1: HSJ657D12 315458 AL109943 Homo sapiens chromosome X clone RP4-657D12 Homo sapiens 36,475 24-Nov-99 map q22.1-24, *** SEQUENCING IN PROGRESS ***, in unordered pieces. rxa02697 1650 GB_EST20: AA874010 365 AA874010 vw87b05.r1 Stratagene mouse skin (#937313) Mus musculus Mus musculus 39,452 19-MAR-1998 cDNA clone IMAGE: 1261905 5′, mRNA sequence. GB_EST30: AI658486 599 AI658486 tu17a09.x1 NCI_CGAP_Pr28 Homo sapiens cDNA clone Homo sapiens 37,324 10-MAY-1999 IMAGE: 2251288 3′, mRNA sequence. GB_EST20: AA874010 365 AA874010 vw87b05.r1 Stratagene mouse skin (#937313) Mus musculus cDNA Mus musculus 39,452 19-MAR-1998 clone IMAGE: 1261905 5′, mRNA sequence. rxa02700 1359 GB_BA1: SCF85 21420 AL110470 Streptomyces coelicolor cosmid F85. Streptomyces coelicolor 39,497 1-Sep-99 A3(2) GB_HTG5: AC011629 69344 AC011629 Homo sapiens chromosome 15 clone 334_M_8 Homo sapiens 37,462 13-Nov-99 map 15, LOW-PASS SEQUENCE SAMPLING. GB_HTG3: AC010106 157581 AC010106 Homo sapiens clone NH0575J05, Homo sapiens 36,220 11-Sep-99 *** SEQUENCING IN PROGRESS ***, 1 unordered pieces. rxa02701 1431 GB_BA1: MTCI65 34331 Z95584 Mycobacterium tuberculosis H37Rv complete genome; Mycobacterium 41,867 17-Jun-98 segment 50/162. tuberculosis GB_BA1: MSGY348 40056 AD000020 Mycobacterium tuberculosis sequence from clone y348. Mycobacterium 43,338 10-DEC-1996 tuberculosis GB_PR2: AP000117 151516 AP000117 Homo sapiens genomic DNA of 21q22.1, GART and AML related, Homo sapiens 36,037 25-Sep-99 Q78C10-149C3 region, segment 20/20, complete sequence. rxa02712 918 GB_BA2: AF124600 4115 AF124600 Corynebacterium glutamicum chorismate synthase (aroC), Corynebacterium 37,294 04-MAY-1999 shikimate kinase (aroK), and 3-dehydroquinate synthase (aroB) genes, complete cds; and putative cytoplasmic peptidase (pepQ) glutamicum gene, partial cds. GB_BA2: AF053071 1083 AF053071 Corynebacterium glutamicum dehydroquinate synthetase Corynebacterium 39,675 12-Sep-98 (aroB) gene, complete cds. glutamicum GB_BA1: BSTHRZ 19861 Z80360 B. subtilis thrZ downstream chromosomal region. Bacillus subtilis 34,002 24-Jun-98 rxa02714 552 GB_PL2: ATF9F13 109936 AL080253 Arabidopsis thaliana DNA chromosome 4, BAC clone F9F13 (ESSA project). Arabidopsis thaliana 39,252 16-Aug-99 GB_PL2: ATT29H11 87011 AL049659 Arabidopsis thaliana DNA chromosome 3, BAC clone T29H11. Arabidopsis thaliana 34,249 9-Jun-99 GB_EST4: H37460 489 H37460 15589 Lambda-PRL2 Arabidopsis thaliana cDNA clone Arabidopsis thaliana 45,869 30-DEC-1997 181N17T7, mRNA sequence. rxa02715 513 GB_GSS13: AQ454067 534 AQ454067 HS_5176_B1_A09_T7A RPCI-11 Human Male BAC Library Homo sapiens 40,854 21-Apr-99 Homo sapiens genomic clone Plate = 752 Col = 17 Row = B, genomic survey sequence. GB_PR3: AC005495 185254 AC005495 Homo sapiens chromosome 17, clone hRPK.293_K_20, complete sequence. Homo sapiens 33,200 30-OCT-1998 GB_PR3: AC005495 185254 AC005495 Homo sapiens chromosome 17, clone hRPK.293_K_20, complete sequence. Homo sapiens 36,273 30-OCT-1998 rxa02720 825 GB_BA1: AB003132 4116 AB003132 Corynebacterium glutamicum gene for MurC, FtsQ, FtsZ, complete cds. Corynebacterium 98,788 4-Aug-97 glutamicum GB_BA1: BLFTSZ 5546 Y08964 B. lactofermentum murC, ftsQ or divD & ftsZ genes. Corynebacterium 100,000 08-OCT-1998 glutamicum GB_HTG4: AC009764 213581 AC009764 Homo sapiens chromosome 11 clone 381_O_22 map 11, Homo sapiens 35,504 21-OCT-1999 *** SEQUENCING IN PROGRESS ***, 40 unordered pieces. rxa02721 861 GB_BA1: BLFTSZ 5546 Y08964 B. lactofermentum murC, ftsQ or divD & ftsZ genes. Corynebacterium 98,606 08-OCT-1998 glutamicum GB_BA1: AB003132 4116 AB003132 Corynebacterium glutamicum gene for MurC, FtsQ, FtsZ, complete cds. Corynebacterium 97,561 4-Aug-97 glutamicum GB_BA1: SCI51 40745 AL109848 Streptomyces coelicolor cosmid I51. Streptomyces coelicolor 39,110 16-Aug-99 A3(2) rxa02725 735 GB_BA1: CGU43535 2531 U43535 Corynebacterium glutamicum multidrug resistance protein (cmr) gene, complete cds. Corynebacterium 42,043 9-Apr-97 glutamicum GB_EST1: D40448 361 D40448 RICS2437A Rice shoot Oryza sativa cDNA, mRNA sequence. Oryza sativa 41,944 11-Nov-94 GB_BA2: AF038430 8330 AF038430 Thiobacillus neapolitanus carboxysome operon, complete sequence. Thiobacillus neapolitanus 39,202 21-Aug-98 rxa02727 1035 GB_BA1: MTCY270 37586 Z95388 Mycobacterium tuberculosis H37Rv complete genome; segment 96/162. Mycobacterium 37,427 10-Feb-99 tuberculosis GB_BA1: MTAG84 1458 X77129 M. tuberculosis Ag84 (CIE) gene. Mycobacterium 49,339 21-Jul-95 tuberculosis GB_BA1: AP000064 247695 AP000064 Aeropyrum pernix genomic DNA, section 7/7. Aeropyrum pernix 38,790 22-Jun-99 rxa02735 828 GB_BA1: TVCPT 1923 X56901 T. vulgaris cpT gene for carboxypeptidase T. Thermoactinomyces 37,688 30-OCT-1991 vulgaris GB_GSS4: AQ682162 355 AQ682162 HS_5503_B2_C11_SP6E RPCI-11 Human Male BAC Homo sapiens 35,294 28-Jun-99 Library Homo sapiens genomic clone Plate = 1079 Col = 22 Row = F, genomic survey sequence. GB_EST21: AA915356 456 AA915356 vz29a08.r1 Soares 2NbMT Mus musculus cDNA clone IMAGE: Mus musculus 42,609 14-Apr-98 1327862 5′, mRNA sequence. rxa02736 1080 GB_PAT: E13655 2260 E13655 gDNA encoding Corynebacterium 99,620 24-Jun-98 glucose-6-phosphate dehydrogenase. glutamicum GB_GSS13: AQ447106 711 AQ447106 mgxb0004P18f CUGI Rice Blast BAC Library Magnaporthe grisea 38,158 8-Apr-99 Magnaporthe grisea genomic clone mgxb0004P18f, genomic survey sequence. GB_EST36: AI900850 670 AI900850 sb95c03.y1 Gm-c1012 Glycine max cDNA clone Glycine max 37,479 06-DEC-1999 GENOME SYSTEMS CLONE ID: Gm-c1012-413 5′ similar to SW: IF4Z_TOBAC Q40468 EUKARYOTIC INITIATION FACTOR 4A-15;, mRNA sequence. rxa02744 927 GB_PR1: AB026898 270000 AB026898 Homo sapiens DNA, DLEC1 to ORCTL4 gene region, Homo sapiens 39,364 15-MAY-1999 section 1/2 (DLEC1, ORCTL3, ORCTL4 genes, complete cds). GB_PR1: AB026898 270000 AB026898 Homo sapiens DNA, DLEC1 to ORCTL4 gene region, Homo sapiens 36,275 15-MAY-1999 section 1/2 (DLEC1, ORCTL3, ORCTL4 genes, complete cds). GB_PR2: AP000498 100000 AP000498 Homo sapiens genomic DNA, chromosome 3p21.3, clone: 603 to Homo sapiens 39,364 28-Sep-99 320, anti-oncogene region, section 1/3. rxa02751 597 GB_HTG4: AC010127 189552 AC010127 Homo sapiens chromosome unknown clone Homo sapiens 36,149 29-OCT-1999 NH0002I08, WORKING DRAFT SEQUENCE, in unordered pieces. GB_HTG4: AC010127 189552 AC010127 Homo sapiens chromosome unknown clone Homo sapiens 36,149 29-OCT-1999 NH0002I08, WORKING DRAFT SEQUENCE, in unordered pieces. GB_HTG4: AC010127 189552 AC010127 Homo sapiens chromosome unknown clone NH0002I08, Homo sapiens 35,924 29-OCT-1999 WORKING DRAFT SEQUENCE, in unordered pieces. rxa02756 1014 GB_RO: CRUGIPR 2785 D38103 Hamster mRNA for GIP (gastric inhibitory Cricetulus sp. 38,501 8-Feb-99 polypeptide) receptor, complete cds. GB_HTG1: CNS01DRV 224372 AL118558 Homo sapiens chromosome 14 clone R-1017G21, *** Homo sapiens 38,667 15-OCT-1999 SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG1: CNS01DRV 224372 AL118558 Homo sapiens chromosome 14 clone R-1017G21, *** Homo sapiens 38,667 15-OCT-1999 SEQUENCING IN PROGRESS ***, in unordered pieces. rxa02757 669 GB_RO: RNU35245 2051 U35245 Rat vacuolar protein sorting homolog r-vps33b mRNA, complete cds. Rattus norvegicus 39,058 15-Jan-97 GB_RO: RNU35245 2051 U35245 Rat vacuolar protein sorting homolog r-vps33b mRNA, complete cds. Rattus norvegicus 37,481 15-Jan-97 rxa02765 882 GB_EST4: H46883 459 H46883 yo19f06.r1 Soares adult brain N2b5HB55Y Homo sapiens cDNA Homo sapiens 40,132 31-Jul-95 clone IMAGE: 178403 5′, mRNA sequence. GB_PL1: NTA6235 3931 AJ006235 Nicotiana tabacum DNA fragment for K-alpha right T-DNA border. Nicotiana tabacum 34,247 6-Feb-99 GB_HTG3: AC011519 57287 AC011519 Homo sapiens chromosome 19 clone LLNL-F_192H5, *** Homo sapiens 38,497 07-OCT-1999 SEQUENCING IN PROGRESS ***, 36 unordered pieces. rxa02766 516 GB_GSS13: AQ489419 554 AQ489419 RPCI-11-246A3.TV RPCI-11 Homo sapiens genomic clone Homo sapiens 37,821 24-Apr-99 RPCI-11-246A3, genomic survey sequence. GB_PR3: HS90L6 190837 Z97353 Human DNA sequence from clone 90L6 on chromosome 22q11.21-11.23. Homo sapiens 38,160 23-Nov-99 Contains an RPL15 (60S Ribosomal Protein L15) pseudogene, ESTs, STSs and GSSs, complete sequence. GB_BA1: MTCY373 35516 Z73419 Mycobacterium tuberculosis H37Rv complete genome; segment 57/162. Mycobacterium 36,701 17-Jun-98 tuberculosis rxa02770 1689 GB_BA2: AF038651 4077 AF038651 Corynebacterium glutamicum dipeptide-binding Corynebacterium 100,000 14-Sep-98 protein (dciAE) gene, partial cds; adenine phosphoribosyltransferase (apt) and GTP pyrophosphokinase (rel) genes, complete cds; and glutamicum unknown gene. GB_OV: AF061275 6756 AF061275 Ictalurus punctatus estrogen receptor type alpha mRNA, complete cds. Ictalurus punctatus 37,117 31-OCT-1998 GB_RO: MMSCSELN4 3840 X61756 M. musculus rearranged T-cell receptor beta variable region (Vb17a). Mus musculus 37,933 03-DEC-1991 rxa02774 494 GB_HTG2: AF129408 138685 AF129408 Homo sapiens chromosome 21 clone PAC 31K18 map 21q22.3, Homo sapiens 38,241 04-MAR-1999 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG2: AF129408 138685 AF129408 Homo sapiens chromosome 21 clone PAC 31K18 map 21q22.3, Homo sapiens 38,241 04-MAR-1999 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_PR3: AF064859 122571 AF064859 Homo sapiens chromosome 21q22.3 PAC 141B3, complete sequence, Homo sapiens 37,910 2-Jun-98 containing ribosomal protein homologue pseudogene L23a. rxa02775 348 GB_PR3: HSU19F10 31474 Z81145 Human DNA sequence from cosmid U19F10, Homo sapiens 36,443 23-Nov-99 between markers DXS366 and DXS87 on chromosome X contains ESTs. GB_EST11: AA211850 293 AA211850 zr90e04.s1 NCI_CGAP_GCB1 Homo sapiens cDNA clone Homo sapiens 30,479 13-Aug-97 IMAGE: 682974 3′ similar to TR: G1224065 G1224065 MER37 TRANSPOSABLE ELEMENT, COMPLETE CONSENSUS SEQUENCE.;, mRNA sequence. GB_EST13: AA372532 400 AA372532 EST84441 Colon adenocarcinoma IV Homo sapiens cDNA Homo sapiens 40,104 21-Apr-97 5′ end, mRNA sequence. rxa02776 465 GB_GSS9: AQ096114 383 AQ096114 HS_3030_A2_D11_MF CIT Approved Human Genomic Sperm Library Homo sapiens 44,643 27-Aug-98 D Homo sapiens genomic clone Plate = 3030 Col = 22 Row = G, genomic survey sequence. GB_RO: AF139518 8827 AF139518 Rattus norvegicus A-kinase anchor protein mRNA, complete cds. Rattus norvegicus 39,722 16-Jun-99 GB_EST32: AI728295 564 AI728295 BNLGHi10386 Six-day Cotton fiber Gossypium hirsutum cDNA Gossypium hirsutum 37,049 11-Jun-99 5′ similar to (AF076274) contains similarity to rat p47 protein (GB: AB002086) [Arabidopsis thaliana], mRNA sequence. rxa02777 1230 GB_HTG3: AC009407 207973 AC009407 Homo sapiens clone NH0223I10, *** Homo sapiens 39,784 21-Aug-99 SEQUENCING IN PROGRESS ***, 16 unordered pieces. GB_HTG3: AC009407 207973 AC009407 Homo sapiens clone NH0223I10, *** SEQUENCING IN Homo sapiens 39,784 21-Aug-99 PROGRESS ***, 16 unordered pieces. GB_BA2: AE001137 44380 AE001137 Borrelia burgdorferi (section 23 of 70) Borrelia burgdorferi 39,105 15-DEC-1997 of the complete genome. rxa02778 348 GB_EST37: AI940900 668 AI940900 sb79d08.y1 Gm-c1010 Glycine max cDNA clone GENOME Glycine max 35,036 3-Aug-99 SYSTEMS CLONE ID: Gm-c1010-1192 5′ similar to SW: ITRA_SOYBN P01070 TRYPSIN INHIBITORS A AND C PRECURSOR;, mRNA sequence. GB_HTG4: AC008940 131864 AC008940 Homo sapiens chromosome 5 clone CITB-H1_2319M24, *** Homo sapiens 33,043 31-OCT-1999 SEQUENCING IN PROGRESS ***, 3 ordered pieces. GB_HTG4: AC008940 131864 AC008940 Homo sapiens chromosome 5 clone CITB-H1_2319M24, *** Homo sapiens 33,043 31-OCT-1999 SEQUENCING IN PROGRESS ***, 3 ordered pieces. rxa02779 402 GB_PR1: AB020876 100000 AB020876 Homo sapiens genomic DNA of 9q32 anti-oncogene of flat Homo sapiens 35,000 21-MAY-1999 epitherium cancer, segment 8/10. GB_EST26: AI339126 415 AI339126 qt06d03.x1 NCI_CGAP_GC4 Homo sapiens cDNA clone IMAGE: Homo sapiens 35,876 29-DEC-1998 1946789 3′ similar to gb: L25444 60S RIBOSOMAL PROTEIN L35A (HUMAN);, mRNA sequence. GB_PR1: AB020876 100000 AB020876 Homo sapiens genomic DNA of 9q32 anti-oncogene of Homo sapiens 35,678 21-MAY-1999 flat epitherium cancer, segment 8/10. rxa02780 450 GB_GSS14: AQ524732 591 AQ524732 HS_5236_A1_D09_SP6E RPCI-11 Human Male BAC Homo sapiens 39,726 11-MAY-1999 Library Homo sapiens genomic clone Plate = 812 Col = 17 Row = G, genomic survey sequence. GB_PR4: AC006051 38903 AC006051 Homo sapiens 12p13.3 PAC RPCI5-1103G8 (Roswell Park Homo sapiens 35,068 26-Nov-98 Cancer Institute Human PAC Library) complete sequence. GB_PR4: AC006051 38903 AC006051 Homo sapiens 12p13.3 PAC RPCI5-1103G8 (Roswell Park Homo sapiens 37,273 26-Nov-98 Cancer Institute Human PAC Library) complete sequence. rxa02781 1314 GB_VI: BHV1CGEN 135301 AJ004801 Bovine herpesvirus 1 complete genome. Bovine herpesvirus type 41,053 11-Jan-99 1.1 GB_BA1: SHGCPIR 107379 X86780 S. hygroscopicus gene cluster for polyketide immunosuppressant rapamycin. Streptomyces 40,551 16-Aug-96 hygroscopicus GB_BA1: SHGCPIR 107379 X86780 S. hygroscopicus gene cluster for polyketide immunosuppressant rapamycin. Streptomyces 39,598 16-Aug-96 hygroscopicus rxa02782 1422 GB_IN1: DSV28T23 5218 X60176 D. silvestris clone U28T2 non-LTR retrotransposon DNA (5218 bp). Drosophila silvestris 38,695 25-MAR-1992 GB_IN1: DSV28T24 7779 X60177 D. silvestris clone U28T2 non-LTR retrotransposon DNA (7779 bp). Drosophila silvestris 38,844 30-Nov-93 GB_BA2: MPU34795 24888 U34795 Mycoplasma pneumoniae cosmid pcosMPGT9 25 kb EcoRI fragment. Mycoplasma pneumoniae 37,832 06-MAR-1996 rxa02783 672 GB_EST2: R13483 481 R13483 yf77g03.r1 Soares infant brain 1NIB Homo sapiens cDNA clone Homo sapiens 36,243 12-Apr-95 IMAGE: 28494 5′, mRNA sequence. GB_HTG3: AC011333 159160 AC011333 Homo sapiens chromosome 5 clone CIT-HSPC_229L21, Homo sapiens 38,246 06-OCT-1999 *** SEQUENCING IN PROGRESS ***, 23 unordered pieces. GB_HTG3: AC011333 159160 AC011333 Homo sapiens chromosome 5 clone CIT-HSPC_229L21, Homo sapiens 38,246 06-OCT-1999 *** SEQUENCING IN PROGRESS ***, 23 unordered pieces. rxa02784 309 GB_PR3: HS474A14 107352 AL023285 Human DNA sequence from clone 474A14 on chromosome Homo sapiens 37,868 23-Nov-99 1q24.1-25.2 Contains EST, CA repeat, 5′UTR (tenascin-R), GSS, complete sequence. GB_GSS12: AQ374565 441 AQ374565 RPCI-11-159P12.TV RPCI-11 Homo sapiens genomic clone Homo sapiens 36,522 20-MAY-1999 RPCI-11-159P12, genomic survey sequence. GB_GSS5: AQ780184 686 AQ780184 HS_3138_B1_F11_MR CIT Approved Human Genomic Sperm Homo sapiens 44,186 2-Aug-99 Library D Homo sapiens genomic clone Plate = 3138 Col = 21 Row = L, genomic survey sequence. rxa02786 830 GB_PL1: SCYBL033C 1794 Z35794 S. cerevisiae chromosome II reading frame ORF YBL033c. Saccharomyces cerevisiae 39,264 11-MAR-1998 GB_PL1: ECRIB1GN 1747 Z21617 S. cerevisiae RIB1 gene encoding GTP cyclohydrolase II. Saccharomyces cerevisiae 37,118 28-Jan-95 GB_PAT: A38763 1747 A38763 Sequence 1 from Patent WO9411515. Saccharomyces cerevisiae 37,118 05-MAR-1997 rxa02789 669 GB_EST34: AV146372 295 AV146372 AV146372 Mus musculus C57BL/6J 10-11 day embryo Mus musculus Mus musculus 65,432 3-Jul-99 cDNA clone 2810453K19, mRNA sequence. GB_GSS5: AQ785226 524 AQ785226 HS_2025_B2_A07_T7C CIT Approved Human Genomic Sperm Homo sapiens 40,342 3-Aug-99 Library D Homo sapiens genomic clone Plate = 2025 Col = 14 Row = B, genomic survey sequence. GB_BA1: SCE94 38532 AL049628 Streptomyces coelicolor cosmid E94. Streptomyces coelicolor 35,346 12-Apr-99 rxa02793 825 GB_HTG2: AC006514 247029 AC006514 Homo sapiens clone RPCI11-656E20, *** SEQUENCING Homo sapiens 33,742 1-Apr-99 IN PROGRESS ***, 90 unordered pieces. GB_HTG2: AC006514 247029 AC006514 Homo sapiens clone RPCI11-656E20, *** Homo sapiens 33,742 1-Apr-99 SEQUENCING IN PROGRESS ***, 90 unordered pieces. GB_EST22: AI033150 384 AI033150 ow94b01.s1 Soares_fetal_liver_spleen_1NFLS_S1 Homo sapiens 38,951 28-Aug-98 Homo sapiens cDNA clone IMAGE: 1654441 3′ similar to TR: O02711 O02711 PRO-POL-DUTPASE POLYPROTEIN;, mRNA sequence. rxa02796 672 GB_OV: AF172144 1101 AF172144 Xenopus laevis potassium channel beta 2 subunit mRNA, partial cds. Xenopus laevis 40,000 25-Sep-99 GB_HTG1: AP000572 84439 AP000572 Homo sapiens chromosome 11 clone P28D2 map 11q13, Homo sapiens 35,725 09-OCT-1999 *** SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG1: AP000572 84439 AP000572 Homo sapiens chromosome 11 clone P28D2 map 11q13, Homo sapiens 35,725 09-OCT-1999 *** SEQUENCING IN PROGRESS ***, in unordered pieces. rxa02798 1548 GB_EST10: AA155097 322 AA155097 mr24h12.r1 Soares mouse 3NbMS Mus musculus cDNA clone IMAGE: Mus musculus 41,195 16-Feb-97 598439 5′, mRNA sequence. GB_GSS9: AQ150317 489 AQ150317 HS_3178_B1_F12_T7 CIT Approved Human Genomic Sperm Homo sapiens 39,549 08-OCT-1998 Library D Homo sapiens genomic clone Plate = 3178 Col = 23 Row = L, genomic survey sequence. GB_BA2: AE001731 10186 AE001731 Thermotoga maritima section 43 of 136 of the complete genome. Thermotoga maritima 35,747 2-Jun-99 rxa02799 396 GB_IN2: AF139876 1562 AF139876 Giardia intestinalis histone H4 gene, complete cds. Giardia intestinalis 34,848 02-OCT-1999 GB_HTG5: AC011614 176606 AC011614 Drosophila melanogaster chromosome X clone BACR48L05 (D1142) Drosophila melanogaster 38,817 19-Nov-99 RPCI-98 48.L.5 map 16F-17A strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 114 unordered pieces. GB_GSS10: AQ254726 565 AQ254726 EP(3)3517 Drosophila melanogaster EP line Drosophila melanogaster 38,798 28-Jun-99 Drosophila melanogaster genomic Sequence recovered from Both 5′ and 3′ ends of P element, genomic survey sequence. rxa02812 rxa02815 552 GB_BA2: PAU32853 1961 U32853 Pseudomonas aeruginosa mucC and mucD genes, complete cds. Pseudomonas aeruginosa 39,925 06-MAR-1996 GB_BA2: PAU49151 4587 U49151 Pseudomonas aeruginosa alternate sigma factor (algU), mucA, Pseudomonas aeruginosa 39,925 13-MAR-1996 mucB, mucC and mucD genes, complete cds. GB_BA2: PAU49151 4587 U49151 Pseudomonas aeruginosa alternate sigma factor (algU), mucA, Pseudomonas aeruginosa 35,922 13-MAR-1996 mucB, mucC and mucD genes, complete cds. rxa02817 499 GB_BA1: CORAIA 4705 L09232 Corynebacterium glutamicum acetohydroxy acid synthase (ilvB) and Corynebacterium 38,554 23-Feb-95 (ilvN) genes, and acetohydroxy acid isomeroreductase (ilvC) gene, complete cds. glutamicum GB_EST22: AI004214 475 AI004214 ot94h01.x1 Soares_total_fetus_Nb2HF8_9w Homo sapiens cDNA Homo sapiens 51,092 27-Aug-98 clone IMAGE: 1624465 3′, mRNA sequence. GB_EST27: AI457904 455 AI457904 tj48b08.x1 Soares_NSF_F8_9W_OT_PA_P_S1 Homo sapiens Homo sapiens 37,381 13-Apr-99 cDNA clone IMAGE: 2144727 3′, mRNA sequence. rxa02818 606 GB_PL1: MZEADH1CM 6167 M32984 Z. mays alcohol dehydrogenase (ADH-1 C-m allele) gene, complete cds. Zea mays 33,111 27-Apr-93 GB_PL1: ZMADH1ALL 6158 X17556 Z. mays DNA for Adh1-Cm allele. Zea mays 33,111 23-Jan-92 GB_PL1: MZEADH1CM 6167 M32984 Z. mays alcohol dehydrogenase (ADH-1 C-m allele) gene, complete cds. Zea mays 38,065 27-Apr-93 rxa02823 370 GB_PL2: AF077130 4392 AF077130 Oryza sativa receptor-like protein kinase gene, complete cds. Oryza sativa 33,243 25-Jul-98 GB_HTG1: CNS00M8S 214599 AL079302 Homo sapiens chromosome 14 clone R-1089B7, Homo sapiens 38,420 15-OCT-1999 *** SEQUENCING IN PROGRESS ***, in ordered pieces. GB_HTG1: CNS00M8S 214599 AL079302 Homo sapiens chromosome 14 clone R-1089B7, Homo sapiens 38,420 15-OCT-1999 *** SEQUENCING IN PROGRESS ***, in ordered pieces. rxa02825 1962 GB_PL1: ZMU17350 1289 U17350 Zea mays thiamine biosynthetic enzyme (thi1-1) mRNA, complete cds. Zea mays 40,710 12-Apr-96 GB_GSS13: AQ440082 432 AQ440082 HS_5080_B1_B12_SP6E RPCI-11 Human Homo sapiens 41,121 31-MAR-1999 Male BAC Library Homo sapiens genomic clone Plate = 656 Col = 23 Row = D, genomic survey sequence. GB_EST10: AA141278 579 AA141278 CK01542.3prime CK Drosophila melanogaster embryo Drosophila melanogaster 42,424 29-Nov-98 BlueScript Drosophila melanogaster cDNA clone CK01542 3prime, mRNA sequence. rxa02827 523 GB_BA2: AF054624 6984 AF054624 Lactobacillus sakel transcription-repair coupling Lactobacillus sakel 37,241 12-Jan-99 factor (mfd) gene, partial cds; L-lactate dehydrogenase (ldhL) gene, complete cds; and unknown genes. GB_BA2: AF023181 6616 AF023181 Listeria monocytogenes transcription-repair coupling factor (mfdL), Listeria monocytogenes 61,228 1-Jan-99 low temperature requirement B protein (ltrB), and DivIC homolog (divL) genes, complete cds. GB_HTG3: AC009213 114735 AC009213 Drosophila melanogaster chromosome 3 clone BACR09F18 Drosophila melanogaster 32,427 23-Aug-99 (D812) RPCI-98 09.F.18 map 98D-98D strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 109 unordered pieces. rxa02838 528 GB_BA2: AE000069 12230 AE000069 Rhizobium sp. NGR234 plasmid pNGR234a, section 6 Rhizobium sp. NGR234 57,803 12-DEC-1997 of 46 of the complete plasmid sequence. GB_OM: SSU19994 2004 U19994 Sus scrofa p55 TNF receptor mRNA, complete cds. Sus scrofa 34,848 30-Jan-96 GB_BA2: AE000069 12230 AE000069 Rhizobium sp. NGR234 plasmid pNGR234a, section Rhizobium sp. NGR234 36,505 12-DEC-1997 6 of 46 of the complete plasmid sequence. rxa02840 273 GB_BA2: ECU73857 128824 U73857 Escherichia coli chromosome minutes 6-8. Escherichia coli 100,000 14-Jul-99 GB_BA2: AE000145 11448 AE000145 Escherichia coli K-12 MG1655 section 35 of 400 of the complete genome. Escherichia coli 100,000 12-Nov-98 GB_BA1: ECORFABC 3044 X76979 E. coli orf302, 0rf303 and orf101 sequence. Escherichia coli 40,672 28-Aug-96 rxa02841 558 GB_GSS4: AQ724171 407 AQ724171 HS_5380_B1_H09_SP6E RPCI-11 Human Male Homo sapiens 35,135 14-Jul-99 BAC Library Homo sapiens genomic clone Plate = 956 Col = 17 Row = P, genomic survey sequence. GB_PL1: PSFERR 1023 X64417 P. sativum mRNA for ferritin. Pisum sativum 41,985 30-Jun-93 GB_PL1: PSFERRI 1023 X73369 P. sativum mRNA for ferritin. Pisum sativum 41,985 21-Jul-95 rxa02842 365 GB_EST32: AI723928 435 AI723928 RHIZ1_35_B10.y1_A001 Rhizome1 Sorghum halepense 32,616 11-Jun-99 Sorghum halepense cDNA, mRNA sequence. GB_PR2: HS212A2 212753 Z95114 Human DNA sequence from clone 212A2 on chromosome Homo sapiens 38,279 23-Nov-99 22q12 Contains gene for TNF-inducible protein CG12-1, 3′ end of a gene similar to apolipoprotein L, ESTs, STSs, CA repeat, GSSs and CpG islands, complete sequence. GB_OV: AF116856 4634 AF116856 Gallus gallus neurocan core protein precursor, mRNA, complete cds. Gallus gallus 41,176 20-MAY-1999 rxa02845 615 GB_PR3: AC005934 43699 AC005934 Homo sapiens chromosome 19, cosmid R30813, complete sequence. Homo sapiens 35,225 5-Nov-98 GB_PR3: AC005340 36705 AC005340 Homo sapiens chromosome 19, cosmid F19544, complete sequence. Homo sapiens 35,225 30-Jul-98 GB_PR3: AC005934 43699 AC005934 Homo sapiens chromosome 19, cosmid R30813, complete sequence. Homo sapiens 39,153 5-Nov-98 rxa02846 873 GB_GSS5: AQ749564 838 AQ749564 HS_5575_A1_B11_SP6 RPCI-11 Human Male BAC Homo sapiens 36,286 19-Jul-99 Library Homo sapiens genomic clone Plate = 1151 Col = 21 Row = C, genomic survey sequence. GB_GSS5: AQ749564 838 AQ749564 HS_5575_A1_B11_SP6 RPCI-11 Human Male Homo sapiens 38,591 19-Jul-99 BAC Library Homo sapiens genomic clone Plate = 1151 Col = 21 Row = C, genomic survey sequence. rxa02847 1135 GB_BA1: MSGB13GS 42923 L78823 Mycobacterium leprae cosmid B13 DNA sequence. Mycobacterium leprae 47,559 15-Jun-96 GB_HTG4: AC009557 128590 AC009557 Homo sapiens chromosome 15 clone 76_D_16 Homo sapiens 36,289 25-OCT-1999 map 15, LOW-PASS SEQUENCE SAMPLING. GB_HTG4: AC009557 128590 AC009557 Homo sapiens chromosome 15 clone 76_D_16 Homo sapiens 36,289 25-OCT-1999 map 15, LOW-PASS SEQUENCE SAMPLING. rxa02848 499 GB_BA1: AB018531 4961 AB018531 Corynebacterium glutamicum dtsR1 and dtsR2 genes, complete cds. Corynebacterium 98,397 19-OCT-1998 glutamicum GB_PAT: E17019 4961 E17019 Brevibacterium lactofermentum dtsR and dtsR2 genes. Corynebacterium 98,397 28-Jul-99 glutamicum GB_OM: CFU08596 1780 U08596 Canis familiaris delayed rectifier K+ channel mRNA, partial cds. Canis familiaris 43,265 21-DEC-1994 rxa02849 305 GB_VI: AF121950 9395 AF121950 Hepatitis G virus strain lowan, complete genome. Hepatitis G virus 33,110 24-MAY-1999 GB_PAT: AR049304 9327 AR049304 Sequence 234 from patent U.S. Pat. No. 5824507. Unknown. 31,803 29-Sep-99 GB_PAT: AR026878 9327 AR026878 Sequence 234 from patent U.S. Pat. No. 5856134. Unknown. 31,803 29-Sep-99 

1. An isolated nucleic acid molecule selected from the group consisting of a) an isolated nucleic acid molecule from Corynebacterium glutamicum encoding an MCP protein, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1, or a complement thereof; b) an isolated Corynebacterium glutamicum nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of those sequences set forth in Appendix A, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1, or a complement thereof; c) an isolated nucleic acid molecule which encodes a polypeptide comprising an amino acid sequence selected from the group consisting of those sequences set forth in Appendix B, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1, or a complement thereof; d) an isolated nucleic acid molecule which encodes a naturally occurring allelic variant of a polypeptide comprising an amino acid sequence selected from the group consisting of those sequences set forth in Appendix B, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1, or a complement thereof; e) an isolated nucleic acid molecule comprising a nucleotide sequence which is at least 50% identical to an entire nucleotide sequence selected from the group consisting of those sequences set forth in Appendix A, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1, or a complement thereof; and f) an isolated nucleic acid molecule comprising a fragment of at least 15 contiguous nucleotides of a nucleotide sequence selected from the group consisting of those sequences set forth in Appendix A, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1, or a complement thereof.
 2. The isolated nucleic acid molecule of claim 1, wherein said nucleic acid molecule from Corynebacterium glutamicum encodes an MCP protein involved in the production of a fine chemical.
 3. An isolated nucleic acid molecule comprising the nucleic acid molecule of claim 1 and a nucleotide sequence encoding a heterologous polypeptide.
 4. A vector comprising the nucleic acid molecule of claim
 1. 5. The vector of claim 4, which is an expression vector.
 6. A host cell transfected with the expression vector of claim
 5. 7. The host cell of claim 6, wherein said cell is a microorganism.
 8. The host cell of claim 7, wherein said cell belongs to the genus Corynebacterium or Brevibacterium.
 9. A method of producing a polypeptide comprising culturing the host cell of claim 6 in an appropriate culture medium to, thereby, produce the polypeptide.
 10. A method for producing a fine chemical, comprising culturing the cell of claim 6 such that the fine chemical is produced.
 11. The method of claim 10, wherein said method further comprises the step of recovering the fine chemical from said culture.
 12. The method of claim 10, wherein said cell belongs to the genus Corynebacterium or Brevibacterium.
 13. The method of claim 10, wherein said cell is selected from the group consisting of Corynebacterium glutamicum, Corynebacterium herculis, Corynebacterium, lilium, Corynebacterium acetoacidophilum, Corynebacterium acetoglutamicum, Corynebacterium acetophilum, Corynebacterium ammoniagenes, Corynebacterium fujiokense, Corynebacterium nitrilophilus, Brevibacterium ammoniagenes, Brevibacterium butanicum, Brevibacterium divaricatum, Brevibacterium flavum, Brevibacterium healii, Brevibacterium ketoglutamicum, Brevibacterium ketosoreductum, Brevibacterium lactofermentum, Brevibacterium linens, Brevibacterium paraffinolyticum, and those strains set forth in Table
 3. 14. The method of claim 10, wherein expression of the nucleic acid molecule from said vector results in modulation of production of said fine chemical.
 15. The method of claim 10, wherein said fine chemical is selected from the group consisting of organic acids, proteinogenic and nonproteinogenic amino acids, purine and pyrimidine bases, nucleosides, nucleotides, lipids, saturated and unsaturated fatty acids, diols, carbohydrates, aromatic compounds, vitamins, cofactors, polyketides, and enzymes.
 16. The method of claim 10, wherein said fine chemical is an amino acid selected from the group consisting of lysine, glutamate, glutamine, alanine, aspartate, glycine, serine, threonine, methionine, cysteine, valine, leucine, isoleucine, arginine, proline, histidine, tyrosine, phenylalanine, and tryptophan.
 17. An isolated polypeptide selected from the group consisting of a) an isolated MCP polypeptide from Corynebacterium glutamicum; b) an isolated polypeptide comprising an amino acid sequence selected from the group consisting of those sequences set forth in Appendix B, provided that the amino acid sequence is not encoded by any of the F-designated genes set forth in Table 1; c) an isolated polypeptide comprising a naturally occurring allelic variant of a polypeptide comprising an amino acid sequence selected from the group consisting of those sequences set forth in Appendix B, provided that the amino acid sequence is not encoded by any of the F-designated genes set forth in Table 1; d) an isolated polypeptide which is encoded by a nucleic acid molecule comprising a nucleotide sequence which is at least 50% identical to an entire nucleotide sequence selected from the group consisting of those sequences set forth in Appendix A, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1; e) an isolated polypeptide comprising an amino acid sequence which is at least 50% identical to an entire amino acid sequence selected from the group consisting of those sequences set forth in Appendix B, provided that the amino acid sequence is not encoded by any of the F-designated genes set forth in Table 1; and f) an isolated polypeptide comprising a fragment of a polypeptide comprising an amino acid sequence selected from the group consisting of those sequences set forth in Appendix B, provided that the amino acid sequence is not encoded by any of the F-designated genes set forth in Table 1, wherein said polypeptide fragment maintains a biological activity of the polypeptide comprising the amino sequence.
 18. The isolated polypeptide of claim 17, wherein said polypeptide is involved in the production of a fine chemical.
 19. The isolated polypeptide of claim 17, further comprising heterologous amino acid sequences.
 20. A method for diagnosing the presence or activity of Corynebacterium diphtheriae in a subject, comprising detecting the presence of at least one of the nucleic acid molecules of claim 1, thereby diagnosing the presence or activity of Corynebacterium diphtheriae in the subject.
 21. A method for diagnosing the presence or activity of Corynebacterium diphtheriae in a subject, comprising detecting the presence of at least one of the polypeptide molecules of claim 17, thereby diagnosing the presence or activity of Corynebacterium diphtheriae in the subject.
 22. A host cell comprising a nucleic acid molecule selected from the group consisting of a) a nucleic acid molecule set forth in Appendix A, wherein the nucleic acid molecule is disrupted by at least one technique selected from the group consisting of a point mutation, a truncation, an inversion, a deletion, an addition, a substitution and homologous recombination; b) a nucleic acid molecule set forth in Appendix A, wherein the nucleic acid molecule comprises one or more nucleic acid modifications as compared to the sequence set forth in Appendix A, wherein the modification is selected from the group consisting of a point mutation, a truncation, an inversion, a deletion, an addition and a substitution; and c) a nucleic acid molecule set forth in Appendix A, wherein the regulatory region of the nucleic acid molecule is modified relative to the wild-type regulatory region of the molecule by at least one technique selected from the group consisting of a point mutation, a truncation, an inversion, a deletion, an addition, a substitution and homologous recombination. 